Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4921
Gene name	Discoidin domain receptor tyrosine kinase 2
Gene symbol	DDR2
Synonyms (NCBI Gene)	MIG20aNTRKR3TKTTYRO10WRCN
Chromosome	1
Chromosome location	1q23.3
Summary	This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor

Show/Hide all (16)

SNP ID	Visualize variation	Clinical significance	Consequence
rs115169993	G>A	Likely-pathogenic, benign, not-provided	Genic downstream transcript variant, downstream transcript variant, missense variant, coding sequence variant
rs121964863	C>T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121964864	T>G	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs121964865	C>A,T	Pathogenic	Genic downstream transcript variant, missense variant, coding sequence variant
rs141801107	C>T	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Coding sequence variant, synonymous variant
rs144594252	C>G	Likely-pathogenic, not-provided	Coding sequence variant, missense variant
rs267598140	T>A,G	Not-provided, pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs376303676	G>A,T	Not-provided, likely-pathogenic	Coding sequence variant, missense variant
rs397514747	G>A	Pathogenic	Coding sequence variant, missense variant
rs578015216	T>C,G	Uncertain-significance, likely-pathogenic	Coding sequence variant, missense variant
rs1057519789	A>G,T	Likely-pathogenic, not-provided	Genic downstream transcript variant, missense variant, coding sequence variant
rs1057519790	G>T	Likely-pathogenic, not-provided	Genic downstream transcript variant, missense variant, coding sequence variant
rs1558079436	T>C	Pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1558081627	A>G	Pathogenic	Missense variant, coding sequence variant, genic downstream transcript variant
rs1571295161	->C	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1571325076	G>A	Pathogenic	Splice donor variant, genic downstream transcript variant

