Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4734
Gene name Gene Name - the full gene name approved by the HGNC.	NEDD4 E3 ubiquitin protein ligase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NEDD4
Synonyms (NCBI Gene) Gene synonyms aliases	NEDD4-1, RPF1
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q21.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001612	hsa-let-7b-5p	pSILAC	18668040
MIRT007131	hsa-miR-30c-5p	qRT-PCR	23418453
MIRT016194	hsa-miR-590-3p	Sequencing	20371350
MIRT022426	hsa-miR-124-3p	Microarray	18668037
MIRT001612	hsa-let-7b-5p	Proteomics;Other	18668040
MIRT1179628	hsa-miR-10a	CLIP-seq
MIRT1179629	hsa-miR-10b	CLIP-seq
MIRT1179630	hsa-miR-1179	CLIP-seq
MIRT1179631	hsa-miR-1183	CLIP-seq
MIRT1179632	hsa-miR-1229	CLIP-seq
MIRT1179633	hsa-miR-1231	CLIP-seq
MIRT1179634	hsa-miR-124	CLIP-seq
MIRT1179635	hsa-miR-1244	CLIP-seq
MIRT1179636	hsa-miR-1254	CLIP-seq
MIRT1179637	hsa-miR-128	CLIP-seq
MIRT1179638	hsa-miR-1283	CLIP-seq
MIRT1179639	hsa-miR-1284	CLIP-seq
MIRT1179640	hsa-miR-1299	CLIP-seq
MIRT1179641	hsa-miR-18a	CLIP-seq
MIRT1179642	hsa-miR-18b	CLIP-seq
MIRT1179643	hsa-miR-199a-3p	CLIP-seq
MIRT1179644	hsa-miR-199b-3p	CLIP-seq
MIRT1179645	hsa-miR-200b	CLIP-seq
MIRT1179646	hsa-miR-200c	CLIP-seq
MIRT1179647	hsa-miR-21	CLIP-seq
MIRT1179648	hsa-miR-22	CLIP-seq
MIRT1179649	hsa-miR-224	CLIP-seq
MIRT1179650	hsa-miR-2682	CLIP-seq
MIRT1179651	hsa-miR-27a	CLIP-seq
MIRT1179652	hsa-miR-27b	CLIP-seq
MIRT1179653	hsa-miR-300	CLIP-seq
MIRT1179654	hsa-miR-302a	CLIP-seq
MIRT1179655	hsa-miR-302b	CLIP-seq
MIRT1179656	hsa-miR-302c	CLIP-seq
MIRT1179657	hsa-miR-302d	CLIP-seq
MIRT1179658	hsa-miR-302e	CLIP-seq
MIRT1179659	hsa-miR-30a	CLIP-seq
MIRT1179660	hsa-miR-30b	CLIP-seq
MIRT1179661	hsa-miR-30c	CLIP-seq
MIRT1179662	hsa-miR-30d	CLIP-seq
MIRT1179663	hsa-miR-30e	CLIP-seq
MIRT1179664	hsa-miR-31	CLIP-seq
MIRT1179665	hsa-miR-3116	CLIP-seq
MIRT1179666	hsa-miR-3120-5p	CLIP-seq
MIRT1179667	hsa-miR-3121-3p	CLIP-seq
MIRT1179668	hsa-miR-3126-3p	CLIP-seq
MIRT1179669	hsa-miR-3128	CLIP-seq
MIRT1179670	hsa-miR-3129-5p	CLIP-seq
MIRT1179671	hsa-miR-3137	CLIP-seq
MIRT1179672	hsa-miR-3149	CLIP-seq
MIRT1179673	hsa-miR-3152-5p	CLIP-seq
MIRT1179674	hsa-miR-3163	CLIP-seq
MIRT1179675	hsa-miR-3168	CLIP-seq
MIRT1179676	hsa-miR-3185	CLIP-seq
MIRT1179677	hsa-miR-3192	CLIP-seq
MIRT1179678	hsa-miR-3201	CLIP-seq
MIRT1179679	hsa-miR-342-3p	CLIP-seq
MIRT1179680	hsa-miR-3545-3p	CLIP-seq
MIRT1179681	hsa-miR-3607-3p	CLIP-seq
MIRT1179682	hsa-miR-3609	CLIP-seq
MIRT1179683	hsa-miR-3618	CLIP-seq
MIRT1179684	hsa-miR-3622b-5p	CLIP-seq
MIRT1179685	hsa-miR-3647-3p	CLIP-seq
MIRT1179686	hsa-miR-3650	CLIP-seq
MIRT1179687	hsa-miR-3653	CLIP-seq
MIRT1179688	hsa-miR-3658	CLIP-seq
MIRT1179689	hsa-miR-3660	CLIP-seq
MIRT1179690	hsa-miR-3677-5p	CLIP-seq
MIRT1179691	hsa-miR-3686	CLIP-seq
MIRT1179692	hsa-miR-3691-5p	CLIP-seq
MIRT1179693	hsa-miR-3714	CLIP-seq
MIRT1179694	hsa-miR-371-5p	CLIP-seq
MIRT1179695	hsa-miR-371b-5p	CLIP-seq
MIRT1179696	hsa-miR-372	CLIP-seq
MIRT1179697	hsa-miR-373	CLIP-seq
MIRT1179698	hsa-miR-374c	CLIP-seq
MIRT1179699	hsa-miR-381	CLIP-seq
MIRT1179700	hsa-miR-3910	CLIP-seq
MIRT1179701	hsa-miR-3922-5p	CLIP-seq
MIRT1179702	hsa-miR-3924	CLIP-seq
MIRT1179703	hsa-miR-3945	CLIP-seq
MIRT1179704	hsa-miR-409-3p	CLIP-seq
MIRT1179705	hsa-miR-4253	CLIP-seq
MIRT1179706	hsa-miR-4256	CLIP-seq
MIRT1179707	hsa-miR-4259	CLIP-seq
MIRT1179708	hsa-miR-4264	CLIP-seq
MIRT1179709	hsa-miR-4277	CLIP-seq
MIRT1179710	hsa-miR-4282	CLIP-seq
MIRT1179711	hsa-miR-429	CLIP-seq
MIRT1179712	hsa-miR-4314	CLIP-seq
MIRT1179713	hsa-miR-4328	CLIP-seq
MIRT1179714	hsa-miR-4424	CLIP-seq
MIRT1179715	hsa-miR-4432	CLIP-seq
MIRT1179716	hsa-miR-4446-5p	CLIP-seq
MIRT1179717	hsa-miR-4455	CLIP-seq
MIRT1179718	hsa-miR-4462	CLIP-seq
MIRT1179719	hsa-miR-4477b	CLIP-seq
MIRT1179720	hsa-miR-4484	CLIP-seq
MIRT1179721	hsa-miR-449c	CLIP-seq
MIRT1179722	hsa-miR-4517	CLIP-seq
