Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
5010
Gene name Gene Name - the full gene name approved by the HGNC.
Claudin 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CLDN11
Synonyms (NCBI Gene) Gene synonyms aliases
HLD22, OSP, OTM
Disease Acronyms (UniProt) Disease acronyms from UniProt database
HLD22
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q26.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellula
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT532808 hsa-miR-3646 PAR-CLIP 22012620
MIRT532807 hsa-miR-1252-3p PAR-CLIP 22012620
MIRT532806 hsa-miR-6882-5p PAR-CLIP 22012620
MIRT532805 hsa-miR-9500 PAR-CLIP 22012620
MIRT532804 hsa-miR-4635 PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005198 Function Structural molecule activity IEA
GO:0005515 Function Protein binding IPI 20375010, 32296183, 32814053
GO:0005811 Component Lipid droplet IDA
GO:0005883 Component Neurofilament IDA 30734065
GO:0005886 Component Plasma membrane IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601326 8514 ENSG00000013297
Protein
UniProt ID O75508
Protein name Claudin-11 (Oligodendrocyte-specific protein)
Protein function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00822 PMP22_Claudin 4 175 PMP-22/EMP/MP20/Claudin family Family
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Virion - Hepatitis viruses
Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Hepatitis C
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Multiple sclerosis Multiple Sclerosis, Multiple Sclerosis, Acute Fulminating rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039
View all (4 more)
25911099
Unknown
Disease term Disease name Evidence References Source
Leukodystrophy leukodystrophy, hypomyelinating, 22 GenCC
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Restless Legs Syndrome Restless Legs Syndrome GWAS
Associations from Text Mining
Disease Name Relationship Type References
Arrest of spermatogenesis Associate 20850723
Breast Neoplasms Associate 33714203, 33971623
Carcinogenesis Associate 19956721
Carcinoma Squamous Cell Associate 27234382, 27992079, 31551535
COVID 19 Inhibit 34436630
Dermatitis Allergic Contact Associate 31783056
Dysplastic Nevus Syndrome Associate 24999589
Ehlers Danlos syndrome type 3 Associate 27518164
Eye Abnormalities Associate 33313762
Focal Cortical Dysplasia Associate 34301297