PIWIL3 (piwi like RNA-mediated gene silencing 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
440822
Gene name Gene Name - the full gene name approved by the HGNC.
Piwi like RNA-mediated gene silencing 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PIWIL3
Synonyms (NCBI Gene) Gene synonyms aliases
HIWI3
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q11.23
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to fun
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(12)
miRTarBase ID miRNA Experiments Reference
MIRT1237069 hsa-miR-3148 CLIP-seq
MIRT1237070 hsa-miR-3170 CLIP-seq
MIRT1237071 hsa-miR-342-5p CLIP-seq
MIRT1237072 hsa-miR-4651 CLIP-seq
MIRT1237073 hsa-miR-4664-5p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding IEA
GO:0005634 Component Nucleus IDA 28025795
GO:0005737 Component Cytoplasm IDA 28025795
GO:0006417 Process Regulation of translation IEA
GO:0007275 Process Multicellular organism development IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
610314 18443 ENSG00000184571
Protein
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Q7Z3Z3
Protein name Piwi-like protein 3
Protein function May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elem
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02170 PAZ 292 → 428 PAZ domain Domain
PF02171 Piwi 578 → 868 Piwi domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:12906857}.
Sequence 
MPGRARTRARGRARRRESYQQEAPGGPRAPGSATTQEPPQLQSTPRPLQEEVPVVRPLQP
RAARGGAGGGAQSQGVKEPGPEAGLHTAPLQERRIGGVFQDLVVNTRQDMKHVKDSKTGS
EGTVVQLLANHFRVISRPQWVAYKYNVDYKPDIEDGNLRTILLDQHRRKFGERHIFDGNS
LLLSRPLKERRVEWLSTTKDKNIVKITVEFSKELTPTSPDCLRYYNILFRRTFKLLDFEQ
VGRNYYTKKKAIQLYRHGTSLEIWLGYVTSVLQYENSITLCADVSHKLLRIETAYDFIKR
TSAQAQTGNIREEVTNKLIGSIVLTKYNNKTYRVDDIDWKQNPEDTFNKSDGSKITYIDY
YRQQHKEIVTVKKQPLLVSQGRWKKGLTGTQREPILLIPQLCHMTGLTDEICKDYSIVKE
LAKHTRLSPRRRHHTLKEFINTLQDNKKVRELLQLWDLKFDTNFLSVPGRVLKNANIVQG
RRMVKANSQGDWSREIRELPLLNAMPLHSWLILYSRSSHREAMSLKGHLQSVTAPMGITM
KPAEMIEVDGDANSYIDTLRKYTRPTLQMGMSCLLVFKVICILPNDDKRRYDSIKRYLCT
KCPIPSQCVVKKTLEKVQARTIVTKIAQQMNCKMGGALWKVETDVQRTMFVGIDCFHDIV
NRQKSIAGFVASTNAELTKWYSQCVIQKTGEELVKELEICLKAALDVWCKNESSMPHSVI
VYRDGVGDGQLQALLDHEAKKMSTYLKTISPNNFTLAFIVVKKRINTRFFLKHGSNFQNP
PPGTVIDVELTRNEWYDFFIVSQSVQDGTVTPTHYNVIYDTIGLSPDTVQRLTYCLCHMY
YNLPGIIRVPAPCHYAHKLAYLVGQSIHQEPNRSLSTRLFYL
Sequence length 882
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Oligospermia Oligospermia rs1602125411, rs377712900 20940137
Show/Hide Text Mining Associations (11)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 27177224
Carcinoma Ovarian Epithelial Associate 24440970
Carcinoma Renal Cell Associate 24509249
HIV Infections Associate 35170353
Infertility Male Associate 29286006, 29317647
Neoplasms Stimulate 22670175
Neoplasms Associate 24509249, 40729068
Primary Ovarian Insufficiency Associate 34718612
Sarcoma Associate 22748119
Stomach Neoplasms Associate 22670175