NFATC3 (nuclear factor of activated T cells 3)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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4775 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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Nuclear factor of activated T cells 3 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NFATC3 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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NF-AT4c, NFAT4, NFATX, n339260 |
Chromosome
Chromosome number
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16 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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16q22.1 |
Summary
Summary of gene provided in NCBI Entrez Gene.
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The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor ( |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | ||||||||||||||||
UniProt ID | Q12968 | |||||||||||||||
Protein name | Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c) | |||||||||||||||
Protein function | Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 ex | |||||||||||||||
PDB | 2XRW , 2XS0 | |||||||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: [Isoform 1]: Predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. {ECO:0000269|PubMed:9759864}.; TISSUE SPECIFICITY: [Isoform 2]: Predominantly expressed in skeletal muscle (PubMed:9759864). Al | |||||||||||||||
Sequence |
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Sequence length | 1075 | |||||||||||||||
Interactions | View interactions |
Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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