Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5099
Gene name Gene Name - the full gene name approved by the HGNC.	Protocadherin 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PCDH7
Synonyms (NCBI Gene) Gene synonyms aliases	BH-Pcdh, BHPCDH, PPP1R120
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4p15.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to functio

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023562	hsa-miR-1-3p	Proteomics	18668040
MIRT026282	hsa-miR-192-5p	Microarray	19074876
MIRT050339	hsa-miR-25-3p	CLASH	23622248
MIRT676932	hsa-miR-8485	HITS-CLIP	21572407
MIRT676933	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT676931	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT676930	hsa-miR-603	HITS-CLIP	21572407
MIRT707334	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707333	hsa-miR-4530	HITS-CLIP	21572407
MIRT707332	hsa-miR-338-3p	HITS-CLIP	21572407
MIRT676925	hsa-miR-3941	HITS-CLIP	21572407
MIRT310008	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707331	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707330	hsa-miR-6512-3p	HITS-CLIP	21572407
MIRT707328	hsa-miR-6720-5p	HITS-CLIP	21572407
MIRT707329	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT676932	hsa-miR-8485	HITS-CLIP	23824327
MIRT676933	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT676931	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT676930	hsa-miR-603	HITS-CLIP	23824327
MIRT676928	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT676929	hsa-miR-8076	HITS-CLIP	23824327
MIRT676927	hsa-miR-3688-3p	HITS-CLIP	23824327
MIRT676926	hsa-miR-4261	HITS-CLIP	23824327
MIRT676925	hsa-miR-3941	HITS-CLIP	23824327
MIRT676932	hsa-miR-8485	HITS-CLIP	21572407
MIRT676933	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT676931	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT676930	hsa-miR-603	HITS-CLIP	21572407
MIRT707334	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT707333	hsa-miR-4530	HITS-CLIP	21572407
MIRT707332	hsa-miR-338-3p	HITS-CLIP	21572407
MIRT676925	hsa-miR-3941	HITS-CLIP	21572407
MIRT310008	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707331	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707330	hsa-miR-6512-3p	HITS-CLIP	21572407
MIRT707328	hsa-miR-6720-5p	HITS-CLIP	21572407
MIRT707329	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT676932	hsa-miR-8485	HITS-CLIP	23824327
MIRT676933	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT676931	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT676930	hsa-miR-603	HITS-CLIP	23824327
MIRT676928	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT676929	hsa-miR-8076	HITS-CLIP	23824327
MIRT676927	hsa-miR-3688-3p	HITS-CLIP	23824327
MIRT676926	hsa-miR-4261	HITS-CLIP	23824327
MIRT676925	hsa-miR-3941	HITS-CLIP	23824327
MIRT1216882	hsa-miR-326	CLIP-seq
MIRT1216883	hsa-miR-330-5p	CLIP-seq
MIRT1216884	hsa-miR-4768-5p	CLIP-seq
MIRT1216885	hsa-miR-4782-5p	CLIP-seq
MIRT1216886	hsa-miR-101	CLIP-seq
MIRT1216887	hsa-miR-144	CLIP-seq
MIRT1216888	hsa-miR-3155	CLIP-seq
MIRT1216889	hsa-miR-3155b	CLIP-seq
MIRT1216890	hsa-miR-4326	CLIP-seq
MIRT1216891	hsa-miR-4691-5p	CLIP-seq
MIRT1216892	hsa-miR-484	CLIP-seq
MIRT1216893	hsa-miR-548c-3p	CLIP-seq
MIRT1216894	hsa-miR-936	CLIP-seq
MIRT2062594	hsa-miR-200b	CLIP-seq
MIRT2062595	hsa-miR-200c	CLIP-seq
MIRT2062596	hsa-miR-374c	CLIP-seq
MIRT2062597	hsa-miR-429	CLIP-seq
MIRT2062598	hsa-miR-452	CLIP-seq
MIRT2062599	hsa-miR-4676-3p	CLIP-seq
MIRT2062600	hsa-miR-544	CLIP-seq
MIRT2062601	hsa-miR-655	CLIP-seq
MIRT2062602	hsa-miR-3977	CLIP-seq
MIRT2062603	hsa-miR-633	CLIP-seq
MIRT2291023	hsa-miR-1270	CLIP-seq
MIRT2291024	hsa-miR-129-5p	CLIP-seq
MIRT2291025	hsa-miR-142-5p	CLIP-seq
MIRT2291026	hsa-miR-185	CLIP-seq
MIRT2291027	hsa-miR-3938	CLIP-seq
