Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4327
Gene name Gene Name - the full gene name approved by the HGNC.	Matrix metallopeptidase 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MMP19
Synonyms (NCBI Gene) Gene synonyms aliases	CODA, MMP18, RASI-1
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CODA
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as a

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023166	hsa-miR-124-3p	Microarray	18668037
MIRT735022	hsa-miR-4270	Luciferase reporter assay, Western blotting, qRT-PCR, Flow cytometry	33024586
MIRT1153348	hsa-miR-1256	CLIP-seq
MIRT1153349	hsa-miR-1278	CLIP-seq
MIRT1153350	hsa-miR-200b	CLIP-seq
MIRT1153351	hsa-miR-200c	CLIP-seq
MIRT1153352	hsa-miR-3663-5p	CLIP-seq
MIRT1153353	hsa-miR-429	CLIP-seq
MIRT1153354	hsa-miR-4441	CLIP-seq
MIRT1153355	hsa-miR-4724-5p	CLIP-seq
MIRT2043915	hsa-miR-4653-3p	CLIP-seq
MIRT2043916	hsa-miR-4678	CLIP-seq
MIRT2273263	hsa-miR-106a	CLIP-seq
MIRT2273264	hsa-miR-106b	CLIP-seq
MIRT2273265	hsa-miR-1245	CLIP-seq
MIRT2273266	hsa-miR-1343	CLIP-seq
MIRT2273267	hsa-miR-150	CLIP-seq
MIRT2273268	hsa-miR-17	CLIP-seq
MIRT2273269	hsa-miR-1976	CLIP-seq
MIRT2273270	hsa-miR-20a	CLIP-seq
MIRT2273271	hsa-miR-20b	CLIP-seq
MIRT2273272	hsa-miR-302a	CLIP-seq
MIRT2273273	hsa-miR-302b	CLIP-seq
MIRT2273274	hsa-miR-302c	CLIP-seq
MIRT2273275	hsa-miR-302d	CLIP-seq
MIRT2273276	hsa-miR-302e	CLIP-seq
MIRT2273277	hsa-miR-3130-3p	CLIP-seq
MIRT2273278	hsa-miR-3157-5p	CLIP-seq
MIRT2273279	hsa-miR-3159	CLIP-seq
MIRT2273280	hsa-miR-3545-3p	CLIP-seq
MIRT2273281	hsa-miR-3651	CLIP-seq
MIRT2273282	hsa-miR-370	CLIP-seq
MIRT2273283	hsa-miR-372	CLIP-seq
MIRT2273284	hsa-miR-373	CLIP-seq
MIRT2273285	hsa-miR-378g	CLIP-seq
MIRT2273286	hsa-miR-3977	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2273288	hsa-miR-4437	CLIP-seq
MIRT2273289	hsa-miR-4674	CLIP-seq
MIRT2273290	hsa-miR-4680-5p	CLIP-seq
MIRT2273291	hsa-miR-4768-5p	CLIP-seq
MIRT2273292	hsa-miR-4793-3p	CLIP-seq
MIRT2273293	hsa-miR-519d	CLIP-seq
MIRT2273294	hsa-miR-520a-3p	CLIP-seq
MIRT2273295	hsa-miR-520b	CLIP-seq
MIRT2273296	hsa-miR-520c-3p	CLIP-seq
MIRT2273297	hsa-miR-520d-3p	CLIP-seq
MIRT2273298	hsa-miR-520e	CLIP-seq
MIRT2273299	hsa-miR-520g	CLIP-seq
MIRT2273300	hsa-miR-520h	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2273302	hsa-miR-93	CLIP-seq
MIRT2390980	hsa-miR-942	CLIP-seq
MIRT2454280	hsa-miR-1236	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2454282	hsa-miR-28-5p	CLIP-seq
MIRT2454283	hsa-miR-3139	CLIP-seq
MIRT2454284	hsa-miR-3150b-3p	CLIP-seq
MIRT2454285	hsa-miR-3154	CLIP-seq
MIRT2454286	hsa-miR-3185	CLIP-seq
MIRT2454287	hsa-miR-345	CLIP-seq
MIRT2454288	hsa-miR-3679-3p	CLIP-seq
MIRT2454289	hsa-miR-3921	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2454292	hsa-miR-4649-3p	CLIP-seq
MIRT2454293	hsa-miR-4653-5p	CLIP-seq
MIRT2454294	hsa-miR-4689	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2454297	hsa-miR-4747-5p	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2454299	hsa-miR-4784	CLIP-seq
MIRT2454300	hsa-miR-618	CLIP-seq
MIRT2454301	hsa-miR-660	CLIP-seq
MIRT2454302	hsa-miR-708	CLIP-seq
MIRT2454303	hsa-miR-760	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2572064	hsa-miR-1266	CLIP-seq
MIRT2572065	hsa-miR-1275	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2572066	hsa-miR-1324	CLIP-seq
MIRT2454285	hsa-miR-3154	CLIP-seq
MIRT2454286	hsa-miR-3185	CLIP-seq
MIRT2572067	hsa-miR-3200-5p	CLIP-seq
MIRT2572068	hsa-miR-3202	CLIP-seq
MIRT2572069	hsa-miR-3617	CLIP-seq
MIRT2572070	hsa-miR-3647-3p	CLIP-seq
MIRT2572071	hsa-miR-3664-3p	CLIP-seq
MIRT2572072	hsa-miR-3922-5p	CLIP-seq
MIRT2572073	hsa-miR-3926	CLIP-seq
MIRT2572074	hsa-miR-4259	CLIP-seq
