Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	4149
Gene name	MYC associated factor X
Gene symbol	MAX
Synonyms (NCBI Gene)	PDMCSbHLHd4
Chromosome	14
Chromosome location	14q23.3
Summary	The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncopro

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SNP ID	Visualize variation	Clinical significance	Consequence
rs387906649	T>C	Risk-factor, pathogenic	Upstream transcript variant, genic upstream transcript variant, intron variant, initiator codon variant, missense variant, non coding transcript variant, 5 prime UTR variant
rs387906650	G>A	Risk-factor, pathogenic	Coding sequence variant, intron variant, genic downstream transcript variant, stop gained, non coding transcript variant, 5 prime UTR variant
rs587781931	->T	Likely-pathogenic, pathogenic	Intron variant, frameshift variant, 5 prime UTR variant, coding sequence variant, genic downstream transcript variant, non coding transcript variant
rs752477890	C>A	Pathogenic	Stop gained, intron variant, non coding transcript variant, genic upstream transcript variant, 5 prime UTR variant, upstream transcript variant, coding sequence variant
rs786203385	C>T	Pathogenic, risk-factor	Intron variant, splice donor variant, non coding transcript variant, genic downstream transcript variant
rs876659610	A>T	Likely-pathogenic	Coding sequence variant, 5 prime UTR variant, non coding transcript variant, missense variant, intron variant, genic downstream transcript variant
rs876660073	G>A,T	Pathogenic	Coding sequence variant, stop gained, 3 prime UTR variant, non coding transcript variant, missense variant, intron variant, genic downstream transcript variant
rs1060500101	ACTGGATATAT>-	Pathogenic	Intron variant, genic downstream transcript variant, frameshift variant, non coding transcript variant, coding sequence variant, 5 prime UTR variant
rs1167538050	G>A	Likely-pathogenic, pathogenic	Intron variant, genic downstream transcript variant, non coding transcript variant, coding sequence variant, stop gained, synonymous variant
rs1193255946	A>G,T	Pathogenic	Synonymous variant, 5 prime UTR variant, coding sequence variant, non coding transcript variant, intron variant, stop gained, genic downstream transcript variant
rs1555340550	C>-	Pathogenic	5 prime UTR variant, coding sequence variant, intron variant, frameshift variant, non coding transcript variant, genic downstream transcript variant
rs1566600827	T>-	Risk-factor	5 prime UTR variant, coding sequence variant, intron variant, frameshift variant, non coding transcript variant, genic downstream transcript variant
rs1595130972	G>-	Likely-pathogenic	Frameshift variant, coding sequence variant, genic downstream transcript variant, 5 prime UTR variant, intron variant, non coding transcript variant