110

Show/Hide all (110)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030671	hsa-miR-21-5p	Microarray	18591254
MIRT668768	hsa-miR-4687-5p	HITS-CLIP	23824327
MIRT668767	hsa-miR-6779-3p	HITS-CLIP	23824327
MIRT668766	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT668765	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT668764	hsa-miR-892c-5p	HITS-CLIP	23824327
MIRT668763	hsa-miR-506-5p	HITS-CLIP	23824327
MIRT668762	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT668761	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT668760	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT668759	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT668758	hsa-miR-6759-3p	HITS-CLIP	23824327
MIRT668757	hsa-miR-7976	HITS-CLIP	23824327
MIRT668755	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT668756	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT668754	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT668753	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT659143	hsa-miR-645	HITS-CLIP	23824327
MIRT659142	hsa-miR-3119	HITS-CLIP	23824327
MIRT659140	hsa-miR-3125	HITS-CLIP	23824327
MIRT659141	hsa-miR-3916	HITS-CLIP	23824327
MIRT659139	hsa-miR-6859-5p	HITS-CLIP	23824327
MIRT659138	hsa-miR-302a-5p	HITS-CLIP	23824327
MIRT659137	hsa-miR-3928-3p	HITS-CLIP	23824327
MIRT659136	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT497471	hsa-miR-618	PAR-CLIP	22291592
MIRT497470	hsa-miR-519a-3p	PAR-CLIP	22291592
MIRT497469	hsa-miR-519b-3p	PAR-CLIP	22291592
MIRT497468	hsa-miR-519c-3p	PAR-CLIP	22291592
MIRT497467	hsa-miR-302a-3p	PAR-CLIP	22291592
MIRT497466	hsa-miR-302b-3p	PAR-CLIP	22291592
MIRT497465	hsa-miR-302c-3p	PAR-CLIP	22291592
MIRT497464	hsa-miR-302d-3p	PAR-CLIP	22291592
MIRT497463	hsa-miR-302e	PAR-CLIP	22291592
MIRT497462	hsa-miR-372-3p	PAR-CLIP	22291592
MIRT497461	hsa-miR-373-3p	PAR-CLIP	22291592
MIRT497460	hsa-miR-520a-3p	PAR-CLIP	22291592
MIRT497459	hsa-miR-520b	PAR-CLIP	22291592
MIRT497458	hsa-miR-520c-3p	PAR-CLIP	22291592
MIRT497457	hsa-miR-520d-3p	PAR-CLIP	22291592
MIRT497456	hsa-miR-520e	PAR-CLIP	22291592
MIRT497455	hsa-miR-4637	PAR-CLIP	22291592
MIRT497454	hsa-miR-4513	PAR-CLIP	22291592
MIRT497453	hsa-miR-6855-3p	PAR-CLIP	22291592
MIRT497452	hsa-miR-6857-3p	PAR-CLIP	22291592
MIRT497451	hsa-miR-5189-3p	PAR-CLIP	22291592
MIRT497450	hsa-miR-3136-5p	PAR-CLIP	22291592
MIRT497449	hsa-miR-4439	PAR-CLIP	22291592
MIRT497448	hsa-miR-943	PAR-CLIP	22291592
MIRT030671	hsa-miR-21-5p	Microarray	33439992
MIRT668768	hsa-miR-4687-5p	HITS-CLIP	23824327
MIRT668767	hsa-miR-6779-3p	HITS-CLIP	23824327
MIRT668766	hsa-miR-129-1-3p	HITS-CLIP	23824327
MIRT668765	hsa-miR-129-2-3p	HITS-CLIP	23824327
MIRT668764	hsa-miR-892c-5p	HITS-CLIP	23824327
MIRT668763	hsa-miR-506-5p	HITS-CLIP	23824327
MIRT668762	hsa-miR-4704-3p	HITS-CLIP	23824327
MIRT668761	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT668760	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT668759	hsa-miR-4732-3p	HITS-CLIP	23824327
MIRT668758	hsa-miR-6759-3p	HITS-CLIP	23824327
MIRT668757	hsa-miR-7976	HITS-CLIP	23824327
MIRT668755	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT668756	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT668754	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT668753	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT659143	hsa-miR-645	HITS-CLIP	23824327
MIRT659142	hsa-miR-3119	HITS-CLIP	23824327
MIRT659140	hsa-miR-3125	HITS-CLIP	23824327
MIRT659141	hsa-miR-3916	HITS-CLIP	23824327
MIRT659139	hsa-miR-6859-5p	HITS-CLIP	23824327
MIRT659138	hsa-miR-302a-5p	HITS-CLIP	23824327
MIRT659137	hsa-miR-3928-3p	HITS-CLIP	23824327
MIRT659136	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT497471	hsa-miR-618	PAR-CLIP	22291592
MIRT497470	hsa-miR-519a-3p	PAR-CLIP	22291592
MIRT497469	hsa-miR-519b-3p	PAR-CLIP	22291592
MIRT497468	hsa-miR-519c-3p	PAR-CLIP	22291592
MIRT497467	hsa-miR-302a-3p	PAR-CLIP	22291592
MIRT497466	hsa-miR-302b-3p	PAR-CLIP	22291592
MIRT497465	hsa-miR-302c-3p	PAR-CLIP	22291592
MIRT497464	hsa-miR-302d-3p	PAR-CLIP	22291592
MIRT497463	hsa-miR-302e	PAR-CLIP	22291592
MIRT497462	hsa-miR-372-3p	PAR-CLIP	22291592
MIRT497461	hsa-miR-373-3p	PAR-CLIP	22291592
MIRT497460	hsa-miR-520a-3p	PAR-CLIP	22291592
MIRT497459	hsa-miR-520b	PAR-CLIP	22291592
MIRT497458	hsa-miR-520c-3p	PAR-CLIP	22291592
MIRT497457	hsa-miR-520d-3p	PAR-CLIP	22291592
MIRT497456	hsa-miR-520e	PAR-CLIP	22291592
MIRT497455	hsa-miR-4637	PAR-CLIP	22291592
MIRT497454	hsa-miR-4513	PAR-CLIP	22291592
MIRT497453	hsa-miR-6855-3p	PAR-CLIP	22291592
MIRT497452	hsa-miR-6857-3p	PAR-CLIP	22291592
MIRT497451	hsa-miR-5189-3p	PAR-CLIP	22291592
MIRT497450	hsa-miR-3136-5p	PAR-CLIP	22291592
MIRT497449	hsa-miR-4439	PAR-CLIP	22291592
MIRT497448	hsa-miR-943	PAR-CLIP	22291592
MIRT1975220	hsa-miR-1321	CLIP-seq
MIRT1975221	hsa-miR-3162-5p	CLIP-seq
MIRT1975222	hsa-miR-4739	CLIP-seq
MIRT1975223	hsa-miR-4756-5p	CLIP-seq
MIRT1975220	hsa-miR-1321	CLIP-seq
MIRT1975221	hsa-miR-3162-5p	CLIP-seq
MIRT2210604	hsa-miR-4537	CLIP-seq
MIRT1975222	hsa-miR-4739	CLIP-seq
MIRT2210605	hsa-miR-4751	CLIP-seq
MIRT1975223	hsa-miR-4756-5p	CLIP-seq
MIRT2210606	hsa-miR-492	CLIP-seq
MIRT2210607	hsa-miR-643	CLIP-seq

