Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	4986
Gene name	Opioid receptor kappa 1
Gene symbol	OPRK1
Synonyms (NCBI Gene)	K-OR-1KOPKORKOR-1KOR1OPRK
Chromosome	8
Chromosome location	8q11.23
Summary	This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020420	hsa-miR-106b-5p	Microarray	17242205
MIRT755694	hsa-miR-144-3p	Luciferase reporter assayWestern blottingMicroarrayqRT-PCR	37455648
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204462	hsa-miR-140-3p	CLIP-seq
MIRT1204463	hsa-miR-1539	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204465	hsa-miR-203	CLIP-seq
MIRT1204466	hsa-miR-2467-3p	CLIP-seq
MIRT1204467	hsa-miR-28-3p	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT1204470	hsa-miR-3193	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204472	hsa-miR-3688-5p	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT1204476	hsa-miR-3940-5p	CLIP-seq
MIRT1204477	hsa-miR-4470	CLIP-seq
MIRT1204478	hsa-miR-4507	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT1204480	hsa-miR-4691-3p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT1204483	hsa-miR-4777-3p	CLIP-seq
MIRT1204484	hsa-miR-515-5p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT1204486	hsa-miR-629	CLIP-seq
MIRT1204487	hsa-miR-635	CLIP-seq
MIRT1204488	hsa-miR-885-5p	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204466	hsa-miR-2467-3p	CLIP-seq
MIRT2058995	hsa-miR-3065-3p	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2058996	hsa-miR-3123	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2058997	hsa-miR-3919	CLIP-seq
MIRT2058998	hsa-miR-4291	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT2058999	hsa-miR-4693-3p	CLIP-seq
MIRT2059000	hsa-miR-4708-3p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT2059001	hsa-miR-4756-3p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2059003	hsa-miR-653	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204466	hsa-miR-2467-3p	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2287122	hsa-miR-3143	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT2287123	hsa-miR-3192	CLIP-seq
MIRT2287124	hsa-miR-3605-3p	CLIP-seq
MIRT2287125	hsa-miR-3672	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT2287126	hsa-miR-3976	CLIP-seq
MIRT2287127	hsa-miR-4300	CLIP-seq
MIRT2287128	hsa-miR-4303	CLIP-seq
MIRT2287129	hsa-miR-4433	CLIP-seq
MIRT2287130	hsa-miR-4633-3p	CLIP-seq
MIRT2287131	hsa-miR-4649-3p	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT2058999	hsa-miR-4693-3p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2287132	hsa-miR-4778-5p	CLIP-seq
MIRT2287133	hsa-miR-4786-3p	CLIP-seq
MIRT2287134	hsa-miR-4786-5p	CLIP-seq
MIRT2287135	hsa-miR-490-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT2287136	hsa-miR-543	CLIP-seq
MIRT2287137	hsa-miR-548p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT2287138	hsa-miR-769-5p	CLIP-seq
MIRT2287139	hsa-miR-802	CLIP-seq
MIRT2287140	hsa-miR-920	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2287124	hsa-miR-3605-3p	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT2287126	hsa-miR-3976	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2431802	hsa-miR-1299	CLIP-seq
MIRT2431803	hsa-miR-4766-3p	CLIP-seq
MIRT2287137	hsa-miR-548p	CLIP-seq
MIRT2431804	hsa-miR-875-3p	CLIP-seq
MIRT2431802	hsa-miR-1299	CLIP-seq
MIRT2431803	hsa-miR-4766-3p	CLIP-seq
MIRT2287137	hsa-miR-548p	CLIP-seq
MIRT2431804	hsa-miR-875-3p	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT2455657	hsa-miR-186	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2455658	hsa-miR-3133	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2455659	hsa-miR-4684-5p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2455660	hsa-miR-548c-3p	CLIP-seq
MIRT2455661	hsa-miR-587	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT2455657	hsa-miR-186	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2455658	hsa-miR-3133	CLIP-seq
MIRT2455661	hsa-miR-587	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT2585305	hsa-miR-3611	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2585306	hsa-miR-4289	CLIP-seq
MIRT2585307	hsa-miR-4443	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2585308	hsa-miR-616	CLIP-seq
MIRT2585309	hsa-miR-626	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT2585305	hsa-miR-3611	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2585306	hsa-miR-4289	CLIP-seq
MIRT2585307	hsa-miR-4443	CLIP-seq
MIRT2455659	hsa-miR-4684-5p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT2455660	hsa-miR-548c-3p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2585308	hsa-miR-616	CLIP-seq
MIRT2585309	hsa-miR-626	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq

