Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4923
Gene name Gene Name - the full gene name approved by the HGNC.	Neurotensin receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NTSR1
Synonyms (NCBI Gene) Gene synonyms aliases	NTR
Chromosome Chromosome number	20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	20q13.33
Summary Summary of gene provided in NCBI Entrez Gene.	Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secre

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017517	hsa-miR-335-5p	Microarray	18185580
MIRT029363	hsa-miR-26b-5p	Microarray	19088304
MIRT1196327	hsa-miR-1231	CLIP-seq
MIRT1196328	hsa-miR-1254	CLIP-seq
MIRT1196329	hsa-miR-1275	CLIP-seq
MIRT1196330	hsa-miR-1293	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196334	hsa-miR-149	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196337	hsa-miR-193a-5p	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT1196341	hsa-miR-3116	CLIP-seq
MIRT1196342	hsa-miR-3120-5p	CLIP-seq
MIRT1196343	hsa-miR-3126-5p	CLIP-seq
MIRT1196344	hsa-miR-3156-5p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT1196347	hsa-miR-3622b-5p	CLIP-seq
MIRT1196348	hsa-miR-3650	CLIP-seq
MIRT1196349	hsa-miR-3677-3p	CLIP-seq
MIRT1196350	hsa-miR-3921	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT1196353	hsa-miR-4253	CLIP-seq
MIRT1196354	hsa-miR-4286	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196356	hsa-miR-4421	CLIP-seq
MIRT1196357	hsa-miR-4440	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT1196359	hsa-miR-4455	CLIP-seq
MIRT1196360	hsa-miR-4466	CLIP-seq
MIRT1196361	hsa-miR-4483	CLIP-seq
MIRT1196362	hsa-miR-4525	CLIP-seq
MIRT1196363	hsa-miR-4653-5p	CLIP-seq
MIRT1196364	hsa-miR-4665-5p	CLIP-seq
MIRT1196365	hsa-miR-4682	CLIP-seq
MIRT1196366	hsa-miR-4699-5p	CLIP-seq
MIRT1196367	hsa-miR-4711-3p	CLIP-seq
MIRT1196368	hsa-miR-4717-5p	CLIP-seq
MIRT1196369	hsa-miR-4723-5p	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT1196371	hsa-miR-4794	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq
MIRT1196373	hsa-miR-541	CLIP-seq
MIRT1196374	hsa-miR-609	CLIP-seq
MIRT1196375	hsa-miR-625	CLIP-seq
MIRT1196376	hsa-miR-637	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT1196378	hsa-miR-654-5p	CLIP-seq
MIRT1196379	hsa-miR-675	CLIP-seq
MIRT1196380	hsa-miR-760	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056965	hsa-miR-3151	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT2056968	hsa-miR-3199	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT2056969	hsa-miR-3919	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT2056973	hsa-miR-4704-3p	CLIP-seq
MIRT2056974	hsa-miR-4747-3p	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056976	hsa-miR-561	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT2056979	hsa-miR-665	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196327	hsa-miR-1231	CLIP-seq
MIRT2285393	hsa-miR-146b-3p	CLIP-seq
MIRT1196334	hsa-miR-149	CLIP-seq
MIRT2285394	hsa-miR-1915	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT1196342	hsa-miR-3120-5p	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056965	hsa-miR-3151	CLIP-seq
MIRT2285395	hsa-miR-3173-5p	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT2285396	hsa-miR-339-5p	CLIP-seq
MIRT2285397	hsa-miR-342-5p	CLIP-seq
MIRT2285398	hsa-miR-3652	CLIP-seq
MIRT2056969	hsa-miR-3919	CLIP-seq
MIRT1196350	hsa-miR-3921	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT2285399	hsa-miR-4265	CLIP-seq
MIRT2285400	hsa-miR-4281	CLIP-seq
MIRT2285401	hsa-miR-4296	CLIP-seq
MIRT2285402	hsa-miR-4322	CLIP-seq
MIRT1196356	hsa-miR-4421	CLIP-seq
MIRT2285403	hsa-miR-4430	CLIP-seq
MIRT2285404	hsa-miR-4447	CLIP-seq
MIRT2285405	hsa-miR-4449	CLIP-seq
MIRT2285406	hsa-miR-4472	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT1196363	hsa-miR-4653-5p	CLIP-seq
MIRT2285407	hsa-miR-4664-5p	CLIP-seq
MIRT1196365	hsa-miR-4682	CLIP-seq
MIRT2285408	hsa-miR-4685-5p	CLIP-seq
MIRT2285409	hsa-miR-4691-3p	CLIP-seq
MIRT1196371	hsa-miR-4794	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2285410	hsa-miR-596	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196380	hsa-miR-760	CLIP-seq
MIRT2285411	hsa-miR-874	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT2583502	hsa-miR-24	CLIP-seq
MIRT2583503	hsa-miR-2467-5p	CLIP-seq
