LMOD2 (leiomodin 2)

Gene

• Entrez ID: 442721
• Gene name: Leiomodin 2
• Gene symbol: LMOD2
• Synonyms (NCBI Gene): C-LMOD, CLMOD, CMD2G
• Chromosome: 7
• Chromosome location: 7q31.32

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT536278	hsa-miR-5692a	PAR-CLIP	22012620
MIRT536277	hsa-miR-944	PAR-CLIP	22012620
MIRT536276	hsa-miR-3163	PAR-CLIP	22012620
MIRT536275	hsa-miR-137	PAR-CLIP	22012620
MIRT536278	hsa-miR-5692a	PAR-CLIP	22012620
MIRT536277	hsa-miR-944	PAR-CLIP	22012620
MIRT536276	hsa-miR-3163	PAR-CLIP	22012620
MIRT536275	hsa-miR-137	PAR-CLIP	22012620
MIRT1112025	hsa-miR-3673	CLIP-seq
MIRT1112026	hsa-miR-4753-3p	CLIP-seq
MIRT1112027	hsa-miR-9	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IDA	18403713, 20685966, 26370058
GO:0003779	Function	Actin binding	IEA
GO:0003785	Function	Actin monomer binding	IMP	25250574
GO:0005523	Function	Tropomyosin binding	IBA
GO:0005523	Function	Tropomyosin binding	IEA
GO:0005523	Function	Tropomyosin binding	IMP	25250574
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005865	Component	Striated muscle thin filament	IBA
GO:0005884	Component	Actin filament	IDA	26370058
GO:0006936	Process	Muscle contraction	IBA
GO:0007015	Process	Actin filament organization	IBA
GO:0030016	Component	Myofibril	IBA
GO:0030016	Component	Myofibril	IDA	20685966
GO:0030016	Component	Myofibril	IEA
GO:0030017	Component	Sarcomere	IDA	18403713, 20685966, 26370058
GO:0030017	Component	Sarcomere	IEA
GO:0030041	Process	Actin filament polymerization	IEA
GO:0030239	Process	Myofibril assembly	IBA
GO:0030838	Process	Positive regulation of actin filament polymerization	IDA	26370058
GO:0031430	Component	M band	IDA	18403713, 20685966
GO:0031430	Component	M band	IEA
GO:0045010	Process	Actin nucleation	IDA	20685966, 26370058
GO:0045010	Process	Actin nucleation	IMP	25250574
GO:0045214	Process	Sarcomere organization	IEA
GO:0045214	Process	Sarcomere organization	IMP	18403713
GO:0051694	Process	Pointed-end actin filament capping	IEA

Other IDs

• MIM: 608006
• HGNC: 6648
• e!Ensembl: ENSG00000170807

Protein

• UniProt ID: Q6P5Q4
• Protein name: Leiomodin-2 (Cardiac leiomodin) (C-LMOD) (Leiomodin)
• Protein function: Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal s
• PDB: 4RWT, 5WFN, 6UT2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03250	Tropomodulin	6 → 148	Tropomodulin	Family

• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in heart and skeletal muscles, with higher levels in heart (at protein level). Not expressed in other tissues. {ECO:0000269|PubMed:11318603, ECO:0000269|PubMed:25250574}.
• Sequence:

  MSTFGYRRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTP
  TGTFSREALMAYWEKESQKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEEVYTEE
  EEEESQEEEEEEDSDEEERTIETAKGINGTVNYDSVNSDNSKPKIFKSQIENINLTNGSN
  GRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRFAEALKDNT
  VVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRALQHNTVLTE
  LRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRL
  QEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRSRPLSPVAT
  PPPPPPPPPPPPPSSQRLPPPPPPPPPPLPEKKLITRNIAEVIKQQESAQRALQNGQKKK
  KGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRGSSIKQLKRV
  EVPEALR

• Sequence length: 547

Pathways

KEGG:

Cytoskeleton in muscle cells

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Associated diseases

Unknown
Disease merge term	Disease name	Evidence	References	Source
Cardiomyopathy	cardiomyopathy, dilated, 2G	N/A	N/A	GenCC

Associations from Text Mining
Disease Name	Relationship Type	References
Cardiomyopathies	Associate	37296576
Cardiomyopathy Dilated	Associate	35082396, 37296576, 39437564
familial dilated cardiomyopathy	Associate	26873245
Heart Diseases	Associate	35082396
Heart Failure	Associate	37296576