COPS7A (COP9 signalosome subunit 7A)

Gene

• Entrez ID: 50813
• Gene name: COP9 signalosome subunit 7A
• Gene symbol: COPS7A
• Synonyms (NCBI Gene): CSN7, CSN7A, SGN7a
• Chromosome: 12
• Chromosome location: 12p13.31
• Summary: This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been de

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024503	hsa-miR-215-5p	Microarray	19074876
MIRT026890	hsa-miR-192-5p	Microarray	19074876
MIRT030594	hsa-miR-24-3p	Microarray	19748357
MIRT048306	hsa-miR-107	CLASH	23622248
MIRT047795	hsa-miR-30d-5p	CLASH	23622248
MIRT044110	hsa-miR-361-5p	CLASH	23622248
MIRT038117	hsa-miR-423-5p	CLASH	23622248
MIRT904089	hsa-miR-1224-3p	CLIP-seq
MIRT904090	hsa-miR-1266	CLIP-seq
MIRT904091	hsa-miR-1279	CLIP-seq
MIRT904092	hsa-miR-1324	CLIP-seq
MIRT904093	hsa-miR-3127-5p	CLIP-seq
MIRT904094	hsa-miR-3144-3p	CLIP-seq
MIRT904095	hsa-miR-3664-3p	CLIP-seq
MIRT904096	hsa-miR-3674	CLIP-seq
MIRT904097	hsa-miR-376a	CLIP-seq
MIRT904098	hsa-miR-376b	CLIP-seq
MIRT904099	hsa-miR-380	CLIP-seq
MIRT904100	hsa-miR-3918	CLIP-seq
MIRT904101	hsa-miR-3935	CLIP-seq
MIRT904102	hsa-miR-4447	CLIP-seq
MIRT904103	hsa-miR-4455	CLIP-seq
MIRT904104	hsa-miR-4472	CLIP-seq
MIRT904105	hsa-miR-448	CLIP-seq
MIRT904106	hsa-miR-4488	CLIP-seq
MIRT904107	hsa-miR-4518	CLIP-seq
MIRT904108	hsa-miR-4520a-5p	CLIP-seq
MIRT904109	hsa-miR-4520b-5p	CLIP-seq
MIRT904110	hsa-miR-4670-5p	CLIP-seq
MIRT904111	hsa-miR-4697-5p	CLIP-seq
MIRT904112	hsa-miR-544	CLIP-seq
MIRT904113	hsa-miR-548m	CLIP-seq
MIRT904114	hsa-miR-586	CLIP-seq
MIRT904115	hsa-miR-656	CLIP-seq
MIRT904116	hsa-miR-875-5p	CLIP-seq
MIRT904117	hsa-miR-888	CLIP-seq
MIRT904090	hsa-miR-1266	CLIP-seq
MIRT904118	hsa-miR-135a	CLIP-seq
MIRT904119	hsa-miR-135b	CLIP-seq
MIRT904120	hsa-miR-224	CLIP-seq
MIRT904121	hsa-miR-3125	CLIP-seq
MIRT904122	hsa-miR-3613-3p	CLIP-seq
MIRT904095	hsa-miR-3664-3p	CLIP-seq
MIRT904123	hsa-miR-3916	CLIP-seq
MIRT904124	hsa-miR-4257	CLIP-seq
MIRT904102	hsa-miR-4447	CLIP-seq
MIRT904103	hsa-miR-4455	CLIP-seq
MIRT904104	hsa-miR-4472	CLIP-seq
MIRT904106	hsa-miR-4488	CLIP-seq
MIRT904107	hsa-miR-4518	CLIP-seq
MIRT904125	hsa-miR-4640-5p	CLIP-seq
MIRT904111	hsa-miR-4697-5p	CLIP-seq
MIRT904126	hsa-miR-4719	CLIP-seq
MIRT904127	hsa-miR-4726-5p	CLIP-seq
MIRT904128	hsa-miR-485-5p	CLIP-seq
MIRT904129	hsa-miR-548k	CLIP-seq
MIRT904113	hsa-miR-548m	CLIP-seq
MIRT904130	hsa-miR-711	CLIP-seq
MIRT904131	hsa-miR-760	CLIP-seq
MIRT904132	hsa-miR-767-3p	CLIP-seq
MIRT1921967	hsa-miR-1207-3p	CLIP-seq
MIRT1921967	hsa-miR-1207-3p	CLIP-seq
MIRT1968047	hsa-miR-1224-5p	CLIP-seq
MIRT1968048	hsa-miR-1827	CLIP-seq
MIRT1968049	hsa-miR-192	CLIP-seq
MIRT1968050	hsa-miR-215	CLIP-seq
MIRT1968051	hsa-miR-3065-5p	CLIP-seq
