Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4986
Gene name Gene Name - the full gene name approved by the HGNC.	Opioid receptor kappa 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	OPRK1
Synonyms (NCBI Gene) Gene synonyms aliases	K-OR-1, KOP, KOR, KOR-1, KOR1, OPRK
Chromosome Chromosome number	8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	8q11.23
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in in

Show/Hide all(158)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020420	hsa-miR-106b-5p	Microarray	17242205
MIRT755694	hsa-miR-144-3p	Luciferase reporter assay, Western blotting, Microarray, qRT-PCR	37455648
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204462	hsa-miR-140-3p	CLIP-seq
MIRT1204463	hsa-miR-1539	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204465	hsa-miR-203	CLIP-seq
MIRT1204466	hsa-miR-2467-3p	CLIP-seq
MIRT1204467	hsa-miR-28-3p	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT1204470	hsa-miR-3193	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204472	hsa-miR-3688-5p	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT1204476	hsa-miR-3940-5p	CLIP-seq
MIRT1204477	hsa-miR-4470	CLIP-seq
MIRT1204478	hsa-miR-4507	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT1204480	hsa-miR-4691-3p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT1204483	hsa-miR-4777-3p	CLIP-seq
MIRT1204484	hsa-miR-515-5p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT1204486	hsa-miR-629	CLIP-seq
MIRT1204487	hsa-miR-635	CLIP-seq
MIRT1204488	hsa-miR-885-5p	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204466	hsa-miR-2467-3p	CLIP-seq
MIRT2058995	hsa-miR-3065-3p	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2058996	hsa-miR-3123	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2058997	hsa-miR-3919	CLIP-seq
MIRT2058998	hsa-miR-4291	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT2058999	hsa-miR-4693-3p	CLIP-seq
MIRT2059000	hsa-miR-4708-3p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT2059001	hsa-miR-4756-3p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2059003	hsa-miR-653	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204466	hsa-miR-2467-3p	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2287122	hsa-miR-3143	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT2287123	hsa-miR-3192	CLIP-seq
MIRT2287124	hsa-miR-3605-3p	CLIP-seq
MIRT2287125	hsa-miR-3672	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT2287126	hsa-miR-3976	CLIP-seq
MIRT2287127	hsa-miR-4300	CLIP-seq
MIRT2287128	hsa-miR-4303	CLIP-seq
MIRT2287129	hsa-miR-4433	CLIP-seq
MIRT2287130	hsa-miR-4633-3p	CLIP-seq
MIRT2287131	hsa-miR-4649-3p	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT2058999	hsa-miR-4693-3p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2287132	hsa-miR-4778-5p	CLIP-seq
MIRT2287133	hsa-miR-4786-3p	CLIP-seq
MIRT2287134	hsa-miR-4786-5p	CLIP-seq
MIRT2287135	hsa-miR-490-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT2287136	hsa-miR-543	CLIP-seq
MIRT2287137	hsa-miR-548p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT2287138	hsa-miR-769-5p	CLIP-seq
MIRT2287139	hsa-miR-802	CLIP-seq
MIRT2287140	hsa-miR-920	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2287124	hsa-miR-3605-3p	CLIP-seq
MIRT1204473	hsa-miR-370	CLIP-seq
MIRT2287126	hsa-miR-3976	CLIP-seq
MIRT1204479	hsa-miR-4663	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2431802	hsa-miR-1299	CLIP-seq
MIRT2431803	hsa-miR-4766-3p	CLIP-seq
MIRT2287137	hsa-miR-548p	CLIP-seq
MIRT2431804	hsa-miR-875-3p	CLIP-seq
MIRT2431802	hsa-miR-1299	CLIP-seq
MIRT2431803	hsa-miR-4766-3p	CLIP-seq
MIRT2287137	hsa-miR-548p	CLIP-seq
MIRT2431804	hsa-miR-875-3p	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT2455657	hsa-miR-186	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2455658	hsa-miR-3133	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2455659	hsa-miR-4684-5p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2455660	hsa-miR-548c-3p	CLIP-seq
MIRT2455661	hsa-miR-587	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT2455657	hsa-miR-186	CLIP-seq
MIRT1204468	hsa-miR-3074-5p	CLIP-seq
MIRT2455658	hsa-miR-3133	CLIP-seq
MIRT2455661	hsa-miR-587	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT2585305	hsa-miR-3611	CLIP-seq
MIRT1204471	hsa-miR-3613-3p	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2585306	hsa-miR-4289	CLIP-seq
MIRT2585307	hsa-miR-4443	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2585308	hsa-miR-616	CLIP-seq
MIRT2585309	hsa-miR-626	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq
MIRT1204461	hsa-miR-1285	CLIP-seq
MIRT1204464	hsa-miR-1827	CLIP-seq
MIRT1204469	hsa-miR-3187-5p	CLIP-seq
MIRT2585305	hsa-miR-3611	CLIP-seq
MIRT1204474	hsa-miR-371-5p	CLIP-seq
MIRT1204475	hsa-miR-371b-5p	CLIP-seq
MIRT2585306	hsa-miR-4289	CLIP-seq
MIRT2585307	hsa-miR-4443	CLIP-seq
MIRT2455659	hsa-miR-4684-5p	CLIP-seq
MIRT1204481	hsa-miR-4722-5p	CLIP-seq
MIRT1204482	hsa-miR-4768-3p	CLIP-seq
MIRT2059002	hsa-miR-508-5p	CLIP-seq
MIRT2455660	hsa-miR-548c-3p	CLIP-seq
MIRT1204485	hsa-miR-612	CLIP-seq
MIRT2585308	hsa-miR-616	CLIP-seq
MIRT2585309	hsa-miR-626	CLIP-seq
MIRT2059004	hsa-miR-661	CLIP-seq
MIRT2059005	hsa-miR-766	CLIP-seq
MIRT1204489	hsa-miR-940	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0004985	Function	Opioid receptor activity	IDA	22437504
GO:0005515	Function	Protein binding	IPI	16431922, 22200678, 32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IMP	7624359
GO:0006955	Process	Immune response	IDA	8755601
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	TAS	7624359
GO:0007200	Process	Phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
GO:0007218	Process	Neuropeptide signaling pathway	IBA	21873635
GO:0007268	Process	Chemical synaptic transmission	TAS	7624359
GO:0007600	Process	Sensory perception	TAS	7624359
GO:0007626	Process	Locomotory behavior	ISS
GO:0016021	Component	Integral component of membrane	IDA	22437504
GO:0019233	Process	Sensory perception of pain	IBA	21873635
GO:0019233	Process	Sensory perception of pain	ISS
GO:0031635	Process	Adenylate cyclase-inhibiting opioid receptor signaling pathway	IDA	22437504
GO:0038003	Process	Opioid receptor signaling pathway	IBA	21873635
GO:0038003	Process	Opioid receptor signaling pathway	IDA	8755601
GO:0038048	Function	Dynorphin receptor activity	IBA	21873635
GO:0038048	Function	Dynorphin receptor activity	IDA	8755601
GO:0038048	Function	Dynorphin receptor activity	IMP	7624359
GO:0042277	Function	Peptide binding	IBA	21873635
GO:0042923	Function	Neuropeptide binding	IBA	21873635
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0045202	Component	Synapse	IEA
GO:0046877	Process	Regulation of saliva secretion	ISS
GO:0051607	Process	Defense response to virus	IDA	8755601

