Gene Gene information from NCBI Gene database.
Entrez ID 4836
Gene name N-myristoyltransferase 1
Gene symbol NMT1
Synonyms (NCBI Gene)
HsNMT1NMT
Chromosome 17
Chromosome location 17q21.31
Summary Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer o
miRNA miRNA information provided by mirtarbase database.
406
miRTarBase ID miRNA Experiments Reference
MIRT047822 hsa-miR-30d-5p CLASH 23622248
MIRT046372 hsa-miR-23b-3p CLASH 23622248
MIRT045083 hsa-miR-186-5p CLASH 23622248
MIRT041243 hsa-miR-193b-3p CLASH 23622248
MIRT039990 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0001701 Process In utero embryonic development IEA
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IBA
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IDA 25255805, 32103017, 32111831, 32686708, 34999170
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity IEA
GO:0004379 Function Glycylpeptide N-tetradecanoyltransferase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
160993 7857 ENSG00000136448
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30419
Protein name Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-)
Protein function Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoy
PDB 1RXT , 3IU1 , 3IU2 , 3IWE , 3JTK , 4C2Y , 4C2Z , 5MU6 , 5NPQ , 5O6H , 5O6J , 5O9S , 5O9T , 5O9U , 5O9V , 5UUT , 6EHJ , 6F56 , 6FZ2 , 6FZ3 , 6FZ5 , 6PAV , 6QRM , 6SJZ , 6SK2 , 6SK3 , 6SK8 , 6SKJ , 7OWM , 7OWN , 7OWO , 7OWP , 7OWQ , 7OWR , 7OWU , 7RK3 , 8Q23 , 8Q24 , 8Q26 , 8Q2Z , 8Q3D , 8Q3S , 8Q3T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01233 NMT 137 294 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain Domain
PF02799 NMT_C 308 494 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Heart, gut, kidney, liver and placenta. {ECO:0000269|PubMed:1570339}.
Sequence
Sequence length 496
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Late Phase of HIV Life Cycle
Inactivation, recovery and regulation of the phototransduction cascade
Activation, myristolyation of BID and translocation to mitochondria
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Gastric cancer Uncertain significance rs150418753 RCV005929281
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 30154572
Carcinoma Hepatocellular Associate 36617552
Carcinoma Non Small Cell Lung Associate 36551208
Colorectal Neoplasms Associate 16600465
Communicable Diseases Associate 29579063
Dementia Associate 31784277
HIV Infections Associate 29579063
Immune System Diseases Associate 29579063
Lymphatic Metastasis Associate 28951630
Lymphoma Large B Cell Diffuse Associate 27835906