MIRT2572075	hsa-miR-4278	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2572076	hsa-miR-4424	CLIP-seq
MIRT2572077	hsa-miR-4433	CLIP-seq
MIRT2572078	hsa-miR-4446-3p	CLIP-seq
MIRT2572079	hsa-miR-4459	CLIP-seq
MIRT2572080	hsa-miR-4488	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2572081	hsa-miR-4518	CLIP-seq
MIRT2572082	hsa-miR-4533	CLIP-seq
MIRT2043915	hsa-miR-4653-3p	CLIP-seq
MIRT2572083	hsa-miR-4665-5p	CLIP-seq
MIRT2572084	hsa-miR-4675	CLIP-seq
MIRT2572085	hsa-miR-4682	CLIP-seq
MIRT2572086	hsa-miR-4694-3p	CLIP-seq
MIRT2572087	hsa-miR-4697-5p	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2572088	hsa-miR-4741	CLIP-seq
MIRT2454297	hsa-miR-4747-5p	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2572089	hsa-miR-4762-5p	CLIP-seq
MIRT2572090	hsa-miR-4768-3p	CLIP-seq
MIRT2572091	hsa-miR-513c	CLIP-seq
MIRT2572092	hsa-miR-514b-5p	CLIP-seq
MIRT2572093	hsa-miR-571	CLIP-seq
MIRT2572094	hsa-miR-626	CLIP-seq
MIRT2572095	hsa-miR-641	CLIP-seq
MIRT2572096	hsa-miR-642b	CLIP-seq
MIRT2454303	hsa-miR-760	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2572097	hsa-miR-939	CLIP-seq
MIRT2572064	hsa-miR-1266	CLIP-seq
MIRT2572065	hsa-miR-1275	CLIP-seq
MIRT2454281	hsa-miR-1321	CLIP-seq
MIRT2572066	hsa-miR-1324	CLIP-seq
MIRT2685135	hsa-miR-205	CLIP-seq
MIRT2454284	hsa-miR-3150b-3p	CLIP-seq
MIRT2454285	hsa-miR-3154	CLIP-seq
MIRT2454286	hsa-miR-3185	CLIP-seq
MIRT2572067	hsa-miR-3200-5p	CLIP-seq
MIRT2572068	hsa-miR-3202	CLIP-seq
MIRT2572069	hsa-miR-3617	CLIP-seq
MIRT2572071	hsa-miR-3664-3p	CLIP-seq
MIRT2454289	hsa-miR-3921	CLIP-seq
MIRT2572073	hsa-miR-3926	CLIP-seq
MIRT2572074	hsa-miR-4259	CLIP-seq
MIRT2572075	hsa-miR-4278	CLIP-seq
MIRT2273287	hsa-miR-4300	CLIP-seq
MIRT2454290	hsa-miR-4419a	CLIP-seq
MIRT2572076	hsa-miR-4424	CLIP-seq
MIRT2572077	hsa-miR-4433	CLIP-seq
MIRT2572078	hsa-miR-4446-3p	CLIP-seq
MIRT2572079	hsa-miR-4459	CLIP-seq
MIRT2572080	hsa-miR-4488	CLIP-seq
MIRT2454291	hsa-miR-4510	CLIP-seq
MIRT2572081	hsa-miR-4518	CLIP-seq
MIRT2572082	hsa-miR-4533	CLIP-seq
MIRT2685136	hsa-miR-4645-5p	CLIP-seq
MIRT2454292	hsa-miR-4649-3p	CLIP-seq
MIRT2043915	hsa-miR-4653-3p	CLIP-seq
MIRT2454293	hsa-miR-4653-5p	CLIP-seq
MIRT2572083	hsa-miR-4665-5p	CLIP-seq
MIRT2685137	hsa-miR-4673	CLIP-seq
MIRT2572084	hsa-miR-4675	CLIP-seq
MIRT2572085	hsa-miR-4682	CLIP-seq
MIRT2454294	hsa-miR-4689	CLIP-seq
MIRT2572086	hsa-miR-4694-3p	CLIP-seq
MIRT2572087	hsa-miR-4697-5p	CLIP-seq
MIRT2454295	hsa-miR-4728-5p	CLIP-seq
MIRT2454296	hsa-miR-4739	CLIP-seq
MIRT2572088	hsa-miR-4741	CLIP-seq
MIRT2454297	hsa-miR-4747-5p	CLIP-seq
MIRT2454298	hsa-miR-4756-5p	CLIP-seq
MIRT2572089	hsa-miR-4762-5p	CLIP-seq
MIRT2572090	hsa-miR-4768-3p	CLIP-seq
MIRT2454299	hsa-miR-4784	CLIP-seq
MIRT2572093	hsa-miR-571	CLIP-seq
MIRT2572094	hsa-miR-626	CLIP-seq
MIRT2572095	hsa-miR-641	CLIP-seq
MIRT2572096	hsa-miR-642b	CLIP-seq
MIRT2454303	hsa-miR-760	CLIP-seq
MIRT2273301	hsa-miR-920	CLIP-seq
MIRT2572097	hsa-miR-939	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001525	Process	Angiogenesis	IEA
GO:0001541	Process	Ovarian follicle development	IEA
GO:0001542	Process	Ovulation from ovarian follicle	IEA
GO:0001554	Process	Luteolysis	IEA
GO:0004222	Function	Metalloendopeptidase activity	EXP	10809722
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA	21873635
GO:0006508	Process	Proteolysis	NAS	9020145
GO:0008270	Function	Zinc ion binding	IEA
GO:0009725	Process	Response to hormone	IEA
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030154	Process	Cell differentiation	IEA
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0030574	Process	Collagen catabolic process	IBA	21873635
GO:0031012	Component	Extracellular matrix	NAS	10809722
GO:0051591	Process	Response to cAMP	IEA

