Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4192
Gene name Gene Name - the full gene name approved by the HGNC.	Midkine
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MDK
Synonyms (NCBI Gene) Gene synonyms aliases	ARAP, MK, NEGF2
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11p11.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targete

Show/Hide all(205)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022440	hsa-miR-124-3p	Microarray	18668037
MIRT050887	hsa-miR-17-5p	CLASH	23622248
MIRT040730	hsa-miR-92b-3p	CLASH	23622248
MIRT036299	hsa-miR-1229-3p	CLASH	23622248
MIRT022440	hsa-miR-124-3p	PAR-CLIP	27292025
MIRT1138628	hsa-miR-1275	CLIP-seq
MIRT1138629	hsa-miR-1470	CLIP-seq
MIRT1138630	hsa-miR-188-5p	CLIP-seq
MIRT1138631	hsa-miR-2110	CLIP-seq
MIRT1138632	hsa-miR-219-2-3p	CLIP-seq
MIRT1138633	hsa-miR-223	CLIP-seq
MIRT1138634	hsa-miR-23a	CLIP-seq
MIRT1138635	hsa-miR-23b	CLIP-seq
MIRT1138636	hsa-miR-23c	CLIP-seq
MIRT1138637	hsa-miR-2467-5p	CLIP-seq
MIRT1138638	hsa-miR-3148	CLIP-seq
MIRT1138639	hsa-miR-3151	CLIP-seq
MIRT1138640	hsa-miR-3192	CLIP-seq
MIRT1138641	hsa-miR-3199	CLIP-seq
MIRT1138642	hsa-miR-326	CLIP-seq
MIRT1138643	hsa-miR-330-5p	CLIP-seq
MIRT1138644	hsa-miR-4260	CLIP-seq
MIRT1138645	hsa-miR-4265	CLIP-seq
MIRT1138646	hsa-miR-4271	CLIP-seq
MIRT1138647	hsa-miR-4286	CLIP-seq
MIRT1138648	hsa-miR-4296	CLIP-seq
MIRT1138649	hsa-miR-4314	CLIP-seq
MIRT1138650	hsa-miR-4322	CLIP-seq
MIRT1138651	hsa-miR-4328	CLIP-seq
MIRT1138652	hsa-miR-4447	CLIP-seq
MIRT1138653	hsa-miR-4472	CLIP-seq
MIRT1138654	hsa-miR-4525	CLIP-seq
MIRT1138655	hsa-miR-4646-3p	CLIP-seq
MIRT1138656	hsa-miR-4646-5p	CLIP-seq
MIRT1138657	hsa-miR-4665-5p	CLIP-seq
MIRT1138658	hsa-miR-4667-3p	CLIP-seq
MIRT1138659	hsa-miR-4668-5p	CLIP-seq
MIRT1138660	hsa-miR-4723-5p	CLIP-seq
MIRT1138661	hsa-miR-4725-3p	CLIP-seq
MIRT1138662	hsa-miR-4780	CLIP-seq
MIRT1138663	hsa-miR-491-5p	CLIP-seq
MIRT1138664	hsa-miR-623	CLIP-seq
MIRT1138665	hsa-miR-625	CLIP-seq
MIRT1138666	hsa-miR-760	CLIP-seq
MIRT1138667	hsa-miR-124	CLIP-seq
MIRT1138628	hsa-miR-1275	CLIP-seq
MIRT1138631	hsa-miR-2110	CLIP-seq
MIRT1138632	hsa-miR-219-2-3p	CLIP-seq
MIRT1138633	hsa-miR-223	CLIP-seq
MIRT1138638	hsa-miR-3148	CLIP-seq
MIRT1138639	hsa-miR-3151	CLIP-seq
MIRT1138640	hsa-miR-3192	CLIP-seq
MIRT1138641	hsa-miR-3199	CLIP-seq
MIRT1138642	hsa-miR-326	CLIP-seq
MIRT1138643	hsa-miR-330-5p	CLIP-seq
MIRT1138645	hsa-miR-4265	CLIP-seq
MIRT1138646	hsa-miR-4271	CLIP-seq
MIRT1138648	hsa-miR-4296	CLIP-seq
MIRT1138649	hsa-miR-4314	CLIP-seq
