Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4919
Gene name	Receptor tyrosine kinase like orphan receptor 1
Gene symbol	ROR1
Synonyms (NCBI Gene)	NTRKR1dJ537F10.1
Chromosome	1
Chromosome location	1p31.3
Summary	This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is

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SNP ID	Visualize variation	Clinical significance	Consequence
rs1553163562	G>C	Pathogenic	Genic downstream transcript variant, coding sequence variant, missense variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022495	hsa-miR-124-3p	Microarray	18668037
MIRT025759	hsa-miR-7-5p	Microarray	19073608
MIRT027572	hsa-miR-98-5p	Microarray	19088304
MIRT031179	hsa-miR-19b-3p	Sequencing	20371350
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT732071	hsa-miR-27b-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26576539
MIRT732071	hsa-miR-27b-3p	ImmunohistochemistryLuciferase reporter assayqRT-PCRWestern blot	26576539
MIRT610481	hsa-miR-3176	HITS-CLIP	28735896
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	28735896
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	28735896
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT610482	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT610481	hsa-miR-3176	HITS-CLIP	23824327
MIRT610480	hsa-miR-3922-3p	HITS-CLIP	23824327
MIRT1315125	hsa-miR-5095	CLIP-seq
MIRT1315126	hsa-miR-552	CLIP-seq
MIRT1315127	hsa-miR-128	CLIP-seq
MIRT1315128	hsa-miR-3617	CLIP-seq
MIRT1315129	hsa-miR-4738-3p	CLIP-seq
MIRT1315130	hsa-miR-641	CLIP-seq
MIRT2318156	hsa-miR-1254	CLIP-seq
MIRT2318157	hsa-miR-1273f	CLIP-seq
MIRT2318158	hsa-miR-1289	CLIP-seq
MIRT2318159	hsa-miR-3116	CLIP-seq
MIRT2318160	hsa-miR-3198	CLIP-seq
MIRT2318161	hsa-miR-4294	CLIP-seq
MIRT2318162	hsa-miR-4309	CLIP-seq
MIRT2318163	hsa-miR-4423-5p	CLIP-seq
MIRT2318164	hsa-miR-4534	CLIP-seq
MIRT2318165	hsa-miR-4781-3p	CLIP-seq
MIRT2318166	hsa-miR-661	CLIP-seq

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Transcription factor	Regulation	Reference
STAT3	Unknown	20686606

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001725	Component	Stress fiber	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	IBA
GO:0004714	Function	Transmembrane receptor protein tyrosine kinase activity	TAS	8875995
GO:0005515	Function	Protein binding	IPI	22439932
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	TAS	8875995
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	27162350
GO:0005886	Component	Plasma membrane	TAS	1334494, 8875995
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IBA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	TAS	1334494
GO:0007605	Process	Sensory perception of sound	IMP	27162350
GO:0008283	Process	Cell population proliferation	IDA	36949068
GO:0008283	Process	Cell population proliferation	IDA	36949068
GO:0009986	Component	Cell surface	IEA
GO:0014002	Process	Astrocyte development	IEA
GO:0015026	Function	Coreceptor activity	IEA
GO:0015026	Function	Coreceptor activity	TAS	24431302
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0017147	Function	Wnt-protein binding	IBA
GO:0017147	Function	Wnt-protein binding	IEA
GO:0017147	Function	Wnt-protein binding	IPI	18287027
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0038023	Function	Signaling receptor activity	IDA	36949068
GO:0042813	Function	Wnt receptor activity	IMP	27162350
GO:0042995	Component	Cell projection	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IMP	27162350
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0043679	Component	Axon terminus	IEA
GO:0043679	Component	Axon terminus	ISS
GO:0048839	Process	Inner ear development	IEA
GO:0048839	Process	Inner ear development	ISS
GO:0051092	Process	Positive regulation of NF-kappaB transcription factor activity	IMP	27162350

MIM	HGNC	e!Ensembl
602336	10256	ENSG00000185483

Q01973

Protein name

Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1)

Protein function

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signa

PDB

5Z55 , 6BA5 , 6BAN , 6TU9 , 7TNG

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	58 → 148	Immunoglobulin I-set domain	Domain
PF01392	Fz	170 → 290	Fz domain	Domain
PF00051	Kringle	313 → 391	Kringle domain	Domain
PF07714	PK_Tyr_Ser-Thr	473 → 746	Protein tyrosine and serine/threonine kinase	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

Sequence

MHRPRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTL
DEPMNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRN
LDTTDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACAR
FIGNRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSS
VPKPRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIG
IPMADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHS
YCRNPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIAL
LFFFICVCRNNQKSSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELG
ECAFGKIYKGHLYLPGMDHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLG
AVTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIA
AGMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMP
PEAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPR
MYSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSN
LSNPRYPNYMFPSQGITPQGQIAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHYQPTG
PPRVIQHCPPPKSRSPSSASGSTSTGHVTSLPSSGSNQEANIPLLPHMSIPNHPGGMGIT
VFGNKSQKPYKIDSKQASLLGDANIHGHTESMISAEL

