TAS2R14 (taste 2 receptor member 14)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
50840
Gene name Gene Name - the full gene name approved by the HGNC.
Taste 2 receptor member 14
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TAS2R14
Synonyms (NCBI Gene) Gene synonyms aliases
T2R14, TRB1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12p13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organiz
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
GO ID Ontology Definition Evidence Reference
GO:0001580 Process Detection of chemical stimulus involved in sensory perception of bitter taste IBA
GO:0001580 Process Detection of chemical stimulus involved in sensory perception of bitter taste IDA 16720576, 20022913
GO:0004930 Function G protein-coupled receptor activity IEA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604790 14920 ENSG00000212127
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9NYV8
Protein name Taste receptor type 2 member 14 (T2R14) (Taste receptor family B member 1) (TRB1)
Protein function Gustducin-linked G-protein coupled receptor that plays a role in the perception of bitterness (PubMed:38600377, PubMed:38776963). The activity of this receptor stimulates GNAT3, activating the gustducin G-protein pathway (PubMed:38600377, PubMed
PDB 8RQL , 8VY7 , 8VY9 , 8XQL , 8XQN , 8XQO , 8XQP , 8XQR , 8XQS , 8XQT , 8YKY , 9IIW , 9IIX , 9IJ9 , 9IJA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05296 TAS2R 1 → 299 Taste receptor protein (TAS2R) Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in cerebellum, pancreas, small intestine and thymus; also expressed in adipose, aorta, skin and tongue, but at significantly lower levels (PubMed:38600377). Expressed in subsets of taste receptor cells of the tongue an
Sequence
Sequence length 317
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Taste transduction   G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Hypertension Idiopathic intracranial hypertension N/A N/A GWAS
Show/Hide Text Mining Associations (9)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 35624283
Adrenocortical Carcinoma Associate 35624283
Carcinoma Pancreatic Ductal Associate 36382671
Disease Resistance Associate 30817817
Esophageal Neoplasms Associate 26635288
Obesity Morbid Associate 34371946
Precancerous Conditions Stimulate 20534144
Squamous Cell Carcinoma of Head and Neck Associate 37995679
Urinary Bladder Neoplasms Associate 35624283