Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4987
Gene name Gene Name - the full gene name approved by the HGNC.	Opioid related nociceptin receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	OPRL1
Synonyms (NCBI Gene) Gene synonyms aliases	KOR-3, KOR3, NOCIR, NOP, NOPr, OOR, OPRL, ORL1, PNOCR
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a va

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miRTarBase ID	miRNA	Experiments	Reference
MIRT529744	hsa-miR-6733-3p	PAR-CLIP	22012620
MIRT529742	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT529741	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT529740	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT529739	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT529738	hsa-miR-331-3p	PAR-CLIP	22012620
MIRT529737	hsa-miR-125a-5p	PAR-CLIP	22012620
MIRT529736	hsa-miR-125b-5p	PAR-CLIP	22012620
MIRT529735	hsa-miR-4319	PAR-CLIP	22012620
MIRT529734	hsa-miR-544b	PAR-CLIP	22012620
MIRT529733	hsa-miR-7162-3p	PAR-CLIP	22012620
MIRT529732	hsa-miR-6786-3p	PAR-CLIP	22012620
MIRT529731	hsa-let-7a-5p	PAR-CLIP	22012620
MIRT529730	hsa-let-7b-5p	PAR-CLIP	22012620
MIRT529729	hsa-let-7c-5p	PAR-CLIP	22012620
MIRT529728	hsa-let-7d-5p	PAR-CLIP	22012620
MIRT529727	hsa-let-7e-5p	PAR-CLIP	22012620
MIRT529726	hsa-let-7f-5p	PAR-CLIP	22012620
MIRT529725	hsa-let-7g-5p	PAR-CLIP	22012620
MIRT529724	hsa-let-7i-5p	PAR-CLIP	22012620
MIRT529723	hsa-miR-4458	PAR-CLIP	22012620
MIRT529722	hsa-miR-4500	PAR-CLIP	22012620
MIRT529721	hsa-miR-98-5p	PAR-CLIP	22012620
MIRT529720	hsa-miR-202-3p	PAR-CLIP	22012620
MIRT529719	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT529718	hsa-miR-324-5p	PAR-CLIP	22012620
MIRT529744	hsa-miR-6733-3p	PAR-CLIP	22012620
MIRT529742	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT529741	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT529740	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT529739	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT529738	hsa-miR-331-3p	PAR-CLIP	22012620
MIRT529737	hsa-miR-125a-5p	PAR-CLIP	22012620
MIRT529736	hsa-miR-125b-5p	PAR-CLIP	22012620
MIRT529735	hsa-miR-4319	PAR-CLIP	22012620
MIRT529734	hsa-miR-544b	PAR-CLIP	22012620
MIRT529733	hsa-miR-7162-3p	PAR-CLIP	22012620
MIRT529732	hsa-miR-6786-3p	PAR-CLIP	22012620
MIRT529731	hsa-let-7a-5p	PAR-CLIP	22012620
MIRT529730	hsa-let-7b-5p	PAR-CLIP	22012620
MIRT529729	hsa-let-7c-5p	PAR-CLIP	22012620
MIRT529728	hsa-let-7d-5p	PAR-CLIP	22012620
MIRT529727	hsa-let-7e-5p	PAR-CLIP	22012620
MIRT529726	hsa-let-7f-5p	PAR-CLIP	22012620
MIRT529725	hsa-let-7g-5p	PAR-CLIP	22012620
MIRT529724	hsa-let-7i-5p	PAR-CLIP	22012620
MIRT529723	hsa-miR-4458	PAR-CLIP	22012620
MIRT529722	hsa-miR-4500	PAR-CLIP	22012620
MIRT529721	hsa-miR-98-5p	PAR-CLIP	22012620
MIRT529720	hsa-miR-202-3p	PAR-CLIP	22012620
MIRT529719	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT529718	hsa-miR-324-5p	PAR-CLIP	22012620
MIRT1204490	hsa-miR-1255a	CLIP-seq
MIRT1204491	hsa-miR-1255b	CLIP-seq
MIRT1204492	hsa-miR-25	CLIP-seq
MIRT1204493	hsa-miR-3130-3p	CLIP-seq
MIRT1204494	hsa-miR-3135b	CLIP-seq
MIRT1204495	hsa-miR-32	CLIP-seq
MIRT1204496	hsa-miR-363	CLIP-seq
MIRT1204497	hsa-miR-367	CLIP-seq
MIRT1204498	hsa-miR-3909	CLIP-seq
MIRT1204499	hsa-miR-4270	CLIP-seq
MIRT1204500	hsa-miR-4441	CLIP-seq
MIRT1204501	hsa-miR-4640-5p	CLIP-seq
MIRT1204502	hsa-miR-4691-3p	CLIP-seq
MIRT1204503	hsa-miR-4717-3p	CLIP-seq
MIRT1204504	hsa-miR-4726-5p	CLIP-seq
MIRT1204505	hsa-miR-92a	CLIP-seq
MIRT1204506	hsa-miR-92b	CLIP-seq
MIRT1204507	hsa-miR-125b	CLIP-seq
MIRT1204508	hsa-miR-1266	CLIP-seq
MIRT1204509	hsa-miR-146b-3p	CLIP-seq
MIRT1204510	hsa-miR-1915	CLIP-seq
MIRT1204511	hsa-miR-22	CLIP-seq
MIRT1204492	hsa-miR-25	CLIP-seq
MIRT1204494	hsa-miR-3135b	CLIP-seq
MIRT1204512	hsa-miR-3150b-3p	CLIP-seq
MIRT1204513	hsa-miR-3155	CLIP-seq
MIRT1204514	hsa-miR-3155b	CLIP-seq
MIRT1204515	hsa-miR-3173-5p	CLIP-seq
MIRT1204495	hsa-miR-32	CLIP-seq
MIRT1204496	hsa-miR-363	CLIP-seq
MIRT1204497	hsa-miR-367	CLIP-seq
MIRT1204498	hsa-miR-3909	CLIP-seq
MIRT1204516	hsa-miR-4267	CLIP-seq
MIRT1204499	hsa-miR-4270	CLIP-seq
MIRT1204500	hsa-miR-4441	CLIP-seq
MIRT1204517	hsa-miR-4518	CLIP-seq
MIRT1204501	hsa-miR-4640-5p	CLIP-seq
MIRT1204518	hsa-miR-4689	CLIP-seq
MIRT1204502	hsa-miR-4691-3p	CLIP-seq
MIRT1204519	hsa-miR-4726-3p	CLIP-seq
MIRT1204504	hsa-miR-4726-5p	CLIP-seq
MIRT1204520	hsa-miR-4782-5p	CLIP-seq
MIRT1204521	hsa-miR-4784	CLIP-seq
MIRT1204522	hsa-miR-484	CLIP-seq
MIRT1204523	hsa-miR-760	CLIP-seq
MIRT1204524	hsa-miR-874	CLIP-seq
MIRT1204505	hsa-miR-92a	CLIP-seq
MIRT1204506	hsa-miR-92b	CLIP-seq
MIRT2059006	hsa-miR-3667-3p	CLIP-seq
MIRT1204515	hsa-miR-3173-5p	CLIP-seq
MIRT2442427	hsa-miR-1200	CLIP-seq
MIRT2442428	hsa-miR-3186-3p	CLIP-seq
MIRT2442429	hsa-miR-4324	CLIP-seq
MIRT2442430	hsa-miR-4329	CLIP-seq
MIRT2442431	hsa-miR-566	CLIP-seq
MIRT2455662	hsa-miR-3136-3p	CLIP-seq
MIRT2455663	hsa-miR-4668-5p	CLIP-seq
MIRT2442427	hsa-miR-1200	CLIP-seq
MIRT2442428	hsa-miR-3186-3p	CLIP-seq
MIRT2442429	hsa-miR-4324	CLIP-seq
MIRT2442430	hsa-miR-4329	CLIP-seq
MIRT2442431	hsa-miR-566	CLIP-seq
MIRT2442427	hsa-miR-1200	CLIP-seq
MIRT2442428	hsa-miR-3186-3p	CLIP-seq
MIRT2442429	hsa-miR-4324	CLIP-seq
MIRT2442430	hsa-miR-4329	CLIP-seq
MIRT2442431	hsa-miR-566	CLIP-seq

