Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4324
Gene name Gene Name - the full gene name approved by the HGNC.	Matrix metallopeptidase 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MMP15
Synonyms (NCBI Gene) Gene synonyms aliases	MMP-15, MT2-MMP, MT2MMP, MTMMP2, SMCP-2
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic deve

Show/Hide all(178)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005383	hsa-miR-29b-3p	Luciferase reporter assay, qRT-PCR	21305051
MIRT005384	hsa-miR-29c-3p	Luciferase reporter assay, qRT-PCR	21305051
MIRT448066	hsa-miR-4476	PAR-CLIP	22100165
MIRT448064	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT448063	hsa-miR-3158-3p	PAR-CLIP	22100165
MIRT448062	hsa-miR-3921	PAR-CLIP	22100165
MIRT448061	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448060	hsa-miR-4649-3p	PAR-CLIP	22100165
MIRT448059	hsa-miR-7162-3p	PAR-CLIP	22100165
MIRT448057	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT448058	hsa-miR-3202	PAR-CLIP	22100165
MIRT448056	hsa-miR-6822-3p	PAR-CLIP	22100165
MIRT448055	hsa-miR-760	PAR-CLIP	22100165
MIRT448054	hsa-miR-3915	PAR-CLIP	22100165
MIRT448053	hsa-miR-8057	PAR-CLIP	22100165
MIRT448066	hsa-miR-4476	PAR-CLIP	22100165
MIRT448064	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT448063	hsa-miR-3158-3p	PAR-CLIP	22100165
MIRT448062	hsa-miR-3921	PAR-CLIP	22100165
MIRT448061	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448060	hsa-miR-4649-3p	PAR-CLIP	22100165
MIRT448059	hsa-miR-7162-3p	PAR-CLIP	22100165
MIRT448057	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT448058	hsa-miR-3202	PAR-CLIP	22100165
MIRT448056	hsa-miR-6822-3p	PAR-CLIP	22100165
MIRT448055	hsa-miR-760	PAR-CLIP	22100165
MIRT448054	hsa-miR-3915	PAR-CLIP	22100165
MIRT448053	hsa-miR-8057	PAR-CLIP	22100165
MIRT448066	hsa-miR-4476	PAR-CLIP	22100165
MIRT448064	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT448063	hsa-miR-3158-3p	PAR-CLIP	22100165
MIRT448062	hsa-miR-3921	PAR-CLIP	22100165
MIRT448061	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448060	hsa-miR-4649-3p	PAR-CLIP	22100165
MIRT448059	hsa-miR-7162-3p	PAR-CLIP	22100165
MIRT448057	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT448058	hsa-miR-3202	PAR-CLIP	22100165
MIRT448056	hsa-miR-6822-3p	PAR-CLIP	22100165
MIRT448055	hsa-miR-760	PAR-CLIP	22100165
MIRT448054	hsa-miR-3915	PAR-CLIP	22100165
MIRT448053	hsa-miR-8057	PAR-CLIP	22100165
MIRT448066	hsa-miR-4476	PAR-CLIP	22100165
MIRT448064	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT448063	hsa-miR-3158-3p	PAR-CLIP	22100165
MIRT448062	hsa-miR-3921	PAR-CLIP	22100165
MIRT448061	hsa-miR-4653-5p	PAR-CLIP	22100165
MIRT448060	hsa-miR-4649-3p	PAR-CLIP	22100165
MIRT448059	hsa-miR-7162-3p	PAR-CLIP	22100165
MIRT448057	hsa-miR-3928-3p	PAR-CLIP	22100165
