MTNR1A (melatonin receptor 1A)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4543
Gene name Gene Name - the full gene name approved by the HGNC.
Melatonin receptor 1A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MTNR1A
Synonyms (NCBI Gene) Gene synonyms aliases
MEL-1A-R, MT1
Chromosome Chromosome number
4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
4q35.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0004930 Function G protein-coupled receptor activity IBA 21873635
GO:0005515 Function Protein binding IPI 17215244, 20859254, 25770211, 26514267, 28298427, 32296183
GO:0005886 Component Plasma membrane IBA 21873635
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IDA 10531408
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600665 7463 ENSG00000168412
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P48039
Protein name Melatonin receptor type 1A (Mel-1A-R) (Mel1a receptor)
Protein function High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity. Possibly invo
PDB 6ME2 , 6ME3 , 6ME4 , 6ME5 , 7DB6 , 7VGY , 7VGZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00001 7tm_1 44 → 295 7 transmembrane receptor (rhodopsin family) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
Sequence
Sequence length 350
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neuroactive ligand-receptor interaction
Circadian entrainment 		  Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Autism spectrum disorder Autism Spectrum Disorders rs724159978, rs75184679, rs119103221, rs9332964, rs121912562, rs1594344233, rs727504317, rs111033204, rs1801086, rs587784464, rs724159948, rs764659822, rs794727977, rs796052733, rs796052728
View all (51 more)		 20657642
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 21526376
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Show/Hide Text Mining Associations (30)
Associations from Text Mining
Disease Name Relationship Type References
Alzheimer Disease Associate 29982836
Arthritis Associate 31815152
Breast Neoplasms Inhibit 31358835
Breast Neoplasms Associate 31358835
Carcinogenesis Associate 18452558
Carcinoma Basal Cell Associate 29104467
Death Stimulate 39201396
Depressive Disorder Associate 38217063
Diabetes Gestational Associate 28084098
Diabetes Mellitus Type 2 Associate 37259752, 38217063