MIRT1968052	hsa-miR-3123	CLIP-seq
MIRT1968053	hsa-miR-3152-5p	CLIP-seq
MIRT904122	hsa-miR-3613-3p	CLIP-seq
MIRT1968054	hsa-miR-3649	CLIP-seq
MIRT1968055	hsa-miR-3921	CLIP-seq
MIRT1968056	hsa-miR-3925-5p	CLIP-seq
MIRT1968057	hsa-miR-4435	CLIP-seq
MIRT1968058	hsa-miR-4514	CLIP-seq
MIRT1968059	hsa-miR-4649-3p	CLIP-seq
MIRT1968060	hsa-miR-4653-5p	CLIP-seq
MIRT1968061	hsa-miR-4667-5p	CLIP-seq
MIRT1968062	hsa-miR-4688	CLIP-seq
MIRT1968063	hsa-miR-4692	CLIP-seq
MIRT1968064	hsa-miR-4700-5p	CLIP-seq
MIRT904126	hsa-miR-4719	CLIP-seq
MIRT1968065	hsa-miR-4751	CLIP-seq
MIRT1968066	hsa-miR-4774-3p	CLIP-seq
MIRT904129	hsa-miR-548k	CLIP-seq
MIRT904131	hsa-miR-760	CLIP-seq
MIRT1968067	hsa-miR-940	CLIP-seq
MIRT1921967	hsa-miR-1207-3p	CLIP-seq
MIRT1968048	hsa-miR-1827	CLIP-seq
MIRT2203953	hsa-miR-185	CLIP-seq
MIRT2203954	hsa-miR-3159	CLIP-seq
MIRT2203955	hsa-miR-3653	CLIP-seq
MIRT2203956	hsa-miR-3658	CLIP-seq
MIRT2203957	hsa-miR-3670	CLIP-seq
MIRT2203958	hsa-miR-3908	CLIP-seq
MIRT2203959	hsa-miR-4261	CLIP-seq
MIRT2203960	hsa-miR-4306	CLIP-seq
MIRT2203961	hsa-miR-4477b	CLIP-seq
MIRT2203962	hsa-miR-4496	CLIP-seq
MIRT1968058	hsa-miR-4514	CLIP-seq
MIRT2203963	hsa-miR-4644	CLIP-seq
MIRT1968063	hsa-miR-4692	CLIP-seq
MIRT2203964	hsa-miR-4706	CLIP-seq
MIRT2203965	hsa-miR-4749-5p	CLIP-seq
MIRT2203966	hsa-miR-4769-3p	CLIP-seq
MIRT2203967	hsa-miR-4781-5p	CLIP-seq
MIRT904131	hsa-miR-760	CLIP-seq
MIRT2203968	hsa-miR-885-3p	CLIP-seq
MIRT2203969	hsa-miR-939	CLIP-seq
MIRT1968067	hsa-miR-940	CLIP-seq
MIRT1921967	hsa-miR-1207-3p	CLIP-seq
MIRT1968047	hsa-miR-1224-5p	CLIP-seq
MIRT2507165	hsa-miR-1265	CLIP-seq
MIRT904090	hsa-miR-1266	CLIP-seq
MIRT2507166	hsa-miR-1273f	CLIP-seq
MIRT904118	hsa-miR-135a	CLIP-seq
MIRT904119	hsa-miR-135b	CLIP-seq
MIRT1968048	hsa-miR-1827	CLIP-seq
MIRT2203953	hsa-miR-185	CLIP-seq
MIRT2507167	hsa-miR-186	CLIP-seq
MIRT1968049	hsa-miR-192	CLIP-seq
MIRT1968050	hsa-miR-215	CLIP-seq
MIRT904120	hsa-miR-224	CLIP-seq
MIRT2507168	hsa-miR-2392	CLIP-seq
MIRT1968051	hsa-miR-3065-5p	CLIP-seq
MIRT1968052	hsa-miR-3123	CLIP-seq
MIRT2203954	hsa-miR-3159	CLIP-seq
MIRT2507169	hsa-miR-3170	CLIP-seq
MIRT2507170	hsa-miR-3179	CLIP-seq
MIRT2507171	hsa-miR-337-5p	CLIP-seq
MIRT904122	hsa-miR-3613-3p	CLIP-seq
MIRT1968054	hsa-miR-3649	CLIP-seq
MIRT2203955	hsa-miR-3653	CLIP-seq
MIRT2203956	hsa-miR-3658	CLIP-seq
MIRT904095	hsa-miR-3664-3p	CLIP-seq
MIRT2203957	hsa-miR-3670	CLIP-seq
MIRT2507172	hsa-miR-3689d	CLIP-seq
MIRT2203958	hsa-miR-3908	CLIP-seq
MIRT904100	hsa-miR-3918	CLIP-seq
MIRT1968055	hsa-miR-3921	CLIP-seq
MIRT1968056	hsa-miR-3925-5p	CLIP-seq
MIRT2507173	hsa-miR-4260	CLIP-seq
MIRT2203959	hsa-miR-4261	CLIP-seq
MIRT2507174	hsa-miR-4278	CLIP-seq