Show/Hide all(31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001626	Function	Nociceptin receptor activity	IBA
GO:0001626	Function	Nociceptin receptor activity	IDA	10571060, 12568343
GO:0001626	Function	Nociceptin receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IMP	8137918
GO:0004930	Function	G protein-coupled receptor activity	IPI	10571060
GO:0004985	Function	G protein-coupled opioid receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	23597562, 28298427, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	8137918, 12568343
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	8137918, 12568343
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	10965058
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IPI	10571060
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007270	Process	Neuron-neuron synaptic transmission	IEA
GO:0007600	Process	Sensory perception	TAS	7566152
GO:0008528	Function	G protein-coupled peptide receptor activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0019233	Process	Sensory perception of pain	IBA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0019233	Process	Sensory perception of pain	ISS
GO:0019722	Process	Calcium-mediated signaling	IDA	10571060
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0038003	Process	G protein-coupled opioid receptor signaling pathway	IEA
GO:0042923	Function	Neuropeptide binding	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0097060	Component	Synaptic membrane	IEA

MIM	HGNC	e!Ensembl
602548	8155	ENSG00000125510

Protein

UniProt ID

P41146

Protein name

Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor)

Protein function

G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the

PDB

4EA3 , 5DHG , 5DHH , 8F7X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	68 → 319	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}.

Sequence

MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA

Sequence length

370

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling		Peptide ligand-binding receptors G alpha (i) signalling events

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Diabetes	Type 2 diabetes, Triglyceride levels in non-type 2 diabetes	N/A	N/A	GWAS
Duodenal Ulcer	Duodenal ulcer	N/A	N/A	GWAS
Metabolic Syndrome	Metabolic syndrome	N/A	N/A	GWAS

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	30152845
Arthritis Infectious	Associate	21324928
Bronchopulmonary Dysplasia	Stimulate	35509863
Cholangitis Sclerosing	Associate	38302916
Colitis Ulcerative	Associate	38302916
Inflammation	Associate	21547539, 39652903
Inflammatory Bowel Diseases	Associate	39652903
Metabolic Syndrome	Associate	35168826
Neoplasms	Associate	21324928, 36011316
Pain	Associate	30466988, 39652903
Uterine Cervical Neoplasms	Associate	36011316

OPRL1 (opioid related nociceptin receptor 1)