500

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016436	hsa-miR-193b-3p	Microarray	20304954
MIRT438021	hsa-miR-365a-3p	In situ hybridizationRTPCRLuciferase reporter assayMicroarrayWestern blot	24374827
MIRT016436	hsa-miR-193b-3p	In situ hybridizationRTPCRLuciferase reporter assayMicroarrayWestern blot	24374827
MIRT438021	hsa-miR-365a-3p	In situ hybridizationRTPCRLuciferase reporter assayMicroarrayWestern blot	24374827
MIRT016436	hsa-miR-193b-3p	In situ hybridizationRTPCRLuciferase reporter assayMicroarrayWestern blot	24374827
MIRT623295	hsa-miR-548ac	HITS-CLIP	23824327
MIRT623294	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT623293	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT623292	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT623291	hsa-miR-548z	HITS-CLIP	23824327
MIRT623290	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT623289	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT623288	hsa-miR-3148	HITS-CLIP	23824327
MIRT623287	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT473541	hsa-miR-4428	PAR-CLIP	23592263
MIRT473540	hsa-miR-5093	PAR-CLIP	23592263
MIRT473539	hsa-miR-4533	PAR-CLIP	23592263
MIRT473538	hsa-miR-4271	PAR-CLIP	23592263
MIRT473537	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT473536	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT473535	hsa-miR-6755-3p	PAR-CLIP	23592263
MIRT473534	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT473533	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT473532	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT473531	hsa-miR-2110	PAR-CLIP	23592263
MIRT473530	hsa-miR-3912-5p	PAR-CLIP	23592263
MIRT030633	hsa-miR-22-3p	PAR-CLIP	23592263
MIRT473529	hsa-miR-320a	PAR-CLIP	23592263
MIRT473528	hsa-miR-320b	PAR-CLIP	23592263
MIRT473527	hsa-miR-320c	PAR-CLIP	23592263
MIRT473526	hsa-miR-320d	PAR-CLIP	23592263
MIRT473525	hsa-miR-4429	PAR-CLIP	23592263
MIRT473523	hsa-miR-4259	PAR-CLIP	23592263
MIRT473524	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT473522	hsa-miR-4480	PAR-CLIP	23592263
MIRT473521	hsa-miR-4651	PAR-CLIP	23592263
MIRT473520	hsa-miR-608	PAR-CLIP	23592263
MIRT473519	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT473518	hsa-miR-609	PAR-CLIP	23592263
MIRT473517	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT473516	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT473515	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT473514	hsa-miR-3170	PAR-CLIP	23592263
MIRT473512	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT473513	hsa-miR-5572	PAR-CLIP	23592263
MIRT030633	hsa-miR-22-3p	qRT-PCR	31578247
MIRT623295	hsa-miR-548ac	HITS-CLIP	23824327
MIRT623294	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT623293	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT623292	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT623291	hsa-miR-548z	HITS-CLIP	23824327
MIRT623290	hsa-miR-548as-3p	HITS-CLIP	23824327
MIRT623289	hsa-miR-651-3p	HITS-CLIP	23824327
MIRT623288	hsa-miR-3148	HITS-CLIP	23824327
MIRT623287	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT473541	hsa-miR-4428	PAR-CLIP	23592263
MIRT473540	hsa-miR-5093	PAR-CLIP	23592263
MIRT473539	hsa-miR-4533	PAR-CLIP	23592263
MIRT473538	hsa-miR-4271	PAR-CLIP	23592263
MIRT473537	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT473536	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT473535	hsa-miR-6755-3p	PAR-CLIP	23592263
MIRT473534	hsa-let-7f-2-3p	PAR-CLIP	23592263
MIRT473533	hsa-miR-1185-1-3p	PAR-CLIP	23592263
MIRT473532	hsa-miR-1185-2-3p	PAR-CLIP	23592263
MIRT473531	hsa-miR-2110	PAR-CLIP	23592263
MIRT473530	hsa-miR-3912-5p	PAR-CLIP	23592263
MIRT030633	hsa-miR-22-3p	PAR-CLIP	23592263
MIRT473529	hsa-miR-320a	PAR-CLIP	23592263
MIRT473528	hsa-miR-320b	PAR-CLIP	23592263
MIRT473527	hsa-miR-320c	PAR-CLIP	23592263
