NMT1 (N-myristoyltransferase 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 4836 |
| Gene name | N-myristoyltransferase 1 |
| Gene symbol | NMT1 |
| Synonyms (NCBI Gene) |
HsNMT1NMT
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| Chromosome | 17 |
| Chromosome location | 17q21.31 |
| Summary | Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer o |
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miRNA
miRNA information provided by mirtarbase database.
406
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P30419 | |||||||||||||||
| Protein name | Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) | |||||||||||||||
| Protein function | Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoy | |||||||||||||||
| PDB | 1RXT , 3IU1 , 3IU2 , 3IWE , 3JTK , 4C2Y , 4C2Z , 5MU6 , 5NPQ , 5O6H , 5O6J , 5O9S , 5O9T , 5O9U , 5O9V , 5UUT , 6EHJ , 6F56 , 6FZ2 , 6FZ3 , 6FZ5 , 6PAV , 6QRM , 6SJZ , 6SK2 , 6SK3 , 6SK8 , 6SKJ , 7OWM , 7OWN , 7OWO , 7OWP , 7OWQ , 7OWR , 7OWU , 7RK3 , 8Q23 , 8Q24 , 8Q26 , 8Q2Z , 8Q3D , 8Q3S , 8Q3T | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Heart, gut, kidney, liver and placenta. {ECO:0000269|PubMed:1570339}. | |||||||||||||||
| Sequence |
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| Sequence length | 496 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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