Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4923
Gene name	Neurotensin receptor 1
Gene symbol	NTSR1
Synonyms (NCBI Gene)	NTR
Chromosome	20
Chromosome location	20q13.33
Summary	Neurotensin receptor 1 belongs to the large superfamily of G-protein coupled receptors. NTSR1 mediates the multiple functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secre

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017517	hsa-miR-335-5p	Microarray	18185580
MIRT029363	hsa-miR-26b-5p	Microarray	19088304
MIRT1196327	hsa-miR-1231	CLIP-seq
MIRT1196328	hsa-miR-1254	CLIP-seq
MIRT1196329	hsa-miR-1275	CLIP-seq
MIRT1196330	hsa-miR-1293	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196334	hsa-miR-149	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196337	hsa-miR-193a-5p	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT1196341	hsa-miR-3116	CLIP-seq
MIRT1196342	hsa-miR-3120-5p	CLIP-seq
MIRT1196343	hsa-miR-3126-5p	CLIP-seq
MIRT1196344	hsa-miR-3156-5p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT1196347	hsa-miR-3622b-5p	CLIP-seq
MIRT1196348	hsa-miR-3650	CLIP-seq
MIRT1196349	hsa-miR-3677-3p	CLIP-seq
MIRT1196350	hsa-miR-3921	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT1196353	hsa-miR-4253	CLIP-seq
MIRT1196354	hsa-miR-4286	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196356	hsa-miR-4421	CLIP-seq
MIRT1196357	hsa-miR-4440	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT1196359	hsa-miR-4455	CLIP-seq
MIRT1196360	hsa-miR-4466	CLIP-seq
MIRT1196361	hsa-miR-4483	CLIP-seq
MIRT1196362	hsa-miR-4525	CLIP-seq
MIRT1196363	hsa-miR-4653-5p	CLIP-seq
MIRT1196364	hsa-miR-4665-5p	CLIP-seq
MIRT1196365	hsa-miR-4682	CLIP-seq
MIRT1196366	hsa-miR-4699-5p	CLIP-seq
MIRT1196367	hsa-miR-4711-3p	CLIP-seq
MIRT1196368	hsa-miR-4717-5p	CLIP-seq
MIRT1196369	hsa-miR-4723-5p	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT1196371	hsa-miR-4794	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq
MIRT1196373	hsa-miR-541	CLIP-seq
MIRT1196374	hsa-miR-609	CLIP-seq
MIRT1196375	hsa-miR-625	CLIP-seq
MIRT1196376	hsa-miR-637	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT1196378	hsa-miR-654-5p	CLIP-seq
MIRT1196379	hsa-miR-675	CLIP-seq
MIRT1196380	hsa-miR-760	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056965	hsa-miR-3151	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT2056968	hsa-miR-3199	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT2056969	hsa-miR-3919	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT2056973	hsa-miR-4704-3p	CLIP-seq
MIRT2056974	hsa-miR-4747-3p	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056976	hsa-miR-561	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT2056979	hsa-miR-665	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196327	hsa-miR-1231	CLIP-seq
MIRT2285393	hsa-miR-146b-3p	CLIP-seq
MIRT1196334	hsa-miR-149	CLIP-seq
MIRT2285394	hsa-miR-1915	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT1196340	hsa-miR-3064-5p	CLIP-seq
MIRT1196342	hsa-miR-3120-5p	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056965	hsa-miR-3151	CLIP-seq
MIRT2285395	hsa-miR-3173-5p	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT2285396	hsa-miR-339-5p	CLIP-seq
MIRT2285397	hsa-miR-342-5p	CLIP-seq
MIRT2285398	hsa-miR-3652	CLIP-seq
MIRT2056969	hsa-miR-3919	CLIP-seq
MIRT1196350	hsa-miR-3921	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT2285399	hsa-miR-4265	CLIP-seq
MIRT2285400	hsa-miR-4281	CLIP-seq
MIRT2285401	hsa-miR-4296	CLIP-seq
MIRT2285402	hsa-miR-4322	CLIP-seq
MIRT1196356	hsa-miR-4421	CLIP-seq
MIRT2285403	hsa-miR-4430	CLIP-seq
MIRT2285404	hsa-miR-4447	CLIP-seq
MIRT2285405	hsa-miR-4449	CLIP-seq
MIRT2285406	hsa-miR-4472	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT1196363	hsa-miR-4653-5p	CLIP-seq
MIRT2285407	hsa-miR-4664-5p	CLIP-seq
MIRT1196365	hsa-miR-4682	CLIP-seq
MIRT2285408	hsa-miR-4685-5p	CLIP-seq
MIRT2285409	hsa-miR-4691-3p	CLIP-seq
MIRT1196371	hsa-miR-4794	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2285410	hsa-miR-596	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196380	hsa-miR-760	CLIP-seq
MIRT2285411	hsa-miR-874	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196331	hsa-miR-1305	CLIP-seq
MIRT2056962	hsa-miR-2110	CLIP-seq
MIRT2056963	hsa-miR-3144-5p	CLIP-seq
MIRT2056964	hsa-miR-3150a-3p	CLIP-seq
MIRT2056966	hsa-miR-3175	CLIP-seq
MIRT2056967	hsa-miR-3191	CLIP-seq
MIRT1196346	hsa-miR-3612	CLIP-seq
MIRT2056970	hsa-miR-4259	CLIP-seq
MIRT1196355	hsa-miR-432	CLIP-seq
MIRT1196358	hsa-miR-4443	CLIP-seq
MIRT2056971	hsa-miR-4651	CLIP-seq
MIRT2056972	hsa-miR-4652-5p	CLIP-seq
MIRT2056975	hsa-miR-491-5p	CLIP-seq
MIRT2056977	hsa-miR-571	CLIP-seq
MIRT2056978	hsa-miR-608	CLIP-seq
MIRT1196377	hsa-miR-650	CLIP-seq
MIRT2056980	hsa-miR-939	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT2583502	hsa-miR-24	CLIP-seq
MIRT2583503	hsa-miR-2467-5p	CLIP-seq
MIRT2583504	hsa-miR-3136-3p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT2583505	hsa-miR-4494	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT2583506	hsa-miR-499a-5p	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq
MIRT1196332	hsa-miR-148a	CLIP-seq
MIRT1196333	hsa-miR-148b	CLIP-seq
MIRT1196335	hsa-miR-152	CLIP-seq
MIRT1196336	hsa-miR-1825	CLIP-seq
MIRT1196338	hsa-miR-199a-5p	CLIP-seq
MIRT1196339	hsa-miR-199b-5p	CLIP-seq
MIRT2583502	hsa-miR-24	CLIP-seq
MIRT2583503	hsa-miR-2467-5p	CLIP-seq
MIRT2583504	hsa-miR-3136-3p	CLIP-seq
MIRT1196345	hsa-miR-3176	CLIP-seq
MIRT1196351	hsa-miR-3922-3p	CLIP-seq
MIRT1196352	hsa-miR-3925-3p	CLIP-seq
MIRT2583505	hsa-miR-4494	CLIP-seq
MIRT1196370	hsa-miR-4757-5p	CLIP-seq
MIRT2583506	hsa-miR-499a-5p	CLIP-seq
MIRT1196372	hsa-miR-508-5p	CLIP-seq

