NNMT (nicotinamide N-methyltransferase)

Gene

• Entrez ID: 4837
• Gene name: Nicotinamide N-methyltransferase
• Gene symbol: NNMT
• Synonyms (NCBI Gene): -
• Chromosome: 11
• Chromosome location: 11q23.2
• Summary: N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor. [provided by RefSeq, Jul 200

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022959	hsa-miR-124-3p	Microarray	18668037
MIRT027710	hsa-miR-98-5p	Microarray	19088304
MIRT689992	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT689991	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT689990	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689989	hsa-miR-4459	HITS-CLIP	23313552
MIRT689988	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT689987	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT689986	hsa-miR-6086	HITS-CLIP	23313552
MIRT689985	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT689984	hsa-miR-1304-5p	HITS-CLIP	23313552
MIRT689992	hsa-miR-3614-5p	HITS-CLIP	23313552
MIRT689991	hsa-miR-6500-3p	HITS-CLIP	23313552
MIRT689990	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689989	hsa-miR-4459	HITS-CLIP	23313552
MIRT689988	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT689987	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT689986	hsa-miR-6086	HITS-CLIP	23313552
MIRT689985	hsa-miR-6765-5p	HITS-CLIP	23313552
MIRT689984	hsa-miR-1304-5p	HITS-CLIP	23313552

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006769	Process	Nicotinamide metabolic process	IDA	8182091, 21823666
GO:0006769	Process	Nicotinamide metabolic process	IEA
GO:0008112	Function	Nicotinamide N-methyltransferase activity	IBA
GO:0008112	Function	Nicotinamide N-methyltransferase activity	IDA	8182091, 21823666
GO:0008112	Function	Nicotinamide N-methyltransferase activity	IEA
GO:0008112	Function	Nicotinamide N-methyltransferase activity	IMP	23455543
GO:0008112	Function	Nicotinamide N-methyltransferase activity	TAS
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030760	Function	Pyridine N-methyltransferase activity	TAS
GO:0032259	Process	Methylation	IEA
GO:0032259	Process	Methylation	IEA
GO:0032259	Process	Methylation	TAS
GO:0034355	Process	NAD+ biosynthetic process via the salvage pathway	TAS
GO:0045722	Process	Positive regulation of gluconeogenesis	IEA
GO:0045722	Process	Positive regulation of gluconeogenesis	ISS
GO:0090312	Process	Positive regulation of protein deacetylation	ISS

Other IDs

• MIM: 600008
• HGNC: 7861
• e!Ensembl: ENSG00000166741

Protein

• UniProt ID: P40261
• Protein name: Nicotinamide N-methyltransferase (EC 2.1.1.1)
• Protein function: Catalyzes the N-methylation of nicotinamide using the universal methyl donor S-adenosyl-L-methionine to form N1-methylnicotinamide and S-adenosyl-L-homocysteine, a predominant nicotinamide/vitamin B3 clearance pathway (PubMed:21823666, PubMed:23
• PDB: 2IIP, 3ROD, 5YJF, 6CHH, 6ORR, 6PVE, 6PVS, 7BKG, 7BLE, 7EGU, 7EHZ, 7EI2, 7ET7, 7EU5, 7NBJ, 7NBM, 7NBQ, 7RKK, 7RKL, 7SOK, 7WMC, 7WMT, 9ATV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01234	NNMT_PNMT_TEMT	1 → 259	NNMT/PNMT/TEMT family	Family

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas. {ECO:0000269|PubMed:8182091}.
• Sequence:

  MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLI
  DIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGN
  RVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRAL
  RNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
  SYSSTMANNEGLFSLVARKLSRPL

• Sequence length: 264

Pathways

KEGG:

Nicotinate and nicotinamide metabolism
Metabolic pathways

Reactome:

Methylation
Nicotinamide salvaging