MIRT448058	hsa-miR-3202	PAR-CLIP	22100165
MIRT448056	hsa-miR-6822-3p	PAR-CLIP	22100165
MIRT448055	hsa-miR-760	PAR-CLIP	22100165
MIRT448054	hsa-miR-3915	PAR-CLIP	22100165
MIRT448053	hsa-miR-8057	PAR-CLIP	22100165
MIRT1153182	hsa-miR-1197	CLIP-seq
MIRT1153183	hsa-miR-1252	CLIP-seq
MIRT1153184	hsa-miR-148a	CLIP-seq
MIRT1153185	hsa-miR-148b	CLIP-seq
MIRT1153186	hsa-miR-152	CLIP-seq
MIRT1153187	hsa-miR-24	CLIP-seq
MIRT1153188	hsa-miR-3122	CLIP-seq
MIRT1153189	hsa-miR-3125	CLIP-seq
MIRT1153190	hsa-miR-3664-3p	CLIP-seq
MIRT1153191	hsa-miR-3913-5p	CLIP-seq
MIRT1153192	hsa-miR-3916	CLIP-seq
MIRT1153193	hsa-miR-4276	CLIP-seq
MIRT1153194	hsa-miR-4283	CLIP-seq
MIRT1153195	hsa-miR-4287	CLIP-seq
MIRT1153196	hsa-miR-4292	CLIP-seq
MIRT1153197	hsa-miR-4308	CLIP-seq
MIRT1153198	hsa-miR-4436a	CLIP-seq
MIRT1153199	hsa-miR-4437	CLIP-seq
MIRT1153200	hsa-miR-4469	CLIP-seq
MIRT1153201	hsa-miR-4489	CLIP-seq
MIRT1153202	hsa-miR-4533	CLIP-seq
MIRT1153203	hsa-miR-4685-3p	CLIP-seq
MIRT1153204	hsa-miR-4699-3p	CLIP-seq
MIRT1153205	hsa-miR-4747-5p	CLIP-seq
MIRT1153206	hsa-miR-583	CLIP-seq
MIRT1153207	hsa-miR-885-3p	CLIP-seq
MIRT1153182	hsa-miR-1197	CLIP-seq
MIRT2043855	hsa-miR-1231	CLIP-seq
MIRT1153183	hsa-miR-1252	CLIP-seq
MIRT2043856	hsa-miR-1587	CLIP-seq
MIRT1153187	hsa-miR-24	CLIP-seq
MIRT2043857	hsa-miR-2467-5p	CLIP-seq
MIRT2043858	hsa-miR-3120-5p	CLIP-seq
MIRT1153188	hsa-miR-3122	CLIP-seq
MIRT1153189	hsa-miR-3125	CLIP-seq
MIRT2043859	hsa-miR-3150a-3p	CLIP-seq
MIRT2043860	hsa-miR-3175	CLIP-seq
MIRT2043861	hsa-miR-3188	CLIP-seq
MIRT2043862	hsa-miR-339-5p	CLIP-seq
MIRT1153190	hsa-miR-3664-3p	CLIP-seq
MIRT1153191	hsa-miR-3913-5p	CLIP-seq
MIRT1153192	hsa-miR-3916	CLIP-seq
MIRT2043863	hsa-miR-3938	CLIP-seq
MIRT2043864	hsa-miR-3975	CLIP-seq
MIRT1153194	hsa-miR-4283	CLIP-seq
MIRT1153195	hsa-miR-4287	CLIP-seq
MIRT1153196	hsa-miR-4292	CLIP-seq
MIRT1153197	hsa-miR-4308	CLIP-seq
MIRT2043865	hsa-miR-4417	CLIP-seq
MIRT2043866	hsa-miR-4420	CLIP-seq
MIRT2043867	hsa-miR-4421	CLIP-seq
MIRT1153198	hsa-miR-4436a	CLIP-seq
MIRT1153199	hsa-miR-4437	CLIP-seq
MIRT2043868	hsa-miR-4468	CLIP-seq
MIRT1153200	hsa-miR-4469	CLIP-seq
MIRT2043869	hsa-miR-4488	CLIP-seq
MIRT1153201	hsa-miR-4489	CLIP-seq
MIRT2043870	hsa-miR-4492	CLIP-seq
MIRT2043871	hsa-miR-4498	CLIP-seq
MIRT1153202	hsa-miR-4533	CLIP-seq
MIRT2043872	hsa-miR-4651	CLIP-seq
MIRT2043873	hsa-miR-4656	CLIP-seq
MIRT2043874	hsa-miR-4667-5p	CLIP-seq
MIRT2043875	hsa-miR-4675	CLIP-seq
MIRT1153203	hsa-miR-4685-3p	CLIP-seq
MIRT2043876	hsa-miR-4697-5p	CLIP-seq
MIRT2043877	hsa-miR-4700-5p	CLIP-seq
MIRT2043878	hsa-miR-4731-5p	CLIP-seq
MIRT2043879	hsa-miR-4741	CLIP-seq
MIRT1153205	hsa-miR-4747-5p	CLIP-seq
MIRT2043880	hsa-miR-4787-5p	CLIP-seq
MIRT2043881	hsa-miR-485-5p	CLIP-seq