MIM	HGNC	e!Ensembl
165196	8154	ENSG00000082556

Protein

UniProt ID

P41145

Protein name

Kappa-type opioid receptor (K-OR-1) (KOR-1)

Protein function

G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diter

PDB

4DJH , 6B73 , 6VI4 , 7T10 , 7T11 , 7UL2 , 7UL3 , 7UL5 , 7Y1F , 7YIT , 7YMJ , 8DZP , 8DZQ , 8DZR , 8DZS , 8F7W , 8FEG , 8HNN , 8K2W , 8VVE , 8VVF , 8VVG , 9D61

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	76 → 330	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Detected in brain and placenta. {ECO:0000269|PubMed:7624359, ECO:0000269|PubMed:8060324}.

Sequence

MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV

Sequence length

380

Interactions

View interactions

	KEGG		Reactome
	Neuroactive ligand-receptor interaction Hormone signaling		Peptide ligand-binding receptors G alpha (i) signalling events

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Seizure	Complex partial seizures, Generalized seizures, Visual seizure, Tonic - clonic seizures, Single Seizure	rs587784365, rs28939683, rs74315390, rs28939684, rs74315391, rs267607198, rs74315392, rs118192244, rs118192250, rs121917749, rs121917750, rs121917751, rs121917752, rs267606670, rs267607061 View all (179 more)	1675896, 18042875

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Mental Depression, Depressive disorder		25286107, 23293139, 23101464, 17601558, 19924112	ClinVar

Show/Hide Text Mining Associations (30)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Associate	23308242
Alzheimer Disease	Associate	30152845
Anhedonia	Associate	30936032
Arthritis Rheumatoid	Associate	15880345
Breast Neoplasms	Associate	34461834
Carcinoma	Associate	11118638
Carcinoma Hepatocellular	Associate	28821282
Carcinoma Non Small Cell Lung	Inhibit	22343623
Chronic Pain	Associate	33547588
Cognition Disorders	Associate	29925858
Depression Postpartum	Associate	30936032
Heredodegenerative Disorders Nervous System	Associate	26742690
HIV Infections	Associate	23392455, 24405578
Hypoxia Brain	Associate	28117678
Inflammation	Associate	15880345
Mental Disorders	Associate	20808262
Mood Disorders	Associate	23277131
Neoplasm Metastasis	Associate	25241033, 33639684
Neoplasms	Associate	22343623, 24238043, 33220939
Neoplasms	Inhibit	28821282
Nerve Degeneration	Associate	29925858
Neuroectodermal Tumors Primitive	Associate	25241033
Opioid Related Disorders	Associate	33547588
Osteoarthritis	Associate	15880345
Pain	Associate	33547588, 38118075
Pathological Conditions Anatomical	Associate	28117678
Prostatic Neoplasms	Associate	34806485, 35365763
Prostatic Neoplasms Castration Resistant	Stimulate	35365763
Pruritus	Associate	17611580
Substance Related Disorders	Associate	38118075

OPRK1 (opioid receptor kappa 1)