Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
4836
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
N-myristoyltransferase 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
NMT1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
HsNMT1, NMT |
Chromosome
Chromosome number
|
17 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
17q21.31 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer o |
UniProt ID |
P30419
|
Protein name |
Glycylpeptide N-tetradecanoyltransferase 1 (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase 1) (HsNMT1) (NMT 1) (Type I N-myristoyltransferase) (Peptide N-myristoyltransferase 1) (Protein-lysine myristoyltransferase NMT1) (EC 2.3.1.-) |
Protein function |
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoy |
PDB |
1RXT
,
3IU1
,
3IU2
,
3IWE
,
3JTK
,
4C2Y
,
4C2Z
,
5MU6
,
5NPQ
,
5O6H
,
5O6J
,
5O9S
,
5O9T
,
5O9U
,
5O9V
,
5UUT
,
6EHJ
,
6F56
,
6FZ2
,
6FZ3
,
6FZ5
,
6PAV
,
6QRM
,
6SJZ
,
6SK2
,
6SK3
,
6SK8
,
6SKJ
,
7OWM
,
7OWN
,
7OWO
,
7OWP
,
7OWQ
,
7OWR
,
7OWU
,
7RK3
,
8Q23
,
8Q24
,
8Q26
,
8Q2Z
,
8Q3D
,
8Q3S
,
8Q3T
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01233
|
NMT |
137 → 294 |
Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain |
Domain |
PF02799
|
NMT_C |
308 → 494 |
Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain |
Domain |
|
Tissue specificity |
TISSUE SPECIFICITY: Heart, gut, kidney, liver and placenta. {ECO:0000269|PubMed:1570339}. |
Sequence |
|
Sequence length |
496 |
Interactions |
View interactions
|