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Transcription factor	Regulation	Reference
ATF4	Activation	20564243

Show/Hide all (75)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001503	Process	Ossification	IEA
GO:0003416	Process	Endochondral bone growth	IEA
GO:0003416	Process	Endochondral bone growth	ISS
GO:0004672	Function	Protein kinase activity	IEA
GO:0004713	Function	Protein tyrosine kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IDA	20004161
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	TAS	9659899
GO:0005515	Function	Protein binding	IPI	17703188, 22939624, 25036637, 33961781, 35384245
GO:0005518	Function	Collagen binding	IBA
GO:0005518	Function	Collagen binding	IDA	20004161
GO:0005518	Function	Collagen binding	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9659899
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	TAS	9659899
GO:0007165	Process	Signal transduction	TAS	9659899
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0008284	Process	Positive regulation of cell population proliferation	IEA
GO:0010715	Process	Regulation of extracellular matrix disassembly	IEA
GO:0010715	Process	Regulation of extracellular matrix disassembly	TAS	16626936
GO:0010763	Process	Positive regulation of fibroblast migration	IEA
GO:0010763	Process	Positive regulation of fibroblast migration	ISS
GO:0010763	Process	Positive regulation of fibroblast migration	TAS	16626936
GO:0010976	Process	Positive regulation of neuron projection development	IBA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0018108	Process	Peptidyl-tyrosine phosphorylation	IDA	20004161
GO:0030199	Process	Collagen fibril organization	IEA
GO:0030199	Process	Collagen fibril organization	ISS
GO:0030500	Process	Regulation of bone mineralization	IMP	20564243
GO:0031214	Process	Biomineral tissue development	IEA
GO:0031214	Process	Biomineral tissue development	ISS
GO:0032967	Process	Positive regulation of collagen biosynthetic process	IEA
GO:0034103	Process	Regulation of tissue remodeling	IMP	30449416
GO:0035988	Process	Chondrocyte proliferation	IEA
GO:0035988	Process	Chondrocyte proliferation	ISS
GO:0035988	Process	Chondrocyte proliferation	TAS	16626936
GO:0035994	Process	Response to muscle stretch	IEA
GO:0038062	Function	Protein tyrosine kinase collagen receptor activity	IBA
GO:0038062	Function	Protein tyrosine kinase collagen receptor activity	IDA	9659899
GO:0038062	Function	Protein tyrosine kinase collagen receptor activity	IEA
GO:0038063	Process	Collagen-activated tyrosine kinase receptor signaling pathway	IDA	16186108
GO:0038063	Process	Collagen-activated tyrosine kinase receptor signaling pathway	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0043235	Component	Receptor complex	IBA
GO:0045669	Process	Positive regulation of osteoblast differentiation	IMP	20564243
GO:0045860	Process	Positive regulation of protein kinase activity	IMP	20564243
GO:0046777	Process	Protein autophosphorylation	IDA	16186108
GO:0048146	Process	Positive regulation of fibroblast proliferation	IEA
GO:0048146	Process	Positive regulation of fibroblast proliferation	ISS
GO:0051091	Process	Positive regulation of DNA-binding transcription factor activity	IMP	20564243
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IEA
GO:0071456	Process	Cellular response to hypoxia	IEA
GO:0071560	Process	Cellular response to transforming growth factor beta stimulus	IEA
GO:0090091	Process	Positive regulation of extracellular matrix disassembly	IEA
GO:0090091	Process	Positive regulation of extracellular matrix disassembly	ISS
GO:0090303	Process	Positive regulation of wound healing	IEA
GO:1900087	Process	Positive regulation of G1/S transition of mitotic cell cycle	IEA
GO:1901299	Process	Negative regulation of hydrogen peroxide-mediated programmed cell death	IEA
GO:1904385	Process	Cellular response to angiotensin	IEA
GO:1904707	Process	Positive regulation of vascular associated smooth muscle cell proliferation	IEA
GO:1904754	Process	Positive regulation of vascular associated smooth muscle cell migration	IEA
GO:1904899	Process	Positive regulation of hepatic stellate cell proliferation	IEA
GO:2000491	Process	Positive regulation of hepatic stellate cell activation	IEA