MIM	HGNC	e!Ensembl
601807	7165	ENSG00000123342

Protein

UniProt ID

Q99542

Protein name

Matrix metalloproteinase-19 (MMP-19) (EC 3.4.24.-) (Matrix metalloproteinase RASI) (Matrix metalloproteinase-18) (MMP-18)

Protein function

Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01471	PG_binding_1	29 → 80	Putative peptidoglycan binding domain	Domain
PF00413	Peptidase_M10	103 → 256	Matrixin	Domain
PF00045	Hemopexin	337 → 377	Hemopexin	Repeat
PF00045	Hemopexin	380 → 427	Hemopexin	Repeat
PF00045	Hemopexin	429 → 472	Hemopexin	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial f

Sequence

MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYLQKPLEGSNNFKPEDITEALRAF
QEASELPVSGQLDDATRARMRQPRCGLEDPFNQKTLKYLLLGRWRKKHLTFRILNLPSTL
PPHTARAALRQAFQDWSNVAPLTFQEVQAGAADIRLSFHGRQSSYCSNTFDGPGRVLAHA
DIPELGSVHFDEDEFWTEGTYRGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPH
FKLHPDDVAGIQALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGP
RGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGNLDAAVYSPRTQWIHFFKGDKVWRY
INFKMSPGFPKKLNRVEPNLDAALYWPLNQKVFLFKGSGYWQWDELARTDFSSYPKPIKG
LFTGVPNQPSAAMSWQDGRVYFFKGKVYWRLNQQLRVEKGYPRNISHNWMHCRPRTIDTT
PSGGNTTPSGTGITLDTTLSATETTFEY

Sequence length

508

Interactions

View interactions

	Reactome
			Degradation of the extracellular matrix

MMP19 (matrix metallopeptidase 19)