Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4855
Gene name Gene Name - the full gene name approved by the HGNC.
Notch receptor 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NOTCH4
Synonyms (NCBI Gene) Gene synonyms aliases
INT3
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.32
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an in
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT003211 hsa-miR-181c-5p Luciferase reporter assay, qRT-PCR, Western blot 20080834
MIRT006192 hsa-miR-34c-5p EMSA, Luciferase reporter assay, Western blot 22074923
MIRT006192 hsa-miR-34c-5p EMSA, Luciferase reporter assay, Western blot 22074923
MIRT006192 hsa-miR-34c-5p EMSA, Luciferase reporter assay, Western blot 22074923
MIRT006192 hsa-miR-34c-5p EMSA, Luciferase reporter assay, Western blot 22074923
Transcription factors
Transcription factor Regulation Reference
PPARG Unknown 20436223
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IMP 17984306
GO:0000139 Component Golgi membrane TAS
GO:0001569 Process Branching involved in blood vessel morphogenesis ISS
GO:0001709 Process Cell fate determination TAS 11823422
GO:0001763 Process Morphogenesis of a branching structure ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
164951 7884 ENSG00000204301
Protein
UniProt ID Q99466
Protein name Neurogenic locus notch homolog protein 4 (Notch 4) (hNotch4) [Cleaved into: Notch 4 extracellular truncation; Notch 4 intracellular domain]
Protein function Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with R
PDB 7OR3 , 7OR5 , 7OR7
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12661 hEGF 35 57 Human growth factor-like EGF Domain
PF12661 hEGF 127 149 Human growth factor-like EGF Domain
PF00008 EGF 160 189 EGF-like domain Domain
PF07645 EGF_CA 194 238 Calcium-binding EGF domain Domain
PF00008 EGF 238 272 EGF-like domain Domain
PF00008 EGF 280 308 EGF-like domain Domain
PF07645 EGF_CA 314 356 Calcium-binding EGF domain Domain
PF12661 hEGF 364 385 Human growth factor-like EGF Domain
PF07645 EGF_CA 432 474 Calcium-binding EGF domain Domain
PF00008 EGF 479 509 EGF-like domain Domain
PF00008 EGF 517 547 EGF-like domain Domain
PF07645 EGF_CA 551 590 Calcium-binding EGF domain Domain
PF00008 EGF 593 623 EGF-like domain Domain
PF00008 EGF 695 725 EGF-like domain Domain
PF00008 EGF 771 801 EGF-like domain Domain
PF00008 EGF 810 838 EGF-like domain Domain
PF07645 EGF_CA 845 886 Calcium-binding EGF domain Domain
PF00008 EGF 896 926 EGF-like domain Domain
PF00008 EGF 934 964 EGF-like domain Domain
PF00008 EGF 972 1002 EGF-like domain Domain
PF00008 EGF 1050 1083 EGF-like domain Domain
PF00066 Notch 1167 1204 LNR domain Domain
PF00066 Notch 1211 1246 LNR domain Domain
PF00066 Notch 1248 1285 LNR domain Domain
PF06816 NOD 1295 1344 NOTCH protein Family
PF07684 NODP 1378 1440 NOTCH protein Family
PF12796 Ank_2 1638 1731 Ankyrin repeats (3 copies) Repeat
PF12796 Ank_2 1712 1797 Ankyrin repeats (3 copies) Repeat
Tissue specificity TISSUE SPECIFICITY: Highly expressed in the heart, moderately in the lung and placenta and at low levels in the liver, skeletal muscle, kidney, pancreas, spleen, lymph node, thymus, bone marrow and fetal liver. No expression was seen in adult brain or per
Sequence
MQPPSLLLLLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGE
TCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAKLED
PCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQC
HCPPGFEGH
ACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPP
RGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPD
CEVNPDNCVSHQCQNGGTCQDGLDTYTC
LCPETWTG
WDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCI
AATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLC
QPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECL
SQPCHPGSTCLDLLATFHCLCPPGLEGQL
CEVETNECASAPCLNHADCHDLLNGFQCICL
PGFSGTR
CEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPV
GASCLDLPGAFFCLCPSGFTGQL
CEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAP
PEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTG
YTGPT
CSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGG
TCVNRPGTFSCLCAMGFQGPR
CEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGS
CQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSL
CHNGGLCVDSGPSYFCHCPPGFQGSL
CQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGY
DGQN
CSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGT
AACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFE
GPT
CSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPC
LYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDG
GDCS
LGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCH
DHFHNGHCEKGCNTAECGWDGGDCR
PEDGDPEWGPSLALLVVLSPPALDQQLFALARVLS
LTLRVGLWVRKDRDGRDMVYPYPG
ARAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAG
FVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAP

PANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRR
RPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGA
LPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLL
DGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAR
EVCQLLLRSRQTAVDARTEDGTTPLMLAARL
AVEDLVEELIAAQADVGARDKWGKTALHW
AAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRD
QAG
LAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPR
CRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGM
RGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGS
PQLDCGPPALQEMPINQGGEGKK
Sequence length 2003
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocrine resistance
Notch signaling pathway
Thyroid hormone signaling pathway
Human papillomavirus infection
Pathways in cancer
MicroRNAs in cancer
Breast cancer
  Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
NOTCH4 Activation and Transmission of Signal to the Nucleus
Negative regulation of NOTCH4 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
21036696, 21679465
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
21679465, 21036696
Carcinoma Squamous cell carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 27923803
Colonic neoplasms Malignant tumor of colon rs267607789, rs774277300, rs781222233, rs1060502734, rs1060503333, rs1339238483 30529582
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 21804548 ClinVar, GWAS
Sarcoidosis Sarcoidosis 22952805 ClinVar, GWAS
Crohn Disease Crohn Disease GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 21107268
Adenocarcinoma Inhibit 29769567
Adenocarcinoma of Lung Associate 29769567, 37268635
Alzheimer Disease Associate 14966150
Anxiety Associate 36814110
Arthritis Psoriatic Associate 23161900
Arthritis Rheumatoid Associate 14730600, 19143814, 23161900, 26686423
Asthma Associate 21804548, 27177148, 31605414, 32929274, 39643224
Astrocytoma Associate 19424825
Atrioventricular Septal Defect Associate 33093519