CRIM1 (cysteine rich transmembrane BMP regulator 1)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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51232 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Cysteine rich transmembrane BMP regulator 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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CRIM1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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CRIM-1, S52 |
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Chromosome
Chromosome number
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2 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2p22.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth f |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt ID | Q9NZV1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein name | Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Protein function | May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its pr | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). {ECO:0000269|PubMed:10642437, ECO:0000269|PubMed:12464430}. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sequence |
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| Sequence length | 1036 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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