Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	4987
Gene name	Opioid related nociceptin receptor 1
Gene symbol	OPRL1
Synonyms (NCBI Gene)	KOR-3KOR3NOCIRNOPNOPrOOROPRLORL1PNOCR
Chromosome	20
Chromosome location	20q13.33
Summary	The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a va

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miRTarBase ID	miRNA	Experiments	Reference
MIRT529744	hsa-miR-6733-3p	PAR-CLIP	22012620
MIRT529742	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT529741	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT529740	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT529739	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT529738	hsa-miR-331-3p	PAR-CLIP	22012620
MIRT529737	hsa-miR-125a-5p	PAR-CLIP	22012620
MIRT529736	hsa-miR-125b-5p	PAR-CLIP	22012620
MIRT529735	hsa-miR-4319	PAR-CLIP	22012620
MIRT529734	hsa-miR-544b	PAR-CLIP	22012620
MIRT529733	hsa-miR-7162-3p	PAR-CLIP	22012620
MIRT529732	hsa-miR-6786-3p	PAR-CLIP	22012620
MIRT529731	hsa-let-7a-5p	PAR-CLIP	22012620
MIRT529730	hsa-let-7b-5p	PAR-CLIP	22012620
MIRT529729	hsa-let-7c-5p	PAR-CLIP	22012620
MIRT529728	hsa-let-7d-5p	PAR-CLIP	22012620
MIRT529727	hsa-let-7e-5p	PAR-CLIP	22012620
MIRT529726	hsa-let-7f-5p	PAR-CLIP	22012620
MIRT529725	hsa-let-7g-5p	PAR-CLIP	22012620
MIRT529724	hsa-let-7i-5p	PAR-CLIP	22012620
MIRT529723	hsa-miR-4458	PAR-CLIP	22012620
MIRT529722	hsa-miR-4500	PAR-CLIP	22012620
MIRT529721	hsa-miR-98-5p	PAR-CLIP	22012620
MIRT529720	hsa-miR-202-3p	PAR-CLIP	22012620
MIRT529719	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT529718	hsa-miR-324-5p	PAR-CLIP	22012620
MIRT529744	hsa-miR-6733-3p	PAR-CLIP	22012620
MIRT529742	hsa-miR-6729-3p	PAR-CLIP	22012620
MIRT529741	hsa-miR-6793-3p	PAR-CLIP	22012620
MIRT529740	hsa-miR-6801-3p	PAR-CLIP	22012620
MIRT529739	hsa-miR-6810-3p	PAR-CLIP	22012620
MIRT529738	hsa-miR-331-3p	PAR-CLIP	22012620
MIRT529737	hsa-miR-125a-5p	PAR-CLIP	22012620
MIRT529736	hsa-miR-125b-5p	PAR-CLIP	22012620
MIRT529735	hsa-miR-4319	PAR-CLIP	22012620
MIRT529734	hsa-miR-544b	PAR-CLIP	22012620
MIRT529733	hsa-miR-7162-3p	PAR-CLIP	22012620
MIRT529732	hsa-miR-6786-3p	PAR-CLIP	22012620
MIRT529731	hsa-let-7a-5p	PAR-CLIP	22012620
MIRT529730	hsa-let-7b-5p	PAR-CLIP	22012620
MIRT529729	hsa-let-7c-5p	PAR-CLIP	22012620
MIRT529728	hsa-let-7d-5p	PAR-CLIP	22012620
MIRT529727	hsa-let-7e-5p	PAR-CLIP	22012620
MIRT529726	hsa-let-7f-5p	PAR-CLIP	22012620
MIRT529725	hsa-let-7g-5p	PAR-CLIP	22012620
MIRT529724	hsa-let-7i-5p	PAR-CLIP	22012620
MIRT529723	hsa-miR-4458	PAR-CLIP	22012620
MIRT529722	hsa-miR-4500	PAR-CLIP	22012620
MIRT529721	hsa-miR-98-5p	PAR-CLIP	22012620
MIRT529720	hsa-miR-202-3p	PAR-CLIP	22012620
MIRT529719	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT529718	hsa-miR-324-5p	PAR-CLIP	22012620
MIRT1204490	hsa-miR-1255a	CLIP-seq
MIRT1204491	hsa-miR-1255b	CLIP-seq
MIRT1204492	hsa-miR-25	CLIP-seq
MIRT1204493	hsa-miR-3130-3p	CLIP-seq
MIRT1204494	hsa-miR-3135b	CLIP-seq
MIRT1204495	hsa-miR-32	CLIP-seq
MIRT1204496	hsa-miR-363	CLIP-seq
MIRT1204497	hsa-miR-367	CLIP-seq
MIRT1204498	hsa-miR-3909	CLIP-seq
MIRT1204499	hsa-miR-4270	CLIP-seq
MIRT1204500	hsa-miR-4441	CLIP-seq
MIRT1204501	hsa-miR-4640-5p	CLIP-seq
MIRT1204502	hsa-miR-4691-3p	CLIP-seq
MIRT1204503	hsa-miR-4717-3p	CLIP-seq
MIRT1204504	hsa-miR-4726-5p	CLIP-seq
MIRT1204505	hsa-miR-92a	CLIP-seq
MIRT1204506	hsa-miR-92b	CLIP-seq
MIRT1204507	hsa-miR-125b	CLIP-seq
MIRT1204508	hsa-miR-1266	CLIP-seq
MIRT1204509	hsa-miR-146b-3p	CLIP-seq
MIRT1204510	hsa-miR-1915	CLIP-seq
MIRT1204511	hsa-miR-22	CLIP-seq
MIRT1204492	hsa-miR-25	CLIP-seq
MIRT1204494	hsa-miR-3135b	CLIP-seq
MIRT1204512	hsa-miR-3150b-3p	CLIP-seq
MIRT1204513	hsa-miR-3155	CLIP-seq
MIRT1204514	hsa-miR-3155b	CLIP-seq
MIRT1204515	hsa-miR-3173-5p	CLIP-seq
MIRT1204495	hsa-miR-32	CLIP-seq
