Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4591
Gene name Gene Name - the full gene name approved by the HGNC.
Tripartite motif containing 37
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TRIM37
Synonyms (NCBI Gene) Gene synonyms aliases
MUL, POB1, TEF3
Disease Acronyms (UniProt) Disease acronyms from UniProt database
MUL
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q22
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif
SNPs SNP information provided by dbSNP.
SNP ID Visualize variation Clinical significance Consequence
rs112762655 C>A,T Conflicting-interpretations-of-pathogenicity, uncertain-significance Coding sequence variant, non coding transcript variant, missense variant
rs121908391 C>G Pathogenic 5 prime UTR variant, intron variant, coding sequence variant, non coding transcript variant, missense variant
rs373520509 G>A,T Pathogenic Synonymous variant, stop gained, coding sequence variant, 5 prime UTR variant, non coding transcript variant
rs386833416 C>- Pathogenic Non coding transcript variant, coding sequence variant, frameshift variant
rs386833999 ->ATCT Likely-pathogenic Non coding transcript variant, coding sequence variant, frameshift variant
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022999 hsa-miR-124-3p Microarray 18668037
MIRT047093 hsa-miR-183-5p CLASH 23622248
MIRT044117 hsa-miR-30e-3p CLASH 23622248
MIRT039127 hsa-miR-769-3p CLASH 23622248
MIRT545479 hsa-miR-4428 PAR-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 25470042
GO:0003682 Function Chromatin binding IEA
GO:0003713 Function Transcription coactivator activity IDA 23077300
GO:0004842 Function Ubiquitin-protein transferase activity IDA 15885686
GO:0005164 Function Tumor necrosis factor receptor binding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605073 7523 ENSG00000108395
Protein
UniProt ID O94972
Protein name E3 ubiquitin-protein ligase TRIM37 (EC 2.3.2.27) (Mulibrey nanism protein) (RING-type E3 ubiquitin transferase TRIM37) (Tripartite motif-containing protein 37)
Protein function E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:23769972). Mediates monoubiquitination of 'Lys-119
PDB 3LRQ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00643 zf-B_box 90 132 B-box zinc finger Domain
PF00917 MATH 283 404 MATH domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous (PubMed:10888877). Highly expressed in testis, while it is weakly expressed in other tissues (PubMed:16310976). {ECO:0000269|PubMed:10888877, ECO:0000269|PubMed:16310976}.
Sequence
MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWLTEQRAQCPHCRAPLQL
RELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKLSVFCWTCKKCICHQCALW
GGMHGGHTFKPL
AEIYEQHVTKVNEEVAKLRRRLMELISLVQEVERNVEAVRNAKDERVR
EIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELLESLLQEVEHQLRSCSKSELISK
SSEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSYDSATFVLENFSTLRQRADPVYSPP
LQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAGLPETSKYEYRVEMVHQSCNDPTKNII
REFASDFEVGECWGYNRFFRLDLLANEGYLNPQNDTVILRFQVR
SPTFFQKSRDQHWYIT
QLEAAQTSYIQQINNLKERLTIELSRTQKSRDLSPPDNHLSPQNDDALETRAKKSACSDM
LLEGGPTTASVREAKEDEEDEEKIQNEDYHHELSDGDLDLDLVYEDEVNQLDGSSSSASS
TATSNTEENDIDEETMSGENDVEYNNMELEEGELMEDAAAAGPAGSSHGYVGSSSRISRR
THLCSAATSSLLDIDPLILIHLLDLKDRSSIENLWGLQPRPPASLLQPTASYSRKDKDQR
KQQAMWRVPSDLKMLKRLKTQMAEVRCMKTDVKNTLSEIKSSSAASGDMQTSLFSADQAA
LAACGTENSGRLQDLGMELLAKSSVANCYIRNSTNKKSNSPKPARSSVAGSLSLRRAVDP
GENSRSKGDCQTLSEGSPGSSQSGSRHSSPRALIHGSIGDILPKTEDRQCKALDSDAVVV
AVFSGLPAVEKRRKMVTLGANAKGGHLEGLQMTDLENNSETGELQPVLPEGASAAPEEGM
SSDSDIECDTENEEQEEHTSVGGFHDSFMVMTQPPDEDTHSSFPDGEQIGPEDLSFNTDE
NSGR
Sequence length 964
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Ubiquitin mediated proteolysis   Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Joubert syndrome Joubert syndrome 1 rs201108965, rs13297509, rs121918128, rs121918129, rs121918130, rs2109050324, rs118204052, rs118204053, rs121918197, rs121918198, rs121918199, rs121918200, rs121918204, rs387906243, rs145665129
View all (432 more)
Macrocephaly Macrocephaly rs786204854, rs764333096, rs1557739557
Nephroblastoma Nephroblastoma rs1553551874, rs1555913934, rs769116796
Retinitis pigmentosa Retinitis Pigmentosa rs267606794, rs200691042, rs397704718, rs202193201, rs267606793, rs2147483647, rs779886453, rs267606691, rs794728002, rs878853253, rs137853189, rs137853190, rs137853112, rs137853113, rs137853114
View all (1830 more)
Unknown
Disease term Disease name Evidence References Source
Congestive heart failure Congestive heart failure ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 11331760, 11774034, 31409898, 32908313, 35864973, 35959349
Carcinogenesis Associate 32329860
Carcinoma Hepatocellular Associate 35142083
Colorectal Neoplasms Associate 28081740, 34373442
Colorectal Neoplasms Stimulate 28098873
Congenital Abnormalities Associate 39225643
Dystonic Disorders Associate 19329943
Growth Disorders Associate 29940807, 39225643
Heart Diseases Associate 32908313
Heart Failure Associate 39225643