MIRT2583504	hsa-miR-3136-3p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT2583505	hsa-miR-4494	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT2583506	hsa-miR-499a-5p	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT2583502	hsa-miR-24	CLIP-seq
MIRT2583503	hsa-miR-2467-5p	CLIP-seq
MIRT2583504	hsa-miR-3136-3p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT2583505	hsa-miR-4494	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT2583506	hsa-miR-499a-5p	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001659	Process	Temperature homeostasis	IEA
GO:0003085	Process	Negative regulation of systemic arterial blood pressure	IEA
GO:0003254	Process	Regulation of membrane depolarization	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8381365
GO:0005515	Function	Protein binding	IPI	17620610, 23597562
GO:0005783	Component	Endoplasmic reticulum	TAS	9763490
GO:0005794	Component	Golgi apparatus	TAS	9763490
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	8381365
GO:0005886	Component	Plasma membrane	TAS	8381365
GO:0006171	Process	CAMP biosynthetic process	IEA
GO:0006950	Process	Response to stress	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8381365
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IDA	21725197
GO:0007218	Process	Neuropeptide signaling pathway	IGI	21806946
GO:0007268	Process	Chemical synaptic transmission	TAS	9763490
GO:0007612	Process	Learning	IEA
GO:0008306	Process	Associative learning	IEA
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010628	Process	Positive regulation of gene expression	IGI	21806946
GO:0014049	Process	Positive regulation of glutamate secretion	IEA
GO:0014054	Process	Positive regulation of gamma-aminobutyric acid secretion	IEA
GO:0016020	Component	Membrane	IEA
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IBA
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IDA	21725197
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IEA
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IMP	8381365
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0032094	Process	Response to food	IEA
GO:0032280	Component	Symmetric synapse	IEA
GO:0032960	Process	Regulation of inositol trisphosphate biosynthetic process	IEA
GO:0033993	Process	Response to lipid	IEA
GO:0040017	Process	Positive regulation of locomotion	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	17620610
GO:0043025	Component	Neuronal cell body	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21725197
GO:0043195	Component	Terminal bouton	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043198	Component	Dendritic shaft	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043576	Process	Regulation of respiratory gaseous exchange	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0044309	Component	Neuron spine	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IDA	21725197
GO:0045121	Component	Membrane raft	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA
GO:0051280	Process	Negative regulation of release of sequestered calcium ion into cytosol	IEA
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	IEA
GO:0060732	Process	Positive regulation of inositol phosphate biosynthetic process	IEA
GO:0070779	Process	D-aspartate import across plasma membrane	IEA
GO:0071545	Process	Inositol phosphate catabolic process	IEA
GO:0071625	Process	Vocalization behavior	IEA
GO:0090238	Process	Positive regulation of arachidonate secretion	IEA
GO:0097151	Process	Positive regulation of inhibitory postsynaptic potential	IEA
GO:0098712	Process	L-glutamate import across plasma membrane	IEA
GO:1990708	Process	Conditioned place preference	IEA
GO:2000822	Process	Regulation of behavioral fear response	IEA

MIM	HGNC	e!Ensembl
162651	8039	ENSG00000101188

Protein

UniProt ID

P30989

Protein name

Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)

Protein function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to

PDB

2LYW , 6OS9 , 6OSA , 6PWC , 6UP7 , 7UL2 , 8JPB , 8JPC , 8JPF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	80 → 364	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:8381365}.

Sequence

MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY

Sequence length

418

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction		Peptide ligand-binding receptors G alpha (q) signalling events

NTSR1 (neurotensin receptor 1)