Gene Gene information from NCBI Gene database.
Entrez ID 5010
Gene name Claudin 11
Gene symbol CLDN11
Synonyms (NCBI Gene)
HLD22OSPOTM
Chromosome 3
Chromosome location 3q26.2
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellula
miRNA miRNA information provided by mirtarbase database.
537
miRTarBase ID miRNA Experiments Reference
MIRT532808 hsa-miR-3646 PAR-CLIP 22012620
MIRT532807 hsa-miR-1252-3p PAR-CLIP 22012620
MIRT532806 hsa-miR-6882-5p PAR-CLIP 22012620
MIRT532805 hsa-miR-9500 PAR-CLIP 22012620
MIRT532804 hsa-miR-4635 PAR-CLIP 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26
GO ID Ontology Definition Evidence Reference
GO:0005198 Function Structural molecule activity IEA
GO:0005515 Function Protein binding IPI 20375010, 32296183, 32814053
GO:0005811 Component Lipid droplet IDA
GO:0005883 Component Neurofilament IDA 30734065
GO:0005886 Component Plasma membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
601326 8514 ENSG00000013297
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75508
Protein name Claudin-11 (Oligodendrocyte-specific protein)
Protein function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00822 PMP22_Claudin 4 175 PMP-22/EMP/MP20/Claudin family Family
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Virion - Hepatitis viruses
Cell adhesion molecules
Tight junction
Leukocyte transendothelial migration
Pathogenic Escherichia coli infection
Hepatitis C
 
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Leukodystrophy, hypomyelinating, 22 Pathogenic rs2108249442 RCV001431513
RCV001431515
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Marfanoid habitus and intellectual disability Uncertain significance rs1577466242 RCV000850417
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Arrest of spermatogenesis Associate 20850723
Breast Neoplasms Associate 33714203, 33971623
Carcinogenesis Associate 19956721
Carcinoma Squamous Cell Associate 27234382, 27992079, 31551535
COVID 19 Inhibit 34436630
Dermatitis Allergic Contact Associate 31783056
Dysplastic Nevus Syndrome Associate 24999589
Ehlers Danlos syndrome type 3 Associate 27518164
Eye Abnormalities Associate 33313762
Focal Cortical Dysplasia Associate 34301297