MIRT1138650	hsa-miR-4322	CLIP-seq
MIRT1138651	hsa-miR-4328	CLIP-seq
MIRT1138652	hsa-miR-4447	CLIP-seq
MIRT1138653	hsa-miR-4472	CLIP-seq
MIRT1138656	hsa-miR-4646-5p	CLIP-seq
MIRT1138657	hsa-miR-4665-5p	CLIP-seq
MIRT1138659	hsa-miR-4668-5p	CLIP-seq
MIRT1138661	hsa-miR-4725-3p	CLIP-seq
MIRT1138663	hsa-miR-491-5p	CLIP-seq
MIRT1138668	hsa-miR-506	CLIP-seq
MIRT1138665	hsa-miR-625	CLIP-seq
MIRT1138666	hsa-miR-760	CLIP-seq
MIRT1138669	hsa-miR-939	CLIP-seq
MIRT1138628	hsa-miR-1275	CLIP-seq
MIRT1138631	hsa-miR-2110	CLIP-seq
MIRT1138632	hsa-miR-219-2-3p	CLIP-seq
MIRT1138633	hsa-miR-223	CLIP-seq
MIRT1138638	hsa-miR-3148	CLIP-seq
MIRT1138639	hsa-miR-3151	CLIP-seq
MIRT1138640	hsa-miR-3192	CLIP-seq
MIRT1138641	hsa-miR-3199	CLIP-seq
MIRT1138642	hsa-miR-326	CLIP-seq
MIRT1138643	hsa-miR-330-5p	CLIP-seq
MIRT1138645	hsa-miR-4265	CLIP-seq
MIRT1138646	hsa-miR-4271	CLIP-seq
MIRT1138648	hsa-miR-4296	CLIP-seq
MIRT1138649	hsa-miR-4314	CLIP-seq
MIRT1138650	hsa-miR-4322	CLIP-seq
MIRT1138651	hsa-miR-4328	CLIP-seq
MIRT1138652	hsa-miR-4447	CLIP-seq
MIRT1138653	hsa-miR-4472	CLIP-seq
MIRT1138656	hsa-miR-4646-5p	CLIP-seq
MIRT1138657	hsa-miR-4665-5p	CLIP-seq
MIRT1138659	hsa-miR-4668-5p	CLIP-seq
MIRT1138661	hsa-miR-4725-3p	CLIP-seq
MIRT1138663	hsa-miR-491-5p	CLIP-seq
MIRT1138665	hsa-miR-625	CLIP-seq
MIRT1138666	hsa-miR-760	CLIP-seq
MIRT1138669	hsa-miR-939	CLIP-seq
MIRT1138667	hsa-miR-124	CLIP-seq
MIRT1138628	hsa-miR-1275	CLIP-seq
MIRT1138631	hsa-miR-2110	CLIP-seq
MIRT1138632	hsa-miR-219-2-3p	CLIP-seq
MIRT1138634	hsa-miR-23a	CLIP-seq
MIRT1138635	hsa-miR-23b	CLIP-seq
MIRT1138636	hsa-miR-23c	CLIP-seq
MIRT1138639	hsa-miR-3151	CLIP-seq
MIRT2269416	hsa-miR-3189-3p	CLIP-seq
MIRT1138640	hsa-miR-3192	CLIP-seq
MIRT1138641	hsa-miR-3199	CLIP-seq
MIRT1138642	hsa-miR-326	CLIP-seq
MIRT1138643	hsa-miR-330-5p	CLIP-seq
MIRT1138645	hsa-miR-4265	CLIP-seq
MIRT1138646	hsa-miR-4271	CLIP-seq
MIRT1138648	hsa-miR-4296	CLIP-seq
MIRT1138649	hsa-miR-4314	CLIP-seq
MIRT1138650	hsa-miR-4322	CLIP-seq
MIRT1138652	hsa-miR-4447	CLIP-seq
MIRT2269417	hsa-miR-4448	CLIP-seq
MIRT1138653	hsa-miR-4472	CLIP-seq
MIRT2269418	hsa-miR-4642	CLIP-seq
MIRT2269419	hsa-miR-4645-5p	CLIP-seq
MIRT1138656	hsa-miR-4646-5p	CLIP-seq
MIRT1138657	hsa-miR-4665-5p	CLIP-seq
MIRT2269420	hsa-miR-4673	CLIP-seq
MIRT1138661	hsa-miR-4725-3p	CLIP-seq
MIRT2269421	hsa-miR-4733-3p	CLIP-seq
MIRT1138663	hsa-miR-491-5p	CLIP-seq
MIRT1138668	hsa-miR-506	CLIP-seq
MIRT2269422	hsa-miR-541	CLIP-seq
MIRT1138665	hsa-miR-625	CLIP-seq
MIRT1138666	hsa-miR-760	CLIP-seq
MIRT1138669	hsa-miR-939	CLIP-seq
MIRT1138628	hsa-miR-1275	CLIP-seq
