NPR1 (natriuretic peptide receptor 1)

Gene

• Entrez ID: 4881
• Gene name: Natriuretic peptide receptor 1
• Gene symbol: NPR1
• Synonyms (NCBI Gene): ANPRA, ANPa, GUC2A, GUCY2A, NPRA
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surfac

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT006575	hsa-miR-320a	Luciferase reporter assay, Western blot	22134529
MIRT006575	hsa-miR-320a	Luciferase reporter assay, Western blot	22134529
MIRT006575	hsa-miR-320a	Luciferase reporter assay, Western blot	22134529
MIRT006575	hsa-miR-320a	Luciferase reporter assay, Western blot	22134529
MIRT022739	hsa-miR-124-3p	Microarray	18668037
MIRT693189	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT693188	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT693187	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT693186	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT516396	hsa-miR-4794	HITS-CLIP	23313552
MIRT516395	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT693185	hsa-miR-4775	HITS-CLIP	23313552
MIRT693184	hsa-miR-3149	HITS-CLIP	23313552
MIRT693183	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT693182	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT693181	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT693180	hsa-miR-940	HITS-CLIP	23313552
MIRT674799	hsa-miR-3929	HITS-CLIP	23313552
MIRT674800	hsa-miR-4419b	HITS-CLIP	23313552
MIRT674798	hsa-miR-4478	HITS-CLIP	23313552
MIRT693179	hsa-miR-6890-5p	HITS-CLIP	23313552
MIRT693178	hsa-miR-665	HITS-CLIP	23313552
MIRT693177	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT693176	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT693175	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT693174	hsa-miR-1827	HITS-CLIP	23313552
MIRT674791	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT674790	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT693173	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT693172	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT693171	hsa-miR-342-5p	HITS-CLIP	23313552
MIRT693170	hsa-miR-4664-5p	HITS-CLIP	23313552
MIRT693169	hsa-miR-4651	HITS-CLIP	23313552
MIRT693168	hsa-miR-608	HITS-CLIP	23313552
MIRT693167	hsa-miR-6747-5p	HITS-CLIP	23313552
MIRT693166	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT693165	hsa-miR-6737-5p	HITS-CLIP	23313552
MIRT693164	hsa-miR-6812-5p	HITS-CLIP	23313552
MIRT693163	hsa-miR-6819-5p	HITS-CLIP	23313552
MIRT674799	hsa-miR-3929	HITS-CLIP	23824327
MIRT674800	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674798	hsa-miR-4478	HITS-CLIP	23824327
MIRT674797	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT674796	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT674795	hsa-miR-4770	HITS-CLIP	23824327
MIRT674794	hsa-miR-6088	HITS-CLIP	23824327
MIRT674793	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT674792	hsa-miR-1273f	HITS-CLIP	23824327
MIRT674791	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT674790	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT674789	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674788	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674787	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674786	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674785	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674784	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674783	hsa-miR-7977	HITS-CLIP	23824327
MIRT674782	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT674781	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT674780	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT674779	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674778	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674777	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674776	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674775	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674774	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674773	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674772	hsa-miR-1228-5p	HITS-CLIP	23824327
MIRT674771	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT674770	hsa-miR-3122	HITS-CLIP	23824327
MIRT674769	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT674768	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT674767	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT663111	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT663110	hsa-miR-3607-5p	HITS-CLIP	23824327
MIRT663108	hsa-miR-6072	HITS-CLIP	23824327
MIRT663109	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT663107	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT663106	hsa-miR-6131	HITS-CLIP	23824327
MIRT663105	hsa-miR-8070	HITS-CLIP	23824327
MIRT646050	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT646049	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT646048	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT646047	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT646046	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT646045	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT646043	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT646044	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT646042	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT646041	hsa-miR-1976	HITS-CLIP	23824327