MIRT1179723	hsa-miR-4526	CLIP-seq
MIRT1179724	hsa-miR-4646-5p	CLIP-seq
MIRT1179725	hsa-miR-4652-3p	CLIP-seq
MIRT1179726	hsa-miR-4666-3p	CLIP-seq
MIRT1179727	hsa-miR-4666-5p	CLIP-seq
MIRT1179728	hsa-miR-4677-3p	CLIP-seq
MIRT1179729	hsa-miR-4679	CLIP-seq
MIRT1179730	hsa-miR-4698	CLIP-seq
MIRT1179731	hsa-miR-4701-5p	CLIP-seq
MIRT1179732	hsa-miR-4707-5p	CLIP-seq
MIRT1179733	hsa-miR-4711-5p	CLIP-seq
MIRT1179734	hsa-miR-4715-5p	CLIP-seq
MIRT1179735	hsa-miR-4719	CLIP-seq
MIRT1179736	hsa-miR-4720-5p	CLIP-seq
MIRT1179737	hsa-miR-4729	CLIP-seq
MIRT1179738	hsa-miR-4735-3p	CLIP-seq
MIRT1179739	hsa-miR-4736	CLIP-seq
MIRT1179740	hsa-miR-4742-5p	CLIP-seq
MIRT1179741	hsa-miR-4747-5p	CLIP-seq
MIRT1179742	hsa-miR-4752	CLIP-seq
MIRT1179743	hsa-miR-4774-3p	CLIP-seq
MIRT1179744	hsa-miR-4789-5p	CLIP-seq
MIRT1179745	hsa-miR-4791	CLIP-seq
MIRT1179746	hsa-miR-4797-3p	CLIP-seq
MIRT1179747	hsa-miR-4799-3p	CLIP-seq
MIRT1179748	hsa-miR-4802-3p	CLIP-seq
MIRT1179749	hsa-miR-495	CLIP-seq
MIRT1179750	hsa-miR-506	CLIP-seq
MIRT1179751	hsa-miR-5096	CLIP-seq
MIRT1179752	hsa-miR-513a-3p	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT1179754	hsa-miR-518a-5p	CLIP-seq
MIRT1179755	hsa-miR-520a-3p	CLIP-seq
MIRT1179756	hsa-miR-520b	CLIP-seq
MIRT1179757	hsa-miR-520c-3p	CLIP-seq
MIRT1179758	hsa-miR-520d-3p	CLIP-seq
MIRT1179759	hsa-miR-520d-5p	CLIP-seq
MIRT1179760	hsa-miR-520e	CLIP-seq
MIRT1179761	hsa-miR-524-5p	CLIP-seq
MIRT1179762	hsa-miR-527	CLIP-seq
MIRT1179763	hsa-miR-541	CLIP-seq
MIRT1179764	hsa-miR-548a-3p	CLIP-seq
MIRT1179765	hsa-miR-548ae	CLIP-seq
MIRT1179766	hsa-miR-548ah	CLIP-seq
MIRT1179767	hsa-miR-548aj	CLIP-seq
MIRT1179768	hsa-miR-548am	CLIP-seq
MIRT1179769	hsa-miR-548an	CLIP-seq
MIRT1179770	hsa-miR-548c-3p	CLIP-seq
MIRT1179771	hsa-miR-548e	CLIP-seq
MIRT1179772	hsa-miR-548f	CLIP-seq
MIRT1179773	hsa-miR-548x	CLIP-seq
MIRT1179774	hsa-miR-549	CLIP-seq
MIRT1179775	hsa-miR-579	CLIP-seq
MIRT1179776	hsa-miR-582-5p	CLIP-seq
MIRT1179777	hsa-miR-587	CLIP-seq
MIRT1179778	hsa-miR-588	CLIP-seq
MIRT1179779	hsa-miR-590-5p	CLIP-seq
MIRT1179780	hsa-miR-645	CLIP-seq
MIRT1179781	hsa-miR-654-5p	CLIP-seq
MIRT1179782	hsa-miR-655	CLIP-seq
MIRT1179783	hsa-miR-660	CLIP-seq
MIRT1179784	hsa-miR-661	CLIP-seq
MIRT1179785	hsa-miR-7	CLIP-seq
MIRT1179786	hsa-miR-875-3p	CLIP-seq
MIRT1179787	hsa-miR-936	CLIP-seq
MIRT1179788	hsa-miR-940	CLIP-seq
MIRT1179634	hsa-miR-124	CLIP-seq
MIRT1179635	hsa-miR-1244	CLIP-seq
MIRT1179636	hsa-miR-1254	CLIP-seq
MIRT1179637	hsa-miR-128	CLIP-seq
MIRT1179639	hsa-miR-1284	CLIP-seq
MIRT1179789	hsa-miR-144	CLIP-seq
MIRT1179641	hsa-miR-18a	CLIP-seq
MIRT1179642	hsa-miR-18b	CLIP-seq
MIRT1179643	hsa-miR-199a-3p	CLIP-seq
MIRT1179644	hsa-miR-199b-3p	CLIP-seq
MIRT1179647	hsa-miR-21	CLIP-seq
MIRT1179650	hsa-miR-2682	CLIP-seq
MIRT1179651	hsa-miR-27a	CLIP-seq
MIRT1179652	hsa-miR-27b	CLIP-seq
MIRT1179653	hsa-miR-300	CLIP-seq
MIRT1179659	hsa-miR-30a	CLIP-seq
MIRT1179660	hsa-miR-30b	CLIP-seq
MIRT1179661	hsa-miR-30c	CLIP-seq
MIRT1179662	hsa-miR-30d	CLIP-seq
MIRT1179663	hsa-miR-30e	CLIP-seq
MIRT1179665	hsa-miR-3116	CLIP-seq
MIRT1179670	hsa-miR-3129-5p	CLIP-seq
MIRT1179675	hsa-miR-3168	CLIP-seq
MIRT1179790	hsa-miR-323b-3p	CLIP-seq
MIRT1179791	hsa-miR-338-5p	CLIP-seq
MIRT1179681	hsa-miR-3607-3p	CLIP-seq
MIRT1179691	hsa-miR-3686	CLIP-seq
MIRT1179693	hsa-miR-3714	CLIP-seq
MIRT1179694	hsa-miR-371-5p	CLIP-seq
MIRT1179695	hsa-miR-371b-5p	CLIP-seq
MIRT1179792	hsa-miR-376a	CLIP-seq
MIRT1179793	hsa-miR-376b	CLIP-seq
MIRT1179794	hsa-miR-377	CLIP-seq
MIRT1179699	hsa-miR-381	CLIP-seq
MIRT1179700	hsa-miR-3910	CLIP-seq
MIRT1179701	hsa-miR-3922-5p	CLIP-seq
MIRT1179795	hsa-miR-410	CLIP-seq
MIRT1179796	hsa-miR-425	CLIP-seq
MIRT1179797	hsa-miR-4251	CLIP-seq
MIRT1179798	hsa-miR-4257	CLIP-seq
MIRT1179707	hsa-miR-4259	CLIP-seq
MIRT1179708	hsa-miR-4264	CLIP-seq
MIRT1179718	hsa-miR-4462	CLIP-seq
MIRT1179799	hsa-miR-4464	CLIP-seq
MIRT1179719	hsa-miR-4477b	CLIP-seq
