Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	4190
Gene name Gene Name - the full gene name approved by the HGNC.	Malate dehydrogenase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	MDH1
Synonyms (NCBI Gene) Gene synonyms aliases	DEE88, EIEE88, HEL-S-32, KAR, MDH-s, MDHA, MGC:1375, MOR2
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p15
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028752	hsa-miR-26b-5p	Microarray	19088304
MIRT046497	hsa-miR-15b-5p	CLASH	23622248
MIRT045287	hsa-miR-186-5p	CLASH	23622248
MIRT1138602	hsa-miR-3662	CLIP-seq
MIRT1138603	hsa-miR-4719	CLIP-seq
MIRT1138604	hsa-miR-486-5p	CLIP-seq
MIRT1138605	hsa-miR-513b	CLIP-seq
MIRT1138606	hsa-miR-616	CLIP-seq
MIRT1138607	hsa-miR-649	CLIP-seq
MIRT1138608	hsa-miR-548g	CLIP-seq
MIRT1138602	hsa-miR-3662	CLIP-seq
MIRT1138603	hsa-miR-4719	CLIP-seq
MIRT1138609	hsa-miR-4760-5p	CLIP-seq
MIRT1138604	hsa-miR-486-5p	CLIP-seq
MIRT1138605	hsa-miR-513b	CLIP-seq
MIRT1138608	hsa-miR-548g	CLIP-seq
MIRT1138606	hsa-miR-616	CLIP-seq
MIRT1138610	hsa-miR-627	CLIP-seq
MIRT1138607	hsa-miR-649	CLIP-seq
MIRT2039329	hsa-miR-1263	CLIP-seq
MIRT1138610	hsa-miR-627	CLIP-seq
MIRT2269403	hsa-miR-127-5p	CLIP-seq
MIRT1138603	hsa-miR-4719	CLIP-seq
MIRT1138609	hsa-miR-4760-5p	CLIP-seq
MIRT1138604	hsa-miR-486-5p	CLIP-seq
MIRT1138605	hsa-miR-513b	CLIP-seq
MIRT1138608	hsa-miR-548g	CLIP-seq
MIRT1138606	hsa-miR-616	CLIP-seq
MIRT1138607	hsa-miR-649	CLIP-seq
MIRT2269404	hsa-miR-802	CLIP-seq
MIRT2568589	hsa-miR-1179	CLIP-seq
MIRT2039329	hsa-miR-1263	CLIP-seq
MIRT2269403	hsa-miR-127-5p	CLIP-seq
MIRT1138602	hsa-miR-3662	CLIP-seq
MIRT2568590	hsa-miR-4457	CLIP-seq
MIRT1138603	hsa-miR-4719	CLIP-seq
MIRT1138609	hsa-miR-4760-5p	CLIP-seq
MIRT2568591	hsa-miR-4795-3p	CLIP-seq
MIRT1138604	hsa-miR-486-5p	CLIP-seq
MIRT2568592	hsa-miR-5096	CLIP-seq
MIRT1138605	hsa-miR-513b	CLIP-seq
MIRT1138606	hsa-miR-616	CLIP-seq
MIRT1138610	hsa-miR-627	CLIP-seq
MIRT1138607	hsa-miR-649	CLIP-seq
MIRT2269404	hsa-miR-802	CLIP-seq
MIRT2568589	hsa-miR-1179	CLIP-seq
MIRT2039329	hsa-miR-1263	CLIP-seq
MIRT2269403	hsa-miR-127-5p	CLIP-seq
MIRT1138602	hsa-miR-3662	CLIP-seq
MIRT2568590	hsa-miR-4457	CLIP-seq
MIRT1138603	hsa-miR-4719	CLIP-seq
MIRT1138609	hsa-miR-4760-5p	CLIP-seq
MIRT2568591	hsa-miR-4795-3p	CLIP-seq
MIRT1138604	hsa-miR-486-5p	CLIP-seq
MIRT2568592	hsa-miR-5096	CLIP-seq
MIRT1138605	hsa-miR-513b	CLIP-seq
MIRT1138606	hsa-miR-616	CLIP-seq
MIRT1138610	hsa-miR-627	CLIP-seq
MIRT1138607	hsa-miR-649	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003824	Function	Catalytic activity	IEA
GO:0004470	Function	Malic enzyme activity	TAS	8786100
GO:0005515	Function	Protein binding	IPI	21044950
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005737	Component	Cytoplasm	IDA	34547241
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS	8786100
GO:0006099	Process	Tricarboxylic acid cycle	IBA
GO:0006099	Process	Tricarboxylic acid cycle	IEA
GO:0006107	Process	Oxaloacetate metabolic process	IBA
GO:0006108	Process	Malate metabolic process	IBA
GO:0006108	Process	Malate metabolic process	IEA
GO:0006739	Process	NADP+ metabolic process	IDA	34547241
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016615	Function	Malate dehydrogenase activity	IEA
GO:0016616	Function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA
GO:0019674	Process	NAD+ metabolic process	IBA
GO:0019674	Process	NAD+ metabolic process	IDA	34547241
GO:0019674	Process	NAD+ metabolic process	IEA
GO:0019752	Process	Carboxylic acid metabolic process	IEA
GO:0030060	Function	L-malate dehydrogenase (NAD+) activity	EXP	3052244
GO:0030060	Function	L-malate dehydrogenase (NAD+) activity	IBA
GO:0030060	Function	L-malate dehydrogenase (NAD+) activity	IEA
GO:0043490	Process	Malate-aspartate shuttle	IEA
GO:0043490	Process	Malate-aspartate shuttle	IMP	37647199
GO:0043490	Process	Malate-aspartate shuttle	TAS
GO:0047860	Function	Diiodophenylpyruvate reductase (NAD+) activity	IEA
GO:0047995	Function	(2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
154200	6970	ENSG00000014641

Protein

UniProt ID

P40925

Protein name

Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)

Protein function

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxi

PDB

7RM9 , 7RRL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00056	Ldh_1_N	5 → 153	lactate/malate dehydrogenase, NAD binding domain	Family
PF02866	Ldh_1_C	156 → 331	lactate/malate dehydrogenase, alpha/beta C-terminal domain	Domain

Sequence

MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDC
ALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYA
KKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKN
VIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKL
SSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFV
EGLPINDFSREKMDLTAKELTEEKESAFEFLSSA

Sequence length

334

Interactions

View interactions

	KEGG		Reactome
	Citrate cycle (TCA cycle) Cysteine and methionine metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways Carbon metabolism Proximal tubule bicarbonate reclamation		Gluconeogenesis

MDH1 (malate dehydrogenase 1)