Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4692
Gene name Gene Name - the full gene name approved by the HGNC.
Necdin, MAGE family member
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NDN
Synonyms (NCBI Gene) Gene synonyms aliases
HsT16328, PWCR
Chromosome Chromosome number
15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
15q11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This intronless gene is located in the Prader-Willi syndrome deletion region. It is an imprinted gene and is expressed exclusively from the paternal allele. Studies in mouse suggest that the protein encoded by this gene may suppress growth in postmitotic
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019333 hsa-miR-148b-3p Microarray 17612493
MIRT2280570 hsa-miR-4798-3p CLIP-seq
MIRT2280571 hsa-miR-561 CLIP-seq
MIRT2438958 hsa-miR-145 CLIP-seq
MIRT2438959 hsa-miR-3591-5p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
GO:0001228 Function DNA-binding transcription activator activity, RNA polymerase II-specific IEA
GO:0001764 Process Neuron migration IEA
GO:0003016 Process Respiratory system process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602117 7675 ENSG00000182636
Protein
UniProt ID Q99608
Protein name Necdin
Protein function Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01454 MAGE 157 273 MAGE family Family
Tissue specificity TISSUE SPECIFICITY: Almost ubiquitous. Detected in fetal brain, lung, liver and kidney; in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Not detected in pe
Sequence
MSEQSKDLSDPNFAAEAPNSEVHSSPGVSEGVPPSATLAEPQSPPLGPTAAPQAAPPPQA
PNDEGDPKALQQAAEEGRAHQAPSAAQPGPAPPAPAQLVQKAHELMWYVLVKDQKKMIIW
FPDMVKDVIGSYKKWCRSILRRTSLILARVFGLHLRLTSLHTMEFALVKALEPEELDRVA
LSNRMPMTGLLLMILSLIYVKGRGARESAVWNVLRILGLRPWKKHSTFGDVRKLITEEFV
QMNYLKYQRVPYVEPPEYEFFWGSRASREITKM
QIMEFLARVFKKDPQAWPSRYREALEE
ARALREANPTAHYPRSSVSED
Sequence length 321
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Interleukin-4 and Interleukin-13 signaling
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Acromicric dysplasia Acromicric Dysplasia rs387906622, rs387906623, rs387906624, rs1131692052, rs387906626, rs587776863, rs1064797059, rs363806, rs1060501041, rs1555400049
Attention deficit hyperactivity disorder Attention deficit hyperactivity disorder rs786205019
Carcinoma Carcinoma, Carcinoma, Spindle-Cell, Undifferentiated carcinoma rs121912654, rs555607708, rs786202962, rs1564055259 21489049
Cryptorchidism Cryptorchidism rs121912555, rs104894697, rs104894698, rs398122886
Unknown
Disease term Disease name Evidence References Source
Prader-willi syndrome Prader-Willi Syndrome, Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1, Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2, Prader-Willi syndrome due to imprinting mutation, Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15 ClinVar
Specific learning disorder Specific learning disability ClinVar
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 34252262
Autistic Disorder Associate 18835857
Breast Neoplasms Inhibit 22046235
Endometrial Neoplasms Associate 32170852
Esophageal Squamous Cell Carcinoma Associate 12901795
Glioblastoma Inhibit 21525872
Inflammation Associate 32330594
Insulin Resistance Associate 22138333
Melanoma Inhibit 22046235
Neoplasms Associate 10347180, 22691188, 23549060, 32330594