MIRT1179721	hsa-miR-449c	CLIP-seq
MIRT1179800	hsa-miR-4643	CLIP-seq
MIRT1179726	hsa-miR-4666-3p	CLIP-seq
MIRT1179730	hsa-miR-4698	CLIP-seq
MIRT1179733	hsa-miR-4711-5p	CLIP-seq
MIRT1179734	hsa-miR-4715-5p	CLIP-seq
MIRT1179735	hsa-miR-4719	CLIP-seq
MIRT1179737	hsa-miR-4729	CLIP-seq
MIRT1179738	hsa-miR-4735-3p	CLIP-seq
MIRT1179739	hsa-miR-4736	CLIP-seq
MIRT1179801	hsa-miR-4748	CLIP-seq
MIRT1179746	hsa-miR-4797-3p	CLIP-seq
MIRT1179802	hsa-miR-494	CLIP-seq
MIRT1179750	hsa-miR-506	CLIP-seq
MIRT1179751	hsa-miR-5096	CLIP-seq
MIRT1179803	hsa-miR-511	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT1179804	hsa-miR-539	CLIP-seq
MIRT1179805	hsa-miR-548b-3p	CLIP-seq
MIRT1179770	hsa-miR-548c-3p	CLIP-seq
MIRT1179775	hsa-miR-579	CLIP-seq
MIRT1179779	hsa-miR-590-5p	CLIP-seq
MIRT1179806	hsa-miR-603	CLIP-seq
MIRT1179780	hsa-miR-645	CLIP-seq
MIRT1179784	hsa-miR-661	CLIP-seq
MIRT1179787	hsa-miR-936	CLIP-seq
MIRT1179788	hsa-miR-940	CLIP-seq
MIRT1179807	hsa-miR-944	CLIP-seq
MIRT1179709	hsa-miR-4277	CLIP-seq
MIRT2051948	hsa-miR-105	CLIP-seq
MIRT1179630	hsa-miR-1179	CLIP-seq
MIRT2051949	hsa-miR-1185	CLIP-seq
MIRT2051950	hsa-miR-1224-5p	CLIP-seq
MIRT1179635	hsa-miR-1244	CLIP-seq
MIRT1179636	hsa-miR-1254	CLIP-seq
MIRT2051951	hsa-miR-1271	CLIP-seq
MIRT1179637	hsa-miR-128	CLIP-seq
MIRT1179639	hsa-miR-1284	CLIP-seq
MIRT2051952	hsa-miR-1287	CLIP-seq
MIRT1179641	hsa-miR-18a	CLIP-seq
MIRT1179642	hsa-miR-18b	CLIP-seq
MIRT1179643	hsa-miR-199a-3p	CLIP-seq
MIRT1179644	hsa-miR-199b-3p	CLIP-seq
MIRT2051953	hsa-miR-204	CLIP-seq
MIRT2051954	hsa-miR-211	CLIP-seq
MIRT2051955	hsa-miR-2115	CLIP-seq
MIRT2051956	hsa-miR-219-2-3p	CLIP-seq
MIRT1179649	hsa-miR-224	CLIP-seq
MIRT2051957	hsa-miR-23a	CLIP-seq
MIRT2051958	hsa-miR-23b	CLIP-seq
MIRT2051959	hsa-miR-23c	CLIP-seq
MIRT1179650	hsa-miR-2682	CLIP-seq
MIRT1179651	hsa-miR-27a	CLIP-seq
MIRT1179652	hsa-miR-27b	CLIP-seq
MIRT2051960	hsa-miR-2964a-3p	CLIP-seq
MIRT1179653	hsa-miR-300	CLIP-seq
MIRT2051961	hsa-miR-302f	CLIP-seq
MIRT2051962	hsa-miR-3065-3p	CLIP-seq
MIRT1179659	hsa-miR-30a	CLIP-seq
MIRT1179660	hsa-miR-30b	CLIP-seq
MIRT1179661	hsa-miR-30c	CLIP-seq
MIRT1179662	hsa-miR-30d	CLIP-seq
MIRT1179663	hsa-miR-30e	CLIP-seq
MIRT1179665	hsa-miR-3116	CLIP-seq
MIRT1179668	hsa-miR-3126-3p	CLIP-seq
MIRT1179669	hsa-miR-3128	CLIP-seq
MIRT1179670	hsa-miR-3129-5p	CLIP-seq
MIRT2051963	hsa-miR-3135b	CLIP-seq
MIRT2051964	hsa-miR-3140-3p	CLIP-seq
MIRT1179673	hsa-miR-3152-5p	CLIP-seq
MIRT2051965	hsa-miR-3156-5p	CLIP-seq
MIRT1179676	hsa-miR-3185	CLIP-seq
MIRT1179677	hsa-miR-3192	CLIP-seq
MIRT2051966	hsa-miR-320e	CLIP-seq
MIRT1179790	hsa-miR-323b-3p	CLIP-seq
MIRT2051967	hsa-miR-3605-5p	CLIP-seq
MIRT1179682	hsa-miR-3609	CLIP-seq
MIRT1179684	hsa-miR-3622b-5p	CLIP-seq
MIRT1179685	hsa-miR-3647-3p	CLIP-seq
MIRT1179687	hsa-miR-3653	CLIP-seq
MIRT1179688	hsa-miR-3658	CLIP-seq
MIRT2051968	hsa-miR-3665	CLIP-seq
MIRT2051969	hsa-miR-3671	CLIP-seq
MIRT2051970	hsa-miR-3672	CLIP-seq
MIRT1179690	hsa-miR-3677-5p	CLIP-seq
MIRT2051971	hsa-miR-3679-5p	CLIP-seq
MIRT1179694	hsa-miR-371-5p	CLIP-seq
MIRT1179695	hsa-miR-371b-5p	CLIP-seq
MIRT1179794	hsa-miR-377	CLIP-seq
MIRT1179699	hsa-miR-381	CLIP-seq
MIRT2051972	hsa-miR-3915	CLIP-seq
MIRT2051973	hsa-miR-3934	CLIP-seq
MIRT1179703	hsa-miR-3945	CLIP-seq
MIRT2051974	hsa-miR-3977	CLIP-seq
MIRT1179795	hsa-miR-410	CLIP-seq
MIRT1179705	hsa-miR-4253	CLIP-seq
MIRT1179708	hsa-miR-4264	CLIP-seq
MIRT1179710	hsa-miR-4282	CLIP-seq
MIRT1179712	hsa-miR-4314	CLIP-seq
MIRT1179713	hsa-miR-4328	CLIP-seq
MIRT1179715	hsa-miR-4432	CLIP-seq
MIRT2051975	hsa-miR-4436a	CLIP-seq
MIRT1179716	hsa-miR-4446-5p	CLIP-seq
MIRT1179718	hsa-miR-4462	CLIP-seq
MIRT1179719	hsa-miR-4477b	CLIP-seq
MIRT1179721	hsa-miR-449c	CLIP-seq
MIRT2051976	hsa-miR-4502	CLIP-seq
MIRT2051977	hsa-miR-450b-5p	CLIP-seq
MIRT1179722	hsa-miR-4517	CLIP-seq
MIRT1179800	hsa-miR-4643	CLIP-seq
MIRT1179724	hsa-miR-4646-5p	CLIP-seq