MIRT2043882	hsa-miR-516b	CLIP-seq
MIRT2043883	hsa-miR-541	CLIP-seq
MIRT1153206	hsa-miR-583	CLIP-seq
MIRT2043884	hsa-miR-608	CLIP-seq
MIRT2043885	hsa-miR-637	CLIP-seq
MIRT2043886	hsa-miR-654-5p	CLIP-seq
MIRT2043887	hsa-miR-670	CLIP-seq
MIRT2043888	hsa-miR-762	CLIP-seq
MIRT2043889	hsa-miR-939	CLIP-seq
MIRT1153183	hsa-miR-1252	CLIP-seq
MIRT1153184	hsa-miR-148a	CLIP-seq
MIRT1153185	hsa-miR-148b	CLIP-seq
MIRT1153186	hsa-miR-152	CLIP-seq
MIRT2273245	hsa-miR-3138	CLIP-seq
MIRT2273246	hsa-miR-3612	CLIP-seq
MIRT2273247	hsa-miR-3675-5p	CLIP-seq
MIRT1153193	hsa-miR-4276	CLIP-seq
MIRT1153195	hsa-miR-4287	CLIP-seq
MIRT2043865	hsa-miR-4417	CLIP-seq
MIRT2273248	hsa-miR-4462	CLIP-seq
MIRT2043869	hsa-miR-4488	CLIP-seq
MIRT1153202	hsa-miR-4533	CLIP-seq
MIRT2043872	hsa-miR-4651	CLIP-seq
MIRT1153203	hsa-miR-4685-3p	CLIP-seq
MIRT2273249	hsa-miR-4695-5p	CLIP-seq
MIRT2043876	hsa-miR-4697-5p	CLIP-seq
MIRT1153204	hsa-miR-4699-3p	CLIP-seq
MIRT1153205	hsa-miR-4747-5p	CLIP-seq
MIRT2043880	hsa-miR-4787-5p	CLIP-seq
MIRT2043883	hsa-miR-541	CLIP-seq
MIRT2043884	hsa-miR-608	CLIP-seq
MIRT2043885	hsa-miR-637	CLIP-seq
MIRT2273250	hsa-miR-650	CLIP-seq
MIRT2043886	hsa-miR-654-5p	CLIP-seq
MIRT2273251	hsa-miR-765	CLIP-seq
MIRT2043856	hsa-miR-1587	CLIP-seq
MIRT2043865	hsa-miR-4417	CLIP-seq
MIRT2043869	hsa-miR-4488	CLIP-seq
MIRT2043870	hsa-miR-4492	CLIP-seq
MIRT2043871	hsa-miR-4498	CLIP-seq
MIRT2043872	hsa-miR-4651	CLIP-seq
MIRT2043873	hsa-miR-4656	CLIP-seq
MIRT2043875	hsa-miR-4675	CLIP-seq
MIRT2043876	hsa-miR-4697-5p	CLIP-seq
MIRT2043879	hsa-miR-4741	CLIP-seq
MIRT2043880	hsa-miR-4787-5p	CLIP-seq
MIRT2043883	hsa-miR-541	CLIP-seq
MIRT2043884	hsa-miR-608	CLIP-seq
MIRT2043885	hsa-miR-637	CLIP-seq
MIRT2043886	hsa-miR-654-5p	CLIP-seq
MIRT2043888	hsa-miR-762	CLIP-seq
MIRT1153202	hsa-miR-4533	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	TAS	7649159
GO:0005515	Function	Protein binding	IPI	15248212
GO:0005615	Component	Extracellular space	IBA
GO:0005886	Component	Plasma membrane	TAS	7649159
GO:0006508	Process	Proteolysis	IEA
GO:0006508	Process	Proteolysis	TAS	14645246
GO:0008047	Function	Enzyme activator activity	TAS	7559440
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	TAS	7649159
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0022617	Process	Extracellular matrix disassembly	TAS
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030574	Process	Collagen catabolic process	IBA
GO:0030574	Process	Collagen catabolic process	TAS
GO:0031012	Component	Extracellular matrix	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0035987	Process	Endodermal cell differentiation	IEP	23154389
GO:0036211	Process	Protein modification process	TAS	7559440
GO:0046872	Function	Metal ion binding	IEA
GO:0070006	Function	Metalloaminopeptidase activity	TAS	14645246

