Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	4661
Gene name	Myelin transcription factor 1
Gene symbol	MYT1
Synonyms (NCBI Gene)	C20orf36MTF1MYTINZF2PLPB1ZC2H2C1ZC2HC4A
Chromosome	20
Chromosome location	20q13.33
Summary	The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous system and plays a role in the developing ne

Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT001770	hsa-miR-27a-3p	Western blot	18006846
MIRT001770	hsa-miR-27a-3p	Luciferase reporter assay	18006846
MIRT001770	hsa-miR-27a-3p	Other	18006846
MIRT1170656	hsa-miR-1208	CLIP-seq
MIRT1170657	hsa-miR-1273g	CLIP-seq
MIRT1170658	hsa-miR-136	CLIP-seq
MIRT1170659	hsa-miR-150	CLIP-seq
MIRT1170660	hsa-miR-1915	CLIP-seq
MIRT1170661	hsa-miR-200b	CLIP-seq
MIRT1170662	hsa-miR-200c	CLIP-seq
MIRT1170663	hsa-miR-2054	CLIP-seq
MIRT1170664	hsa-miR-219-1-3p	CLIP-seq
MIRT1170665	hsa-miR-224	CLIP-seq
MIRT1170666	hsa-miR-3147	CLIP-seq
MIRT1170667	hsa-miR-34b	CLIP-seq
MIRT1170668	hsa-miR-3684	CLIP-seq
MIRT1170669	hsa-miR-3929	CLIP-seq
MIRT1170670	hsa-miR-4259	CLIP-seq
MIRT1170671	hsa-miR-429	CLIP-seq
MIRT1170672	hsa-miR-4294	CLIP-seq
MIRT1170673	hsa-miR-4318	CLIP-seq
MIRT1170674	hsa-miR-4419b	CLIP-seq
MIRT1170675	hsa-miR-4433	CLIP-seq
MIRT1170676	hsa-miR-4459	CLIP-seq
MIRT1170677	hsa-miR-4478	CLIP-seq
MIRT1170678	hsa-miR-4677-3p	CLIP-seq
MIRT1170679	hsa-miR-4681	CLIP-seq
MIRT1170680	hsa-miR-4684-3p	CLIP-seq
MIRT1170681	hsa-miR-4693-5p	CLIP-seq
MIRT1170682	hsa-miR-4698	CLIP-seq
MIRT1170683	hsa-miR-4713-5p	CLIP-seq
MIRT1170684	hsa-miR-4726-3p	CLIP-seq
MIRT1170685	hsa-miR-4768-3p	CLIP-seq
MIRT1170686	hsa-miR-4768-5p	CLIP-seq
MIRT1170687	hsa-miR-511	CLIP-seq
MIRT1170688	hsa-miR-518a-5p	CLIP-seq
MIRT1170689	hsa-miR-527	CLIP-seq
MIRT1170690	hsa-miR-532-3p	CLIP-seq
MIRT1170691	hsa-miR-571	CLIP-seq
MIRT1170692	hsa-miR-885-5p	CLIP-seq
MIRT1170693	hsa-miR-892a	CLIP-seq
MIRT2278264	hsa-miR-128	CLIP-seq
MIRT2278265	hsa-miR-1302	CLIP-seq
MIRT2278266	hsa-miR-144	CLIP-seq
MIRT2278267	hsa-miR-1587	CLIP-seq
MIRT2278268	hsa-miR-27a	CLIP-seq
MIRT2278269	hsa-miR-27b	CLIP-seq
MIRT2278270	hsa-miR-4298	CLIP-seq
MIRT2278271	hsa-miR-4417	CLIP-seq
MIRT2278272	hsa-miR-4446-5p	CLIP-seq
MIRT2278273	hsa-miR-4492	CLIP-seq
MIRT2278274	hsa-miR-4498	CLIP-seq
MIRT2278275	hsa-miR-4505	CLIP-seq
MIRT2278276	hsa-miR-4656	CLIP-seq
MIRT2278277	hsa-miR-4675	CLIP-seq
MIRT2278278	hsa-miR-4741	CLIP-seq
MIRT2278279	hsa-miR-4755-5p	CLIP-seq
MIRT2278280	hsa-miR-4773	CLIP-seq
MIRT2278281	hsa-miR-490-5p	CLIP-seq
MIRT2278282	hsa-miR-541	CLIP-seq
MIRT2278283	hsa-miR-642a	CLIP-seq
MIRT2278284	hsa-miR-654-5p	CLIP-seq
MIRT2278285	hsa-miR-759	CLIP-seq
MIRT2278286	hsa-miR-762	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	NAS	1280325
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	1280325
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	1280325
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	NAS	1280325
GO:0030154	Process	Cell differentiation	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
600379	7622	ENSG00000196132

Q01538

Protein name

Myelin transcription factor 1 (MyT1) (Myelin transcription factor I) (MyTI) (PLPB1) (Proteolipid protein-binding protein)

