MCC (MCC regulator of Wnt signaling pathway)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 4163 |
| Gene name | MCC regulator of Wnt signaling pathway |
| Gene symbol | MCC |
| Synonyms (NCBI Gene) |
MCC1
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| Chromosome | 5 |
| Chromosome location | 5q22.2 |
| Summary | This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpr |
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SNPs
SNP information provided by dbSNP.
2
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miRNA
miRNA information provided by mirtarbase database.
689
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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P23508 | |||||||||||||||
| Protein name | Colorectal mutant cancer protein (Protein MCC) | |||||||||||||||
| Protein function | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cel | |||||||||||||||
| PDB | 6MTU , 6MTV | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in a variety of tissues. | |||||||||||||||
| Sequence |
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| Sequence length | 829 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
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