MIM	HGNC	e!Ensembl
602261	7161	ENSG00000102996

Protein

UniProt ID

P51511

Protein name

Matrix metalloproteinase-15 (MMP-15) (EC 3.4.24.-) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP-2)

Protein function

Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01471	PG_binding_1	49 → 106	Putative peptidoglycan binding domain	Domain
PF00413	Peptidase_M10	138 → 304	Matrixin	Domain
PF00045	Hemopexin	374 → 417	Hemopexin	Repeat
PF00045	Hemopexin	419 → 463	Hemopexin	Repeat
PF00045	Hemopexin	466 → 512	Hemopexin	Repeat
PF00045	Hemopexin	515 → 559	Hemopexin	Repeat
PF11857	DUF3377	602 → 669	Domain of unknown function (DUF3377)	Family

Tissue specificity

TISSUE SPECIFICITY: Appeared to be synthesized preferentially in liver, placenta, testis, colon and intestine. Substantial amounts are also detected in pancreas, kidney, lung, heart and skeletal muscle.

Sequence

MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLY
GYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVR
VKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQ
EVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEP
WTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQ
QLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATE
RPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDIS
AAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFF
FQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNE
RLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGD
FGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLY
CKRSLQEWV

Sequence length

669

Interactions

View interactions

	KEGG		Reactome
	Parathyroid hormone synthesis, secretion and action		Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Colorectal Cancer	Colorectal cancer	These findings revealed that MMP15, MRPL48, CALN1 and HADHB genes knockout might facilitate the sensitivity of CRC cell line Caco-2 to CTX.	33048115	CBGDA

Show/Hide Text Mining Associations (31)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Stimulate	16093241
Adrenal Gland Diseases	Associate	33278774
Arthritis Rheumatoid	Associate	10531073
Astrocytoma	Associate	10027400
Breast Neoplasms	Associate	15739263, 18503039, 19243594, 19531263, 25029110
Breast Neoplasms	Stimulate	23568046
Carcinogenesis	Stimulate	22576687
Carcinoma Adenoid Cystic	Associate	33278774
Carcinoma Non Small Cell Lung	Associate	25031779
Cartilage Diseases	Associate	31470617
Colorectal Neoplasms	Associate	22576687, 33048115
Esophageal Neoplasms	Associate	25031779
Glioblastoma	Associate	10027400, 9708803
Infections	Stimulate	31470617
Insulin Resistance	Inhibit	22471305
Lung Neoplasms	Associate	25031779
Lymphatic Metastasis	Associate	25031779
Medulloblastoma	Stimulate	9708803
Melanoma	Stimulate	21119930
Neoplasm Metastasis	Associate	16093241, 25973093, 27184932
Neoplasms	Stimulate	10027400, 25031779, 25973093
Neoplasms	Associate	15739263, 16093241, 16465195, 20586027, 27184932, 32035133, 32049862, 35062057
Neoplasms	Inhibit	22576687
Peri Implantitis	Associate	40004451
Pre Eclampsia	Stimulate	22768148
Prostatic Neoplasms	Associate	15928670
Sleep Apnea Obstructive	Associate	36574455
Squamous Cell Carcinoma of Head and Neck	Inhibit	36941602
Stomach Neoplasms	Associate	21451793, 25973093
Urinary Bladder Neoplasms	Associate	20586027, 32049862
Uterine Cervical Neoplasms	Associate	32887509

MMP15 (matrix metallopeptidase 15)