MT3 (metallothionein 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4504
Gene name Gene Name - the full gene name approved by the HGNC.
Metallothionein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MT3
Synonyms (NCBI Gene) Gene synonyms aliases
GIF, GIFB, GRIF, ZnMT3
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the metallothionein family of genes. Proteins encoded by this gene family are low in molecular weight, are cysteine-rich, lack aromatic residues, and bind divalent heavy metal ions. This gene family member displays tissue-specific
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
miRTarBase ID miRNA Experiments Reference
MIRT2046464 hsa-miR-3974 CLIP-seq
MIRT2046465 hsa-miR-4691-5p CLIP-seq
MIRT2046466 hsa-miR-616 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(78)
GO ID Ontology Definition Evidence Reference
GO:0001666 Process Response to hypoxia IDA 12763630
GO:0001934 Process Positive regulation of protein phosphorylation IDA 18295594
GO:0005507 Function Copper ion binding IDA 21320589
GO:0005507 Function Copper ion binding IEA
GO:0005507 Function Copper ion binding TAS 8751715
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
139255 7408 ENSG00000087250
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P25713
Protein name Metallothionein-3 (MT-3) (GIFB) (GIF) (Growth inhibitory factor) (Metallothionein-III) (MT-III)
Protein function Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro.
PDB 2F5H , 2FJ4 , 2FJ5
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00131 Metallothio 1 → 68 Metallothionein Domain
Tissue specificity TISSUE SPECIFICITY: Abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the Alzheimer disease (AD) brain.
Sequence
Sequence length 68
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Metallothioneins bind metals
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Eosinophilia Eosinophilic esophagitis N/A N/A GWAS
Show/Hide Text Mining Associations (50)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 21818286
Allergic Fungal Sinusitis Inhibit 33526321
Alzheimer Disease Inhibit 1464312, 17389590, 39993744
Amyotrophic lateral sclerosis 1 Associate 12417341
Astrocytoma Stimulate 30932010
Breast Neoplasms Stimulate 11438449
Breast Neoplasms Associate 25015776, 28545470, 37643511
Carcinogenesis Stimulate 30813460
Carcinoma Basal Cell Associate 23042264, 25290577
Carcinoma Basal Cell Inhibit 25015776