MIRT2203960	hsa-miR-4306	CLIP-seq
MIRT2507175	hsa-miR-4307	CLIP-seq
MIRT2507176	hsa-miR-4320	CLIP-seq
MIRT2507177	hsa-miR-4428	CLIP-seq
MIRT1968057	hsa-miR-4435	CLIP-seq
MIRT904102	hsa-miR-4447	CLIP-seq
MIRT904103	hsa-miR-4455	CLIP-seq
MIRT904104	hsa-miR-4472	CLIP-seq
MIRT2203961	hsa-miR-4477b	CLIP-seq
MIRT904106	hsa-miR-4488	CLIP-seq
MIRT2203962	hsa-miR-4496	CLIP-seq
MIRT1968058	hsa-miR-4514	CLIP-seq
MIRT904107	hsa-miR-4518	CLIP-seq
MIRT2507178	hsa-miR-4643	CLIP-seq
MIRT2203963	hsa-miR-4644	CLIP-seq
MIRT1968059	hsa-miR-4649-3p	CLIP-seq
MIRT1968060	hsa-miR-4653-5p	CLIP-seq
MIRT2507179	hsa-miR-4659a-5p	CLIP-seq
MIRT2507180	hsa-miR-4659b-5p	CLIP-seq
MIRT2507181	hsa-miR-4663	CLIP-seq
MIRT2507182	hsa-miR-4685-5p	CLIP-seq
MIRT1968062	hsa-miR-4688	CLIP-seq
MIRT1968063	hsa-miR-4692	CLIP-seq
MIRT904111	hsa-miR-4697-5p	CLIP-seq
MIRT2203964	hsa-miR-4706	CLIP-seq
MIRT904126	hsa-miR-4719	CLIP-seq
MIRT2507183	hsa-miR-4728-3p	CLIP-seq
MIRT2507184	hsa-miR-4740-3p	CLIP-seq
MIRT2203965	hsa-miR-4749-5p	CLIP-seq
MIRT1968065	hsa-miR-4751	CLIP-seq
MIRT2507185	hsa-miR-4776-3p	CLIP-seq
MIRT2203967	hsa-miR-4781-5p	CLIP-seq
MIRT904129	hsa-miR-548k	CLIP-seq
MIRT904113	hsa-miR-548m	CLIP-seq
MIRT2507186	hsa-miR-665	CLIP-seq
MIRT904131	hsa-miR-760	CLIP-seq
MIRT2203968	hsa-miR-885-3p	CLIP-seq
MIRT2203969	hsa-miR-939	CLIP-seq
MIRT1968067	hsa-miR-940	CLIP-seq
MIRT1921967	hsa-miR-1207-3p	CLIP-seq
MIRT1968047	hsa-miR-1224-5p	CLIP-seq
MIRT904090	hsa-miR-1266	CLIP-seq
MIRT2507166	hsa-miR-1273f	CLIP-seq
MIRT2203953	hsa-miR-185	CLIP-seq
MIRT2507167	hsa-miR-186	CLIP-seq
MIRT904120	hsa-miR-224	CLIP-seq
MIRT1968051	hsa-miR-3065-5p	CLIP-seq
MIRT1968052	hsa-miR-3123	CLIP-seq
MIRT2203954	hsa-miR-3159	CLIP-seq
MIRT2507169	hsa-miR-3170	CLIP-seq
MIRT2507170	hsa-miR-3179	CLIP-seq
MIRT904122	hsa-miR-3613-3p	CLIP-seq
MIRT2203955	hsa-miR-3653	CLIP-seq
MIRT2203956	hsa-miR-3658	CLIP-seq
MIRT904095	hsa-miR-3664-3p	CLIP-seq
MIRT2203957	hsa-miR-3670	CLIP-seq
MIRT2507172	hsa-miR-3689d	CLIP-seq
MIRT2203958	hsa-miR-3908	CLIP-seq
MIRT904100	hsa-miR-3918	CLIP-seq
MIRT1968055	hsa-miR-3921	CLIP-seq
MIRT1968056	hsa-miR-3925-5p	CLIP-seq
MIRT2507173	hsa-miR-4260	CLIP-seq
MIRT2203959	hsa-miR-4261	CLIP-seq
MIRT2507174	hsa-miR-4278	CLIP-seq
MIRT2203960	hsa-miR-4306	CLIP-seq
MIRT2507175	hsa-miR-4307	CLIP-seq
MIRT2507177	hsa-miR-4428	CLIP-seq
MIRT1968057	hsa-miR-4435	CLIP-seq
MIRT904103	hsa-miR-4455	CLIP-seq
MIRT2203961	hsa-miR-4477b	CLIP-seq
MIRT2203962	hsa-miR-4496	CLIP-seq
MIRT904107	hsa-miR-4518	CLIP-seq
MIRT2507178	hsa-miR-4643	CLIP-seq
MIRT2203963	hsa-miR-4644	CLIP-seq
MIRT1968059	hsa-miR-4649-3p	CLIP-seq
MIRT1968060	hsa-miR-4653-5p	CLIP-seq
MIRT2507179	hsa-miR-4659a-5p	CLIP-seq