MIM	HGNC	e!Ensembl
191311	2731	ENSG00000162733

Q16832

Protein name

Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine

Protein function

Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cel

PDB

2WUH , 2Z4F , 6FER , 7AZB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00754	F5_F8_type_C	45 → 182	F5/8 type C domain	Domain
PF07714	PK_Tyr_Ser-Thr	563 → 849	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancrea

Sequence

MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKY
GRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKI
NYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRV
ELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLD
DFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFK
EVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFS
EITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIIL
WRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPD
YQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSV
PAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSAN
QPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENG
DLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGK
NYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWET
FTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRP
SFQEIHLLLLQQGDE

Sequence length

855

Interactions

View interactions

	Reactome
			Non-integrin membrane-ECM interactions

117

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Ovarian serous cystadenocarcinoma	Pathogenic	rs1056323839	RCV005931637
Spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome	Likely pathogenic; Pathogenic	rs2102206250, rs121964863, rs121964864, rs121964865, rs1571325076, rs1647819392, rs397514747	RCV002279764 RCV000013106 RCV000013107 RCV000013108 RCV000013109 RCV003993619 RCV000054530
Warburg-cinotti syndrome	Pathogenic	rs1558079436	RCV000714481

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Connective tissue disorder	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	rs1236758438, rs756623313, rs2271305, rs56351141, rs377626332, rs189870832, rs144293078, rs76156815, rs34722354	RCV002278713 RCV002278714 RCV002277416 RCV002278178 RCV002278335 RCV002278334 RCV002279384 RCV002279624 RCV002279700
DDR2-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs774706415, rs56313008, rs115169993, rs140710321, rs2524974750, rs149841590, rs1350936433, rs2102186500, rs1427124747, rs138537887	RCV003950965 RCV003891935 RCV003930072 RCV003957460 RCV003911730 RCV003977148 RCV003963999 RCV003971572 RCV003966820 RCV003895491
Lung adenocarcinoma	Benign; Uncertain significance	rs527246756, rs2524990838, rs1664193753	RCV003129618 RCV003129668 RCV003129669
Spondyloepimetaphyseal dysplasia	Uncertain significance; Benign; Conflicting classifications of pathogenicity	rs886045500, rs5778295	RCV000404213 RCV000352636 RCV000295491
Squamous cell lung carcinoma	Benign; Uncertain significance; Likely benign	rs2298258, rs1780003, rs1355287, rs1663742530, rs143729297, rs555765842	RCV001250939 RCV001250953 RCV001250956 RCV001250954 RCV001250955 RCV001250957 RCV001250958 RCV001250959
Uterine carcinosarcoma	Uncertain significance	rs137901988	RCV005913660