MIRT1138629	hsa-miR-1470	CLIP-seq
MIRT1138630	hsa-miR-188-5p	CLIP-seq
MIRT1138634	hsa-miR-23a	CLIP-seq
MIRT1138635	hsa-miR-23b	CLIP-seq
MIRT1138636	hsa-miR-23c	CLIP-seq
MIRT1138637	hsa-miR-2467-5p	CLIP-seq
MIRT1138644	hsa-miR-4260	CLIP-seq
MIRT1138647	hsa-miR-4286	CLIP-seq
MIRT1138654	hsa-miR-4525	CLIP-seq
MIRT1138655	hsa-miR-4646-3p	CLIP-seq
MIRT1138657	hsa-miR-4665-5p	CLIP-seq
MIRT1138658	hsa-miR-4667-3p	CLIP-seq
MIRT1138660	hsa-miR-4723-5p	CLIP-seq
MIRT1138662	hsa-miR-4780	CLIP-seq
MIRT1138664	hsa-miR-623	CLIP-seq
MIRT1138665	hsa-miR-625	CLIP-seq
MIRT2269416	hsa-miR-3189-3p	CLIP-seq
MIRT2269417	hsa-miR-4448	CLIP-seq
MIRT2269418	hsa-miR-4642	CLIP-seq
MIRT2269419	hsa-miR-4645-5p	CLIP-seq
MIRT2269420	hsa-miR-4673	CLIP-seq
MIRT2269421	hsa-miR-4733-3p	CLIP-seq
MIRT1138628	hsa-miR-1275	CLIP-seq
MIRT1138629	hsa-miR-1470	CLIP-seq
MIRT1138630	hsa-miR-188-5p	CLIP-seq
MIRT1138634	hsa-miR-23a	CLIP-seq
MIRT1138635	hsa-miR-23b	CLIP-seq
MIRT1138636	hsa-miR-23c	CLIP-seq
MIRT1138637	hsa-miR-2467-5p	CLIP-seq
MIRT1138639	hsa-miR-3151	CLIP-seq
MIRT2269416	hsa-miR-3189-3p	CLIP-seq
MIRT1138644	hsa-miR-4260	CLIP-seq
MIRT1138647	hsa-miR-4286	CLIP-seq
MIRT2269417	hsa-miR-4448	CLIP-seq
MIRT1138654	hsa-miR-4525	CLIP-seq
MIRT2269418	hsa-miR-4642	CLIP-seq
MIRT2269419	hsa-miR-4645-5p	CLIP-seq
MIRT1138655	hsa-miR-4646-3p	CLIP-seq
MIRT1138657	hsa-miR-4665-5p	CLIP-seq
MIRT1138658	hsa-miR-4667-3p	CLIP-seq
MIRT2269420	hsa-miR-4673	CLIP-seq
MIRT1138660	hsa-miR-4723-5p	CLIP-seq
MIRT2269421	hsa-miR-4733-3p	CLIP-seq
MIRT1138662	hsa-miR-4780	CLIP-seq
MIRT1138664	hsa-miR-623	CLIP-seq
MIRT1138665	hsa-miR-625	CLIP-seq
MIRT1138669	hsa-miR-939	CLIP-seq
MIRT1138628	hsa-miR-1275	CLIP-seq
MIRT1138629	hsa-miR-1470	CLIP-seq
MIRT1138630	hsa-miR-188-5p	CLIP-seq
MIRT1138634	hsa-miR-23a	CLIP-seq
MIRT1138635	hsa-miR-23b	CLIP-seq
MIRT1138636	hsa-miR-23c	CLIP-seq
MIRT1138637	hsa-miR-2467-5p	CLIP-seq
MIRT1138639	hsa-miR-3151	CLIP-seq
MIRT2269416	hsa-miR-3189-3p	CLIP-seq
MIRT1138644	hsa-miR-4260	CLIP-seq
MIRT1138647	hsa-miR-4286	CLIP-seq
MIRT2269417	hsa-miR-4448	CLIP-seq
MIRT1138654	hsa-miR-4525	CLIP-seq
MIRT2269418	hsa-miR-4642	CLIP-seq
MIRT2269419	hsa-miR-4645-5p	CLIP-seq
MIRT1138655	hsa-miR-4646-3p	CLIP-seq
MIRT1138657	hsa-miR-4665-5p	CLIP-seq
MIRT1138658	hsa-miR-4667-3p	CLIP-seq
MIRT2269420	hsa-miR-4673	CLIP-seq
MIRT1138660	hsa-miR-4723-5p	CLIP-seq
MIRT2269421	hsa-miR-4733-3p	CLIP-seq
MIRT1138662	hsa-miR-4780	CLIP-seq
MIRT1138664	hsa-miR-623	CLIP-seq
MIRT1138665	hsa-miR-625	CLIP-seq
MIRT1138669	hsa-miR-939	CLIP-seq

