MTNR1A (melatonin receptor 1A)

Gene

• Entrez ID: 4543
• Gene name: Melatonin receptor 1A
• Gene symbol: MTNR1A
• Synonyms (NCBI Gene): MEL-1A-R, MT1
• Chromosome: 4
• Chromosome location: 4q35.2
• Summary: This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	17215244, 20859254, 26514267, 28298427, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	10531408
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	8700109
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IEA
GO:0007187	Process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9645677
GO:0007193	Process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	10531408
GO:0007617	Process	Mating behavior	TAS	7946354
GO:0007623	Process	Circadian rhythm	TAS	9645677
GO:0008502	Function	Melatonin receptor activity	IDA	10531408
GO:0008502	Function	Melatonin receptor activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0042562	Function	Hormone binding	IPI	10531408
GO:0043235	Component	Receptor complex	IDA	10531408

Other IDs

• MIM: 600665
• HGNC: 7463
• e!Ensembl: ENSG00000168412

Protein

• UniProt ID: P48039
• Protein name: Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
• Protein function: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly invo
• PDB: 6ME2, 6ME3, 6ME4, 6ME5, 7DB6, 7VGY, 7VGZ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	44 → 295	7 transmembrane receptor (rhodopsin family)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
• Sequence:

  MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRN
  AGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITG
  IAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFA
  QSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTM
  FVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQ
  NFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV

• Sequence length: 350

Pathways

KEGG:

Neuroactive ligand-receptor interaction
Circadian entrainment

Reactome:

Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events