Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	41
Gene name Gene Name - the full gene name approved by the HGNC.	Acid sensing ion channel subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ASIC1
Synonyms (NCBI Gene) Gene synonyms aliases	ACCN2, ASIC, BNaC2
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12q13.12
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission

Show/Hide all(1)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052268	hsa-let-7b-5p	CLASH	23622248

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001662	Process	Behavioral fear response	IEA
GO:0001975	Process	Response to amphetamine	IEA
GO:0005515	Function	Protein binding	IPI	11802773, 32296183
GO:0005794	Component	Golgi apparatus	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IMP	22760635
GO:0005887	Component	Integral component of plasma membrane	ISS
GO:0006814	Process	Sodium ion transport	NAS	9037075
GO:0007165	Process	Signal transduction	TAS	9037075
GO:0007613	Process	Memory	IEA
GO:0008306	Process	Associative learning	IEA
GO:0009268	Process	Response to pH	TAS	9062189
GO:0009986	Component	Cell surface	IEA
GO:0010447	Process	Response to acidic pH	IEA
GO:0015280	Function	Ligand-gated sodium channel activity	IBA	21873635
GO:0022839	Function	Ion gated channel activity	IEA
GO:0034220	Process	Ion transmembrane transport	TAS
GO:0035725	Process	Sodium ion transmembrane transport	IBA	21873635
GO:0035725	Process	Sodium ion transmembrane transport	IDA	22760635
GO:0035725	Process	Sodium ion transmembrane transport	ISS
GO:0042391	Process	Regulation of membrane potential	IEA
GO:0044736	Function	Acid-sensing ion channel activity	IBA	21873635
GO:0044736	Function	Acid-sensing ion channel activity	IDA	22760635
GO:0044736	Function	Acid-sensing ion channel activity	ISS
GO:0045202	Component	Synapse	IEA
GO:0046929	Process	Negative regulation of neurotransmitter secretion	IEA
GO:0050915	Process	Sensory perception of sour taste	IMP	19812697
GO:0070207	Process	Protein homotrimerization	ISS
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0071467	Process	Cellular response to pH	IDA	22760635

MIM	HGNC	e!Ensembl
602866	100	ENSG00000110881

Protein

UniProt ID

P78348

Protein name

Acid-sensing ion channel 1 (ASIC1) (Amiloride-sensitive cation channel 2, neuronal) (Brain sodium channel 2)

Protein function

Forms voltage-independent, pH-gated trimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system, playing a crucial role in regulating synaptic plasticity, learning, and memory (PubMed:21036899, PubMed:32915133, P

PDB

6L6I , 6L6N , 7CFS , 7CFT , 7RNN

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00858	ASC	21 → 456	Amiloride-sensitive sodium channel	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in neurons throughout the central and peripheral nervous system. {ECO:0000269|PubMed:9037075}.

Sequence

MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV
CTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNN
RYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCS
AEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETS
FEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLD
FFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEY
CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETI
EQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSA
DKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC

Sequence length

528

Interactions

View interactions

	KEGG		Reactome
	Inflammatory mediator regulation of TRP channels		Stimuli-sensing channels

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Schizophrenia	Schizophrenia			GWAS

Show/Hide Text Mining Associations (17)

Disease Name	Relationship Type	References
Associations from Text Mining
Anxiety	Associate	24529281, 25913301
Basal Cell Nevus Syndrome	Associate	34199609
Carcinoma Hepatocellular	Associate	40149892
Diarrhea 5 With Tufting Enteropathy Congenital	Associate	28428534
Glioblastoma	Associate	22130665
Glioblastoma	Inhibit	34515325
Glioma	Associate	26108662, 29057936, 34515325
IgA Vasculitis	Associate	28428534
Intervertebral Disc Degeneration	Associate	33824228
Liver Neoplasms	Stimulate	40149892
Melanoma	Associate	34199609
Neoplasms	Associate	30583668, 34199609, 40149892
Panic Disorder	Associate	24529281, 25913301
Rufous oculocutaneous albinism	Stimulate	28428534
Signs and Symptoms Respiratory	Associate	24529281
Skin Neoplasms	Associate	34199609
Stomach Neoplasms	Associate	30583668

ASIC1 (acid sensing ion channel subunit 1)