Show/Hide all (71)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004985	Function	G protein-coupled opioid receptor activity	IDA	22437504
GO:0004985	Function	G protein-coupled opioid receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	16431922, 22200678, 31668922, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	7624359
GO:0005886	Component	Plasma membrane	TAS	7624359
GO:0006955	Process	Immune response	IDA	8755601
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	7624359
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007268	Process	Chemical synaptic transmission	TAS	7624359
GO:0007600	Process	Sensory perception	TAS	7624359
GO:0007626	Process	Locomotory behavior	IEA
GO:0007626	Process	Locomotory behavior	ISS
GO:0008528	Function	G protein-coupled peptide receptor activity	IEA
GO:0016020	Component	Membrane	IDA	22437504
GO:0016020	Component	Membrane	IEA
GO:0016529	Component	Sarcoplasmic reticulum	IEA
GO:0019233	Process	Sensory perception of pain	IBA
GO:0019233	Process	Sensory perception of pain	IEA
GO:0019233	Process	Sensory perception of pain	ISS
GO:0030315	Component	T-tubule	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031635	Process	Adenylate cyclase-inhibiting opioid receptor signaling pathway	IDA	22437504
GO:0032868	Process	Response to insulin	IEA
GO:0033603	Process	Positive regulation of dopamine secretion	IEA
GO:0033612	Function	Receptor serine/threonine kinase binding	IEA
GO:0033685	Process	Negative regulation of luteinizing hormone secretion	IEA
GO:0035094	Process	Response to nicotine	IEA
GO:0038003	Process	G protein-coupled opioid receptor signaling pathway	IBA
GO:0038003	Process	G protein-coupled opioid receptor signaling pathway	IDA	8755601
GO:0038048	Function	Dynorphin receptor activity	IBA
GO:0038048	Function	Dynorphin receptor activity	IDA	8755601
GO:0038048	Function	Dynorphin receptor activity	IEA
GO:0038048	Function	Dynorphin receptor activity	IMP	7624359
GO:0042220	Process	Response to cocaine	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0042711	Process	Maternal behavior	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042755	Process	Eating behavior	IEA
GO:0042923	Function	Neuropeptide binding	IBA
GO:0043005	Component	Neuron projection	IBA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043627	Process	Response to estrogen	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0044849	Process	Estrous cycle	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045471	Process	Response to ethanol	IEA
GO:0046877	Process	Regulation of saliva secretion	IEA
GO:0046877	Process	Regulation of saliva secretion	ISS
GO:0048148	Process	Behavioral response to cocaine	IEA
GO:0050951	Process	Sensory perception of temperature stimulus	IEA
GO:0051607	Process	Defense response to virus	IDA	8755601
GO:0071222	Process	Cellular response to lipopolysaccharide	IEA
GO:0071333	Process	Cellular response to glucose stimulus	IEA
GO:1900745	Process	Positive regulation of p38MAPK cascade	IEA
GO:1901381	Process	Positive regulation of potassium ion transmembrane transport	IEA
GO:1903937	Process	Response to acrylamide	IEA
GO:1904000	Process	Positive regulation of eating behavior	IEA
GO:1990708	Process	Conditioned place preference	IEA

MIM	HGNC	e!Ensembl
165196	8154	ENSG00000082556

P41145

Protein name

Kappa-type opioid receptor (K-OR-1) (KOR-1)

Protein function

G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diter

PDB

4DJH , 6B73 , 6VI4 , 7T10 , 7T11 , 7UL2 , 7UL3 , 7UL5 , 7Y1F , 7YIT , 7YMJ , 8DZP , 8DZQ , 8DZR , 8DZS , 8F7W , 8FEG , 8HNN , 8K2W , 8VVE , 8VVF , 8VVG , 9D61

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	76 → 330	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.

Sequence

MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV

Sequence length

380

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling		Peptide ligand-binding receptors G alpha (i) signalling events

OPRK1 (opioid receptor kappa 1)