Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4326
Gene name Gene Name - the full gene name approved by the HGNC.	Matrix metallopeptidase 17
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MMP17
Synonyms (NCBI Gene) Gene synonyms aliases	MMP-17, MT4-MMP, MT4MMP, MTMMP4
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q24.33
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic deve

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018145	hsa-miR-335-5p	Microarray	18185580
MIRT690004	hsa-miR-4293	HITS-CLIP	23313552
MIRT690003	hsa-miR-4728-3p	HITS-CLIP	23313552
MIRT690002	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT690001	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT690000	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT689999	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689998	hsa-miR-4459	HITS-CLIP	23313552
MIRT689997	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT689996	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689995	hsa-miR-544b	HITS-CLIP	23313552
MIRT689994	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT689993	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT573519	hsa-miR-6805-5p	PAR-CLIP	20371350
MIRT573520	hsa-miR-5707	PAR-CLIP	20371350
MIRT573518	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT573517	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT573516	hsa-miR-1914-3p	PAR-CLIP	20371350
MIRT573515	hsa-miR-5194	PAR-CLIP	20371350
MIRT573513	hsa-miR-6738-5p	PAR-CLIP	20371350
MIRT573514	hsa-miR-4290	PAR-CLIP	20371350
MIRT573512	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT573511	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT573510	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT573509	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT690004	hsa-miR-4293	HITS-CLIP	23313552
MIRT690003	hsa-miR-4728-3p	HITS-CLIP	23313552
MIRT690002	hsa-miR-3622a-3p	HITS-CLIP	23313552
MIRT690001	hsa-miR-3622b-3p	HITS-CLIP	23313552
MIRT690000	hsa-miR-6765-3p	HITS-CLIP	23313552
MIRT689999	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689998	hsa-miR-4459	HITS-CLIP	23313552
MIRT689997	hsa-miR-4433a-3p	HITS-CLIP	23313552
MIRT689996	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689995	hsa-miR-544b	HITS-CLIP	23313552
MIRT689994	hsa-miR-7162-3p	HITS-CLIP	23313552
MIRT689993	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT573519	hsa-miR-6805-5p	PAR-CLIP	20371350
MIRT573520	hsa-miR-5707	PAR-CLIP	20371350
MIRT573518	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT573517	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT573516	hsa-miR-1914-3p	PAR-CLIP	20371350
MIRT573515	hsa-miR-5194	PAR-CLIP	20371350
MIRT573513	hsa-miR-6738-5p	PAR-CLIP	20371350
MIRT573514	hsa-miR-4290	PAR-CLIP	20371350
MIRT573512	hsa-miR-6834-5p	PAR-CLIP	20371350
MIRT573511	hsa-miR-1226-5p	PAR-CLIP	20371350
MIRT573510	hsa-miR-6734-5p	PAR-CLIP	20371350
MIRT573509	hsa-miR-1304-5p	PAR-CLIP	20371350
MIRT1153323	hsa-miR-1293	CLIP-seq
MIRT1153324	hsa-miR-29a	CLIP-seq
MIRT1153325	hsa-miR-29b	CLIP-seq
MIRT1153326	hsa-miR-29c	CLIP-seq
MIRT1153327	hsa-miR-3170	CLIP-seq
MIRT1153328	hsa-miR-3663-3p	CLIP-seq
MIRT1153329	hsa-miR-3960	CLIP-seq
MIRT1153330	hsa-miR-4265	CLIP-seq
MIRT1153331	hsa-miR-4296	CLIP-seq
MIRT1153332	hsa-miR-4302	CLIP-seq
MIRT1153333	hsa-miR-4322	CLIP-seq
MIRT1153334	hsa-miR-4417	CLIP-seq
MIRT1153335	hsa-miR-4467	CLIP-seq
MIRT1153336	hsa-miR-4483	CLIP-seq
MIRT1153337	hsa-miR-4514	CLIP-seq
MIRT1153338	hsa-miR-4519	CLIP-seq
MIRT1153339	hsa-miR-4645-5p	CLIP-seq
MIRT1153340	hsa-miR-4673	CLIP-seq
MIRT1153341	hsa-miR-4692	CLIP-seq
MIRT1153342	hsa-miR-4695-5p	CLIP-seq
MIRT1153343	hsa-miR-4733-3p	CLIP-seq
MIRT1153344	hsa-miR-4743	CLIP-seq
MIRT1153345	hsa-miR-4746-3p	CLIP-seq
MIRT1153346	hsa-miR-485-5p	CLIP-seq
MIRT1153347	hsa-miR-765	CLIP-seq
MIRT2043912	hsa-miR-1910	CLIP-seq
MIRT1153327	hsa-miR-3170	CLIP-seq
MIRT2043913	hsa-miR-3195	CLIP-seq
MIRT2043914	hsa-miR-566	CLIP-seq
MIRT2273259	hsa-miR-1299	CLIP-seq
MIRT2273260	hsa-miR-4527	CLIP-seq
MIRT2273261	hsa-miR-4781-3p	CLIP-seq
MIRT2273262	hsa-miR-875-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
SNAI2	Unknown	20019845

