Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
4192
Gene name Gene Name - the full gene name approved by the HGNC.
Midkine
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MDK
Synonyms (NCBI Gene) Gene synonyms aliases
ARAP, MK, NEGF2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11p11.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targete
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT022440 hsa-miR-124-3p Microarray 18668037
MIRT050887 hsa-miR-17-5p CLASH 23622248
MIRT040730 hsa-miR-92b-3p CLASH 23622248
MIRT036299 hsa-miR-1229-3p CLASH 23622248
MIRT022440 hsa-miR-124-3p PAR-CLIP 27292025
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0002232 Process Leukocyte chemotaxis involved in inflammatory response IMP 10683378
GO:0002232 Process Leukocyte chemotaxis involved in inflammatory response ISS
GO:0002286 Process T cell activation involved in immune response ISS
GO:0002690 Process Positive regulation of leukocyte chemotaxis ISS
GO:0005515 Function Protein binding IPI 10212223, 10772929, 12084985, 12147681, 12573468, 15466886, 18469519, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
162096 6972 ENSG00000110492
Protein
UniProt ID P21741
Protein name Midkine (MK) (Amphiregulin-associated protein) (ARAP) (Midgestation and kidney protein) (Neurite outgrowth-promoting factor 2) (Neurite outgrowth-promoting protein)
Protein function Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:10212223, PubMed:10772929, PubMed:12084985, PubMed:12122009, PubMed:12573468, PubMed
PDB 1MKC , 1MKN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05196 PTN_MK_N 24 80 PTN/MK heparin-binding protein family, N-terminal domain Domain
PF01091 PTN_MK_C 81 142 PTN/MK heparin-binding protein family, C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in various tumor cell lines. In insulinoma tissue predominantly expressed in precancerous lesions. {ECO:0000269|PubMed:17379400}.
Sequence
Sequence length 143
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    NOTCH2 Activation and Transmission of Signal to the Nucleus
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Glioma Glioma, mixed gliomas, Malignant Glioma rs121909219, rs121909224, rs587776667, rs587776671, rs121909239, rs121909241, rs28933368, rs121913500, rs55863639, rs786201995, rs786202517, rs786201044, rs398123317, rs1057518425, rs121913499
View all (13 more)
21233844
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
21747397, 28540026, 30285260
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 22669742, 36721112
Adenoma Stimulate 10408712
Alzheimer Disease Associate 39380021
Ameloblastoma Associate 22986245, 29383694
Astrocytoma Associate 23349846
Breast Neoplasms Associate 26159850, 27511357, 36594100
Calcinosis Cutis Stimulate 35503453
Carcinogenesis Associate 10408712, 15160348, 17622248, 22099874, 27511357, 29176691
Carcinoma Hepatocellular Associate 12966430, 15160348, 26414287, 27813495
Carcinoma Hepatocellular Stimulate 23719264