Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
51147
Gene name Gene Name - the full gene name approved by the HGNC.
Inhibitor of growth family member 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ING4
Synonyms (NCBI Gene) Gene synonyms aliases
my036, p29ING4
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT000448 hsa-miR-650 Luciferase reporter assay, qRT-PCR, Western blot 20381459
MIRT006028 hsa-miR-214-3p Luciferase reporter assay, qRT-PCR 21106054
MIRT006028 hsa-miR-214-3p Luciferase reporter assay, qRT-PCR 21106054
MIRT006028 hsa-miR-214-3p Luciferase reporter assay, qRT-PCR 21106054
MIRT006028 hsa-miR-214-3p Luciferase reporter assay, qRT-PCR 21106054
Transcription factors
Transcription factor Regulation Reference
RUNX3 Activation 17956589
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000123 Component Histone acetyltransferase complex IDA 16387653
GO:0003713 Function Transcription coactivator activity IDA 16387653
GO:0005515 Function Protein binding IPI 12750254, 15029197, 17157298, 23603392, 25416956, 32296183, 32814053
GO:0005634 Component Nucleus IBA 21873635
GO:0005634 Component Nucleus IDA 15029197
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608524 19423 ENSG00000111653
Protein
UniProt ID Q9UNL4
Protein name Inhibitor of growth protein 4 (p29ING4)
Protein function Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653). Through chromatin acetylation it may function in DNA replication (PubMed:1638
PDB 2K1J , 2M1R , 2PNX , 2VNF , 4AFL
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12998 ING 6 107 Inhibitor of growth proteins N-terminal histone-binding Coiled-coil
Sequence
MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEE
KLALLKQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARF
EADLKEKQIESSD
YDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKTAQKKLKLVRTSPEYGMPSVTFGS
VHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCP
RCSQERKKK
Sequence length 249
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    HATs acetylate histones
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
27806345
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
27806345
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Inhibit 18399550
Adenocarcinoma of Lung Associate 22460125
Adenoma Inhibit 21626442
Astrocytoma Inhibit 19775294
Brain Neoplasms Inhibit 23684856
Breast Neoplasms Inhibit 20716169, 21315418
Breast Neoplasms Associate 23056468, 25792601, 34871062
Carcinogenesis Associate 16973615, 23967213
Carcinoma Hepatocellular Associate 27421660
Carcinoma Non Small Cell Lung Associate 26278569