Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4671
Gene name Gene Name - the full gene name approved by the HGNC.
NLR family apoptosis inhibitory protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NAIP
Synonyms (NCBI Gene) Gene synonyms aliases
BIRC1, NLRB1, psiNAIP
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005295 hsa-miR-221-3p Western blot 18759060
MIRT731786 hsa-miR-145-5p Luciferase reporter assay, qRT-PCR, Western blot 26459459
MIRT731786 hsa-miR-145-5p Luciferase reporter assay, qRT-PCR, Western blot 26459459
MIRT731787 hsa-miR-1-3p Luciferase reporter assay, qRT-PCR, Western blot 26459459
MIRT731787 hsa-miR-1-3p Luciferase reporter assay, qRT-PCR, Western blot 26459459
Transcription factors
Transcription factor Regulation Reference
TEAD1 Unknown 23994529
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 21371431
GO:0005524 Function ATP binding IBA 21873635
GO:0005524 Function ATP binding IMP 21371431
GO:0005737 Component Cytoplasm ISS
GO:0006915 Process Apoptotic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600355 7634 ENSG00000249437
Protein
UniProt ID Q13075
Protein name Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)
Protein function Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the r
PDB 2VM5 , 8FVU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00653 BIR 63 128 Inhibitor of Apoptosis domain Domain
PF00653 BIR 162 228 Inhibitor of Apoptosis domain Domain
PF00653 BIR 281 346 Inhibitor of Apoptosis domain Domain
PF05729 NACHT 464 618 NACHT domain Domain
PF17779 NOD2_WH 687 742 NOD2 winged helix domain Domain
PF17889 NLRC4_HD 766 872 NLRC4 helical domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.
Sequence
MATQQKASDERISQFDHNLLPELSALLGLDAVQLAKELEEEEQKERAKMQKGYNSQMRSE
AKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRF
HPDCGFLL
NKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCV
LSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLR
SKKSSEEITQYI
QSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALA
KAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFLQ
NMKSSAEVTPDLQS
RGELCELLETTSESNLEDSIAVGPIVPEMAQGEAQWFQEAKNLNEQLRAAYTSASFRHMS
LLDISSDLATDHLLGCDLSIASKHISKPVQEPLVLPEVFGNLNSVMCVEGEAGSGKTVLL
KKIAFLWASGCCPLLNRFQLVFYLSLSSTRPDEGLASIICDQLLEKEGSVTEMCVRNIIQ
QLKNQVLFLLDDYKEICSIPQVIGKLIQKNHLSRTCLLIAVRTNRARDIRRYLETILEIK
AFPFYNTVCILRKLFSHN
MTRLRKFMVYFGKNQSLQKIQKTPLFVAAICAHWFQYPFDPS
FDDVAVFKSYMERLSLRNKATAEILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDED
EDLTMCLMSKFTAQRLRPFYRF
LSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINS
PMMTVSAYNNFLNYVSSLPSTKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQ
MQLLRGLWQICPQAYFSMVSEHLLVLALKTAY
QSNTVAACSPFVLQFLQGRTLTLGALNL
QYFFDHPESLSLLRSIHFPIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEW
ERNLAEKEDNVKSYMDMQRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEIL
MTVFSASQRIELHLNHSRGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLE
SLEVSGTIQSQDQIFPNLDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISA
EYDPSKLVKLIQNSPNLHVFHLKCNFFSDFGSLMTMLVSCKKLTEIKFSDSFFQAVPFVA
SLPNFISLKILNLEGQQFPDEETSEKFAYILGSLSNLEELILPTGDGIYRVAKLIIQQCQ
QLHCLRVLSFFKTLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNM
PNLQELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMKER
HPQSKYLTILQKWILPFSPIIQK
Sequence length 1403
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  NOD-like receptor signaling pathway
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Legionellosis
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Spinal muscular atrophy Juvenile Spinal Muscular Atrophy, Muscular Atrophy, Spinal, Type II, Muscular atrophy, spinal, infantile chronic form rs104893922, rs1554066397, rs77804083, rs104893930, rs104893927, rs104893935, rs387906738, rs398123028, rs371707778, rs398123030, rs587780564, rs713993043, rs727505393, rs797044855, rs863223361
View all (22 more)
11912351
Proximal spinal muscular atrophy Proximal spinal muscular atrophy type 1, Proximal spinal muscular atrophy type 3, Proximal spinal muscular atrophy type 2 rs121918358
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Inhibit 17292615
Breast Neoplasms Associate 17923748
Cognition Disorders Associate 17292615
Diabetes Gestational Associate 37873933
Diabetic Nephropathies Associate 36329882
Diffuse Neurofibrillary Tangles with Calcification Associate 17292615
HIV Infections Associate 33861800
Hypersensitivity Immediate Associate 11266116, 11912351, 18533950
Inflammation Associate 22545106
Intervertebral Disc Degeneration Associate 37267294