Show/Hide all (68)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001659	Process	Temperature homeostasis	IEA
GO:0003085	Process	Negative regulation of systemic arterial blood pressure	IEA
GO:0003254	Process	Regulation of membrane depolarization	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	8381365
GO:0005515	Function	Protein binding	IPI	17620610, 23597562
GO:0005783	Component	Endoplasmic reticulum	TAS	9763490
GO:0005794	Component	Golgi apparatus	TAS	9763490
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	IMP	8381365
GO:0005886	Component	Plasma membrane	TAS	8381365
GO:0006171	Process	CAMP biosynthetic process	IEA
GO:0006950	Process	Response to stress	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	8381365
GO:0007218	Process	Neuropeptide signaling pathway	IBA
GO:0007218	Process	Neuropeptide signaling pathway	IDA	21725197
GO:0007218	Process	Neuropeptide signaling pathway	IGI	21806946
GO:0007268	Process	Chemical synaptic transmission	TAS	9763490
GO:0007612	Process	Learning	IEA
GO:0008306	Process	Associative learning	IEA
GO:0008344	Process	Adult locomotory behavior	IEA
GO:0009898	Component	Cytoplasmic side of plasma membrane	IEA
GO:0009986	Component	Cell surface	IEA
GO:0010628	Process	Positive regulation of gene expression	IGI	21806946
GO:0014049	Process	Positive regulation of glutamate secretion	IEA
GO:0014054	Process	Positive regulation of gamma-aminobutyric acid secretion	IEA
GO:0016020	Component	Membrane	IEA
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IBA
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IDA	21725197
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IEA
GO:0016492	Function	G protein-coupled neurotensin receptor activity	IMP	8381365
GO:0030424	Component	Axon	IEA
GO:0030425	Component	Dendrite	IEA
GO:0032094	Process	Response to food	IEA
GO:0032280	Component	Symmetric synapse	IEA
GO:0032960	Process	Regulation of inositol trisphosphate biosynthetic process	IEA
GO:0033993	Process	Response to lipid	IEA
GO:0040017	Process	Positive regulation of locomotion	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	17620610
GO:0043025	Component	Neuronal cell body	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	21725197
GO:0043195	Component	Terminal bouton	IEA
GO:0043197	Component	Dendritic spine	IEA
GO:0043198	Component	Dendritic shaft	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0043576	Process	Regulation of respiratory gaseous exchange	IEA
GO:0043679	Component	Axon terminus	IEA
GO:0044309	Component	Neuron spine	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0045121	Component	Membrane raft	IDA	21725197
GO:0045121	Component	Membrane raft	IEA
GO:0050965	Process	Detection of temperature stimulus involved in sensory perception of pain	IEA
GO:0051280	Process	Negative regulation of release of sequestered calcium ion into cytosol	IEA
GO:0051281	Process	Positive regulation of release of sequestered calcium ion into cytosol	IEA
GO:0060732	Process	Positive regulation of inositol phosphate biosynthetic process	IEA
GO:0070779	Process	D-aspartate import across plasma membrane	IEA
GO:0071545	Process	Inositol phosphate catabolic process	IEA
GO:0071625	Process	Vocalization behavior	IEA
GO:0090238	Process	Positive regulation of arachidonate secretion	IEA
GO:0097151	Process	Positive regulation of inhibitory postsynaptic potential	IEA
GO:0098712	Process	L-glutamate import across plasma membrane	IEA
GO:1990708	Process	Conditioned place preference	IEA
GO:2000822	Process	Regulation of behavioral fear response	IEA