MIRT2291028	hsa-miR-4306	CLIP-seq
MIRT2291029	hsa-miR-4531	CLIP-seq
MIRT2291030	hsa-miR-4644	CLIP-seq
MIRT2291031	hsa-miR-620	CLIP-seq
MIRT2392193	hsa-miR-425	CLIP-seq
MIRT1216887	hsa-miR-144	CLIP-seq
MIRT2588668	hsa-miR-100	CLIP-seq
MIRT2291023	hsa-miR-1270	CLIP-seq
MIRT2588669	hsa-miR-127-5p	CLIP-seq
MIRT2588670	hsa-miR-1276	CLIP-seq
MIRT2588671	hsa-miR-140-5p	CLIP-seq
MIRT2588672	hsa-miR-1972	CLIP-seq
MIRT2588673	hsa-miR-203	CLIP-seq
MIRT2588674	hsa-miR-208a	CLIP-seq
MIRT2588675	hsa-miR-208b	CLIP-seq
MIRT2588676	hsa-miR-2117	CLIP-seq
MIRT2588677	hsa-miR-214	CLIP-seq
MIRT2588678	hsa-miR-2278	CLIP-seq
MIRT2588679	hsa-miR-3126-3p	CLIP-seq
MIRT2588680	hsa-miR-3154	CLIP-seq
MIRT2588681	hsa-miR-3200-5p	CLIP-seq
MIRT2588682	hsa-miR-338-5p	CLIP-seq
MIRT2588683	hsa-miR-3619-5p	CLIP-seq
MIRT2588684	hsa-miR-3622b-5p	CLIP-seq
MIRT2588685	hsa-miR-3658	CLIP-seq
MIRT2588686	hsa-miR-3682-3p	CLIP-seq
MIRT2588687	hsa-miR-3691-3p	CLIP-seq
MIRT2062596	hsa-miR-374c	CLIP-seq
MIRT2062602	hsa-miR-3977	CLIP-seq
MIRT2588688	hsa-miR-4269	CLIP-seq
MIRT2588689	hsa-miR-4273	CLIP-seq
MIRT2588690	hsa-miR-4315	CLIP-seq
MIRT2588691	hsa-miR-4432	CLIP-seq
MIRT2588692	hsa-miR-4463	CLIP-seq
MIRT2588693	hsa-miR-4514	CLIP-seq
MIRT2588694	hsa-miR-4635	CLIP-seq
MIRT2588695	hsa-miR-4643	CLIP-seq
MIRT2588696	hsa-miR-466	CLIP-seq
MIRT2588697	hsa-miR-4662a-3p	CLIP-seq
MIRT2588698	hsa-miR-4677-5p	CLIP-seq
MIRT2588699	hsa-miR-4682	CLIP-seq
MIRT2588700	hsa-miR-4683	CLIP-seq
MIRT2588701	hsa-miR-4690-5p	CLIP-seq
MIRT2588702	hsa-miR-4692	CLIP-seq
MIRT2588703	hsa-miR-4738-3p	CLIP-seq
MIRT2588704	hsa-miR-4742-5p	CLIP-seq
MIRT2588705	hsa-miR-4760-5p	CLIP-seq
MIRT2588706	hsa-miR-4790-3p	CLIP-seq
MIRT2588707	hsa-miR-499-5p	CLIP-seq
MIRT2588708	hsa-miR-510	CLIP-seq
MIRT2588709	hsa-miR-516b	CLIP-seq
MIRT2588710	hsa-miR-548v	CLIP-seq
MIRT2588711	hsa-miR-554	CLIP-seq
MIRT2588712	hsa-miR-556-5p	CLIP-seq
MIRT2588713	hsa-miR-562	CLIP-seq
MIRT2588714	hsa-miR-610	CLIP-seq
MIRT2291031	hsa-miR-620	CLIP-seq
MIRT2588715	hsa-miR-629	CLIP-seq
MIRT2062601	hsa-miR-655	CLIP-seq
MIRT2588716	hsa-miR-761	CLIP-seq
MIRT2588717	hsa-miR-885-5p	CLIP-seq
MIRT1216894	hsa-miR-936	CLIP-seq
MIRT2588718	hsa-miR-99a	CLIP-seq
MIRT2588719	hsa-miR-99b	CLIP-seq
MIRT2588668	hsa-miR-100	CLIP-seq
MIRT2687222	hsa-miR-1258	CLIP-seq
MIRT2687223	hsa-miR-126	CLIP-seq
MIRT2588671	hsa-miR-140-5p	CLIP-seq
MIRT2687224	hsa-miR-154	CLIP-seq
MIRT2588673	hsa-miR-203	CLIP-seq
MIRT2588676	hsa-miR-2117	CLIP-seq
MIRT2687225	hsa-miR-3143	CLIP-seq
MIRT2687226	hsa-miR-3152-3p	CLIP-seq
MIRT2588680	hsa-miR-3154	CLIP-seq
MIRT2687227	hsa-miR-3157-5p	CLIP-seq
MIRT2687228	hsa-miR-323-3p	CLIP-seq
MIRT2588682	hsa-miR-338-5p	CLIP-seq
MIRT2588685	hsa-miR-3658	CLIP-seq
MIRT2588686	hsa-miR-3682-3p	CLIP-seq
MIRT2588687	hsa-miR-3691-3p	CLIP-seq
MIRT2062602	hsa-miR-3977	CLIP-seq
MIRT2687229	hsa-miR-4267	CLIP-seq
MIRT2588689	hsa-miR-4273	CLIP-seq
MIRT2588690	hsa-miR-4315	CLIP-seq
MIRT2687230	hsa-miR-4427	CLIP-seq
MIRT2588697	hsa-miR-4662a-3p	CLIP-seq
MIRT2588698	hsa-miR-4677-5p	CLIP-seq
MIRT2687231	hsa-miR-4680-3p	CLIP-seq
MIRT2687232	hsa-miR-487b	CLIP-seq
MIRT2687233	hsa-miR-520d-5p	CLIP-seq
MIRT2687234	hsa-miR-524-5p	CLIP-seq
MIRT2687235	hsa-miR-543	CLIP-seq
MIRT2588711	hsa-miR-554	CLIP-seq
MIRT2588712	hsa-miR-556-5p	CLIP-seq
MIRT2588713	hsa-miR-562	CLIP-seq
MIRT2588714	hsa-miR-610	CLIP-seq
MIRT2588715	hsa-miR-629	CLIP-seq
MIRT2687236	hsa-miR-668	CLIP-seq
MIRT2588718	hsa-miR-99a	CLIP-seq
MIRT2588719	hsa-miR-99b	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9615233
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0016020	Component	Membrane	IEA
GO:0031092	Component	Platelet alpha granule membrane	TAS
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0098978	Component	Glutamatergic synapse	IBA

