NNMT (nicotinamide N-methyltransferase)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4837
Gene name Gene Name - the full gene name approved by the HGNC.
Nicotinamide N-methyltransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NNMT
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.2
Summary Summary of gene provided in NCBI Entrez Gene.
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 200
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
miRTarBase ID miRNA Experiments Reference
MIRT022959 hsa-miR-124-3p Microarray 18668037
MIRT027710 hsa-miR-98-5p Microarray 19088304
MIRT689992 hsa-miR-3614-5p HITS-CLIP 23313552
MIRT689991 hsa-miR-6500-3p HITS-CLIP 23313552
MIRT689990 hsa-miR-4768-3p HITS-CLIP 23313552
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(22)
GO ID Ontology Definition Evidence Reference
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
GO:0005829 Component Cytosol IEA
GO:0005829 Component Cytosol TAS
GO:0006769 Process Nicotinamide metabolic process IDA 8182091, 21823666
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600008 7861 ENSG00000166741
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P40261
Protein name Nicotinamide N-methyltransferase (EC 2.1.1.1)
Protein function Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23
PDB 2IIP , 3ROD , 5YJF , 6CHH , 6ORR , 6PVE , 6PVS , 7BKG , 7BLE , 7EGU , 7EHZ , 7EI2 , 7ET7 , 7EU5 , 7NBJ , 7NBM , 7NBQ , 7RKK , 7RKL , 7SOK , 7WMC , 7WMT , 9ATV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01234 NNMT_PNMT_TEMT 1 → 259 NNMT/PNMT/TEMT family Family
Tissue specificity TISSUE SPECIFICITY: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas. {ECO:0000269|PubMed:8182091}.
Sequence
Sequence length 264
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Nicotinate and nicotinamide metabolism
Metabolic pathways 		  Methylation
Nicotinamide salvaging
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Asthma N/A N/A GWAS
Show/Hide Text Mining Associations (65)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Alopecia Associate 35181715
Alzheimer Disease Associate 15849667
Alzheimer Disease Stimulate 33387303
Aortic Dissection Associate 36818541
Breast Neoplasms Associate 17922140, 31101119
Carcinogenesis Associate 36750850
Carcinoma Endometrioid Associate 34655178
Carcinoma Hepatocellular Associate 19216803
Carcinoma Renal Cell Associate 21957981, 27128972, 35440542, 35678045, 36750850, 40107723
Carcinoma Squamous Cell Associate 31545452