Show/Hide all(114)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001662	Process	Behavioral fear response	IEA
GO:0002232	Process	Leukocyte chemotaxis involved in inflammatory response	IEA
GO:0002232	Process	Leukocyte chemotaxis involved in inflammatory response	IMP	10683378
GO:0002232	Process	Leukocyte chemotaxis involved in inflammatory response	ISS
GO:0002286	Process	T cell activation involved in immune response	IEA
GO:0002286	Process	T cell activation involved in immune response	ISS
GO:0002690	Process	Positive regulation of leukocyte chemotaxis	IEA
GO:0002690	Process	Positive regulation of leukocyte chemotaxis	ISS
GO:0005515	Function	Protein binding	IPI	10212223, 10772929, 12084985, 12147681, 12573468, 15466886, 18469519, 32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0007010	Process	Cytoskeleton organization	IEA
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0007162	Process	Negative regulation of cell adhesion	IEA
GO:0007162	Process	Negative regulation of cell adhesion	ISS
GO:0007165	Process	Signal transduction	NAS	7835084
GO:0007399	Process	Nervous system development	NAS	9384573
GO:0007614	Process	Short-term memory	IEA
GO:0008083	Function	Growth factor activity	IBA
GO:0008083	Function	Growth factor activity	IEA
GO:0008083	Function	Growth factor activity	NAS	1639750
GO:0008201	Function	Heparin binding	IDA	9384573
GO:0008201	Function	Heparin binding	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0009611	Process	Response to wounding	IEA
GO:0009611	Process	Response to wounding	ISS
GO:0009725	Process	Response to hormone	IEA
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	IEA
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	IMP	19060126
GO:0010667	Process	Negative regulation of cardiac muscle cell apoptotic process	ISS
GO:0010718	Process	Positive regulation of epithelial to mesenchymal transition	IMP	18469519
GO:0010759	Process	Positive regulation of macrophage chemotaxis	IEA
GO:0010759	Process	Positive regulation of macrophage chemotaxis	IMP	10683378
GO:0010759	Process	Positive regulation of macrophage chemotaxis	ISS
GO:0010838	Process	Positive regulation of keratinocyte proliferation	IDA	18469519
GO:0010976	Process	Positive regulation of neuron projection development	IDA	12084985
GO:0010976	Process	Positive regulation of neuron projection development	IMP	15466886
GO:0010996	Process	Response to auditory stimulus	IEA
GO:0010996	Process	Response to auditory stimulus	ISS
GO:0016477	Process	Cell migration	IEA
GO:0021542	Process	Dentate gyrus development	IEA
GO:0021681	Process	Cerebellar granular layer development	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0021987	Process	Cerebral cortex development	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030154	Process	Cell differentiation	NAS	1639750
GO:0030279	Process	Negative regulation of ossification	IEA
GO:0030279	Process	Negative regulation of ossification	ISS
GO:0030325	Process	Adrenal gland development	IEA
GO:0030325	Process	Adrenal gland development	ISS
GO:0030335	Process	Positive regulation of cell migration	IDA	15466886
GO:0030421	Process	Defecation	IEA
GO:0031012	Component	Extracellular matrix	HDA	28327460
GO:0032330	Process	Regulation of chondrocyte differentiation	IEA
GO:0032330	Process	Regulation of chondrocyte differentiation	ISS
GO:0032735	Process	Positive regulation of interleukin-12 production	IMP	22323540
GO:0035374	Function	Chondroitin sulfate binding	IEA
GO:0035374	Function	Chondroitin sulfate binding	ISS
GO:0035556	Process	Intracellular signal transduction	IDA	18469519
