MOS (MOS proto-oncogene, serine/threonine kinase)

Gene
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4342
Gene name Gene Name - the full gene name approved by the HGNC.
MOS proto-oncogene, serine/threonine kinase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MOS
Synonyms (NCBI Gene) Gene synonyms aliases
MSV, OZEMA20
Disease Acronyms (UniProt) Disease acronyms from UniProt database
OZEMA20
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8q12.1
Summary Summary of gene provided in NCBI Entrez Gene.
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(21)
GO ID Ontology Definition Evidence Reference
GO:0000165 Process MAPK cascade IEA
GO:0000186 Process Activation of MAPKK activity ISS
GO:0000187 Process Activation of MAPK activity ISS
GO:0000212 Process Meiotic spindle organization ISS
GO:0004672 Function Protein kinase activity IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
190060 7199 ENSG00000172680
Protein
Gene Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P00540
Protein name Proto-oncogene serine/threonine-protein kinase mos (EC 2.7.11.1) (Oocyte maturation factor mos) (Proto-oncogene c-Mos)
Protein function Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation. {ECO:0000269|PubMed:34779126, ECO:0000269|PubMed:34997960, E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 61 → 337 Protein kinase domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in oocytes. Lower expression is detected in early embryo. {ECO:0000269|PubMed:34779126}.
Sequence
Sequence length 346
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Oocyte meiosis
Regulation of actin cytoskeleton
Progesterone-mediated oocyte maturation 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Lung adenocarcinoma Adenocarcinoma of lung (disorder) rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370
View all (5 more)
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Oocyte Maturation Defect oocyte/zygote/embryo maturation arrest 20 GenCC
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Show/Hide Text Mining Associations (29)
Associations from Text Mining
Disease Name Relationship Type References
Atelosteogenesis type 2 Associate 36672822
Bone Marrow Diseases Associate 23892411
Bone Neoplasms Associate 23199169
Breast Neoplasms Associate 2564734, 2996003
Carcinoma Non Small Cell Lung Associate 11778648
Carcinoma Renal Cell Associate 6961456
Chromosome Aberrations Associate 36672822
Colorectal Neoplasms Associate 15750208
Diabetes Mellitus Type 2 Associate 37781924
Diarrhea Associate 23892411