Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4775
Gene name Gene Name - the full gene name approved by the HGNC.
Nuclear factor of activated T cells 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NFATC3
Synonyms (NCBI Gene) Gene synonyms aliases
NF-AT4c, NFAT4, NFATX, n339260
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT021368 hsa-miR-9-5p Microarray 17612493
MIRT052288 hsa-let-7b-5p CLASH 23622248
MIRT042979 hsa-miR-324-3p CLASH 23622248
MIRT038275 hsa-miR-361-3p CLASH 23622248
MIRT284753 hsa-miR-185-5p Luciferase reporter assay, qRT-PCR, Western blot 24014023
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA 21873635
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 15173172
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602698 7777 ENSG00000072736
Protein
UniProt ID Q12968
Protein name Nuclear factor of activated T-cells, cytoplasmic 3 (NF-ATc3) (NFATc3) (NFATx) (T-cell transcription factor NFAT4) (NF-AT4) (NF-AT4c)
Protein function Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 ex
PDB 2XRW , 2XS0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00554 RHD_DNA_bind 433 592 Rel homology DNA-binding domain Domain
PF16179 RHD_dimer 601 701 Rel homology dimerisation domain Domain
Tissue specificity TISSUE SPECIFICITY: [Isoform 1]: Predominantly expressed in thymus and is also found in peripheral blood leukocytes and kidney. {ECO:0000269|PubMed:9759864}.; TISSUE SPECIFICITY: [Isoform 2]: Predominantly expressed in skeletal muscle (PubMed:9759864). Al
Sequence
MTTANCGAHDELDFKLVFGEDGAPAPPPPGSRPADLEPDDCASIYIFNVDPPPSTLTTPL
CLPHHGLPSHSSVLSPSFQLQSHKNYEGTCEIPESKYSPLGGPKPFECPSIQITSISPNC
HQELDAHEDDLQINDPEREFLERPSRDHLYLPLEPSYRESSLSPSPASSISSRSWFSDAS
SCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEETWHQQYGLGHSLSPRQS
PCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHS
PRGSVTEDTWLNASVHGGSGLGPAVFPFQYCVETDIPLKTRKTSEDQAAILPGKLELCSD
DQGSLSPARETSIDDGLGSQYPLKKDSCGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPL
DWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNEKPINLQM
FIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGI
LKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECS
QRSAQELP
HIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHI
VLEVPPYHNPAVTAAVQVHFYLCNGKRKKSQSQRFTYTPVL
MKQEHREEIDLSSVPSLPV
PHPAQTQRPSSDSGCSHDSVLSGQRSLICSIPQTYASMVTSSHLPQLQCRDESVSKEQHM
IPSPIVHQPFQVTPTPPVGSSYQPMQTNVVYNGPTCLPINAASSQEFDSVLFQQDATLSG
LVNLGCQPLSSIPFHSSNSGSTGHLLAHTPHSVHTLPHLQSMGYHCSNTGQRSLSSPVAD
QITGQPSSQLQPITYGPSHSGSATTASPAASHPLASSPLSGPPSPQLQPMPYQSPSSGTA
SSPSPATRMHSGQHSTQAQSTGQGGLSAPSSLICHSLCDPASFPPDGATVSIKPEPEDRE
PNFATIGLQDITLDDVNEIIGRDMSQISVSQGAGVSRQAPLPSPESLDLGRSDGL
Sequence length 1075
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Efferocytosis
Cellular senescence
Wnt signaling pathway
Axon guidance
C-type lectin receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Oxytocin signaling pathway
Yersinia infection
Hepatitis B
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis
  Calcineurin activates NFAT
FCERI mediated Ca+2 mobilization
CLEC7A (Dectin-1) induces NFAT activation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
25056061, 31268507, 26198764
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 27058892, 34257525
Atrial Fibrillation Associate 16389460
Atrial Fibrillation Stimulate 25422138
Atrial Remodeling Associate 25422138
Bipolar Disorder Stimulate 29507296
Breast Neoplasms Associate 18668201
Bronchopulmonary Dysplasia Associate 37060021
Calcinosis Associate 36257194
Carcinogenesis Associate 33520407
Carcinoma Hepatocellular Associate 33520407