MIRT646040	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT646039	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT646038	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT646037	hsa-miR-197-5p	HITS-CLIP	23824327
MIRT646036	hsa-miR-3132	HITS-CLIP	23824327
MIRT646035	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT646034	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT646033	hsa-miR-1229-5p	HITS-CLIP	23824327
MIRT544284	hsa-miR-5692a	PAR-CLIP	21572407
MIRT544283	hsa-miR-541-5p	PAR-CLIP	21572407
MIRT516397	hsa-miR-944	PAR-CLIP	23446348
MIRT516396	hsa-miR-4794	PAR-CLIP	23446348
MIRT516395	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT516394	hsa-miR-1254	PAR-CLIP	23446348
MIRT516393	hsa-miR-3116	PAR-CLIP	23446348
MIRT516392	hsa-miR-661	PAR-CLIP	23446348
MIRT516391	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT516390	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT516389	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT516388	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT693178	hsa-miR-665	PAR-CLIP	26701625
MIRT693178	hsa-miR-665	PAR-CLIP	26701625
MIRT693177	hsa-miR-6840-3p	PAR-CLIP	26701625
MIRT693177	hsa-miR-6840-3p	PAR-CLIP	26701625
MIRT693189	hsa-miR-590-3p	HITS-CLIP	23313552
MIRT693188	hsa-miR-1228-3p	HITS-CLIP	23313552
MIRT693187	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT693186	hsa-miR-4735-5p	HITS-CLIP	23313552
MIRT516396	hsa-miR-4794	HITS-CLIP	23313552
MIRT516395	hsa-miR-664a-5p	HITS-CLIP	23313552
MIRT693185	hsa-miR-4775	HITS-CLIP	23313552
MIRT693184	hsa-miR-3149	HITS-CLIP	23313552
MIRT693183	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT693182	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT693181	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT693180	hsa-miR-940	HITS-CLIP	23313552
MIRT674799	hsa-miR-3929	HITS-CLIP	23313552
MIRT674800	hsa-miR-4419b	HITS-CLIP	23313552
MIRT674798	hsa-miR-4478	HITS-CLIP	23313552
MIRT693179	hsa-miR-6890-5p	HITS-CLIP	23313552
MIRT693178	hsa-miR-665	HITS-CLIP	23313552
MIRT693177	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT693176	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT693175	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT693174	hsa-miR-1827	HITS-CLIP	23313552
MIRT674791	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT674790	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT693173	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT693172	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT693171	hsa-miR-342-5p	HITS-CLIP	23313552
MIRT693170	hsa-miR-4664-5p	HITS-CLIP	23313552
MIRT693169	hsa-miR-4651	HITS-CLIP	23313552
MIRT693168	hsa-miR-608	HITS-CLIP	23313552
MIRT693167	hsa-miR-6747-5p	HITS-CLIP	23313552
MIRT693166	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT693165	hsa-miR-6737-5p	HITS-CLIP	23313552
MIRT693164	hsa-miR-6812-5p	HITS-CLIP	23313552
MIRT693163	hsa-miR-6819-5p	HITS-CLIP	23313552
MIRT674799	hsa-miR-3929	HITS-CLIP	23824327
MIRT674800	hsa-miR-4419b	HITS-CLIP	23824327
MIRT674798	hsa-miR-4478	HITS-CLIP	23824327
MIRT674797	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT674796	hsa-miR-143-3p	HITS-CLIP	23824327
MIRT674795	hsa-miR-4770	HITS-CLIP	23824327
MIRT674794	hsa-miR-6088	HITS-CLIP	23824327
MIRT674793	hsa-miR-4708-5p	HITS-CLIP	23824327
MIRT674792	hsa-miR-1273f	HITS-CLIP	23824327
MIRT674791	hsa-miR-485-5p	HITS-CLIP	23824327
MIRT674790	hsa-miR-6884-5p	HITS-CLIP	23824327
MIRT674789	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT674788	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT674787	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT674786	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT674785	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT674784	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT674783	hsa-miR-7977	HITS-CLIP	23824327
MIRT674782	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT674781	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT674780	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT674779	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT674778	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT674777	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT674776	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT674775	hsa-miR-3689c	HITS-CLIP	23824327
MIRT674774	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT674773	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT674772	hsa-miR-1228-5p	HITS-CLIP	23824327
MIRT674771	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT674770	hsa-miR-3122	HITS-CLIP	23824327
MIRT674769	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT674768	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT674767	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT663111	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT663110	hsa-miR-3607-5p	HITS-CLIP	23824327
MIRT663108	hsa-miR-6072	HITS-CLIP	23824327
MIRT663109	hsa-miR-6891-3p	HITS-CLIP	23824327
MIRT663107	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT663106	hsa-miR-6131	HITS-CLIP	23824327
MIRT663105	hsa-miR-8070	HITS-CLIP	23824327
