LLGL1 (LLGL scribble cell polarity complex component 1)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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3996 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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LLGL scribble cell polarity complex component 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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LLGL1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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DLG4, HUGL, HUGL-1, HUGL1, LLGL, Lgl1, Mgl1 |
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Chromosome
Chromosome number
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17 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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17p11.2 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine resi |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | ||||||||||||||||
| UniProt ID | Q15334 | |||||||||||||||
| Protein name | Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein) | |||||||||||||||
| Protein function | Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial | |||||||||||||||
| PDB | 8R3Y | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease. {ECO:0000269|P | |||||||||||||||
| Sequence |
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| Sequence length | 1064 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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