MIRT2051978	hsa-miR-4659a-3p	CLIP-seq
MIRT2051979	hsa-miR-4659b-3p	CLIP-seq
MIRT1179726	hsa-miR-4666-3p	CLIP-seq
MIRT2051980	hsa-miR-4689	CLIP-seq
MIRT1179730	hsa-miR-4698	CLIP-seq
MIRT1179731	hsa-miR-4701-5p	CLIP-seq
MIRT1179732	hsa-miR-4707-5p	CLIP-seq
MIRT1179733	hsa-miR-4711-5p	CLIP-seq
MIRT1179735	hsa-miR-4719	CLIP-seq
MIRT1179736	hsa-miR-4720-5p	CLIP-seq
MIRT1179738	hsa-miR-4735-3p	CLIP-seq
MIRT1179741	hsa-miR-4747-5p	CLIP-seq
MIRT2051981	hsa-miR-4751	CLIP-seq
MIRT2051982	hsa-miR-4755-5p	CLIP-seq
MIRT2051983	hsa-miR-4760-3p	CLIP-seq
MIRT2051984	hsa-miR-4762-3p	CLIP-seq
MIRT2051985	hsa-miR-4772-5p	CLIP-seq
MIRT2051986	hsa-miR-4773	CLIP-seq
MIRT1179743	hsa-miR-4774-3p	CLIP-seq
MIRT2051987	hsa-miR-4775	CLIP-seq
MIRT2051988	hsa-miR-4778-5p	CLIP-seq
MIRT1179746	hsa-miR-4797-3p	CLIP-seq
MIRT1179747	hsa-miR-4799-3p	CLIP-seq
MIRT1179802	hsa-miR-494	CLIP-seq
MIRT2051989	hsa-miR-502-5p	CLIP-seq
MIRT1179751	hsa-miR-5096	CLIP-seq
MIRT2051990	hsa-miR-512-5p	CLIP-seq
MIRT1179752	hsa-miR-513a-3p	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT2051991	hsa-miR-516a-3p	CLIP-seq
MIRT2051992	hsa-miR-520a-5p	CLIP-seq
MIRT2051993	hsa-miR-525-5p	CLIP-seq
MIRT1179763	hsa-miR-541	CLIP-seq
MIRT1179764	hsa-miR-548a-3p	CLIP-seq
MIRT1179765	hsa-miR-548ae	CLIP-seq
MIRT1179766	hsa-miR-548ah	CLIP-seq
MIRT1179767	hsa-miR-548aj	CLIP-seq
MIRT1179768	hsa-miR-548am	CLIP-seq
MIRT1179770	hsa-miR-548c-3p	CLIP-seq
MIRT1179771	hsa-miR-548e	CLIP-seq
MIRT1179772	hsa-miR-548f	CLIP-seq
MIRT1179773	hsa-miR-548x	CLIP-seq
MIRT1179774	hsa-miR-549	CLIP-seq
MIRT2051994	hsa-miR-561	CLIP-seq
MIRT1179775	hsa-miR-579	CLIP-seq
MIRT1179777	hsa-miR-587	CLIP-seq
MIRT1179778	hsa-miR-588	CLIP-seq
MIRT2051995	hsa-miR-607	CLIP-seq
MIRT2051996	hsa-miR-623	CLIP-seq
MIRT2051997	hsa-miR-642b	CLIP-seq
MIRT1179780	hsa-miR-645	CLIP-seq
MIRT1179781	hsa-miR-654-5p	CLIP-seq
MIRT2051998	hsa-miR-657	CLIP-seq
MIRT1179784	hsa-miR-661	CLIP-seq
MIRT1179785	hsa-miR-7	CLIP-seq
MIRT1179787	hsa-miR-936	CLIP-seq
MIRT1179788	hsa-miR-940	CLIP-seq
MIRT2051999	hsa-miR-96	CLIP-seq
MIRT2281171	hsa-miR-1184	CLIP-seq
MIRT2281172	hsa-miR-1205	CLIP-seq
MIRT2281173	hsa-miR-1207-3p	CLIP-seq
MIRT2281174	hsa-miR-1225-3p	CLIP-seq
MIRT1179632	hsa-miR-1229	CLIP-seq
MIRT1179634	hsa-miR-124	CLIP-seq
MIRT1179636	hsa-miR-1254	CLIP-seq
MIRT2281175	hsa-miR-125a-3p	CLIP-seq
MIRT2051951	hsa-miR-1271	CLIP-seq
MIRT1179638	hsa-miR-1283	CLIP-seq
MIRT1179639	hsa-miR-1284	CLIP-seq
MIRT2281176	hsa-miR-1301	CLIP-seq
MIRT2281177	hsa-miR-143	CLIP-seq
MIRT1179641	hsa-miR-18a	CLIP-seq
MIRT1179642	hsa-miR-18b	CLIP-seq
MIRT2281178	hsa-miR-1911	CLIP-seq
MIRT1179649	hsa-miR-224	CLIP-seq
MIRT2051957	hsa-miR-23a	CLIP-seq
MIRT2051958	hsa-miR-23b	CLIP-seq
MIRT2051959	hsa-miR-23c	CLIP-seq
MIRT1179650	hsa-miR-2682	CLIP-seq
MIRT1179653	hsa-miR-300	CLIP-seq
MIRT1179665	hsa-miR-3116	CLIP-seq
MIRT2281179	hsa-miR-3144-5p	CLIP-seq
MIRT2281180	hsa-miR-3157-5p	CLIP-seq
MIRT2281181	hsa-miR-3158-5p	CLIP-seq
MIRT2281182	hsa-miR-3179	CLIP-seq
MIRT2281183	hsa-miR-3191	CLIP-seq
MIRT2281184	hsa-miR-3199	CLIP-seq
MIRT2051966	hsa-miR-320e	CLIP-seq
MIRT1179679	hsa-miR-342-3p	CLIP-seq
MIRT1179683	hsa-miR-3618	CLIP-seq
MIRT1179686	hsa-miR-3650	CLIP-seq
MIRT1179693	hsa-miR-3714	CLIP-seq
MIRT1179699	hsa-miR-381	CLIP-seq
MIRT1179700	hsa-miR-3910	CLIP-seq
MIRT2051973	hsa-miR-3934	CLIP-seq
MIRT2281185	hsa-miR-3942-3p	CLIP-seq
MIRT2051974	hsa-miR-3977	CLIP-seq
MIRT1179798	hsa-miR-4257	CLIP-seq
MIRT1179709	hsa-miR-4277	CLIP-seq
MIRT1179717	hsa-miR-4455	CLIP-seq
MIRT1179719	hsa-miR-4477b	CLIP-seq
MIRT1179721	hsa-miR-449c	CLIP-seq
MIRT2281186	hsa-miR-4515	CLIP-seq
MIRT2281187	hsa-miR-4527	CLIP-seq
MIRT2281188	hsa-miR-4652-5p	CLIP-seq
MIRT2281189	hsa-miR-4660	CLIP-seq
MIRT1179726	hsa-miR-4666-3p	CLIP-seq
MIRT2281190	hsa-miR-4667-5p	CLIP-seq
MIRT2281191	hsa-miR-4691-3p	CLIP-seq
MIRT2281192	hsa-miR-4700-5p	CLIP-seq
MIRT2281193	hsa-miR-4727-3p	CLIP-seq