MIRT646050	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT646049	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT646048	hsa-miR-4722-3p	HITS-CLIP	23824327
MIRT646047	hsa-miR-6727-3p	HITS-CLIP	23824327
MIRT646046	hsa-miR-6747-3p	HITS-CLIP	23824327
MIRT646045	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT646043	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT646044	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT646042	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT646041	hsa-miR-1976	HITS-CLIP	23824327
MIRT646040	hsa-miR-6861-5p	HITS-CLIP	23824327
MIRT646039	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT646038	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT646037	hsa-miR-197-5p	HITS-CLIP	23824327
MIRT646036	hsa-miR-3132	HITS-CLIP	23824327
MIRT646035	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT646034	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT646033	hsa-miR-1229-5p	HITS-CLIP	23824327
MIRT544284	hsa-miR-5692a	PAR-CLIP	21572407
MIRT544283	hsa-miR-541-5p	PAR-CLIP	21572407
MIRT516397	hsa-miR-944	PAR-CLIP	23446348
MIRT516396	hsa-miR-4794	PAR-CLIP	23446348
MIRT516395	hsa-miR-664a-5p	PAR-CLIP	23446348
MIRT516394	hsa-miR-1254	PAR-CLIP	23446348
MIRT516393	hsa-miR-3116	PAR-CLIP	23446348
MIRT516392	hsa-miR-661	PAR-CLIP	23446348
MIRT516391	hsa-miR-1271-3p	PAR-CLIP	23446348
MIRT516390	hsa-miR-550a-3-5p	PAR-CLIP	23446348
MIRT516389	hsa-miR-550a-5p	PAR-CLIP	23446348
MIRT516388	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT2582317	hsa-miR-1236	CLIP-seq
MIRT2582318	hsa-miR-299-3p	CLIP-seq
MIRT2582319	hsa-miR-3183	CLIP-seq
MIRT2582320	hsa-miR-331-3p	CLIP-seq
MIRT2582321	hsa-miR-412	CLIP-seq
MIRT2582322	hsa-miR-4265	CLIP-seq
MIRT2582323	hsa-miR-4290	CLIP-seq
MIRT2582324	hsa-miR-4296	CLIP-seq
MIRT2582325	hsa-miR-4322	CLIP-seq
MIRT2582326	hsa-miR-4417	CLIP-seq
MIRT2582327	hsa-miR-4437	CLIP-seq
MIRT2582328	hsa-miR-4674	CLIP-seq
MIRT2582329	hsa-miR-4723-3p	CLIP-seq
MIRT2582317	hsa-miR-1236	CLIP-seq
MIRT2582319	hsa-miR-3183	CLIP-seq
MIRT2582320	hsa-miR-331-3p	CLIP-seq
MIRT2582321	hsa-miR-412	CLIP-seq
MIRT2582322	hsa-miR-4265	CLIP-seq
MIRT2582323	hsa-miR-4290	CLIP-seq
MIRT2582324	hsa-miR-4296	CLIP-seq
MIRT2582325	hsa-miR-4322	CLIP-seq
MIRT2582326	hsa-miR-4417	CLIP-seq
MIRT2582327	hsa-miR-4437	CLIP-seq
MIRT2582328	hsa-miR-4674	CLIP-seq
MIRT2582329	hsa-miR-4723-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0001653	Function	Peptide receptor activity	IBA
GO:0004383	Function	Guanylate cyclase activity	IBA
GO:0004383	Function	Guanylate cyclase activity	IDA	1672777
GO:0004383	Function	Guanylate cyclase activity	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005525	Function	GTP binding	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006182	Process	CGMP biosynthetic process	IBA
GO:0006182	Process	CGMP biosynthetic process	IDA	1672777
GO:0006182	Process	CGMP biosynthetic process	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	NAS	12547834
GO:0007168	Process	Receptor guanylyl cyclase signaling pathway	IBA
GO:0007168	Process	Receptor guanylyl cyclase signaling pathway	IDA	1672777
GO:0007168	Process	Receptor guanylyl cyclase signaling pathway	IEA
GO:0007168	Process	Receptor guanylyl cyclase signaling pathway	ISS
GO:0007168	Process	Receptor guanylyl cyclase signaling pathway	TAS	14737067
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007589	Process	Body fluid secretion	TAS	14960748
GO:0008015	Process	Blood circulation	IEA
GO:0008217	Process	Regulation of blood pressure	IDA	1672777
GO:0008217	Process	Regulation of blood pressure	IEA
GO:0008217	Process	Regulation of blood pressure	ISS
GO:0008217	Process	Regulation of blood pressure	NAS	12727915
GO:0008528	Function	G protein-coupled peptide receptor activity	NAS	12547834
GO:0009190	Process	Cyclic nucleotide biosynthetic process	IEA
GO:0010753	Process	Positive regulation of cGMP-mediated signaling	IEA
GO:0016020	Component	Membrane	IEA
GO:0016525	Process	Negative regulation of angiogenesis	TAS	14737067
GO:0016829	Function	Lyase activity	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IEA
GO:0016941	Function	Natriuretic peptide receptor activity	IDA	1660465, 1672777
GO:0016941	Function	Natriuretic peptide receptor activity	IEA
GO:0017046	Function	Peptide hormone binding	IEA
GO:0017046	Function	Peptide hormone binding	IPI	1660465
GO:0019934	Process	CGMP-mediated signaling	IEA
GO:0030308	Process	Negative regulation of cell growth	NAS	12727915
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035810	Process	Positive regulation of urine volume	TAS	14737067
GO:0035815	Process	Positive regulation of renal sodium excretion	TAS	14960748
GO:0042417	Process	Dopamine metabolic process	IEA
GO:0042562	Function	Hormone binding	IPI	12547834
GO:0043114	Process	Regulation of vascular permeability	IDA	36016499
GO:0043114	Process	Regulation of vascular permeability	TAS	14737067
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0048662	Process	Negative regulation of smooth muscle cell proliferation	IEA
GO:0097746	Process	Blood vessel diameter maintenance	IEA
GO:0097746	Process	Blood vessel diameter maintenance	NAS	7601467
GO:1990620	Component	ANPR-A receptor complex	IEA
GO:1990620	Component	ANPR-A receptor complex	ISS