MIRT473526	hsa-miR-320d	PAR-CLIP	23592263
MIRT473525	hsa-miR-4429	PAR-CLIP	23592263
MIRT473523	hsa-miR-4259	PAR-CLIP	23592263
MIRT473524	hsa-miR-140-3p	PAR-CLIP	23592263
MIRT473522	hsa-miR-4480	PAR-CLIP	23592263
MIRT473521	hsa-miR-4651	PAR-CLIP	23592263
MIRT473520	hsa-miR-608	PAR-CLIP	23592263
MIRT473519	hsa-miR-6747-5p	PAR-CLIP	23592263
MIRT473518	hsa-miR-609	PAR-CLIP	23592263
MIRT473517	hsa-miR-6737-5p	PAR-CLIP	23592263
MIRT473516	hsa-miR-6812-5p	PAR-CLIP	23592263
MIRT473515	hsa-miR-6819-5p	PAR-CLIP	23592263
MIRT473514	hsa-miR-3170	PAR-CLIP	23592263
MIRT473512	hsa-miR-6855-5p	PAR-CLIP	23592263
MIRT473513	hsa-miR-5572	PAR-CLIP	23592263
MIRT1134568	hsa-miR-2052	CLIP-seq
MIRT1134569	hsa-miR-299-5p	CLIP-seq
MIRT1134570	hsa-miR-302f	CLIP-seq
MIRT1134571	hsa-miR-3621	CLIP-seq
MIRT1134572	hsa-miR-3656	CLIP-seq
MIRT1134573	hsa-miR-4699-3p	CLIP-seq
MIRT1134574	hsa-miR-4715-5p	CLIP-seq
MIRT1134575	hsa-miR-548c-3p	CLIP-seq
MIRT1134576	hsa-miR-629	CLIP-seq
MIRT1134577	hsa-miR-659	CLIP-seq
MIRT1134578	hsa-miR-760	CLIP-seq
MIRT1134579	hsa-miR-105	CLIP-seq
MIRT1134580	hsa-miR-1276	CLIP-seq
MIRT1134581	hsa-miR-1285	CLIP-seq
MIRT1134582	hsa-miR-1291	CLIP-seq
MIRT1134583	hsa-miR-1323	CLIP-seq
MIRT1134584	hsa-miR-193a-3p	CLIP-seq
MIRT1134585	hsa-miR-193b	CLIP-seq
MIRT1134570	hsa-miR-302f	CLIP-seq
MIRT1134586	hsa-miR-3141	CLIP-seq
MIRT1134587	hsa-miR-3187-5p	CLIP-seq
MIRT1134588	hsa-miR-328	CLIP-seq
MIRT1134589	hsa-miR-361-5p	CLIP-seq
MIRT1134590	hsa-miR-3616-3p	CLIP-seq
MIRT1134591	hsa-miR-4257	CLIP-seq
MIRT1134592	hsa-miR-4303	CLIP-seq
MIRT1134593	hsa-miR-4311	CLIP-seq
MIRT1134594	hsa-miR-4420	CLIP-seq
MIRT1134595	hsa-miR-4459	CLIP-seq
MIRT1134596	hsa-miR-4496	CLIP-seq
MIRT1134597	hsa-miR-4640-5p	CLIP-seq
MIRT1134598	hsa-miR-4642	CLIP-seq
MIRT1134599	hsa-miR-4649-3p	CLIP-seq
MIRT1134600	hsa-miR-4694-3p	CLIP-seq
MIRT1134601	hsa-miR-4695-5p	CLIP-seq
MIRT1134573	hsa-miR-4699-3p	CLIP-seq
MIRT1134602	hsa-miR-4704-5p	CLIP-seq
MIRT1134603	hsa-miR-4710	CLIP-seq
MIRT1134604	hsa-miR-4715-3p	CLIP-seq
MIRT1134574	hsa-miR-4715-5p	CLIP-seq
MIRT1134605	hsa-miR-4717-5p	CLIP-seq
MIRT1134606	hsa-miR-4719	CLIP-seq
MIRT1134607	hsa-miR-4720-5p	CLIP-seq
MIRT1134608	hsa-miR-4721	CLIP-seq
MIRT1134609	hsa-miR-4726-5p	CLIP-seq
MIRT1134610	hsa-miR-4755-3p	CLIP-seq
MIRT1134611	hsa-miR-4789-5p	CLIP-seq
MIRT1134612	hsa-miR-4799-3p	CLIP-seq
MIRT1134613	hsa-miR-522	CLIP-seq
MIRT1134614	hsa-miR-545	CLIP-seq
MIRT1134615	hsa-miR-548o	CLIP-seq
MIRT1134616	hsa-miR-583	CLIP-seq
MIRT1134617	hsa-miR-612	CLIP-seq
MIRT1134618	hsa-miR-665	CLIP-seq
MIRT1134578	hsa-miR-760	CLIP-seq
MIRT1134619	hsa-miR-873	CLIP-seq
MIRT1134579	hsa-miR-105	CLIP-seq
MIRT1134620	hsa-miR-1197	CLIP-seq
MIRT1134621	hsa-miR-1255a	CLIP-seq
MIRT1134622	hsa-miR-1255b	CLIP-seq
MIRT1134623	hsa-miR-1286	CLIP-seq
MIRT1134624	hsa-miR-3117-5p	CLIP-seq
MIRT1134625	hsa-miR-335	CLIP-seq
MIRT1134626	hsa-miR-339-5p	CLIP-seq
MIRT1134590	hsa-miR-3616-3p	CLIP-seq
MIRT1134627	hsa-miR-3672	CLIP-seq
MIRT1134628	hsa-miR-4329	CLIP-seq
MIRT1134629	hsa-miR-4436a	CLIP-seq
MIRT1134630	hsa-miR-4446-3p	CLIP-seq
MIRT1134631	hsa-miR-4492	CLIP-seq
MIRT1134596	hsa-miR-4496	CLIP-seq
MIRT1134632	hsa-miR-4498	CLIP-seq
MIRT1134633	hsa-miR-4505	CLIP-seq
MIRT1134634	hsa-miR-4645-3p	CLIP-seq
MIRT1134635	hsa-miR-4654	CLIP-seq
MIRT1134636	hsa-miR-4690-5p	CLIP-seq
MIRT1134602	hsa-miR-4704-5p	CLIP-seq
MIRT1134604	hsa-miR-4715-3p	CLIP-seq
MIRT1134608	hsa-miR-4721	CLIP-seq
MIRT1134610	hsa-miR-4755-3p	CLIP-seq
MIRT1134637	hsa-miR-4769-5p	CLIP-seq
MIRT1134611	hsa-miR-4789-5p	CLIP-seq
MIRT1134638	hsa-miR-4795-5p	CLIP-seq
MIRT1134639	hsa-miR-4797-5p	CLIP-seq
MIRT1134640	hsa-miR-541	CLIP-seq
MIRT1134614	hsa-miR-545	CLIP-seq
MIRT1134641	hsa-miR-562	CLIP-seq
MIRT1134642	hsa-miR-654-5p	CLIP-seq
MIRT1134618	hsa-miR-665	CLIP-seq
