Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	51084
Gene name Gene Name - the full gene name approved by the HGNC.	Crystallin lambda 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CRYL1
Synonyms (NCBI Gene) Gene synonyms aliases	GDH, HEL30, gul3DH, lambda-CRY
Chromosome Chromosome number	13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	13q12.11
Summary Summary of gene provided in NCBI Entrez Gene.	The uronate cycle functions as an alternative glucose metabolic pathway, accounting for about 5% of daily glucose catabolism. The product of this gene catalyzes the dehydrogenation of L-gulonate into dehydro-L-gulonate in the uronate cycle. The enzyme req

Show/Hide all(97)

miRTarBase ID	miRNA	Experiments	Reference
MIRT029226	hsa-miR-26b-5p	Microarray	19088304
MIRT911182	hsa-miR-1587	CLIP-seq
MIRT911183	hsa-miR-1915	CLIP-seq
MIRT911184	hsa-miR-3605-3p	CLIP-seq
MIRT911185	hsa-miR-3609	CLIP-seq
MIRT911186	hsa-miR-4417	CLIP-seq
MIRT911187	hsa-miR-4492	CLIP-seq
MIRT911188	hsa-miR-4498	CLIP-seq
MIRT911189	hsa-miR-4632	CLIP-seq
MIRT911190	hsa-miR-4656	CLIP-seq
MIRT911191	hsa-miR-4661-3p	CLIP-seq
MIRT911192	hsa-miR-4675	CLIP-seq
MIRT911193	hsa-miR-4685-5p	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911195	hsa-miR-4741	CLIP-seq
MIRT911196	hsa-miR-4755-3p	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT911198	hsa-miR-520g	CLIP-seq
MIRT911199	hsa-miR-520h	CLIP-seq
MIRT911200	hsa-miR-548ah	CLIP-seq
MIRT911201	hsa-miR-640	CLIP-seq
MIRT911202	hsa-miR-651	CLIP-seq
MIRT911203	hsa-miR-762	CLIP-seq
MIRT1970202	hsa-miR-3190	CLIP-seq
MIRT1970203	hsa-miR-671-5p	CLIP-seq
MIRT2206130	hsa-miR-3155	CLIP-seq
MIRT2206131	hsa-miR-3155b	CLIP-seq
MIRT1970202	hsa-miR-3190	CLIP-seq
MIRT2206132	hsa-miR-4286	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT2206133	hsa-miR-484	CLIP-seq
MIRT2206134	hsa-miR-510	CLIP-seq
MIRT1970203	hsa-miR-671-5p	CLIP-seq
MIRT2509285	hsa-miR-1234	CLIP-seq
MIRT2509286	hsa-miR-1296	CLIP-seq
MIRT911182	hsa-miR-1587	CLIP-seq
MIRT2509287	hsa-miR-3130-3p	CLIP-seq
MIRT2206130	hsa-miR-3155	CLIP-seq
MIRT2206131	hsa-miR-3155b	CLIP-seq
MIRT2509288	hsa-miR-3158-3p	CLIP-seq
MIRT1970202	hsa-miR-3190	CLIP-seq
MIRT911184	hsa-miR-3605-3p	CLIP-seq
MIRT2509289	hsa-miR-3920	CLIP-seq
MIRT2509290	hsa-miR-4255	CLIP-seq
MIRT2206132	hsa-miR-4286	CLIP-seq
MIRT2509291	hsa-miR-4327	CLIP-seq
MIRT911186	hsa-miR-4417	CLIP-seq
MIRT2509292	hsa-miR-4446-3p	CLIP-seq
MIRT911187	hsa-miR-4492	CLIP-seq
MIRT911188	hsa-miR-4498	CLIP-seq
MIRT2509293	hsa-miR-4512	CLIP-seq
MIRT911190	hsa-miR-4656	CLIP-seq
MIRT911191	hsa-miR-4661-3p	CLIP-seq
MIRT911192	hsa-miR-4675	CLIP-seq
MIRT2509294	hsa-miR-4712-3p	CLIP-seq
MIRT2509295	hsa-miR-4721	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911195	hsa-miR-4741	CLIP-seq
MIRT2509296	hsa-miR-4771	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT2206133	hsa-miR-484	CLIP-seq
MIRT2206134	hsa-miR-510	CLIP-seq
MIRT911202	hsa-miR-651	CLIP-seq
MIRT1970203	hsa-miR-671-5p	CLIP-seq
MIRT911203	hsa-miR-762	CLIP-seq
MIRT2509297	hsa-miR-767-5p	CLIP-seq