Other IDs

• MIM: 108960
• HGNC: 7943
• e!Ensembl: ENSG00000169418

Protein

• UniProt ID: P16066
• Protein name: Atrial natriuretic peptide receptor 1 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type A) (ANP-A) (ANPR-A) (NPR-A) (Guanylate cyclase A) (GC-A)
• Protein function: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of
• PDB: 8TG9, 8TGA, 9BCL, 9BCN, 9BCO, 9BCP, 9BCQ, 9BCS, 9BCV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01094	ANF_receptor	54 → 417	Receptor family ligand binding region	Family
  PF07714	PK_Tyr_Ser-Thr	543 → 801	Protein tyrosine and serine/threonine kinase	Domain
  PF00211	Guanylate_cyc	867 → 1053	Adenylate and Guanylate cyclase catalytic domain	Domain

• Sequence:

  MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVE
  LALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVY
  AAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWER
  QALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGR
  VIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDV
  SARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLY
  IQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAF
  RVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGS
  LSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNY
  GSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVG
  ACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGN
  LKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAG
  DVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLM
  QRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLE
  EKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTL
  LNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFR
  IRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSET
  KAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG

• Sequence length: 1061

Pathways

KEGG:

Purine metabolism
Metabolic pathways
cGMP-PKG signaling pathway
cAMP signaling pathway
Hormone signaling
Vascular smooth muscle contraction
Thermogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Aldosterone synthesis and secretion

Reactome:

Physiological factors

<

Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Hypertension	Hypertension	N/A	N/A	GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Asthma	Associate	39293435
Carcinoma Hepatocellular	Associate	20345479
Cardiomyopathy Hypertrophic	Associate	30764827
Colitis Ulcerative	Associate	26530476
Crohn Disease	Associate	26530476
Diabetes Mellitus Type 2	Associate	33788629
Esophageal Squamous Cell Carcinoma	Associate	24885858
Essential Hypertension	Associate	16875975, 26782497
Hypertension	Associate	26782497
Ige Responsiveness Atopic	Associate	39293435
Neoplasms	Associate	24885858
Retinal Degeneration	Associate	26100624
Sarcoidosis	Associate	33276795
Ventricular Dysfunction Left	Associate	16875975
Ventricular Remodeling	Associate	16875975