MIRT2281194	hsa-miR-4731-5p	CLIP-seq
MIRT1179738	hsa-miR-4735-3p	CLIP-seq
MIRT1179739	hsa-miR-4736	CLIP-seq
MIRT2281195	hsa-miR-4770	CLIP-seq
MIRT2281196	hsa-miR-485-3p	CLIP-seq
MIRT2281197	hsa-miR-493	CLIP-seq
MIRT2281198	hsa-miR-496	CLIP-seq
MIRT2051989	hsa-miR-502-5p	CLIP-seq
MIRT2281199	hsa-miR-5047	CLIP-seq
MIRT1179750	hsa-miR-506	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT1179765	hsa-miR-548ae	CLIP-seq
MIRT1179767	hsa-miR-548aj	CLIP-seq
MIRT1179768	hsa-miR-548am	CLIP-seq
MIRT1179805	hsa-miR-548b-3p	CLIP-seq
MIRT1179770	hsa-miR-548c-3p	CLIP-seq
MIRT1179773	hsa-miR-548x	CLIP-seq
MIRT1179776	hsa-miR-582-5p	CLIP-seq
MIRT1179780	hsa-miR-645	CLIP-seq
MIRT1179784	hsa-miR-661	CLIP-seq
MIRT2281200	hsa-miR-764	CLIP-seq
MIRT1179788	hsa-miR-940	CLIP-seq
MIRT2051999	hsa-miR-96	CLIP-seq
MIRT1179788	hsa-miR-940	CLIP-seq
MIRT1179635	hsa-miR-1244	CLIP-seq
MIRT1179636	hsa-miR-1254	CLIP-seq
MIRT1179637	hsa-miR-128	CLIP-seq
MIRT1179643	hsa-miR-199a-3p	CLIP-seq
MIRT1179644	hsa-miR-199b-3p	CLIP-seq
MIRT1179651	hsa-miR-27a	CLIP-seq
MIRT1179652	hsa-miR-27b	CLIP-seq
MIRT1179665	hsa-miR-3116	CLIP-seq
MIRT1179670	hsa-miR-3129-5p	CLIP-seq
MIRT1179687	hsa-miR-3653	CLIP-seq
MIRT1179688	hsa-miR-3658	CLIP-seq
MIRT1179708	hsa-miR-4264	CLIP-seq
MIRT1179718	hsa-miR-4462	CLIP-seq
MIRT1179735	hsa-miR-4719	CLIP-seq
MIRT1179746	hsa-miR-4797-3p	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT1179764	hsa-miR-548a-3p	CLIP-seq
MIRT1179765	hsa-miR-548ae	CLIP-seq
MIRT1179767	hsa-miR-548aj	CLIP-seq
MIRT1179768	hsa-miR-548am	CLIP-seq
MIRT1179771	hsa-miR-548e	CLIP-seq
MIRT1179772	hsa-miR-548f	CLIP-seq
MIRT1179773	hsa-miR-548x	CLIP-seq
MIRT1179774	hsa-miR-549	CLIP-seq
MIRT1179784	hsa-miR-661	CLIP-seq
MIRT1179787	hsa-miR-936	CLIP-seq
MIRT1179637	hsa-miR-128	CLIP-seq
MIRT1179643	hsa-miR-199a-3p	CLIP-seq
MIRT1179644	hsa-miR-199b-3p	CLIP-seq
MIRT1179651	hsa-miR-27a	CLIP-seq
MIRT1179652	hsa-miR-27b	CLIP-seq
MIRT1179670	hsa-miR-3129-5p	CLIP-seq
MIRT1179708	hsa-miR-4264	CLIP-seq
MIRT1179718	hsa-miR-4462	CLIP-seq
MIRT1179735	hsa-miR-4719	CLIP-seq
MIRT1179746	hsa-miR-4797-3p	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT1179774	hsa-miR-549	CLIP-seq
MIRT1179787	hsa-miR-936	CLIP-seq
MIRT2579535	hsa-miR-103a	CLIP-seq
MIRT2579536	hsa-miR-107	CLIP-seq
MIRT1179630	hsa-miR-1179	CLIP-seq
MIRT2579537	hsa-miR-1237	CLIP-seq
MIRT1179635	hsa-miR-1244	CLIP-seq
MIRT1179636	hsa-miR-1254	CLIP-seq
MIRT2281175	hsa-miR-125a-3p	CLIP-seq
MIRT2579538	hsa-miR-1273e	CLIP-seq
MIRT1179637	hsa-miR-128	CLIP-seq
MIRT1179639	hsa-miR-1284	CLIP-seq
MIRT2579539	hsa-miR-129-5p	CLIP-seq
MIRT2579540	hsa-miR-141	CLIP-seq
MIRT2281178	hsa-miR-1911	CLIP-seq
MIRT1179643	hsa-miR-199a-3p	CLIP-seq
MIRT1179644	hsa-miR-199b-3p	CLIP-seq
MIRT2579541	hsa-miR-200a	CLIP-seq
MIRT2579542	hsa-miR-219-5p	CLIP-seq
MIRT2051957	hsa-miR-23a	CLIP-seq
MIRT2051958	hsa-miR-23b	CLIP-seq
MIRT2051959	hsa-miR-23c	CLIP-seq
MIRT1179651	hsa-miR-27a	CLIP-seq
MIRT1179652	hsa-miR-27b	CLIP-seq
MIRT1179653	hsa-miR-300	CLIP-seq
MIRT2051962	hsa-miR-3065-3p	CLIP-seq
MIRT2579543	hsa-miR-3065-5p	CLIP-seq
MIRT1179665	hsa-miR-3116	CLIP-seq
MIRT1179668	hsa-miR-3126-3p	CLIP-seq
MIRT1179670	hsa-miR-3129-5p	CLIP-seq
MIRT2579544	hsa-miR-3144-3p	CLIP-seq
MIRT2579545	hsa-miR-3160-5p	CLIP-seq
MIRT1179677	hsa-miR-3192	CLIP-seq
MIRT2579546	hsa-miR-330-3p	CLIP-seq
MIRT2579547	hsa-miR-3622a-5p	CLIP-seq
MIRT1179687	hsa-miR-3653	CLIP-seq
MIRT1179688	hsa-miR-3658	CLIP-seq
MIRT2579548	hsa-miR-3663-5p	CLIP-seq
MIRT2051970	hsa-miR-3672	CLIP-seq
MIRT1179699	hsa-miR-381	CLIP-seq
MIRT2579549	hsa-miR-3920	CLIP-seq
MIRT2051973	hsa-miR-3934	CLIP-seq
MIRT2579550	hsa-miR-3936	CLIP-seq
MIRT2281185	hsa-miR-3942-3p	CLIP-seq
MIRT2579551	hsa-miR-3973	CLIP-seq
MIRT1179708	hsa-miR-4264	CLIP-seq
MIRT2579552	hsa-miR-4310	CLIP-seq
MIRT1179712	hsa-miR-4314	CLIP-seq
MIRT2579553	hsa-miR-4423-3p	CLIP-seq