MIRT1134643	hsa-miR-762	CLIP-seq
MIRT1134619	hsa-miR-873	CLIP-seq
MIRT1134635	hsa-miR-4654	CLIP-seq
MIRT1134637	hsa-miR-4769-5p	CLIP-seq
MIRT1134638	hsa-miR-4795-5p	CLIP-seq
MIRT1134579	hsa-miR-105	CLIP-seq
MIRT2038314	hsa-miR-1207-5p	CLIP-seq
MIRT1134621	hsa-miR-1255a	CLIP-seq
MIRT1134622	hsa-miR-1255b	CLIP-seq
MIRT2038315	hsa-miR-3173-3p	CLIP-seq
MIRT2038316	hsa-miR-3186-5p	CLIP-seq
MIRT2038317	hsa-miR-3202	CLIP-seq
MIRT1134626	hsa-miR-339-5p	CLIP-seq
MIRT1134590	hsa-miR-3616-3p	CLIP-seq
MIRT1134571	hsa-miR-3621	CLIP-seq
MIRT1134572	hsa-miR-3656	CLIP-seq
MIRT2038318	hsa-miR-4253	CLIP-seq
MIRT2038319	hsa-miR-4286	CLIP-seq
MIRT2038320	hsa-miR-4436b-3p	CLIP-seq
MIRT1134630	hsa-miR-4446-3p	CLIP-seq
MIRT1134631	hsa-miR-4492	CLIP-seq
MIRT1134596	hsa-miR-4496	CLIP-seq
MIRT1134632	hsa-miR-4498	CLIP-seq
MIRT1134633	hsa-miR-4505	CLIP-seq
MIRT2038321	hsa-miR-455-5p	CLIP-seq
MIRT2038322	hsa-miR-4646-5p	CLIP-seq
MIRT1134635	hsa-miR-4654	CLIP-seq
MIRT2038323	hsa-miR-4696	CLIP-seq
MIRT1134608	hsa-miR-4721	CLIP-seq
MIRT2038324	hsa-miR-4747-5p	CLIP-seq
MIRT1134610	hsa-miR-4755-3p	CLIP-seq
MIRT2038325	hsa-miR-4763-3p	CLIP-seq
MIRT1134637	hsa-miR-4769-5p	CLIP-seq
MIRT1134638	hsa-miR-4795-5p	CLIP-seq
MIRT1134614	hsa-miR-545	CLIP-seq
MIRT1134576	hsa-miR-629	CLIP-seq
MIRT1134643	hsa-miR-762	CLIP-seq
MIRT1134619	hsa-miR-873	CLIP-seq
MIRT2268099	hsa-miR-1	CLIP-seq
MIRT1134621	hsa-miR-1255a	CLIP-seq
MIRT1134622	hsa-miR-1255b	CLIP-seq
MIRT2268100	hsa-miR-1324	CLIP-seq
MIRT2268101	hsa-miR-137	CLIP-seq
MIRT2268102	hsa-miR-139-3p	CLIP-seq
MIRT2268103	hsa-miR-1470	CLIP-seq
MIRT2268104	hsa-miR-150	CLIP-seq
MIRT2268105	hsa-miR-1913	CLIP-seq
MIRT2268106	hsa-miR-206	CLIP-seq
MIRT1134586	hsa-miR-3141	CLIP-seq
MIRT2268107	hsa-miR-3176	CLIP-seq
MIRT2038317	hsa-miR-3202	CLIP-seq
MIRT2268108	hsa-miR-324-3p	CLIP-seq
MIRT2268109	hsa-miR-329	CLIP-seq
MIRT1134626	hsa-miR-339-5p	CLIP-seq
MIRT2268110	hsa-miR-342-5p	CLIP-seq
MIRT2268111	hsa-miR-3605-3p	CLIP-seq
MIRT1134590	hsa-miR-3616-3p	CLIP-seq
MIRT2268112	hsa-miR-362-3p	CLIP-seq
MIRT2268113	hsa-miR-3673	CLIP-seq
MIRT2268114	hsa-miR-3913-3p	CLIP-seq
MIRT2268115	hsa-miR-3922-3p	CLIP-seq
MIRT2268116	hsa-miR-3941	CLIP-seq
MIRT2268117	hsa-miR-3942-3p	CLIP-seq
MIRT1134591	hsa-miR-4257	CLIP-seq
MIRT2268118	hsa-miR-4290	CLIP-seq
MIRT2268119	hsa-miR-4315	CLIP-seq
MIRT2268120	hsa-miR-4328	CLIP-seq
MIRT1134630	hsa-miR-4446-3p	CLIP-seq
MIRT1134595	hsa-miR-4459	CLIP-seq
MIRT1134631	hsa-miR-4492	CLIP-seq
MIRT1134596	hsa-miR-4496	CLIP-seq
MIRT1134632	hsa-miR-4498	CLIP-seq
MIRT1134633	hsa-miR-4505	CLIP-seq
MIRT2268121	hsa-miR-450b-5p	CLIP-seq
MIRT2268122	hsa-miR-4534	CLIP-seq
MIRT2038321	hsa-miR-455-5p	CLIP-seq
MIRT1134597	hsa-miR-4640-5p	CLIP-seq
MIRT2038322	hsa-miR-4646-5p	CLIP-seq
MIRT1134635	hsa-miR-4654	CLIP-seq
MIRT2268123	hsa-miR-4664-5p	CLIP-seq
MIRT2268124	hsa-miR-4681	CLIP-seq
MIRT1134636	hsa-miR-4690-5p	CLIP-seq
MIRT2268125	hsa-miR-4693-3p	CLIP-seq
MIRT1134601	hsa-miR-4695-5p	CLIP-seq
MIRT2038323	hsa-miR-4696	CLIP-seq
MIRT1134603	hsa-miR-4710	CLIP-seq
MIRT2268126	hsa-miR-4713-5p	CLIP-seq
MIRT1134604	hsa-miR-4715-3p	CLIP-seq
MIRT1134606	hsa-miR-4719	CLIP-seq
MIRT1134608	hsa-miR-4721	CLIP-seq
MIRT1134609	hsa-miR-4726-5p	CLIP-seq
MIRT2038324	hsa-miR-4747-5p	CLIP-seq
MIRT2268127	hsa-miR-4763-5p	CLIP-seq
MIRT2268128	hsa-miR-4769-3p	CLIP-seq
MIRT1134637	hsa-miR-4769-5p	CLIP-seq
MIRT2268129	hsa-miR-4790-5p	CLIP-seq
MIRT1134638	hsa-miR-4795-5p	CLIP-seq
MIRT2268130	hsa-miR-513b	CLIP-seq
MIRT2268131	hsa-miR-532-3p	CLIP-seq
MIRT1134641	hsa-miR-562	CLIP-seq
MIRT2268132	hsa-miR-587	CLIP-seq
MIRT2268133	hsa-miR-597	CLIP-seq
MIRT2268134	hsa-miR-602	CLIP-seq
MIRT2268135	hsa-miR-603	CLIP-seq
MIRT2268136	hsa-miR-613	CLIP-seq
MIRT1134618	hsa-miR-665	CLIP-seq
MIRT1134643	hsa-miR-762	CLIP-seq
MIRT1134579	hsa-miR-105	CLIP-seq