MIRT2507180	hsa-miR-4659b-5p	CLIP-seq
MIRT2507181	hsa-miR-4663	CLIP-seq
MIRT2507182	hsa-miR-4685-5p	CLIP-seq
MIRT1968062	hsa-miR-4688	CLIP-seq
MIRT2203964	hsa-miR-4706	CLIP-seq
MIRT904126	hsa-miR-4719	CLIP-seq
MIRT2507183	hsa-miR-4728-3p	CLIP-seq
MIRT2507184	hsa-miR-4740-3p	CLIP-seq
MIRT2203965	hsa-miR-4749-5p	CLIP-seq
MIRT1968065	hsa-miR-4751	CLIP-seq
MIRT2507185	hsa-miR-4776-3p	CLIP-seq
MIRT2203967	hsa-miR-4781-5p	CLIP-seq
MIRT904129	hsa-miR-548k	CLIP-seq
MIRT2507186	hsa-miR-665	CLIP-seq
MIRT2203968	hsa-miR-885-3p	CLIP-seq
MIRT2203969	hsa-miR-939	CLIP-seq
MIRT1968057	hsa-miR-4435	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000338	Process	Protein deneddylation	IDA	19141280
GO:0000715	Process	Nucleotide-excision repair, DNA damage recognition	TAS
GO:0005515	Function	Protein binding	IPI	20399188, 24421388, 25043011, 26496610, 28514442, 32911434
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006283	Process	Transcription-coupled nucleotide-excision repair	TAS
GO:0008180	Component	COP9 signalosome	IBA	21873635
GO:0008180	Component	COP9 signalosome	IDA	18850735
GO:0010387	Process	COP9 signalosome assembly	IEA
GO:0016032	Process	Viral process	IEA
GO:0043687	Process	Post-translational protein modification	TAS

Other IDs

• MIM: 616009
• HGNC: 16758
• e!Ensembl: ENSG00000111652

Protein

• UniProt ID: Q9UBW8
• Protein name: COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)
• Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the culli
• PDB: 4D10, 4D18, 4WSN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01399	PCI	52 → 155	PCI domain	Domain
  PF18392	CSN7a_helixI	166 → 215	COP9 signalosome complex subunit 7a helix I domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed at high level in brain, heart and skeletal muscle. {ECO:0000269|PubMed:12020345}.
• Sequence:

  MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDF
  ASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEAL
  ALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVG
  CEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLT
  ELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN

• Sequence length: 275

Pathways

Reactome:

DNA Damage Recognition in GG-NER
Formation of TC-NER Pre-Incision Complex
Cargo recognition for clathrin-mediated endocytosis
Neddylation

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753

Unknown
Disease term	Disease name	Evidence	References	Source
Insomnia	Insomnia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Asthenozoospermia	Stimulate	36471356
Carcinoma Renal Cell	Associate	36180558
Cardiomyopathy Dilated	Associate	36042172
Mental Disorders	Associate	27219343