Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	5064
Gene name Gene Name - the full gene name approved by the HGNC.	Paralemmin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PALM
Synonyms (NCBI Gene) Gene synonyms aliases	PALM1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19p13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the paralemmin protein family. The product of this gene is a prenylated and palmitoylated phosphoprotein that associates with the cytoplasmic face of plasma membranes and is implicated in plasma membrane dynamics in neurons a

Show/Hide all(94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043056	hsa-miR-324-5p	CLASH	23622248
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT718145	hsa-miR-1911-3p	HITS-CLIP	19536157
MIRT718144	hsa-miR-6753-5p	HITS-CLIP	19536157
MIRT718143	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT718142	hsa-miR-4421	HITS-CLIP	19536157
MIRT718141	hsa-miR-5699-3p	HITS-CLIP	19536157
MIRT718140	hsa-miR-6845-3p	HITS-CLIP	19536157
MIRT718139	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT718138	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT718137	hsa-miR-6753-3p	HITS-CLIP	19536157
MIRT718136	hsa-miR-7107-3p	HITS-CLIP	19536157
MIRT718135	hsa-miR-6895-3p	HITS-CLIP	19536157
MIRT718134	hsa-miR-593-3p	HITS-CLIP	19536157
MIRT718133	hsa-miR-6873-3p	HITS-CLIP	19536157
MIRT718132	hsa-miR-6818-3p	HITS-CLIP	19536157
MIRT1211847	hsa-miR-1207-5p	CLIP-seq
MIRT1211848	hsa-miR-1915	CLIP-seq
MIRT1211849	hsa-miR-3135b	CLIP-seq
MIRT1211850	hsa-miR-3652	CLIP-seq
MIRT1211851	hsa-miR-3689d	CLIP-seq
MIRT1211852	hsa-miR-4279	CLIP-seq
MIRT1211853	hsa-miR-4430	CLIP-seq
MIRT1211854	hsa-miR-4436b-3p	CLIP-seq
MIRT1211855	hsa-miR-4512	CLIP-seq
MIRT1211856	hsa-miR-4688	CLIP-seq
MIRT1211857	hsa-miR-4691-3p	CLIP-seq
MIRT1211858	hsa-miR-4726-3p	CLIP-seq
MIRT1211859	hsa-miR-4740-3p	CLIP-seq
MIRT1211860	hsa-miR-4757-5p	CLIP-seq
MIRT1211861	hsa-miR-4761-3p	CLIP-seq
MIRT1211862	hsa-miR-4763-3p	CLIP-seq
MIRT1211863	hsa-miR-4300	CLIP-seq
MIRT1211864	hsa-miR-920	CLIP-seq
MIRT2060789	hsa-miR-122	CLIP-seq
MIRT2060790	hsa-miR-1268	CLIP-seq
MIRT2060791	hsa-miR-1268b	CLIP-seq
MIRT2060792	hsa-miR-2467-3p	CLIP-seq
MIRT2060793	hsa-miR-2861	CLIP-seq
MIRT2060794	hsa-miR-3147	CLIP-seq
MIRT2060795	hsa-miR-3177-3p	CLIP-seq
MIRT2060796	hsa-miR-3180	CLIP-seq
MIRT2060797	hsa-miR-3180-3p	CLIP-seq
MIRT2060798	hsa-miR-3196	CLIP-seq
MIRT2060799	hsa-miR-3659	CLIP-seq
MIRT2060800	hsa-miR-4260	CLIP-seq
MIRT2060801	hsa-miR-4425	CLIP-seq
MIRT2060802	hsa-miR-4459	CLIP-seq
MIRT2060803	hsa-miR-4723-5p	CLIP-seq
MIRT2060804	hsa-miR-4787-5p	CLIP-seq
MIRT2060805	hsa-miR-665	CLIP-seq
MIRT2060806	hsa-miR-760	CLIP-seq
MIRT2289505	hsa-miR-3665	CLIP-seq

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16386234, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA	16386234
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA
GO:0007194	Process	Negative regulation of adenylate cyclase activity	IBA	21873635
GO:0008360	Process	Regulation of cell shape	IEA
GO:0014069	Component	Postsynaptic density	IEA
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0030424	Component	Axon	IEA
GO:0031235	Component	Intrinsic component of the cytoplasmic side of the plasma membrane	TAS	9813098
GO:0031410	Component	Cytoplasmic vesicle	TAS	9813098
GO:0031527	Component	Filopodium membrane	IDA	14978216
GO:0031750	Function	D3 dopamine receptor binding	IEA
GO:0032591	Component	Dendritic spine membrane	IEA
GO:0051491	Process	Positive regulation of filopodium assembly	IBA	21873635
GO:0051491	Process	Positive regulation of filopodium assembly	IDA	14978216
GO:0060074	Process	Synapse maturation	IEA
GO:0060160	Process	Negative regulation of dopamine receptor signaling pathway	IDA	16386234
GO:0071257	Process	Cellular response to electrical stimulus	IEA
GO:0072659	Process	Protein localization to plasma membrane	IEA

MIM	HGNC	e!Ensembl
608134	8594	ENSG00000099864

Protein

UniProt ID

O75781

Protein name

Paralemmin-1 (Paralemmin)

Protein function

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03285	Paralemmin	71 → 387	Paralemmin	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland.

Sequence

MEVLAAETTSQQERLQAIAEKRKRQAEIENKRRQLEDERRQLQHLKSKALRERWLLEGTP
SSASEGDEDLRRQMQDDEQKTRLLEDSVSRLEKEIEVLERGDSAPATAKENAAAPSPVRA
PAPSPAKEERKTEVVMNSQQTPVGTPKDKRVSNTPLRTVDGSPMMKAAMYSVEITVEKDK
VTGETRVLSSTTLLPRQPLPLGIKVYEDETKVVHAVDGTAENGIHPLSSSEVDELIHKAD
EVTLSEAGSTAGAAETRGAVEGAARTTPSRREITGVQAQPGEATSGPPGIQPGQEPPVTM
IFMGYQNVEDEAETKKVLGLQDTITAELVVIEDAAEPKEPAPPNGSAAEPPTEAASREEN
QAGPEATTSDPQDLDMKKHRCKCCSIM

Sequence length

387

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Lung adenocarcinoma	Lung adenocarcinoma	Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors		GWAS, CBGDA

PALM (paralemmin)