IL20 (interleukin 20)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
50604
Gene name Gene Name - the full gene name approved by the HGNC.
Interleukin 20
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
IL20
Synonyms (NCBI Gene) Gene synonyms aliases
IL-20, IL10D, ZCYTO10
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q32.1
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
miRTarBase ID miRNA Experiments Reference
MIRT053417 hsa-miR-624-3p Microarray 23807165
MIRT1064475 hsa-miR-103a CLIP-seq
MIRT1064476 hsa-miR-107 CLIP-seq
MIRT1064477 hsa-miR-1183 CLIP-seq
MIRT1064478 hsa-miR-15a CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IEA
GO:0005576 Component Extracellular region TAS 11470428
GO:0005615 Component Extracellular space IEA
GO:0019221 Process Cytokine-mediated signaling pathway TAS
GO:0042531 Process Positive regulation of tyrosine phosphorylation of STAT protein TAS 11470428
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605619 6002 ENSG00000162891
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9NYY1
Protein name Interleukin-20 (IL-20) (Cytokine Zcyto10)
Protein function Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiat
PDB 4DOH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00726 IL10 20 → 175 Interleukin 10 Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues and five major cell types: epithelial cells (primarily skin, buccal mucosa, tongue, nasal mucosa, lung, ureter, breast, prostate, fallopian tube, and adrenal gland), myoepithelial cells (mainly prostate), endo
Sequence
Sequence length 176
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Cytokine-cytokine receptor interaction
Viral protein interaction with cytokine and cytokine receptor
JAK-STAT signaling pathway 		  Interleukin-20 family signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent, Diabetes Mellitus, Ketosis-Prone, Diabetes Mellitus, Sudden-Onset rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)		 19430480
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Mental depression Unipolar Depression, Major Depressive Disorder 19087313 ClinVar
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Show/Hide Text Mining Associations (27)
Associations from Text Mining
Disease Name Relationship Type References
Arthritis Juvenile Associate 16959027, 23094074
Arthritis Psoriatic Associate 16645593, 16831294, 23006144
Arthritis Rheumatoid Associate 22355377, 23006144, 26968800, 27799070, 35384009
Asthma Associate 25543042
Atherosclerosis Associate 31947776
Breast Neoplasms Associate 27806114, 28514748
Diabetes Mellitus Associate 26354610
Diabetes Mellitus Type 1 Associate 19430480
Diabetes Mellitus Type 2 Associate 26354610
Fibrosis Associate 25404022, 37874141