MIRT2509285	hsa-miR-1234	CLIP-seq
MIRT2509286	hsa-miR-1296	CLIP-seq
MIRT911182	hsa-miR-1587	CLIP-seq
MIRT2509287	hsa-miR-3130-3p	CLIP-seq
MIRT2206130	hsa-miR-3155	CLIP-seq
MIRT2206131	hsa-miR-3155b	CLIP-seq
MIRT2509288	hsa-miR-3158-3p	CLIP-seq
MIRT911184	hsa-miR-3605-3p	CLIP-seq
MIRT2509289	hsa-miR-3920	CLIP-seq
MIRT2509290	hsa-miR-4255	CLIP-seq
MIRT2206132	hsa-miR-4286	CLIP-seq
MIRT2509291	hsa-miR-4327	CLIP-seq
MIRT911186	hsa-miR-4417	CLIP-seq
MIRT2509292	hsa-miR-4446-3p	CLIP-seq
MIRT911187	hsa-miR-4492	CLIP-seq
MIRT911188	hsa-miR-4498	CLIP-seq
MIRT2509293	hsa-miR-4512	CLIP-seq
MIRT911190	hsa-miR-4656	CLIP-seq
MIRT911191	hsa-miR-4661-3p	CLIP-seq
MIRT911192	hsa-miR-4675	CLIP-seq
MIRT2509295	hsa-miR-4721	CLIP-seq
MIRT911194	hsa-miR-4731-3p	CLIP-seq
MIRT911195	hsa-miR-4741	CLIP-seq
MIRT2509296	hsa-miR-4771	CLIP-seq
MIRT911197	hsa-miR-4801	CLIP-seq
MIRT2206133	hsa-miR-484	CLIP-seq
MIRT2206134	hsa-miR-510	CLIP-seq
MIRT911202	hsa-miR-651	CLIP-seq
MIRT911203	hsa-miR-762	CLIP-seq
MIRT2509297	hsa-miR-767-5p	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0019640	Process	D-glucuronate catabolic process to D-xylulose 5-phosphate	IEA
GO:0042803	Function	Protein homodimerization activity	IPI	15809331
GO:0050104	Function	L-gulonate 3-dehydrogenase activity	IBA
GO:0050104	Function	L-gulonate 3-dehydrogenase activity	IDA	15809331
GO:0050104	Function	L-gulonate 3-dehydrogenase activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070403	Function	NAD+ binding	IDA	15809331
GO:0070403	Function	NAD+ binding	IEA

MIM	HGNC	e!Ensembl
609877	18246	ENSG00000165475

Protein

UniProt ID

Q9Y2S2

Protein name

Lambda-crystallin homolog (EC 1.1.1.45) (L-gulonate 3-dehydrogenase) (Gul3DH)

Protein function

Has high L-gulonate 3-dehydrogenase activity. It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate.

PDB

3F3S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02737	3HCDH_N	8 → 190	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain	Domain
PF00725	3HCDH	192 → 283	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed, with highest levels in liver and kidney. {ECO:0000269|PubMed:12527201}.

Sequence

MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAG
SLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILS
SSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIG
QCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLET
MHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQ
WRDECLMRLAKLKSQVQPQ

Sequence length

319

Interactions

View interactions

	KEGG		Reactome
	Pentose and glucuronate interconversions Metabolic pathways		Formation of xylulose-5-phosphate

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Postmenopausal breast cancer	N/A	N/A	GWAS
Glioblastoma	Glioblastoma	N/A	N/A	GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	24958192, 28206976
Carcinogenesis	Associate	28489570
Carcinoma Hepatocellular	Associate	28489570
Hearing Loss Sensorineural	Associate	37683890
Neoplasms	Associate	28489570

CRYL1 (crystallin lambda 1)