MIRT2567810	hsa-miR-1202	CLIP-seq
MIRT2567811	hsa-miR-1207-3p	CLIP-seq
MIRT1134621	hsa-miR-1255a	CLIP-seq
MIRT1134622	hsa-miR-1255b	CLIP-seq
MIRT2567812	hsa-miR-1287	CLIP-seq
MIRT1134582	hsa-miR-1291	CLIP-seq
MIRT1134583	hsa-miR-1323	CLIP-seq
MIRT2268101	hsa-miR-137	CLIP-seq
MIRT2268103	hsa-miR-1470	CLIP-seq
MIRT2268104	hsa-miR-150	CLIP-seq
MIRT2268105	hsa-miR-1913	CLIP-seq
MIRT1134584	hsa-miR-193a-3p	CLIP-seq
MIRT1134585	hsa-miR-193b	CLIP-seq
MIRT2567813	hsa-miR-2467-5p	CLIP-seq
MIRT2567814	hsa-miR-28-5p	CLIP-seq
MIRT1134570	hsa-miR-302f	CLIP-seq
MIRT2567815	hsa-miR-3064-5p	CLIP-seq
MIRT2567816	hsa-miR-3139	CLIP-seq
MIRT2567817	hsa-miR-3144-3p	CLIP-seq
MIRT2268107	hsa-miR-3176	CLIP-seq
MIRT2567818	hsa-miR-3188	CLIP-seq
MIRT2567819	hsa-miR-3194-5p	CLIP-seq
MIRT2038317	hsa-miR-3202	CLIP-seq
MIRT2268108	hsa-miR-324-3p	CLIP-seq
MIRT1134588	hsa-miR-328	CLIP-seq
MIRT1134626	hsa-miR-339-5p	CLIP-seq
MIRT2268110	hsa-miR-342-5p	CLIP-seq
MIRT2268111	hsa-miR-3605-3p	CLIP-seq
MIRT1134590	hsa-miR-3616-3p	CLIP-seq
MIRT1134571	hsa-miR-3621	CLIP-seq
MIRT2567820	hsa-miR-3652	CLIP-seq
MIRT1134572	hsa-miR-3656	CLIP-seq
MIRT2567821	hsa-miR-3663-5p	CLIP-seq
MIRT2567822	hsa-miR-3664-5p	CLIP-seq
MIRT2567823	hsa-miR-3671	CLIP-seq
MIRT1134627	hsa-miR-3672	CLIP-seq
MIRT2567824	hsa-miR-376c	CLIP-seq
MIRT2567825	hsa-miR-377	CLIP-seq
MIRT2268114	hsa-miR-3913-3p	CLIP-seq
MIRT2268115	hsa-miR-3922-3p	CLIP-seq
MIRT2567826	hsa-miR-3972	CLIP-seq
MIRT2567827	hsa-miR-3975	CLIP-seq
MIRT2567828	hsa-miR-3977	CLIP-seq
MIRT2038319	hsa-miR-4286	CLIP-seq
MIRT2268118	hsa-miR-4290	CLIP-seq
MIRT2567829	hsa-miR-4292	CLIP-seq
MIRT2567830	hsa-miR-4308	CLIP-seq
MIRT2567831	hsa-miR-4316	CLIP-seq
MIRT2268120	hsa-miR-4328	CLIP-seq
MIRT2567832	hsa-miR-4330	CLIP-seq
MIRT1134594	hsa-miR-4420	CLIP-seq
MIRT2567833	hsa-miR-4430	CLIP-seq
MIRT2567834	hsa-miR-4431	CLIP-seq
MIRT2567835	hsa-miR-4433	CLIP-seq
MIRT1134629	hsa-miR-4436a	CLIP-seq
MIRT1134630	hsa-miR-4446-3p	CLIP-seq
MIRT2567836	hsa-miR-4456	CLIP-seq
MIRT2567837	hsa-miR-4466	CLIP-seq
MIRT1134631	hsa-miR-4492	CLIP-seq
MIRT1134596	hsa-miR-4496	CLIP-seq
MIRT1134632	hsa-miR-4498	CLIP-seq
MIRT1134633	hsa-miR-4505	CLIP-seq
MIRT2567838	hsa-miR-4521	CLIP-seq
MIRT2567839	hsa-miR-4522	CLIP-seq
MIRT1134598	hsa-miR-4642	CLIP-seq
MIRT1134634	hsa-miR-4645-3p	CLIP-seq
MIRT2038322	hsa-miR-4646-5p	CLIP-seq
MIRT1134635	hsa-miR-4654	CLIP-seq
MIRT2268123	hsa-miR-4664-5p	CLIP-seq
MIRT2567840	hsa-miR-4684-5p	CLIP-seq
MIRT2567841	hsa-miR-4685-5p	CLIP-seq
MIRT2567842	hsa-miR-4686	CLIP-seq
MIRT1134636	hsa-miR-4690-5p	CLIP-seq
MIRT1134573	hsa-miR-4699-3p	CLIP-seq
MIRT2567843	hsa-miR-4701-5p	CLIP-seq
MIRT1134602	hsa-miR-4704-5p	CLIP-seq
MIRT2268126	hsa-miR-4713-5p	CLIP-seq
MIRT1134604	hsa-miR-4715-3p	CLIP-seq
MIRT1134607	hsa-miR-4720-5p	CLIP-seq
MIRT1134608	hsa-miR-4721	CLIP-seq
MIRT2567844	hsa-miR-4722-5p	CLIP-seq
MIRT2038324	hsa-miR-4747-5p	CLIP-seq
MIRT1134610	hsa-miR-4755-3p	CLIP-seq
MIRT2268127	hsa-miR-4763-5p	CLIP-seq
MIRT2268128	hsa-miR-4769-3p	CLIP-seq
MIRT1134637	hsa-miR-4769-5p	CLIP-seq
MIRT1134611	hsa-miR-4789-5p	CLIP-seq
MIRT1134638	hsa-miR-4795-5p	CLIP-seq
MIRT1134639	hsa-miR-4797-5p	CLIP-seq
MIRT1134612	hsa-miR-4799-3p	CLIP-seq
MIRT2567845	hsa-miR-485-5p	CLIP-seq
MIRT2567846	hsa-miR-494	CLIP-seq
MIRT2268131	hsa-miR-532-3p	CLIP-seq
MIRT1134614	hsa-miR-545	CLIP-seq
MIRT1134615	hsa-miR-548o	CLIP-seq
MIRT1134641	hsa-miR-562	CLIP-seq
MIRT2567847	hsa-miR-566	CLIP-seq
MIRT2567848	hsa-miR-588	CLIP-seq
MIRT2567849	hsa-miR-604	CLIP-seq
MIRT2567850	hsa-miR-607	CLIP-seq
MIRT2567851	hsa-miR-628-5p	CLIP-seq
MIRT1134576	hsa-miR-629	CLIP-seq
MIRT2567852	hsa-miR-647	CLIP-seq
MIRT1134618	hsa-miR-665	CLIP-seq
MIRT2567853	hsa-miR-675	CLIP-seq
MIRT2567854	hsa-miR-708	CLIP-seq
MIRT1134643	hsa-miR-762	CLIP-seq
MIRT1134619	hsa-miR-873	CLIP-seq
MIRT2567855	hsa-miR-942	CLIP-seq