Protein function

Binds to the promoter region of genes encoding proteolipid proteins of the central nervous system. May play a role in the development of neurons and oligodendroglia in the CNS. May regulate a critical transition point in oligodendrocyte lineage

PDB

7Q45

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01530	zf-C2HC	29 → 57	Zinc finger, C2HC type	Family
PF01530	zf-C2HC	441 → 468	Zinc finger, C2HC type	Family
PF01530	zf-C2HC	485 → 513	Zinc finger, C2HC type	Family
PF08474	MYT1	560 → 617	Myelin transcription factor 1	Family
PF08474	MYT1	615 → 791	Myelin transcription factor 1	Family
PF01530	zf-C2HC	799 → 827	Zinc finger, C2HC type	Family
PF01530	zf-C2HC	843 → 871	Zinc finger, C2HC type	Family
PF01530	zf-C2HC	892 → 920	Zinc finger, C2HC type	Family
PF01530	zf-C2HC	945 → 973	Zinc finger, C2HC type	Family

Tissue specificity

TISSUE SPECIFICITY: Mostly in developing nervous system. Expressed in neural progenitors and oligodendrocyte lineage cells. More highly expressed in oligodendrocyte progenitors than in differentiated oligodendrocytes. {ECO:0000269|PubMed:8530187}.

Sequence

MSLENEDKRARTRSKALRGPPETTAADLSCPTPGCTGSGHVRGKYSRHRSLQSCPLAKKR
KLEGAEAEHLVSKRKSHPLKLALDEGYGVDSDGSEDTEVKDASVSDESEGTLEGAEAETS
GQDEIHRPETAEGRSPVKSHFGSNPIGSATASSKGSYSSYQGIIATSLLNLGQIAEETLV
EEDLGQAAKPGPGIVHLLQEAAEGAASEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSL
EDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEE
EEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTHSRK
STVTDESEMQDMMTRGNLGLLEQAIALKAEQVRTVCEPGCPPAEQSQLGLGEPGKAAKPL
DTVRKSYYSKDPSRAEKREIKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRIPPEILAMH
ENVLKCPTPGCTGQGHVNSNRNTHRSLSGCPIAAAEKLAKSHEKQQPQTGDPSKSSSNSD
RILRPMCFVKQLEVPPYGSYRPNVAPATPRANLAKELEKFSKVTFDYASFDAQVFGKRML
APKIQTSETSPKAFQCFDYSQDAEAAHMAATAILNLSTRCWEMPENLSTKPQDLPSKSVD
IEVDENGTLDLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSS
QASRQDEWDRPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEERKYPGEVT
LTNFKLKFLSKDIKKELLTCPTPGCDGSGHITGNYASHRSLSGCPLADKSLRNLMAAHSA
DLKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGVKVAPTKDDKEDPELMKCPVPGCVG
LGHISGKYASHRSASGCPLAARRQKEGSLNGSSFSWKSLKNEGPTCPTPGCDGSGHANGS
FLTHRSLSGCPRATFAGKKGKLSGDEVLSPKFKTSDVLENDEEIKQLNQEIRDLNESNSE
MEAAMVQLQSQISSMEKNLKNIEEENKLIEEQNEALFLELSGLSQALIQSLANIRLPHME
PICEQNFDAYVSTLTDMYSNQDPENKDLLESIKQAVRGIQV

Sequence length

1121

Interactions

View interactions

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual disability	Likely pathogenic	rs1983540456	RCV001261388

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Autism spectrum disorder	association	rs1983951845	RCV001291443
Hereditary spastic paraplegia	Affects	rs1983951301	RCV001376697
MYT1-related disorder	Uncertain significance; Benign; Likely benign	rs75329253, rs61746505, rs78568430, rs765299378, rs141771297, rs148972645, rs750624678, rs141745754, rs746131196, rs148041017, rs376151221, rs112888597, rs143133195, rs138396756, rs144371248 View all (22 more)	RCV003906684 RCV003919601 RCV003919720 RCV003924005 RCV003924022 RCV003916891 RCV003916951 RCV003973962 RCV003909571 RCV003929546 RCV003939533 RCV003947096 RCV003922126 RCV003922227 RCV003946862 RCV003952236 RCV003954380 RCV003972321 RCV003971682 RCV003969662 RCV003976600 RCV003964290 RCV003913239 RCV003926124 RCV003972826 RCV003935943 RCV003910565 RCV003940557 RCV003910580 RCV003930702 RCV003913003 RCV003923078 RCV003912994 RCV003922970 RCV003910802 RCV003923150 RCV003926188
Ovarian serous cystadenocarcinoma	Benign	rs145461122	RCV005906007

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Auriculoosteodysplasia	Associate	28612832, 33530447
Breast Neoplasms	Associate	28335434
Encephalitis Herpes Simplex	Associate	14726685
Goldenhar Syndrome	Associate	32871052
Mental Disorders	Associate	21048971
Multiple Sclerosis	Associate	32518073
Neoplasms	Associate	14726685, 24015200
Stomach Neoplasms	Associate	24015200

MYT1 (myelin transcription factor 1)