MIM	HGNC	e!Ensembl
162651	8039	ENSG00000101188

P30989

Protein name

Neurotensin receptor type 1 (NT-R-1) (NTR1) (High-affinity levocabastine-insensitive neurotensin receptor) (NTRH)

Protein function

G-protein coupled receptor for the tridecapeptide neurotensin (NTS) (PubMed:21725197, PubMed:23140271, PubMed:8381365). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to

PDB

2LYW , 6OS9 , 6OSA , 6PWC , 6UP7 , 7UL2 , 8JPB , 8JPC , 8JPF

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	80 → 364	7 transmembrane receptor (rhodopsin family)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:8381365}.

Sequence

MRLNSSAPGTPGTPAADPFQRAQAGLEEALLAPGFGNASGNASERVLAAPSSELDVNTDI
YSKVLVTAVYLALFVVGTVGNTVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLTLLLAM
PVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLM
SRSRTKKFISAIWLASALLAVPMLFTMGEQNRSADGQHAGGLVCTPTIHTATVKVVIQVN
TFMSFIFPMVVISVLNTIIANKLTVMVRQAAEQGQVCTVGGEHSTFSMAIEPGRVQALRH
GVRVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVTNALFYVSSTIN
PILYNLVSANFRHIFLATLACLCPVWRRRRKRPAFSRKADSVSSNHTLSSNATRETLY