MIRT2579554	hsa-miR-4445	CLIP-seq
MIRT2579555	hsa-miR-4449	CLIP-seq
MIRT1179718	hsa-miR-4462	CLIP-seq
MIRT1179719	hsa-miR-4477b	CLIP-seq
MIRT1179724	hsa-miR-4646-5p	CLIP-seq
MIRT1179726	hsa-miR-4666-3p	CLIP-seq
MIRT1179727	hsa-miR-4666-5p	CLIP-seq
MIRT2579556	hsa-miR-4675	CLIP-seq
MIRT1179735	hsa-miR-4719	CLIP-seq
MIRT1179737	hsa-miR-4729	CLIP-seq
MIRT2579557	hsa-miR-4741	CLIP-seq
MIRT2051984	hsa-miR-4762-3p	CLIP-seq
MIRT2579558	hsa-miR-4782-3p	CLIP-seq
MIRT1179746	hsa-miR-4797-3p	CLIP-seq
MIRT1179749	hsa-miR-495	CLIP-seq
MIRT2579559	hsa-miR-508-3p	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT1179759	hsa-miR-520d-5p	CLIP-seq
MIRT1179761	hsa-miR-524-5p	CLIP-seq
MIRT1179764	hsa-miR-548a-3p	CLIP-seq
MIRT1179765	hsa-miR-548ae	CLIP-seq
MIRT1179767	hsa-miR-548aj	CLIP-seq
MIRT1179768	hsa-miR-548am	CLIP-seq
MIRT1179805	hsa-miR-548b-3p	CLIP-seq
MIRT1179771	hsa-miR-548e	CLIP-seq
MIRT1179772	hsa-miR-548f	CLIP-seq
MIRT2579560	hsa-miR-548k	CLIP-seq
MIRT1179773	hsa-miR-548x	CLIP-seq
MIRT1179774	hsa-miR-549	CLIP-seq
MIRT2579561	hsa-miR-568	CLIP-seq
MIRT2579562	hsa-miR-586	CLIP-seq
MIRT2579563	hsa-miR-627	CLIP-seq
MIRT2051997	hsa-miR-642b	CLIP-seq
MIRT1179784	hsa-miR-661	CLIP-seq
MIRT2281200	hsa-miR-764	CLIP-seq
MIRT2579564	hsa-miR-924	CLIP-seq
MIRT1179787	hsa-miR-936	CLIP-seq
MIRT2579535	hsa-miR-103a	CLIP-seq
MIRT2579536	hsa-miR-107	CLIP-seq
MIRT1179630	hsa-miR-1179	CLIP-seq
MIRT2579537	hsa-miR-1237	CLIP-seq
MIRT1179635	hsa-miR-1244	CLIP-seq
MIRT1179636	hsa-miR-1254	CLIP-seq
MIRT2579538	hsa-miR-1273e	CLIP-seq
MIRT1179637	hsa-miR-128	CLIP-seq
MIRT1179639	hsa-miR-1284	CLIP-seq
MIRT2579539	hsa-miR-129-5p	CLIP-seq
MIRT2579540	hsa-miR-141	CLIP-seq
MIRT1179643	hsa-miR-199a-3p	CLIP-seq
MIRT1179644	hsa-miR-199b-3p	CLIP-seq
MIRT2579541	hsa-miR-200a	CLIP-seq
MIRT2579542	hsa-miR-219-5p	CLIP-seq
MIRT1179651	hsa-miR-27a	CLIP-seq
MIRT1179652	hsa-miR-27b	CLIP-seq
MIRT1179653	hsa-miR-300	CLIP-seq
MIRT2051962	hsa-miR-3065-3p	CLIP-seq
MIRT1179665	hsa-miR-3116	CLIP-seq
MIRT1179668	hsa-miR-3126-3p	CLIP-seq
MIRT1179670	hsa-miR-3129-5p	CLIP-seq
MIRT2686135	hsa-miR-3143	CLIP-seq
MIRT1179677	hsa-miR-3192	CLIP-seq
MIRT2686136	hsa-miR-323-3p	CLIP-seq
MIRT2579546	hsa-miR-330-3p	CLIP-seq
MIRT2579547	hsa-miR-3622a-5p	CLIP-seq
MIRT1179687	hsa-miR-3653	CLIP-seq
MIRT1179688	hsa-miR-3658	CLIP-seq
MIRT2579548	hsa-miR-3663-5p	CLIP-seq
MIRT2051970	hsa-miR-3672	CLIP-seq
MIRT1179699	hsa-miR-381	CLIP-seq
MIRT2579549	hsa-miR-3920	CLIP-seq
MIRT2579550	hsa-miR-3936	CLIP-seq
MIRT2579551	hsa-miR-3973	CLIP-seq
MIRT1179708	hsa-miR-4264	CLIP-seq
MIRT2579552	hsa-miR-4310	CLIP-seq
MIRT1179712	hsa-miR-4314	CLIP-seq
MIRT2579553	hsa-miR-4423-3p	CLIP-seq
MIRT2579554	hsa-miR-4445	CLIP-seq
MIRT2579555	hsa-miR-4449	CLIP-seq
MIRT1179718	hsa-miR-4462	CLIP-seq
MIRT1179724	hsa-miR-4646-5p	CLIP-seq
MIRT1179726	hsa-miR-4666-3p	CLIP-seq
MIRT1179727	hsa-miR-4666-5p	CLIP-seq
MIRT2579556	hsa-miR-4675	CLIP-seq
MIRT1179735	hsa-miR-4719	CLIP-seq
MIRT1179737	hsa-miR-4729	CLIP-seq
MIRT2579557	hsa-miR-4741	CLIP-seq
MIRT2051984	hsa-miR-4762-3p	CLIP-seq
MIRT2579558	hsa-miR-4782-3p	CLIP-seq
MIRT1179746	hsa-miR-4797-3p	CLIP-seq
MIRT1179748	hsa-miR-4802-3p	CLIP-seq
MIRT2579559	hsa-miR-508-3p	CLIP-seq
MIRT1179753	hsa-miR-513a-5p	CLIP-seq
MIRT1179759	hsa-miR-520d-5p	CLIP-seq
MIRT1179761	hsa-miR-524-5p	CLIP-seq
MIRT1179764	hsa-miR-548a-3p	CLIP-seq
MIRT1179765	hsa-miR-548ae	CLIP-seq
MIRT1179767	hsa-miR-548aj	CLIP-seq
MIRT1179768	hsa-miR-548am	CLIP-seq
MIRT1179771	hsa-miR-548e	CLIP-seq
MIRT1179772	hsa-miR-548f	CLIP-seq
MIRT2579560	hsa-miR-548k	CLIP-seq
MIRT1179773	hsa-miR-548x	CLIP-seq
MIRT1179774	hsa-miR-549	CLIP-seq
MIRT2579561	hsa-miR-568	CLIP-seq
MIRT2686137	hsa-miR-576-3p	CLIP-seq
MIRT2579562	hsa-miR-586	CLIP-seq
MIRT2579563	hsa-miR-627	CLIP-seq
MIRT2051997	hsa-miR-642b	CLIP-seq
MIRT1179784	hsa-miR-661	CLIP-seq
MIRT2579564	hsa-miR-924	CLIP-seq
MIRT1179787	hsa-miR-936	CLIP-seq