MIRT1134579	hsa-miR-105	CLIP-seq
MIRT2567810	hsa-miR-1202	CLIP-seq
MIRT2567811	hsa-miR-1207-3p	CLIP-seq
MIRT1134621	hsa-miR-1255a	CLIP-seq
MIRT1134622	hsa-miR-1255b	CLIP-seq
MIRT2567812	hsa-miR-1287	CLIP-seq
MIRT1134582	hsa-miR-1291	CLIP-seq
MIRT1134583	hsa-miR-1323	CLIP-seq
MIRT2268101	hsa-miR-137	CLIP-seq
MIRT2268103	hsa-miR-1470	CLIP-seq
MIRT2268104	hsa-miR-150	CLIP-seq
MIRT2268105	hsa-miR-1913	CLIP-seq
MIRT1134584	hsa-miR-193a-3p	CLIP-seq
MIRT1134585	hsa-miR-193b	CLIP-seq
MIRT2567813	hsa-miR-2467-5p	CLIP-seq
MIRT2567814	hsa-miR-28-5p	CLIP-seq
MIRT1134570	hsa-miR-302f	CLIP-seq
MIRT2567815	hsa-miR-3064-5p	CLIP-seq
MIRT2567816	hsa-miR-3139	CLIP-seq
MIRT2567817	hsa-miR-3144-3p	CLIP-seq
MIRT2268107	hsa-miR-3176	CLIP-seq
MIRT2567818	hsa-miR-3188	CLIP-seq
MIRT2567819	hsa-miR-3194-5p	CLIP-seq
MIRT2038317	hsa-miR-3202	CLIP-seq
MIRT2268108	hsa-miR-324-3p	CLIP-seq
MIRT1134588	hsa-miR-328	CLIP-seq
MIRT1134626	hsa-miR-339-5p	CLIP-seq
MIRT2268110	hsa-miR-342-5p	CLIP-seq
MIRT2268111	hsa-miR-3605-3p	CLIP-seq
MIRT1134590	hsa-miR-3616-3p	CLIP-seq
MIRT1134571	hsa-miR-3621	CLIP-seq
MIRT2567820	hsa-miR-3652	CLIP-seq
MIRT1134572	hsa-miR-3656	CLIP-seq
MIRT2567821	hsa-miR-3663-5p	CLIP-seq
MIRT2567822	hsa-miR-3664-5p	CLIP-seq
MIRT2567823	hsa-miR-3671	CLIP-seq
MIRT1134627	hsa-miR-3672	CLIP-seq
MIRT2567824	hsa-miR-376c	CLIP-seq
MIRT2567825	hsa-miR-377	CLIP-seq
MIRT2268114	hsa-miR-3913-3p	CLIP-seq
MIRT2268115	hsa-miR-3922-3p	CLIP-seq
MIRT2567826	hsa-miR-3972	CLIP-seq
MIRT2567827	hsa-miR-3975	CLIP-seq
MIRT2567828	hsa-miR-3977	CLIP-seq
MIRT2038319	hsa-miR-4286	CLIP-seq
MIRT2268118	hsa-miR-4290	CLIP-seq
MIRT2567829	hsa-miR-4292	CLIP-seq
MIRT2567830	hsa-miR-4308	CLIP-seq
MIRT2567831	hsa-miR-4316	CLIP-seq
MIRT2268120	hsa-miR-4328	CLIP-seq
MIRT2567832	hsa-miR-4330	CLIP-seq
MIRT1134594	hsa-miR-4420	CLIP-seq
MIRT2567833	hsa-miR-4430	CLIP-seq
MIRT2567834	hsa-miR-4431	CLIP-seq
MIRT1134629	hsa-miR-4436a	CLIP-seq
MIRT1134630	hsa-miR-4446-3p	CLIP-seq
MIRT2567836	hsa-miR-4456	CLIP-seq
MIRT2567837	hsa-miR-4466	CLIP-seq
MIRT1134631	hsa-miR-4492	CLIP-seq
MIRT1134596	hsa-miR-4496	CLIP-seq
MIRT1134632	hsa-miR-4498	CLIP-seq
MIRT1134633	hsa-miR-4505	CLIP-seq
MIRT2567838	hsa-miR-4521	CLIP-seq
MIRT2567839	hsa-miR-4522	CLIP-seq
MIRT1134598	hsa-miR-4642	CLIP-seq
MIRT1134634	hsa-miR-4645-3p	CLIP-seq
MIRT2038322	hsa-miR-4646-5p	CLIP-seq
MIRT1134635	hsa-miR-4654	CLIP-seq
MIRT2268123	hsa-miR-4664-5p	CLIP-seq
MIRT2567840	hsa-miR-4684-5p	CLIP-seq
MIRT2567841	hsa-miR-4685-5p	CLIP-seq
MIRT2567842	hsa-miR-4686	CLIP-seq
MIRT1134636	hsa-miR-4690-5p	CLIP-seq
MIRT2567843	hsa-miR-4701-5p	CLIP-seq
MIRT1134602	hsa-miR-4704-5p	CLIP-seq
MIRT2268126	hsa-miR-4713-5p	CLIP-seq
MIRT1134604	hsa-miR-4715-3p	CLIP-seq
MIRT1134607	hsa-miR-4720-5p	CLIP-seq
MIRT1134608	hsa-miR-4721	CLIP-seq
MIRT2567844	hsa-miR-4722-5p	CLIP-seq
MIRT2038324	hsa-miR-4747-5p	CLIP-seq
MIRT1134610	hsa-miR-4755-3p	CLIP-seq
MIRT2268127	hsa-miR-4763-5p	CLIP-seq
MIRT2268128	hsa-miR-4769-3p	CLIP-seq
MIRT1134637	hsa-miR-4769-5p	CLIP-seq
MIRT1134611	hsa-miR-4789-5p	CLIP-seq
MIRT1134638	hsa-miR-4795-5p	CLIP-seq
MIRT1134639	hsa-miR-4797-5p	CLIP-seq
MIRT1134612	hsa-miR-4799-3p	CLIP-seq
MIRT2567845	hsa-miR-485-5p	CLIP-seq
MIRT2567846	hsa-miR-494	CLIP-seq
MIRT2268131	hsa-miR-532-3p	CLIP-seq
MIRT1134614	hsa-miR-545	CLIP-seq
MIRT1134615	hsa-miR-548o	CLIP-seq
MIRT1134641	hsa-miR-562	CLIP-seq
MIRT2567847	hsa-miR-566	CLIP-seq
MIRT2567848	hsa-miR-588	CLIP-seq
MIRT2567849	hsa-miR-604	CLIP-seq
MIRT2567850	hsa-miR-607	CLIP-seq
MIRT2567851	hsa-miR-628-5p	CLIP-seq
MIRT1134576	hsa-miR-629	CLIP-seq
MIRT2567852	hsa-miR-647	CLIP-seq
MIRT1134618	hsa-miR-665	CLIP-seq
MIRT2567853	hsa-miR-675	CLIP-seq
MIRT2567854	hsa-miR-708	CLIP-seq
MIRT1134643	hsa-miR-762	CLIP-seq
MIRT1134619	hsa-miR-873	CLIP-seq
MIRT2567855	hsa-miR-942	CLIP-seq

