PLEKHO1 (pleckstrin homology domain containing O1)

Gene
Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51177
Gene name Gene Name - the full gene name approved by the HGNC.
Pleckstrin homology domain containing O1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PLEKHO1
Synonyms (NCBI Gene) Gene synonyms aliases
CKIP-1, CKIP1, JBP, OC120
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.2
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(170)
miRTarBase ID miRNA Experiments Reference
MIRT045557 hsa-miR-149-5p CLASH 23622248
MIRT045557 hsa-miR-149-5p CLASH 23622248
MIRT622703 hsa-miR-8062 HITS-CLIP 23824327
MIRT679959 hsa-miR-6513-3p HITS-CLIP 23824327
MIRT622702 hsa-miR-4722-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 20580715, 21382345, 23032291, 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IEA
GO:0007520 Process Myoblast fusion IEA
GO:0008360 Process Regulation of cell shape IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
608335 24310 ENSG00000023902
Protein
Gene miRNA Gene ontology Other IDs Protein
UniProt ID Q53GL0
Protein name Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)
Protein function Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein
PDB 3AA1
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00169 PH 22 → 132 PH domain Domain
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat. {ECO:0000269|PubMed:17197158}
Sequence 
MMKKNNSAKRGPQDGNQQPAPPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYISEKEV
KDEKNIQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLAHSKQPGNTAPNLIFLAVSPEEK
ESWINALNSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTST
SDGMLTLDLIQEEDPSPEEPTSCAESFRVDLDKSVAQLAGSRRRADSDRIQPSADRASSL
SRPWEKTDKGATYTPQAPKKLTPTEKGRCASLEEILSQRDAASARTLQLRAEEPPTPALP
NPGQLSRIQDLVARKLEETQELLAEVQGLGDGKRKAKDPPRSPPDSESEQLLLETERLLG
EASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTTPHSQYRKSLM
Sequence length 409
Interactions View interactions