Transcription factors

Show/Hide all(1)

Transcription factor	Regulation	Reference
SIRT2	Repression	23175188

Show/Hide all(68)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	ISS
GO:0000209	Process	Protein polyubiquitination	IBA	21873635
GO:0000785	Component	Chromatin	IDA	17996703
GO:0005515	Function	Protein binding	IPI	9305852, 9990509, 10642508, 11359767, 11598133, 12796489, 15231748, 16118794, 17116753, 17719543, 18305167, 19345329, 20086093, 20159449, 20562859, 20676133, 21765395, 22096579, 23665454, 23686771, 23873930, 24981860, 25588945, 29455656
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	12796489
GO:0005794	Component	Golgi apparatus	IDA	16118794
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS	9405440
GO:0005886	Component	Plasma membrane	IDA	16118794
GO:0005886	Component	Plasma membrane	IMP	15126635
GO:0005938	Component	Cell cortex	IDA	9990509
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	20086093, 26263374
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IMP	17218260, 17996703
GO:0006622	Process	Protein targeting to lysosome	IPI	17116753
GO:0007041	Process	Lysosomal transport	IDA	18544533
GO:0007528	Process	Neuromuscular junction development	IBA	21873635
GO:0010766	Process	Negative regulation of sodium ion transport	IDA	10642508
GO:0010768	Process	Negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	IMP	17996703
GO:0014068	Process	Positive regulation of phosphatidylinositol 3-kinase signaling	IMP	17218260
GO:0016241	Process	Regulation of macroautophagy	TAS	25809873
GO:0016327	Component	Apicolateral plasma membrane	TAS	9405440
GO:0016567	Process	Protein ubiquitination	IBA	21873635
GO:0016567	Process	Protein ubiquitination	IDA	17116753, 17996703, 18305167, 25631046, 26280536
GO:0019871	Function	Sodium channel inhibitor activity	IBA	21873635
GO:0019871	Function	Sodium channel inhibitor activity	IDA	10642508
GO:0019899	Function	Enzyme binding	IPI	26006083
GO:0019904	Function	Protein domain specific binding	IPI	12907594
GO:0030948	Process	Negative regulation of vascular endothelial growth factor receptor signaling pathway	ISS
GO:0031175	Process	Neuron projection development	IBA	21873635
GO:0031175	Process	Neuron projection development	IEP	9990509
GO:0031623	Process	Receptor internalization	IBA	21873635
GO:0031623	Process	Receptor internalization	IDA	18544533
GO:0031698	Function	Beta-2 adrenergic receptor binding	IDA	18544533
GO:0032801	Process	Receptor catabolic process	IBA	21873635
GO:0032801	Process	Receptor catabolic process	IDA	18544533
GO:0032991	Component	Protein-containing complex	IDA	17116753
GO:0034644	Process	Cellular response to UV	IMP	17996703
GO:0034765	Process	Regulation of ion transmembrane transport	IDA	17289006
GO:0042391	Process	Regulation of membrane potential	IDA	17289006
GO:0042921	Process	Glucocorticoid receptor signaling pathway	IDA	8649367
GO:0043130	Function	Ubiquitin binding	IDA	9990509
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA	21873635
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP	20086093
GO:0043197	Component	Dendritic spine	IBA	21873635
GO:0044111	Process	Development involved in symbiotic interaction	IMP	15126635
GO:0045732	Process	Positive regulation of protein catabolic process	IBA	21873635
GO:0045732	Process	Positive regulation of protein catabolic process	IDA	14973438
GO:0046755	Process	Viral budding	IMP	15126635
GO:0046824	Process	Positive regulation of nucleocytoplasmic transport	IDA	17218261
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	9990509
GO:0048814	Process	Regulation of dendrite morphogenesis	IBA	21873635
GO:0048814	Process	Regulation of dendrite morphogenesis	ISS
GO:0050807	Process	Regulation of synapse organization	IBA	21873635
GO:0050815	Function	Phosphoserine residue binding	ISS
GO:0050816	Function	Phosphothreonine residue binding	ISS
GO:0050847	Process	Progesterone receptor signaling pathway	IDA	8649367
GO:0051592	Process	Response to calcium ion	TAS	9405440
GO:0061630	Function	Ubiquitin protein ligase activity	IBA	21873635
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	17116753, 17996703, 20086093, 26006083
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0070063	Function	RNA polymerase binding	IPI	17996703
GO:0070064	Function	Proline-rich region binding	IMP	15126635
GO:0070064	Function	Proline-rich region binding	IPI	11342538
GO:0070534	Process	Protein K63-linked ubiquitination	ISS
GO:1901016	Process	Regulation of potassium ion transmembrane transporter activity	IDA	17289006
GO:2000650	Process	Negative regulation of sodium ion transmembrane transporter activity	IBA	21873635
GO:2000650	Process	Negative regulation of sodium ion transmembrane transporter activity	IDA	10642508

MIM	HGNC	e!Ensembl
602278	7727	ENSG00000069869

Protein

UniProt ID

P46934

Protein name

E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)

Protein function

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubM

PDB

2KPZ , 2KQ0 , 2M3O , 2XBB , 2XBF , 3B7Y , 4BBN , 4BE8 , 4N7F , 4N7H , 5AHT , 5C7J , 5C91

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00397	WW	612 → 641	WW domain	Domain
PF00397	WW	769 → 798	WW domain	Domain
PF00397	WW	842 → 871	WW domain	Domain
PF00397	WW	894 → 923	WW domain	Domain
PF00632	HECT	1013 → 1318	HECT-domain (ubiquitin-transferase)	Domain