Show/Hide all (39)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	8521822, 10723141
GO:0000785	Component	Chromatin	IDA	12837246
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	8425219, 8521822
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	8425218
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	8521822
GO:0001227	Function	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	26070438
GO:0003677	Function	DNA binding	IDA	9399572
GO:0003677	Function	DNA binding	IEA
GO:0003700	Function	DNA-binding transcription factor activity	IBA
GO:0005515	Function	Protein binding	IPI	9184233, 10597290, 16189514, 16352593, 16606833, 17157259, 17314511, 17418410, 18003922, 18620061, 20195357, 20691906, 20936779, 21150319, 21807113, 21988832, 23792191, 24951594, 24981860, 25175806, 25416956, 25609649, 26267534, 27705803, 27728805, 31515488, 32296183, 32814053, 3396
GO:0005634	Component	Nucleus	IDA	10723141, 15358760
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	8425218
GO:0005654	Component	Nucleoplasm	TAS
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	8425218
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0030425	Component	Dendrite	IEA
GO:0032993	Component	Protein-DNA complex	IDA	9399572
GO:0032993	Component	Protein-DNA complex	IMP	16171389
GO:0042802	Function	Identical protein binding	IPI	9184233, 25609649
GO:0042995	Component	Cell projection	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	8425218
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IBA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0046983	Function	Protein dimerization activity	IEA
GO:0070443	Component	Mad-Max complex	IPI	12553908
GO:0070888	Function	E-box binding	IMP	16171389
GO:0071339	Component	MLL1 complex	IDA	15960975
GO:0071943	Component	Myc-Max complex	IEA
GO:0071943	Component	Myc-Max complex	IPI	12553908
GO:0090575	Component	RNA polymerase II transcription regulator complex	IBA
GO:0090575	Component	RNA polymerase II transcription regulator complex	IDA	8425219, 8521822
GO:0140297	Function	DNA-binding transcription factor binding	IPI	15674325
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IDA	28473536

