LMOD2 (leiomodin 2)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
442721
Gene name Gene Name - the full gene name approved by the HGNC.
Leiomodin 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LMOD2
Synonyms (NCBI Gene) Gene synonyms aliases
C-LMOD, CLMOD, CMD2G
Disease Acronyms (UniProt) Disease acronyms from UniProt database
CMD2G
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7q31.32
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
miRTarBase ID miRNA Experiments Reference
MIRT536278 hsa-miR-5692a PAR-CLIP 22012620
MIRT536277 hsa-miR-944 PAR-CLIP 22012620
MIRT536276 hsa-miR-3163 PAR-CLIP 22012620
MIRT536275 hsa-miR-137 PAR-CLIP 22012620
MIRT536278 hsa-miR-5692a PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IDA 18403713, 20685966, 26370058
GO:0003785 Function Actin monomer binding IMP 25250574
GO:0005523 Function Tropomyosin binding IBA 21873635
GO:0005523 Function Tropomyosin binding IMP 25250574
GO:0005856 Component Cytoskeleton IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608006 6648 ENSG00000170807
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q6P5Q4
Protein name Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin)
Protein function Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal s
PDB 4RWT , 5WFN , 6UT2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03250 Tropomodulin 6 → 148 Tropomodulin Family
Tissue specificity TISSUE SPECIFICITY: Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues. {ECO:0000269|PubMed:11318603, ECO:0000269|PubMed:25250574}.
Sequence 
MSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTP
TGTFSREALMAYWEKESQKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEE
EEEESQEEEEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSN
GRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNT
VVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTE
LRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRL
QEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVAT
PPPPPPPPPPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKK
KGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRV
EVPEALR
Sequence length 547
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Cytoskeleton in muscle cells  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)		 19254430
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Cardiomyopathy cardiomyopathy, dilated, 2G GenCC
Show/Hide Text Mining Associations (5)
Associations from Text Mining
Disease Name Relationship Type References
Cardiomyopathies Associate 37296576
Cardiomyopathy Dilated Associate 35082396, 37296576, 39437564
familial dilated cardiomyopathy Associate 26873245
Heart Diseases Associate 35082396
Heart Failure Associate 37296576