Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51232
Gene name Gene Name - the full gene name approved by the HGNC.
Cysteine rich transmembrane BMP regulator 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CRIM1
Synonyms (NCBI Gene) Gene synonyms aliases
CRIM-1, S52
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p22.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth f
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT004053 hsa-miR-20b-5p Luciferase reporter assay, qRT-PCR 21042576
MIRT004053 hsa-miR-20b-5p Luciferase reporter assay, qRT-PCR 21042576
MIRT006756 hsa-miR-20a-5p Luciferase reporter assay 21743293
MIRT006756 hsa-miR-20a-5p Luciferase reporter assay 21743293
MIRT020040 hsa-miR-375 Microarray 20215506
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004867 Function Serine-type endopeptidase inhibitor activity IEA
GO:0005010 Function Insulin-like growth factor-activated receptor activity TAS 10642437
GO:0005520 Function Insulin-like growth factor binding IEA
GO:0005576 Component Extracellular region IEA
GO:0005886 Component Plasma membrane IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606189 2359 ENSG00000150938
Protein
UniProt ID Q9NZV1
Protein name Cysteine-rich motor neuron 1 protein (CRIM-1) (Cysteine-rich repeat-containing protein S52) [Cleaved into: Processed cysteine-rich motor neuron 1 protein]
Protein function May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its pr
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00219 IGFBP 37 90 Insulin-like growth factor binding protein Domain
PF00093 VWC 336 390 von Willebrand factor type C domain Family
PF00093 VWC 403 456 von Willebrand factor type C domain Family
PF02822 Antistasin 469 498 Antistasin family Domain
PF02822 Antistasin 505 532 Antistasin family Domain
PF02822 Antistasin 539 564 Antistasin family Domain
PF02822 Antistasin 567 592 Antistasin family Domain
PF00093 VWC 608 662 von Willebrand factor type C domain Family
PF00093 VWC 679 734 von Willebrand factor type C domain Family
PF00093 VWC 753 808 von Willebrand factor type C domain Family
PF00093 VWC 819 873 von Willebrand factor type C domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level). {ECO:0000269|PubMed:10642437, ECO:0000269|PubMed:12464430}.
Sequence
MYLVAGDRGLAGCGHLLVSLLGLLLLLARSGTRALVCLPCDESKCEEPRNCPGSIVQGVC
GCCYTCASQRNESCGGTFGIYGTCDRGLRC
VIRPPLNGDSLTEYEAGVCEDENWTDDQLL
GFKPCNENLIAGCNIINGKCECNTIRTCSNPFEFPSQDMCLSALKRIEEEKPDCSKARCE
VQFSPRCPEDSVLIEGYAPPGECCPLPSRCVCNPAGCLRKVCQPGNLNILVSKASGKPGE
CCDLYECKPVFGVDCRTVECPPVQQTACPPDSYETQVRLTADGCCTLPTRCECLSGLCGF
PVCEVGSTPRIVSRGDGTPGKCCDVFECVNDTKPACVFNNVEYYDGDMFRMDNCRFCRCQ
GGVAICFTAQCGEINCERYYVPEGECCPVC
EDPVYPFNNPAGCYANGLILAHGDRWREDD
CTFCQCVNGERHCVATVCGQTCTNPVKVPGECCPVC
EEPTIITVDPPACGELSNCTLTGK
DCINGFKRDHNGCRTCQC
INTEELCSERKQGCTLNCPFGFLTDAQNCEICECRPRPKKCR
PIICDKYCPLGLLKNKHGCDICRC
KKCPELSCSKICPLGFQQDSHGCLICKCREASASAG
PPILSGTCLTVDGHHHKNEESWHDGCRECYCLNGREMCALITCPVPACGNPTIHPGQCCP
SC
ADDFVVQKPELSTPSICHAPGGEYFVEGETWNIDSCTQCTCHSGRVLCETEVCPPLLC
QNPSRTQDSCCPQC
TDQPFRPSLSRNNSVPNYCKNDEGDIFLAAESWKPDVCTSCICIDS
VISCFSESCPSVSCERPVLRKGQCCPYC
IEDTIPKKVVCHFSGKAYADEERWDLDSCTHC
YCLQGQTLCSTVSCPPLPCVEPINVEGSCCPMC
PEMYVPEPTNIPIEKTNHRGEVDLEVP
LWPTPSENDIVHLPRDMGHLQVDYRDNRLHPSEDSSLDSIASVVVPIIICLSIIIAFLFI
NQKKQWIPLLCWYRTPTKPSSLNNQLVSVDCKKGTRVQVDSSQRMLRIAEPDARFSGFYS
MQKQNHLQADNFYQTV
Sequence length 1036
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 23967269 ClinVar
Macrophthalmia, colobomatous, with microcornea colobomatous macrophthalmia-microcornea syndrome GenCC
Metabolic Syndrome Metabolic Syndrome GWAS
Neuroblastoma Neuroblastoma Loss of SNAI2 function reduces self-renewal, 3D invasion as well as metastatic spread in vivo, while strongly sensitizing neuroblastoma cells to RA-induced growth inhibition. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 32329853
Biliary Atresia Associate 40665272
Cancer Pain Associate 27456940
Carcinogenesis Stimulate 35484574
Carcinoma Renal Cell Associate 29607933
Drug Related Side Effects and Adverse Reactions Associate 33958640
Gastrointestinal Stromal Tumors Associate 25987131
Heart Defects Congenital Associate 35732239
Hematologic Diseases Associate 33958640
Kidney Neoplasms Inhibit 29607933