Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4327
Gene name	Matrix metallopeptidase 19
Gene symbol	MMP19
Synonyms (NCBI Gene)	CODAMMP18RASI-1
Chromosome	12
Chromosome location	12q13.2
Summary	This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as a

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Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023166	hsa-miR-124-3p	Microarray	18668037
MIRT735022	hsa-miR-4270	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	33024586
MIRT1153348	hsa-miR-1256	CLIP-seq
MIRT1153349	hsa-miR-1278	CLIP-seq
MIRT1153350	hsa-miR-200b	CLIP-seq
MIRT1153351	hsa-miR-200c	CLIP-seq
MIRT1153352	hsa-miR-3663-5p	CLIP-seq
MIRT1153353	hsa-miR-429	CLIP-seq
MIRT1153354	hsa-miR-4441	CLIP-seq
MIRT1153355	hsa-miR-4724-5p	CLIP-seq
MIRT2043915	hsa-miR-4653-3p	CLIP-seq
MIRT2043916	hsa-miR-4678	CLIP-seq
MIRT2273263	hsa-miR-106a	CLIP-seq
MIRT2273264	hsa-miR-106b	CLIP-seq
MIRT2273265	hsa-miR-1245	CLIP-seq
MIRT2273266	hsa-miR-1343	CLIP-seq
MIRT2273267	hsa-miR-150	CLIP-seq
MIRT2273268	hsa-miR-17	CLIP-seq
MIRT2273269	hsa-miR-1976	CLIP-seq
MIRT2273270	hsa-miR-20a	CLIP-seq
MIRT2273271	hsa-miR-20b	CLIP-seq
MIRT2273272	hsa-miR-302a	CLIP-seq
MIRT2273273	hsa-miR-302b	CLIP-seq
MIRT2273274	hsa-miR-302c	CLIP-seq
MIRT2273275	hsa-miR-302d	CLIP-seq
MIRT2273276	hsa-miR-302e	CLIP-seq
MIRT2273277	hsa-miR-3130-3p	CLIP-seq
MIRT2273278	hsa-miR-3157-5p	CLIP-seq
MIRT2273279	hsa-miR-3159	CLIP-seq
MIRT2273280	hsa-miR-3545-3p	CLIP-seq
MIRT2273281	hsa-miR-3651	CLIP-seq
MIRT2273282	hsa-miR-370	CLIP-seq
MIRT2273283	hsa-miR-372	CLIP-seq
MIRT2273284	hsa-miR-373	CLIP-seq
MIRT2273285	hsa-miR-378g	CLIP-seq
MIRT2273286	hsa-miR-3977	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2273288	hsa-miR-4437	CLIP-seq
MIRT2273289	hsa-miR-4674	CLIP-seq
MIRT2273290	hsa-miR-4680-5p	CLIP-seq
MIRT2273291	hsa-miR-4768-5p	CLIP-seq
MIRT2273292	hsa-miR-4793-3p	CLIP-seq
MIRT2273293	hsa-miR-519d	CLIP-seq
MIRT2273294	hsa-miR-520a-3p	CLIP-seq
MIRT2273295	hsa-miR-520b	CLIP-seq
MIRT2273296	hsa-miR-520c-3p	CLIP-seq
MIRT2273297	hsa-miR-520d-3p	CLIP-seq
MIRT2273298	hsa-miR-520e	CLIP-seq
MIRT2273299	hsa-miR-520g	CLIP-seq
MIRT2273300	hsa-miR-520h	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2273302	hsa-miR-93	CLIP-seq
MIRT2390980	hsa-miR-942	CLIP-seq
MIRT2454280	hsa-miR-1236	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2454282	hsa-miR-28-5p	CLIP-seq
MIRT2454283	hsa-miR-3139	CLIP-seq
MIRT2454284	hsa-miR-3150b-3p	CLIP-seq
MIRT2454285	hsa-miR-3154	CLIP-seq
MIRT2454286	hsa-miR-3185	CLIP-seq
MIRT2454287	hsa-miR-345	CLIP-seq
MIRT2454288	hsa-miR-3679-3p	CLIP-seq
MIRT2454289	hsa-miR-3921	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2454292	hsa-miR-4649-3p	CLIP-seq
MIRT2454293	hsa-miR-4653-5p	CLIP-seq
MIRT2454294	hsa-miR-4689	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2454297	hsa-miR-4747-5p	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2454299	hsa-miR-4784	CLIP-seq
MIRT2454300	hsa-miR-618	CLIP-seq
MIRT2454301	hsa-miR-660	CLIP-seq
MIRT2454302	hsa-miR-708	CLIP-seq
MIRT2454303	hsa-miR-760	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2572064	hsa-miR-1266	CLIP-seq
MIRT2572065	hsa-miR-1275	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2572066	hsa-miR-1324	CLIP-seq
