Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4836
Gene name Gene Name - the full gene name approved by the HGNC.
N-myristoyltransferase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NMT1
Synonyms (NCBI Gene) Gene synonyms aliases
HsNMT1, NMT
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.31
Summary Summary of gene provided in NCBI Entrez Gene.
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer o
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047822 hsa-miR-30d-5p CLASH 23622248
MIRT046372 hsa-miR-23b-3p CLASH 23622248
MIRT045083 hsa-miR-186-5p CLASH 23622248
MIRT041243 hsa-miR-193b-3p CLASH 23622248
MIRT039990 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IBA 21873635
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IDA 25255805
GO:0005515 Function Protein binding IPI 26621918, 32296183
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
160993 7857 ENSG00000136448
Protein
UniProt ID P30419
Protein name Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-)
Protein function Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoy
PDB 1RXT , 3IU1 , 3IU2 , 3IWE , 3JTK , 4C2Y , 4C2Z , 5MU6 , 5NPQ , 5O6H , 5O6J , 5O9S , 5O9T , 5O9U , 5O9V , 5UUT , 6EHJ , 6F56 , 6FZ2 , 6FZ3 , 6FZ5 , 6PAV , 6QRM , 6SJZ , 6SK2 , 6SK3 , 6SK8 , 6SKJ , 7OWM , 7OWN , 7OWO , 7OWP , 7OWQ , 7OWR , 7OWU , 7RK3 , 8Q23 , 8Q24 , 8Q26 , 8Q2Z , 8Q3D , 8Q3S , 8Q3T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01233 NMT 137 294 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Domain
PF02799 NMT_C 308 494 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Heart, gut, kidney, liver and placenta. {ECO:0000269|PubMed:1570339}.
Sequence
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Late Phase of HIV Life Cycle
Inactivation, recovery and regulation of the phototransduction cascade
Activation, myristolyation of BID and translocation to mitochondria
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Hypertension Hypertension GWAS
Insomnia Insomnia GWAS
Alzheimer disease Alzheimer disease GWAS
Dyslexia Dyslexia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 30154572
Carcinoma Hepatocellular Associate 36617552
Carcinoma Non Small Cell Lung Associate 36551208
Colorectal Neoplasms Associate 16600465
Communicable Diseases Associate 29579063
Dementia Associate 31784277
HIV Infections Associate 29579063
Immune System Diseases Associate 29579063
Lymphatic Metastasis Associate 28951630
Lymphoma Large B Cell Diffuse Associate 27835906