GO:0042246	Process	Tissue regeneration	IEA
GO:0042246	Process	Tissue regeneration	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IDA	12573468
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0044849	Process	Estrous cycle	IEA
GO:0044849	Process	Estrous cycle	ISS
GO:0045582	Process	Positive regulation of T cell differentiation	IEA
GO:0045582	Process	Positive regulation of T cell differentiation	ISS
GO:0045590	Process	Negative regulation of regulatory T cell differentiation	IMP	22323540
GO:0045785	Process	Positive regulation of cell adhesion	IDA	12084985
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046850	Process	Regulation of bone remodeling	IEA
GO:0046850	Process	Regulation of bone remodeling	ISS
GO:0048477	Process	Oogenesis	IEA
GO:0048477	Process	Oogenesis	ISS
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IDA	27445335
GO:0048714	Process	Positive regulation of oligodendrocyte differentiation	IEA
GO:0050729	Process	Positive regulation of inflammatory response	IMP	22323540
GO:0050795	Process	Regulation of behavior	IEA
GO:0051384	Process	Response to glucocorticoid	IEA
GO:0051781	Process	Positive regulation of cell division	IEA
GO:0061036	Process	Positive regulation of cartilage development	IEA
GO:0061036	Process	Positive regulation of cartilage development	ISS
GO:0071673	Process	Positive regulation of smooth muscle cell chemotaxis	IMP	10683378
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	IEA
GO:0090023	Process	Positive regulation of neutrophil chemotaxis	ISS
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	ISS
GO:0106015	Process	Negative regulation of inflammatory response to wounding	IEA
GO:0106015	Process	Negative regulation of inflammatory response to wounding	ISS
GO:0106016	Process	Positive regulation of inflammatory response to wounding	IEA
GO:0106016	Process	Positive regulation of inflammatory response to wounding	ISS
GO:0106091	Process	Glial cell projection elongation	IEA
GO:0106091	Process	Glial cell projection elongation	ISS
GO:1900026	Process	Positive regulation of substrate adhesion-dependent cell spreading	IEA
GO:1900026	Process	Positive regulation of substrate adhesion-dependent cell spreading	ISS
GO:1903039	Process	Positive regulation of leukocyte cell-cell adhesion	IMP	24458438
GO:1904036	Process	Negative regulation of epithelial cell apoptotic process	IEA
GO:1904036	Process	Negative regulation of epithelial cell apoptotic process	ISS
GO:1904399	Function	Heparan sulfate binding	IDA	12084985
GO:1904996	Process	Positive regulation of leukocyte adhesion to vascular endothelial cell	IEA
GO:1904996	Process	Positive regulation of leukocyte adhesion to vascular endothelial cell	ISS
GO:1905555	Process	Positive regulation of blood vessel branching	IMP	19060126
GO:1905564	Process	Positive regulation of vascular endothelial cell proliferation	IEA
GO:1905564	Process	Positive regulation of vascular endothelial cell proliferation	ISS
GO:1905653	Process	Positive regulation of artery morphogenesis	IEA
GO:1905653	Process	Positive regulation of artery morphogenesis	ISS
GO:2000179	Process	Positive regulation of neural precursor cell proliferation	IEA
GO:2000179	Process	Positive regulation of neural precursor cell proliferation	ISS
GO:2000347	Process	Positive regulation of hepatocyte proliferation	IEA
GO:2000347	Process	Positive regulation of hepatocyte proliferation	ISS
GO:2000391	Process	Positive regulation of neutrophil extravasation	IEA
GO:2000391	Process	Positive regulation of neutrophil extravasation	ISS
GO:2001224	Process	Positive regulation of neuron migration	IMP	10212223