Sequence length

418

Interactions

View interactions

	KEGG		Reactome
	Calcium signaling pathway Neuroactive ligand-receptor interaction		Peptide ligand-binding receptors G alpha (q) signalling events

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign	rs59757062	RCV005912034
Gastric cancer	Benign	rs34864360	RCV005904998
Ovarian serous cystadenocarcinoma	Benign	rs59757062	RCV005912035
Uterine carcinosarcoma	Benign	rs34864360	RCV005904999
Uterine corpus endometrial carcinoma	Benign	rs59757062	RCV005912036

Show/Hide Text Mining Associations (61)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Acidosis	Associate	19393580
Adenocarcinoma of Lung	Associate	36439693
Adenomatous Polyposis Coli	Associate	26215716
Alzheimer Disease	Associate	11927634, 22142809
Alzheimer Disease	Inhibit	16539663, 21397006
Anophthalmia with pulmonary hypoplasia	Associate	36949141
Brain Neoplasms	Associate	30959962
Breast Neoplasms	Associate	11359788, 19156213, 21725197, 22161836, 27388253
Carcinogenesis	Associate	26298774
Carcinoid Tumor	Associate	26298774
Carcinoma Ductal	Stimulate	16258511
Carcinoma Hepatocellular	Associate	27611941
Carcinoma Non Small Cell Lung	Associate	24496038, 31614143
Carcinoma Pancreatic Ductal	Associate	29025990
Cerebral Hemorrhage	Associate	21672317
Cognition Disorders	Associate	21397006
Cognitive Dysfunction	Inhibit	16539663
Colitis	Associate	23901225
Colitis Associated Neoplasms	Stimulate	23901225
Colitis Associated Neoplasms	Associate	34680073
Colonic Neoplasms	Associate	9092553
Colorectal Neoplasms	Associate	16984735, 20663927, 26334593, 32764278
Colorectal Neoplasms	Stimulate	28498396
Colorectal Neoplasms Hereditary Nonpolyposis	Associate	34680073
Death	Associate	19156213
Depressive Disorder Major	Associate	26278479
Ectodermal Dysplasia Anhidrotic with Immunodeficiency Osteopetrosis and Lymphedema	Associate	9454839
Epilepsy Familial Mesial Temporal Lobe	Associate	25027171
Essential Tremor	Associate	26297037
Fibrocartilaginous embolism	Associate	16539663, 22142809
Glioma	Associate	23576602, 31028138
Hemorrhage	Stimulate	21672317
Hepatitis C	Associate	16500930
Huntington Disease	Associate	18093249
Hypothyroidism	Inhibit	32597152
Hypothyroidism	Stimulate	34104248
Hypoxia	Associate	19393580
Inflammation	Associate	21212273, 23901225, 34680073
Inflammatory Bowel Diseases	Associate	21212273
Inflammatory Bowel Diseases	Stimulate	23901225
Keratoconus	Associate	16275928
Leukemia B Cell	Associate	23109725
Lymphatic Metastasis	Associate	27388253
Lymphoma Non Hodgkin	Associate	23901225
MASS syndrome	Associate	23901225
Neoplasm Metastasis	Associate	27611941, 29272741, 29794962
Neoplasms	Associate	19156213, 21437237, 21725197, 23901225, 26215716, 27611941, 28849698, 29272741, 30959962, 32764278, 34680073, 35361846, 36949141
Neoplasms	Inhibit	21097678
Neoplasms	Stimulate	26334593, 28498396
Neuroblastoma	Associate	10336437, 11927634
Neuroendocrine Tumors	Associate	26298774, 29272741
Neuroma	Associate	39362479
Pancreatic Neoplasms	Associate	10816627, 19393580, 29025990
Polyps	Associate	23901225
Prostatic Neoplasms	Inhibit	21097678
Prostatic Neoplasms	Associate	28849698, 30959962
Psychotic Disorders	Inhibit	25027171
Retinal Dysplasia	Associate	23901225
Stomach Neoplasms	Associate	25724188, 26215716, 29794962, 34839352
Tertiary Lymphoid Structures	Stimulate	30959962
Thyroiditis Autoimmune	Inhibit	32597152, 34104248

NTSR1 (neurotensin receptor 1)