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA	21873635
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	TAS	14645246
GO:0008047	Function	Enzyme activator activity	TAS	8640782
GO:0008270	Function	Zinc ion binding	IEA
GO:0030198	Process	Extracellular matrix organization	IBA	21873635
GO:0030574	Process	Collagen catabolic process	IBA	21873635
GO:0031012	Component	Extracellular matrix	IEA
GO:0031225	Component	Anchored component of membrane	IEA
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:0070006	Function	Metalloaminopeptidase activity	TAS	14645246

MIM	HGNC	e!Ensembl
602285	7163	ENSG00000198598

Protein

UniProt ID

Q9ULZ9

Protein name

Matrix metalloproteinase-17 (MMP-17) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (MTMMP4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP) (MT4MMP)

Protein function

Endopeptidase that degrades various components of the extracellular matrix, such as fibrin. May be involved in the activation of membrane-bound precursors of growth factors or inflammatory mediators, such as tumor necrosis factor-alpha. May also

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01471	PG_binding_1	45 → 105	Putative peptidoglycan binding domain	Domain
PF00413	Peptidase_M10	132 → 295	Matrixin	Domain
PF00045	Hemopexin	336 → 379	Hemopexin	Repeat
PF00045	Hemopexin	385 → 428	Hemopexin	Repeat
PF00045	Hemopexin	431 → 477	Hemopexin	Repeat
PF00045	Hemopexin	479 → 523	Hemopexin	Repeat

Tissue specificity

TISSUE SPECIFICITY: Expressed in brain, leukocytes, colon, ovary testis and breast cancer. Expressed also in many transformed and non-transformed cell types.

Sequence

MRRRAARGPGPPPPGPGLSRLPLPLLLLLALGTRGGCAAPAPAPRAEDLSLGVEWLSRFG
YLPPADPTTGQLQTQEELSKAITAMQQFGGLEATGILDEATLALMKTPRCSLPDLPVLTQ
ARRRRQAPAPTKWNKRNLSWRVRTFPRDSPLGHDTVRALMYYALKVWSDIAPLNFHEVAG
SAADIQIDFSKADHNDGYPFDGPGGTVAHAFFPGHHHTAGDTHFDDDEAWTFRSSDAHGM
DLFAVAVHEFGHAIGLSHVAAAHSIMRPYYQGPVGDPLRYGLPYEDKVRVWQLYGVRESV
SPTAQPEEPPLLPEPPDNRSSAPPRKDVPHRCSTHFDAVAQIRGEAFFFKGKYFWRLTRD
RHLVSLQPAQMHRFWRGLPLHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRP
VSDFSLPPGGIDAAFSWAHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLD
DAMRWSDGASYFFRGQEYWKVLDGELEVAPGYPQSTARDWLVCGDSQADGSVAAGVDAAE
GPRAPPGQHDQSRSEDGYEVCSCTSGASSPPGAPGPLVAATMLLLLPPLSPGALWTAAQA
LTL

Sequence length

603

Interactions

View interactions

	KEGG		Reactome
	Parathyroid hormone synthesis, secretion and action		Activation of Matrix Metalloproteinases

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Migraine	Migraine Disorders	rs794727411	22683712

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Rheumatoid	Associate	10857781
Breast Neoplasms	Associate	16707440, 22262494
Carcinogenesis	Associate	36042626
Carcinoma Ovarian Epithelial	Associate	36042626
Coronary Artery Disease	Associate	38357816
Hypoxia	Associate	37770592
Lymphatic Metastasis	Stimulate	16707440
Melanoma	Associate	28531887, 36373310
Mucocutaneous Lymph Node Syndrome	Associate	38357816
Neoplasm Metastasis	Associate	16707440, 37434173
Neoplasms	Stimulate	16707440
Neoplasms	Associate	22262494, 37686244
Odontogenic Tumors	Associate	25158190
Ovarian Neoplasms	Associate	36042626, 37434173
Peri Implantitis	Associate	40004451
Polycystic Ovary Syndrome	Associate	39796177
Univentricular Heart	Associate	37770592
Uveal melanoma	Stimulate	34587931
Vascular System Injuries	Associate	38357816

MMP17 (matrix metallopeptidase 17)