MIM	HGNC	e!Ensembl
602988	8659	ENSG00000169851

Protein

UniProt ID

O60245

Protein name

Protocadherin-7 (Brain-heart protocadherin) (BH-Pcdh)

PDB

2YST

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08266	Cadherin_2	33 → 117	Cadherin-like	Domain
PF00028	Cadherin	238 → 299	Cadherin domain	Domain
PF00028	Cadherin	313 → 406	Cadherin domain	Domain
PF00028	Cadherin	429 → 526	Cadherin domain	Domain
PF00028	Cadherin	540 → 630	Cadherin domain	Domain
PF00028	Cadherin	644 → 733	Cadherin domain	Domain
PF00028	Cadherin	752 → 840	Cadherin domain	Domain
PF08374	Protocadherin	842 → 1056	Protocadherin	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed predominantly in brain and heart and at lower levels in various other tissues.

Sequence

MLRMRTAGWARGWCLGCCLLLPLSLSLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTG
SGEVTFSLESGSEYLKIDNLTGELSTSERRIDREKLPQCQMIFDENECFLDFEVSVIGPS
QSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRDFGRNGIERY
ELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEGGGGTNPGGR
SSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQAILRVLITD
VNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAATESVRRLLRL
DETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKI
GRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQLKPASDTEGDQ
NKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTNDNPPMFGQSVV
EVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGDILVNTVLDRE
QTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGM
VTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDP
PRSATATVSLFVMDENDNAPTVTLPKNISYTLLPPSSNVRTVVATVLATDSDDGINADLN
YSIVGGNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQPSQSTTTLVHVFVN
ESVSNATAIDSQIARSLHIPLTQDIAGDPSYEISKQRLSIVIGVVAGIMTVILIILIVVM
ARYCRSKNKNGYEAGKKDHEDFFTPQQHDKSKKPKKDKKNKKSKQPLYSSIVTVEASKPN
GQRYDSVNEKLSDSPSMGRYRSVNGGPGSPDLARHYKSSSPLPTVQLHPQSPTAGKKHQA
VQDLPPANTFVGAGDNISIGSDHCSEYSCQTNNKYSKQMRLHPYITVFG

Sequence length

1069

Interactions

View interactions

	KEGG		Reactome
	Virion - Lassa virus and SFTS virus		Platelet degranulation

Show/Hide Unknown Diseases (5)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Attention Deficit Hyperactivity Disorder	Attention deficit hyperactivity disorder	N/A	N/A	GWAS
Bulimia	Bulimia nervosa	N/A	N/A	GWAS
Epilepsy	Epilepsy	N/A	N/A	GWAS
Prostate cancer	Prostate cancer	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (23)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	34580602
Attention Deficit Disorder with Hyperactivity	Associate	34573389
Bone Diseases Metabolic	Associate	36728938
Breast Neoplasms	Associate	33899544
Dermatitis Exfoliative	Associate	25950944
Epilepsy	Associate	25950944, 28756411
Hereditary leiomyomatosis and renal cell cancer	Associate	37910143
Hodgkin Disease	Associate	37910143
Hypertension	Associate	32315356
Inflammation	Associate	34580602
Lymphatic Metastasis	Inhibit	28381163
Mental Disorders	Associate	25950944
Neoplasm Metastasis	Associate	28381163
Neoplasms	Inhibit	27070091
Neoplasms	Associate	28381163
Non Muscle Invasive Bladder Neoplasms	Associate	27070091
Ovarian Neoplasms	Associate	35132075
Prostatic Neoplasms	Associate	17977648
Sarcoma Endometrial Stromal	Associate	38167455
Stomach Neoplasms	Inhibit	28381163
Stomach Neoplasms	Associate	37894938, 39456895
Urinary Bladder Neoplasms	Inhibit	27070091
Wolf Hirschhorn Syndrome	Associate	36980907

PCDH7 (protocadherin 7)