MIM	HGNC	e!Ensembl
162096	6972	ENSG00000110492

Protein

UniProt ID

P21741

Protein name

Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein)

Protein function

Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:10212223, PubMed:10772929, PubMed:12084985, PubMed:12122009, PubMed:12573468, PubMed

PDB

1MKC , 1MKN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05196	PTN_MK_N	24 → 80	PTN/MK heparin-binding protein family, N-terminal domain	Domain
PF01091	PTN_MK_C	81 → 142	PTN/MK heparin-binding protein family, C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}.

Sequence

MQHRGFLLLTLLALLALTSAVAKKKDKVKKGGPGSECAEWAWGPCTPSSKDCGVGFREGT
CGAQTQRIRCRVPCNWKKEFGADCKYKFENWGACDGGTGTKVRQGTLKKARYNAQCQETI
RVTKPCTPKTKAKAKAKKGKGKD

Sequence length

143

Interactions

View interactions

	Reactome
			NOTCH2 Activation and Transmission of Signal to the Nucleus

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (81)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	22669742, 36721112
Adenoma	Stimulate	10408712
Alzheimer Disease	Associate	39380021
Ameloblastoma	Associate	22986245, 29383694
Astrocytoma	Associate	23349846
Breast Neoplasms	Associate	26159850, 27511357, 36594100
Calcinosis Cutis	Stimulate	35503453
Carcinogenesis	Associate	10408712, 15160348, 17622248, 22099874, 27511357, 29176691
Carcinoma Hepatocellular	Associate	12966430, 15160348, 26414287, 27813495
Carcinoma Hepatocellular	Stimulate	23719264
Carcinoma Non Small Cell Lung	Associate	22669742, 27974680, 34272441, 36822449
Carcinoma Pancreatic Ductal	Stimulate	24567526
Carcinoma Squamous Cell	Associate	36438481
Cell Transformation Neoplastic	Associate	10469340, 33800494
Cholangiocarcinoma	Associate	29486735
Colorectal Neoplasms	Associate	10408712, 22562257
COVID 19	Associate	34723226
Death	Stimulate	26798989
Death	Associate	27974680
Dentigerous Cyst	Associate	29383694
Drug Related Side Effects and Adverse Reactions	Associate	18176965
Endometrial Neoplasms	Associate	18422745, 37081869
Endometriosis	Associate	27412246
Esophageal Neoplasms	Associate	10363587, 12841873
Esophageal Squamous Cell Carcinoma	Associate	12841873, 16610048
Gallbladder Neoplasms	Associate	34171432
Gastrointestinal Neoplasms	Associate	7559083, 9716029
Glioblastoma	Associate	30894197, 31811117
Glioma	Associate	17404502, 30894197
Head and Neck Neoplasms	Associate	17622248
Hepatoblastoma	Associate	39900120
Hypertension Portal	Associate	36628818
Hypoxia	Stimulate	24500281
Hypoxia Brain	Associate	24500281
Immune System Diseases	Associate	32153561
Immunoglobulin G4 Related Disease	Associate	32426497
Inflammation	Associate	24039874, 32153561, 9378726
Inflammation	Stimulate	36364277
Lung Diseases	Associate	24500281
Lung Neoplasms	Associate	31034948
Lupus Erythematosus Systemic	Associate	32153561
Lymphatic Metastasis	Stimulate	24659893
Lymphatic Metastasis	Inhibit	29113102
Melanoma	Associate	23543055
Melanoma	Inhibit	26032414
Meningioma	Stimulate	17181554
Mesothelioma Malignant	Associate	33800494
Mouth Diseases	Associate	36216310
Mouth Neoplasms	Associate	10408712
Neoplasm Metastasis	Associate	17622248, 22099874, 35503453, 37335089, 9716029
Neoplasm Metastasis	Stimulate	36438481
Neoplasms	Associate	10408712, 12841873, 16610048, 17171794, 18682710, 18985819, 19016768, 22099874, 22415659, 22562257, 22576950, 22986245, 23349846, 24567526, 24659893 View all (19 more)
Neoplasms	Stimulate	17622248, 28102487, 32671980
Neoplasms	Inhibit	28982154
Neoplasms Squamous Cell	Associate	12841873
Neuroblastoma	Stimulate	19016768
Neuroblastoma	Associate	26687816
Neurofibroma	Associate	10469340
Neurofibromatosis 1	Associate	10469340
Odontogenic Cysts	Associate	29383694
Odontogenic Tumors	Associate	18329695, 29383694
Osteosarcoma	Associate	22099874, 25613065
Ovarian Neoplasms	Associate	17900261, 22249249
Pancreatic Neoplasms	Associate	18717994, 24567526, 24659893
Phenylketonurias	Associate	30115106
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	26352402, 38350028
Prostatic Neoplasms	Associate	36018546
Rectal Neoplasms	Associate	22562257
Rhabdoid Tumor Predisposition Syndrome 1	Associate	26998479
Sarcoma Alveolar Soft Part	Associate	19146682
Serositis	Associate	32153561
Squamous Cell Carcinoma of Head and Neck	Stimulate	18682710
Squamous Cell Carcinoma of Head and Neck	Associate	26798989, 29113102, 32671980
Stomach Neoplasms	Associate	15649256, 17484808, 22415659, 22576950, 9310258
Synovitis	Associate	9378726
Tarlov Cysts	Associate	24659893
Thyroid Cancer Papillary	Associate	11752453, 37733241
Thyroid Cancer Papillary	Stimulate	25411136
Urinary Bladder Neoplasms	Stimulate	23591195
Uveal melanoma	Associate	35503453
Ventricular Remodeling	Stimulate	32701210

MDK (midkine)