Show/Hide Text Mining Associations (62)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	29043607, 31407221
Ameloblastoma	Stimulate	24723326
Atherosclerosis	Associate	15111304, 15136580, 24723326, 24768818
Atrial Fibrillation	Associate	23593175
Azoospermia	Associate	40215689
Breast Neoplasms	Associate	25667101, 25955408, 28590426, 31570520, 33439992, 35711892, 36404592
Calcinosis	Associate	19110212
Calcinosis Cutis	Associate	25173530
Carcinoma Hepatocellular	Associate	26362312, 34335575, 36471363
Carcinoma Intraductal Noninfiltrating	Stimulate	25667101
Carcinoma Neuroendocrine	Associate	36653904
Carcinoma Non Small Cell Lung	Associate	25173530, 25376516, 26390252, 35709927
Carcinoma Ovarian Epithelial	Associate	36149163
Carcinoma Squamous Cell	Associate	22768234, 23822953, 24296828, 25173530, 29043607, 29129434, 30048458
Cartilage Diseases	Associate	17968949
Congenital Hereditary and Neonatal Diseases and Abnormalities	Associate	24723326
Down Syndrome	Associate	28590426
Drug Related Side Effects and Adverse Reactions	Associate	26390252
Fibrosarcoma	Associate	16186104
Fibrosis	Associate	24768818
Fractures Bone	Associate	25658585
Hereditary leiomyomatosis and renal cell cancer	Associate	15677564
Hip Fractures	Associate	25658585
Hodgkin Disease	Associate	15677564
Idiopathic Noncirrhotic Portal Hypertension	Associate	12765478
Keloid	Associate	30449416
Liposarcoma	Associate	24505276
Liver Cirrhosis	Associate	15136580, 15591520
Liver Cirrhosis Biliary	Stimulate	12765478
Lung Neoplasms	Associate	23822953, 24296828, 24696502, 24768818, 26390252, 28754957, 30048458
Lymphangioleiomyomatosis	Stimulate	15111304
Lymphatic Metastasis	Stimulate	25955408, 29945346
Megaepiphyseal dwarfism	Associate	19110212, 20223752
Mouth Neoplasms	Associate	29945346, 36849997
Neoplasm Invasiveness	Associate	25667101
Neoplasm Metastasis	Associate	25173530, 26362312, 27793038
Neoplasms	Associate	15136580, 16186104, 24723326, 24768818, 25667101, 26619122, 28199989, 28619094, 29129434, 30810094, 31570520, 32195970, 34335575, 34483300, 35711892, 36149163, 37527178, 38538106 View all (3 more)
Neoplasms	Stimulate	26362312, 29043607
Neoplasms Squamous Cell	Associate	25173530, 25348954
Neoplasms Vascular Tissue	Associate	15111304
Neuroblastoma	Associate	38538106
Non Muscle Invasive Bladder Neoplasms	Associate	31011911
Optic Atrophy	Associate	24725993
Osteoarthritis	Associate	17968949, 39213112
Osteoporosis	Associate	25658585, 39213112
Osteoporotic Fractures	Associate	25658585
Ovarian Diseases	Associate	38154356
Ovarian Neoplasms	Associate	30810094, 37303048, 37527178, 38154356
Ovarian Neoplasms	Stimulate	34065317
Sarcoma	Associate	22461510
Sertoli Cell Only Syndrome	Associate	40215689
Smith McCort Dysplasia	Associate	31254341
Spondylometaepiphyseal Dysplasia Short Limb Hand Type	Associate	19110212, 24725993
Squamous Cell Carcinoma of Head and Neck	Associate	25056374, 26619122, 29945346, 32009633
Triple Negative Breast Neoplasms	Associate	25667101, 28590426, 36713812, 40594223
Urethral Neoplasms	Associate	27793038
Urinary Bladder Neoplasms	Associate	27793038
Urologic Neoplasms	Associate	27793038
Vascular System Injuries	Associate	31254341
Vision Disorders	Associate	24725993
Walker Warburg Syndrome	Associate	30449416
Wounds and Injuries	Associate	12765478

DDR2 (discoidin domain receptor tyrosine kinase 2)