MIM	HGNC	e!Ensembl
154950	6913	ENSG00000125952

P61244

Protein name

Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)

Protein function

Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. Ma

PDB

1AN2 , 1HLO , 1NKP , 1NLW , 1R05 , 5EYO , 6G6J , 6G6K , 6G6L , 8OTS , 8OTT

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	24 → 75	Helix-loop-helix DNA-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: High levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.

Sequence

MSDNDDIEVESDEEQPRFQSAADKRAHHNALERKRRDHIKDSFHSLRDSVPSLQGEKASR
AQILDKATEYIQYMRRKNHTHQQDIDDLKRQNALLEQQVRALEKARSSAQLQTNYPSSDN
SLYTNAKGSTISAFDGGSDSSSESEPEEPQSRKKLRMEAS

Sequence length

160

Interactions

View interactions

	KEGG		Reactome
	Polycomb repressive complex MAPK signaling pathway Pathways in cancer Transcriptional misregulation in cancer Small cell lung cancer		Transcription of E2F targets under negative control by DREAM complex Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by E2F6

731

Show/Hide Causal Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Clear cell carcinoma of kidney	Pathogenic	rs2139756352	RCV005931918
Hereditary cancer-predisposing syndrome	Pathogenic; Likely pathogenic	rs786203385, rs587781931, rs1555340265, rs2139886995, rs2504407945, rs2504200802, rs2139756352, rs786202340, rs786203009, rs2063104349, rs2139752868, rs876660073, rs876659610, rs2504175252, rs2139755033 View all (9 more)	RCV002441105 RCV000130290 RCV002255959 RCV004948672 RCV002361709 RCV002407483 RCV002399074 RCV000166666 RCV000165100 RCV000166125 RCV002450501 RCV002431268 RCV000218866 RCV000222188 RCV003188031 RCV003297545 RCV003297547 RCV004513569 RCV000850061 RCV000129940 RCV000562852 RCV000572216 RCV002458041 RCV000850060 RCV001015116
Hereditary pheochromocytoma and paraganglioma	Likely pathogenic; Pathogenic	rs2139963878, rs2139886197, rs786203385, rs2139755167, rs587781931, rs2139886995, rs786202340, rs2139752868, rs2504199587, rs2504510600, rs2504176178, rs2504197333, rs387906650, rs387906651, rs1060500101 View all (7 more)	RCV001389671 RCV001960600 RCV001975100 RCV002002009 RCV005089640 RCV003096311 RCV001850351 RCV005089810 RCV005098264 RCV003043836 RCV003518148 RCV003516764 RCV003635300 RCV000524813 RCV000550085 RCV000461175 RCV000639335 RCV000639341 RCV000815462 RCV000808520 RCV001388072 RCV001044493 RCV001035732
Neoplasm	Pathogenic	rs387906650	RCV004668741
Ovarian serous cystadenocarcinoma	Likely pathogenic	rs1555340265	RCV005930099
Pheochromocytoma	Likely pathogenic; Pathogenic	rs2139963878, rs387906651	RCV003136061 RCV003328552
Pheochromocytoma, susceptibility to	Pathogenic	rs786203385, rs387906649, rs387906650, rs387906651	RCV000022654 RCV000022652 RCV000022653 RCV000022655

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Diffuse midline glioma, H3 K27M-mutant	Conflicting classifications of pathogenicity	rs2063106020	RCV006254245
Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype	Conflicting classifications of pathogenicity	rs2063106020	RCV006254244
Immature ovarian teratoma	Conflicting classifications of pathogenicity	rs2063106020	RCV006254246
Malignant lymphoma, large B-cell, diffuse	Benign	rs762810	RCV005924429
MAX-associated Macrocephaly and Polydactyly syndrome	Conflicting classifications of pathogenicity	rs2063106020	RCV003222266
MAX-related disorder	Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	rs201052112, rs768413473, rs775808138, rs2504173182, rs2139738950, rs368362953, rs141396269, rs370238588, rs200547781, rs145787299, rs148339628, rs2063106020	RCV003960969 RCV004753560 RCV004752807 RCV003402360 RCV003414446 RCV003983479 RCV003961846 RCV003960043 RCV003424008 RCV003970296 RCV003936245 RCV005250156
Neuroblastoma	Conflicting classifications of pathogenicity	rs2063106020	RCV006254243
Polydactyly-macrocephaly syndrome	Uncertain significance; Conflicting classifications of pathogenicity	rs769051095, rs775808138, rs779789251, rs771696396, rs2063106020	RCV005003566 RCV005008186 RCV005392308 RCV005010684 RCV003595722
Retinoblastoma	Conflicting classifications of pathogenicity	rs750459929	RCV000761172
Uterine carcinosarcoma	Benign	rs762810	RCV005924430

Show/Hide Text Mining Associations (16)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adrenal Hyperplasia Congenital	Associate	27838885
Carcinogenesis	Inhibit	26046465
Colorectal Neoplasms	Associate	32140074
Coronary Artery Disease	Associate	26936111
Drug Related Side Effects and Adverse Reactions	Associate	32587329
Gastrointestinal Stromal Tumors	Associate	26555092
Hyperplasia	Associate	27838885
Inflammation	Associate	34789272
Islet cell tumor syndrome	Associate	27838885
Lymphoma Large Cell Anaplastic	Associate	32587329
Lymphoma T Cell Peripheral	Associate	32587329
Megalencephaly	Associate	38141607
Myasthenia Gravis	Associate	34789272
Neoplasms	Inhibit	26555092
Pheochromocytoma	Associate	24925884, 27838885, 29534198
Simpson Golabi Behmel syndrome	Associate	38141607

MAX (MYC associated factor X)