MIRT2454285	hsa-miR-3154	CLIP-seq
MIRT2454286	hsa-miR-3185	CLIP-seq
MIRT2572067	hsa-miR-3200-5p	CLIP-seq
MIRT2572068	hsa-miR-3202	CLIP-seq
MIRT2572069	hsa-miR-3617	CLIP-seq
MIRT2572070	hsa-miR-3647-3p	CLIP-seq
MIRT2572071	hsa-miR-3664-3p	CLIP-seq
MIRT2572072	hsa-miR-3922-5p	CLIP-seq
MIRT2572073	hsa-miR-3926	CLIP-seq
MIRT2572074	hsa-miR-4259	CLIP-seq
MIRT2572075	hsa-miR-4278	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2572076	hsa-miR-4424	CLIP-seq
MIRT2572077	hsa-miR-4433	CLIP-seq
MIRT2572078	hsa-miR-4446-3p	CLIP-seq
MIRT2572079	hsa-miR-4459	CLIP-seq
MIRT2572080	hsa-miR-4488	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2572081	hsa-miR-4518	CLIP-seq
MIRT2572082	hsa-miR-4533	CLIP-seq
MIRT2043915	hsa-miR-4653-3p	CLIP-seq
MIRT2572083	hsa-miR-4665-5p	CLIP-seq
MIRT2572084	hsa-miR-4675	CLIP-seq
MIRT2572085	hsa-miR-4682	CLIP-seq
MIRT2572086	hsa-miR-4694-3p	CLIP-seq
MIRT2572087	hsa-miR-4697-5p	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2572088	hsa-miR-4741	CLIP-seq
MIRT2454297	hsa-miR-4747-5p	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2572089	hsa-miR-4762-5p	CLIP-seq
MIRT2572090	hsa-miR-4768-3p	CLIP-seq
MIRT2572091	hsa-miR-513c	CLIP-seq
MIRT2572092	hsa-miR-514b-5p	CLIP-seq
MIRT2572093	hsa-miR-571	CLIP-seq
MIRT2572094	hsa-miR-626	CLIP-seq
MIRT2572095	hsa-miR-641	CLIP-seq
MIRT2572096	hsa-miR-642b	CLIP-seq
MIRT2454303	hsa-miR-760	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2572097	hsa-miR-939	CLIP-seq
MIRT2572064	hsa-miR-1266	CLIP-seq
MIRT2572065	hsa-miR-1275	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2572066	hsa-miR-1324	CLIP-seq
MIRT2685135	hsa-miR-205	CLIP-seq
MIRT2454284	hsa-miR-3150b-3p	CLIP-seq
MIRT2454285	hsa-miR-3154	CLIP-seq
MIRT2454286	hsa-miR-3185	CLIP-seq
MIRT2572067	hsa-miR-3200-5p	CLIP-seq
MIRT2572068	hsa-miR-3202	CLIP-seq
MIRT2572069	hsa-miR-3617	CLIP-seq
MIRT2572071	hsa-miR-3664-3p	CLIP-seq
MIRT2454289	hsa-miR-3921	CLIP-seq
MIRT2572073	hsa-miR-3926	CLIP-seq
MIRT2572074	hsa-miR-4259	CLIP-seq
MIRT2572075	hsa-miR-4278	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2572076	hsa-miR-4424	CLIP-seq
MIRT2572077	hsa-miR-4433	CLIP-seq
MIRT2572078	hsa-miR-4446-3p	CLIP-seq
MIRT2572079	hsa-miR-4459	CLIP-seq
MIRT2572080	hsa-miR-4488	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2572081	hsa-miR-4518	CLIP-seq
MIRT2572082	hsa-miR-4533	CLIP-seq
MIRT2685136	hsa-miR-4645-5p	CLIP-seq
MIRT2454292	hsa-miR-4649-3p	CLIP-seq
MIRT2043915	hsa-miR-4653-3p	CLIP-seq
MIRT2454293	hsa-miR-4653-5p	CLIP-seq
MIRT2572083	hsa-miR-4665-5p	CLIP-seq
MIRT2685137	hsa-miR-4673	CLIP-seq
MIRT2572084	hsa-miR-4675	CLIP-seq
MIRT2572085	hsa-miR-4682	CLIP-seq
MIRT2454294	hsa-miR-4689	CLIP-seq
MIRT2572086	hsa-miR-4694-3p	CLIP-seq
MIRT2572087	hsa-miR-4697-5p	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2572088	hsa-miR-4741	CLIP-seq
MIRT2454297	hsa-miR-4747-5p	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2572089	hsa-miR-4762-5p	CLIP-seq
MIRT2572090	hsa-miR-4768-3p	CLIP-seq
MIRT2454299	hsa-miR-4784	CLIP-seq
MIRT2572093	hsa-miR-571	CLIP-seq
MIRT2572094	hsa-miR-626	CLIP-seq
MIRT2572095	hsa-miR-641	CLIP-seq
MIRT2572096	hsa-miR-642b	CLIP-seq
MIRT2454303	hsa-miR-760	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2572097	hsa-miR-939	CLIP-seq

Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001541	Process	Ovarian follicle development	IEA
GO:0001542	Process	Ovulation from ovarian follicle	IEA
GO:0001554	Process	Luteolysis	IEA
GO:0004222	Function	Metalloendopeptidase activity	EXP	10809722
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS
GO:0004252	Function	Serine-type endopeptidase activity	TAS
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	NAS	9020145
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009725	Process	Response to hormone	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030154	Process	Cell differentiation	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030574	Process	Collagen catabolic process	IBA
GO:0030574	Process	Collagen catabolic process	IEA
GO:0031012	Component	Extracellular matrix	IEA
GO:0031012	Component	Extracellular matrix	NAS	10809722
GO:0046872	Function	Metal ion binding	IEA
GO:0051591	Process	Response to cAMP	IEA

MIM	HGNC	e!Ensembl
601807	7165	ENSG00000123342

Q99542

Protein name

Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18)

Protein function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01471	PG_binding_1	29 → 80	Putative peptidoglycan binding domain	Domain
PF00413	Peptidase_M10	103 → 256	Matrixin	Domain
PF00045	Hemopexin	337 → 377	Hemopexin	Repeat
PF00045	Hemopexin	380 → 427	Hemopexin	Repeat
PF00045	Hemopexin	429 → 472	Hemopexin	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial f

Sequence

MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT
PSGGNTTPSGTGITLDTTLSATETTFEY

Sequence length

508

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Clear cell carcinoma of kidney	Uncertain significance	rs145293054	RCV005939738
Familial cavitary optic disk anomaly	Uncertain significance; Benign; Conflicting classifications of pathogenicity; Likely benign	rs145293054, rs7294345, rs767415935, rs17844787	RCV005362140 RCV001775526 RCV005399238 RCV002502979
Gastric cancer	Uncertain significance	rs145293054	RCV005939739
Interstitial lung disease 2	Uncertain significance	rs1555176616	RCV000677220
Lung cancer	Uncertain significance	rs145293054	RCV005939742
Malignant tumor of esophagus	Uncertain significance	rs145293054	RCV005939737
MMP19-related disorder	Likely benign; Benign	rs139773431, rs1056784	RCV003912006 RCV003925975
Ovarian serous cystadenocarcinoma	Uncertain significance	rs145293054	RCV005939740
Thyroid cancer, nonmedullary, 1	Uncertain significance	rs145293054	RCV005939741

Show/Hide Text Mining Associations (42)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Stimulate	27227769
Aneurysm	Associate	21955474
Arthritis Psoriatic	Stimulate	12735638
Breast Neoplasms	Associate	19531263
Breast Neoplasms	Inhibit	23568046
Carcinogenesis	Stimulate	22576687
Carcinoma Non Small Cell Lung	Associate	25250855, 31298377
Carcinoma Squamous Cell	Associate	34177903
Cavitary Optic Disc Anomalies	Associate	25581579, 28003733
Chondrosarcoma	Associate	18641983
Chordoma	Associate	18641983
Colonic Diseases	Associate	22576687
Colorectal Neoplasms	Associate	22576687, 31088409, 35352707
Disease	Associate	14708597
Drug Resistant Epilepsy	Associate	27903967
Eczema	Associate	14708597
Familial Primary Pulmonary Hypertension	Associate	25840998
Gastrointestinal Diseases	Associate	25056434
Infections	Associate	14708597
Inflammatory Bowel Diseases	Associate	35352707
Keratoacanthoma	Associate	16699496
Lichen Planus	Associate	12735638
Lung Neoplasms	Stimulate	25250855
Lymphatic Metastasis	Stimulate	31088409
Melanoma	Stimulate	20098411
Melanoma Cutaneous Malignant	Associate	20098411
Myositis	Associate	14708597
Nasopharyngeal Carcinoma	Associate	23956056
Neoplasm Metastasis	Stimulate	20098411
Neoplasm Metastasis	Associate	36871552
Neoplasms	Associate	15868410, 31406154, 35352707
Neoplasms	Stimulate	22576687
Neoplasms	Inhibit	23568046
Neoplasms Squamous Cell	Associate	15868410
Odontogenic Tumors	Associate	25158190
Optic Nerve Diseases	Associate	28003733
Ovarian Neoplasms	Associate	31406154
Pityriasis Lichenoides	Associate	12735638
Pressure Ulcer	Associate	14708598
Psoriasis	Associate	12735638, 14708597
Tinea	Associate	14708597
Wounds and Injuries	Associate	14708598

MMP19 (matrix metallopeptidase 19)