Sequence length

937

Interactions

View interactions

	KEGG		Reactome
	Wnt signaling pathway		WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Adrenocortical carcinoma, hereditary	Uncertain significance	rs201506341	RCV005930594
Hearing loss, autosomal recessive 108	Uncertain significance; Benign; Conflicting classifications of pathogenicity; no classifications from unflagged records	rs760355948, rs1772626, rs7527017, rs6668545, rs2762833, rs137874089, rs777805288, rs1553163562	RCV001329353 RCV001796628 RCV001796647 RCV001796673 RCV001794491 RCV003333773 RCV002505823 RCV000504579
ROR1-related disorder	Likely benign; Benign	rs113606454, rs147481344, rs139114952, rs146764088, rs201257776, rs748338604, rs373461066, rs760104769, rs200186767, rs35586842, rs80063252, rs41302752	RCV003923751 RCV003926289 RCV003943584 RCV003961241 RCV003898666 RCV003939068 RCV003909004 RCV003899774 RCV003952234 RCV003907975 RCV003910383 RCV003918625

Show/Hide Text Mining Associations (61)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	22439932, 23593420, 25978653, 26661061, 26725982, 27830754, 27852699, 31983094, 33172431, 33370472
Adenosarcoma	Associate	33370472
Bipolar Disorder	Associate	19488044, 21494683
Blast Crisis	Associate	33836616
Breast Neoplasms	Associate	23593420, 31085100, 32020017, 37029329
Calcinosis Cutis	Associate	26739507
Carcinogenesis	Associate	36359790
Carcinoma	Associate	27852699
Carcinoma Hepatocellular	Associate	30637779, 31746401
Carcinoma Ovarian Epithelial	Associate	26515598
Carcinoma Pancreatic Ductal	Associate	34763666, 37096681
Colonic Neoplasms	Inhibit	28557546
Colorectal Neoplasms	Associate	28427197, 30907503, 31486489, 31693094, 32096171
Encephalitis	Associate	21061152
Endometrial Neoplasms	Associate	32807831, 34115460, 36708573, 37241228
Episodic Kinesigenic Dyskinesia 2	Associate	23153538, 29849118
Glioblastoma	Associate	36314076
Glioma	Associate	36314076
Hematologic Neoplasms	Associate	25978653, 28328317
Hepatitis B	Associate	20702778
Hypoxia	Stimulate	36314076
Hypoxia Brain	Stimulate	36314076
Idiopathic Pulmonary Fibrosis	Stimulate	33925174
Immunologic Deficiency Syndromes	Associate	23593420
Kidney Diseases	Associate	35618095
Kidney Neoplasms	Associate	21079657
Leukemia	Associate	26739507, 27815263, 28923920, 29859176, 30568170
Leukemia Lymphocytic Chronic B Cell	Associate	18354269, 20686606, 20702778, 21079657, 21813176, 23593420, 26240275, 27086035, 27815263, 28328317, 28923920, 29122990, 29367434, 29849118, 29859176 View all (8 more)
Leukemia Prolymphocytic T Cell	Associate	20813009
Lymphatic Metastasis	Stimulate	27830754, 28427197, 31929567, 34599596
Lymphoma B Cell	Associate	23285131, 38273649
Lymphoma Mantle Cell	Associate	20702778, 31534006, 36359790
Melanoma	Associate	23593420
Mental Disorders	Associate	21494683
Mesothelioma Malignant	Associate	29845703
Metabolic Syndrome	Associate	21494683
Moyamoya Disease	Associate	23518061
Myelocytic leukemia like syndrome familial chronic	Stimulate	33836616
Myotonic Dystrophy	Stimulate	31085100
Neoplasm Metastasis	Associate	29856777, 31693094, 32271410, 36708573, 37096681
Neoplasm Residual	Associate	38273649
Neoplasms	Associate	18354269, 19965642, 20702778, 21079657, 21813176, 23593420, 25978653, 26725982, 26739507, 27852699, 28328317, 28427197, 29849118, 29856777, 29859176 View all (12 more)
Neoplasms	Stimulate	31929567, 34319035
Neuroblastoma	Stimulate	32705280
Osteosarcoma	Associate	33401251
Ovarian Neoplasms	Associate	25056203, 26515598, 27852699, 32989221, 37628927
Pancreatic Neoplasms	Associate	29856777, 34599596, 34763666, 37096681
Pancreatitis	Associate	21494683
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	21813176, 29849118
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	18354269, 21079657, 21813176, 23153538, 23285131, 29849118
Prostatic Neoplasms	Associate	24505114, 35131873
Prostatic Neoplasms Castration Resistant	Associate	35131873
Sarcoma Ewing	Associate	26739507
Schizophrenia	Associate	21494683
Sleep Initiation and Maintenance Disorders	Associate	21494683
Small Cell Lung Carcinoma	Associate	34088900
Stomach Neoplasms	Associate	34319035
Substance Related Disorders	Associate	23593420
Triple Negative Breast Neoplasms	Associate	27852699, 31150511, 32303620, 40427627
Urinary Bladder Neoplasms	Stimulate	31929567
Uterine Cervical Neoplasms	Associate	32271410

ROR1 (receptor tyrosine kinase like orphan receptor 1)