MIRT1204496	hsa-miR-363	CLIP-seq
MIRT1204497	hsa-miR-367	CLIP-seq
MIRT1204498	hsa-miR-3909	CLIP-seq
MIRT1204516	hsa-miR-4267	CLIP-seq
MIRT1204499	hsa-miR-4270	CLIP-seq
MIRT1204500	hsa-miR-4441	CLIP-seq
MIRT1204517	hsa-miR-4518	CLIP-seq
MIRT1204501	hsa-miR-4640-5p	CLIP-seq
MIRT1204518	hsa-miR-4689	CLIP-seq
MIRT1204502	hsa-miR-4691-3p	CLIP-seq
MIRT1204519	hsa-miR-4726-3p	CLIP-seq
MIRT1204504	hsa-miR-4726-5p	CLIP-seq
MIRT1204520	hsa-miR-4782-5p	CLIP-seq
MIRT1204521	hsa-miR-4784	CLIP-seq
MIRT1204522	hsa-miR-484	CLIP-seq
MIRT1204523	hsa-miR-760	CLIP-seq
MIRT1204524	hsa-miR-874	CLIP-seq
MIRT1204505	hsa-miR-92a	CLIP-seq
MIRT1204506	hsa-miR-92b	CLIP-seq
MIRT2059006	hsa-miR-3667-3p	CLIP-seq
MIRT1204515	hsa-miR-3173-5p	CLIP-seq
MIRT2442427	hsa-miR-1200	CLIP-seq
MIRT2442428	hsa-miR-3186-3p	CLIP-seq
MIRT2442429	hsa-miR-4324	CLIP-seq
MIRT2442430	hsa-miR-4329	CLIP-seq
MIRT2442431	hsa-miR-566	CLIP-seq
MIRT2455662	hsa-miR-3136-3p	CLIP-seq
MIRT2455663	hsa-miR-4668-5p	CLIP-seq
MIRT2442427	hsa-miR-1200	CLIP-seq
MIRT2442428	hsa-miR-3186-3p	CLIP-seq
MIRT2442429	hsa-miR-4324	CLIP-seq
MIRT2442430	hsa-miR-4329	CLIP-seq
MIRT2442431	hsa-miR-566	CLIP-seq
MIRT2442427	hsa-miR-1200	CLIP-seq
MIRT2442428	hsa-miR-3186-3p	CLIP-seq
MIRT2442429	hsa-miR-4324	CLIP-seq
MIRT2442430	hsa-miR-4329	CLIP-seq
MIRT2442431	hsa-miR-566	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001626	Function	Nociceptin receptor activity	IBA
GO:0001626	Function	Nociceptin receptor activity	IDA	10571060, 12568343
GO:0001626	Function	Nociceptin receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IMP	8137918
GO:0004930	Function	G protein-coupled receptor activity	IPI	10571060
GO:0004985	Function	G protein-coupled opioid receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	23597562, 28298427, 33961781
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	8137918, 12568343
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP	8137918, 12568343
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	10965058
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IPI	10571060
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007270	Process	Neuron-neuron synaptic transmission	IEA
GO:0007600	Process	Sensory perception	TAS	7566152
GO:0008528	Function	G protein-coupled peptide receptor activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0019233	Process	Sensory perception of pain	IBA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0019233	Process	Sensory perception of pain	ISS
GO:0019722	Process	Calcium-mediated signaling	IDA	10571060
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0038003	Process	G protein-coupled opioid receptor signaling pathway	IEA
GO:0042923	Function	Neuropeptide binding	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0097060	Component	Synaptic membrane	IEA

MIM	HGNC	e!Ensembl
602548	8155	ENSG00000125510

P41146

Protein name

Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor)

Protein function

G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the

PDB

4EA3 , 5DHG , 5DHH , 8F7X

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	68 → 319	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in blood leukocytes. {ECO:0000269|PubMed:7500847}.

Sequence

MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLA
VCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGN
ALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASV
VGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIR
RLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAI
LRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALAC
KTSETVPRPA

Sequence length

370

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling		Peptide ligand-binding receptors G alpha (i) signalling events

OPRL1 (opioid related nociceptin receptor 1)