Sequence

MAQSLRLHFAARRSNTYPLSETSGDDLDSHVHMCFKRPTRISTSNVVQMKLTPRQTALAP
LIKENVQSQERSSVPSSENVNKKSSCLQISLQPTRYSGYLQSSNVLADSDDASFTCILKD
GIYSSAVVDNELNAVNDGHLVSSPAICSGSLSNFSTSDNGSYSSNGSDFGSCASITSGGS
YTNSVISDSSSYTFPPSDDTFLGGNLPSDSTSNRSVPNRNTTPCEIFSRSTSTDPFVQDD
LEHGLEIMKLPVSRNTKIPLKRYSSLVIFPRSPSTTRPTSPTSLCTLLSKGSYQTSHQFI
ISPSEIAHNEDGTSAKGFLSTAVNGLRLSKTICTPGEVRDIRPLHRKGSLQKKIVLSNNT
PRQTVCEKSSEGYSCVSVHFTQRKAATLDCETTNGDCKPEMSEIKLNSDSEYIKLMHRTS
ACLPSSQNVDCQININGELERPHSQMNKNHGILRRSISLGGAYPNISCLSSLKHNCSKGG
PSQLLIKFASGNEGKVDNLSRDSNRDCTNELSNSCKTRDDFLGQVDVPLYPLPTENPRLE
RPYTFKDFVLHPRSHKSRVKGYLRLKMTYLPKTSGSEDDNAEQAEELEPGWVVLDQPDAA
CHLQQQQEPSPLPPGWEERQDILGRTYYVNHESRRTQWKRPTPQDNLTDAENGNIQLQAQ
RAFTTRRQISEETESVDNRESSENWEIIREDEATMYSNQAFPSPPPSSNLDVPTHLAEEL
NARLTIFGNSAVSQPASSSNHSSRRGSLQAYTFEEQPTLPVLLPTSSGLPPGWEEKQDER
GRSYYVDHNSRTTTWTKPTVQATVETSQLTSSQSSAGPQSQASTSDSGQQVTQPSEIEQG
FLPKGWEVRHAPNGRPFFIDHNTKTTTWEDPRLKIPAHLRGKTSLDTSNDLGPLPPGWEE
RTHTDGRIFYINHNIKRTQWEDPRLENVAITGPAVPYSRDYKRKYEFFRRKLKKQNDIPN
KFEMKLRRATVLEDSYRRIMGVKRADFLKARLWIEFDGEKGLDYGGVAREWFFLISKEMF
NPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFFIRPFY
KMMLHKPITLHDMESVDSEYYNSLRWILENDPTELDLRFIIDEELFGQTHQHELKNGGSE
IVVTNKNKKEYIYLVIQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG
DVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAEL
YGSNGPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFDGVD

Sequence length

1319

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis Endocytosis Tight junction Epstein-Barr virus infection		ISG15 antiviral mechanism Downregulation of ERBB4 signaling Regulation of PTEN localization Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158 View all (309 more)

Show/Hide Unknown Diseases (3)

Disease term	Disease name	Source
Unknown
Testicular Germ Cell Tumor	Testicular Germ Cell Tumor	GWAS
Coronary artery disease	Coronary artery disease	GWAS
Rheumatoid arthritis	Rheumatoid arthritis	GWAS

Show/Hide Text Mining Associations (63)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma	Stimulate	29271375
Adenocarcinoma of Lung	Stimulate	29271375
Adenocarcinoma of Lung	Associate	29455656, 34007304, 35090513
Asthenozoospermia	Associate	36471356
Autistic Disorder	Associate	23471985
Bone Diseases Metabolic	Associate	18723765
Breast Neoplasms	Associate	25417742, 26276352, 29851245, 30367623, 31856858, 37291499
Calcinosis Cutis	Associate	35639915
Carcinogenesis	Associate	23180960, 31856858, 35090513
Carcinoma Hepatocellular	Associate	27236156, 27467187, 29480061, 35861040, 38145746
Carcinoma Intraductal Noninfiltrating	Associate	31856858
Carcinoma Non Small Cell Lung	Associate	20889565, 28714370, 29455656
Cholangiocarcinoma	Associate	37285922
Cognition Disorders	Associate	31849325
Colorectal Neoplasms	Associate	24141722, 24312311
Deafness	Associate	30180840
Emphysema	Associate	19723343
Encephalitis Japanese	Associate	28349961
Endometrial Neoplasms	Associate	26193427
Epilepsy Idiopathic Generalized	Associate	29760280
Esophageal Neoplasms	Associate	25395181
Glioblastoma	Associate	35167936
Glioma	Associate	24340059, 28405688, 28627598
Hamartoma Syndrome Multiple	Associate	35227301
Hyperlipidemias	Associate	24907641
Idiopathic Pulmonary Fibrosis	Associate	38215148
Inflammation	Associate	37291499
Influenza Human	Associate	31876380
Intestinal Diseases	Stimulate	23180960
Keloid	Associate	23667473, 25280642
Keratoconus	Associate	31467338
Lung Neoplasms	Stimulate	20889565
Lung Neoplasms	Associate	29455656, 33288736, 37291499
Lymphatic Metastasis	Stimulate	29271375
Melanoma	Associate	33962630
Mental Disorders	Associate	31849325
Myotonic Dystrophy	Associate	24907641
Nasopharyngeal Carcinoma	Associate	28379054
Nasopharyngeal Neoplasms	Associate	28379054
Neoplasm Metastasis	Associate	25395181, 28423617, 29455656
Neoplasm Metastasis	Stimulate	35031788
Neoplasms	Stimulate	20889565
Neoplasms	Associate	24340059, 27467187, 27557663, 28405688, 28627598, 28745938, 29271375, 29480061, 29760280, 31856858, 35031788, 35090513, 35861040, 37291499, 39665584, 9990509 View all (1 more)
Nevus Epithelioid and Spindle Cell	Associate	35639915
Osteoporosis	Associate	33993186
Ovarian Neoplasms	Inhibit	28365935
Pancreatic Neoplasms	Associate	28423617, 37605223
Pancreatic Neoplasms	Stimulate	37291499
Prostatitis	Associate	26276352, 28714370
Psychotic Disorders	Associate	31849325
Pulmonary Disease Chronic Obstructive	Inhibit	19717478
Rabies	Associate	18287095
Retinal Dysplasia	Inhibit	23180960
Sarcoma	Associate	35639915
Sarcoma Synovial	Associate	31595587, 35639915
Schizophrenia	Associate	31849325
Spinocerebellar Ataxia 31	Associate	19878914
Stomach Neoplasms	Stimulate	23180960
Stomach Neoplasms	Associate	25395181, 29455656, 36774408, 38200519
Thyroid Neoplasms	Inhibit	37291499
Triple Negative Breast Neoplasms	Associate	30594392
Urinary Bladder Neoplasms	Associate	28745938, 35031788
Virus Diseases	Associate	18287095

NEDD4 (NEDD4 E3 ubiquitin protein ligase)