LIPE (lipase E, hormone sensitive type)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3991
Gene name Gene Name - the full gene name approved by the HGNC.
Lipase E, hormone sensitive type
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LIPE
Synonyms (NCBI Gene) Gene synonyms aliases
AOMS4, FPLD6, HSL, LHS, REH
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for ster
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
miRTarBase ID miRNA Experiments Reference
MIRT1110590 hsa-miR-15a CLIP-seq
MIRT1110591 hsa-miR-15b CLIP-seq
MIRT1110592 hsa-miR-16 CLIP-seq
MIRT1110593 hsa-miR-195 CLIP-seq
MIRT1110594 hsa-miR-3714 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
NFKB1 Activation 17272828
PPARG Activation 16269451
RELA Activation 17272828
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(38)
GO ID Ontology Definition Evidence Reference
GO:0004771 Function Sterol ester esterase activity IBA
GO:0004771 Function Sterol ester esterase activity IDA 8812477, 15716583
GO:0004771 Function Sterol ester esterase activity IEA
GO:0004806 Function Triacylglycerol lipase activity IBA
GO:0004806 Function Triacylglycerol lipase activity IDA 15716583, 15955102
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
151750 6621 ENSG00000079435
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q05469
Protein name Hormone-sensitive lipase (HSL) (EC 3.1.1.79) (Monoacylglycerol lipase LIPE) (EC 3.1.1.23) (Retinyl ester hydrolase) (REH)
Protein function Lipase with broad substrate specificity, catalyzing the hydrolysis of triacylglycerols (TAGs), diacylglycerols (DAGs), monoacylglycerols (MAGs), cholesteryl esters and retinyl esters (PubMed:15716583, PubMed:15955102, PubMed:19800417, PubMed:881
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06350 HSL_N 307 → 615 Hormone-sensitive lipase (HSL) N-terminus Family
PF07859 Abhydrolase_3 647 → 807 alpha/beta hydrolase fold Domain
PF07859 Abhydrolase_3 930 → 1028 alpha/beta hydrolase fold Domain
Tissue specificity TISSUE SPECIFICITY: Testis. {ECO:0000269|PubMed:8812477}.
Sequence 
MEPGSKSVSRSDWQPEPHQRPITPLEPGPEKTPIAQPESKTLQGSNTQQKPASNQRPLTQ
QETPAQHDAESQKEPRAQQKSASQEEFLAPQKPAPQQSPYIQRVLLTQQEAASQQGPGLG
KESITQQEPALRQRHVAQPGPGPGEPPPAQQEAESTPAAQAKPGAKREPSAPTESTSQET
PEQSDKQTTPVQGAKSKQGSLTELGFLTKLQELSIQRSALEWKALSEWVTDSESESDVGS
SSDTDSPATMGGMVAQGVKLGFKGKSGYKVMSGYSGTSPHEKTSARNHRHYQDTASRLIH
NMDLRTMTQSLVTLAEDNIAFFSSQGPGETAQRLSGVFAGVREQALGLEPALGRLLGVAH
LFDLDPETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRTSHNLAELEAYLAALT
QLRALVYYAQRLLVTNRPGVLFFEGDEGLTADFLREYVTLHKGCFYGRCLGFQFTPAIRP
FLQTISIGLVSFGEHYKRNETGLSVAASSLFTSGRFAIDPELRGAEFERITQNLDVHFWK
AFWNITEMEVLSSLANMASATVRVSRLLSLPPEAFEMPLTADPTLTVTISPPLAHTGPGP
VLVRLISYDLREGQDSEELSSLIKSNGQRSLELWPRPQQAPRSRSLIVHFHGGGFVAQTS
RSHEPYLKSWAQELGAPIISIDYSLAPEAPFPRALEECFFAYCWAIKHCALLGSTGERIC
LAGDSAGGNLCFTVALRAAAYGVRVPDGIMAAYPATMLQPAASPSRLLSLMDPLLPLSVL
SKCVSAYAGAKTEDHSNSDQKALGMMGLVRRDTALLLRDFRLGASSWLNSFLELSGRKSQ
KMSEPIAEPMRRSVSEAALAQPQGPLGTDSLKNLTLRDLSLRGNSETSSDTPEMSLSAET
LSPSTPSDVNFLLPPEDAGEEAEAKNELSPMDRGLGVRAAFPEGFHPRRSSQGATQMPLY
SSPIVKNPFMSPLLAPDSMLKSLPPVHIVACALDPMLDDSVMLARRLRNLGQPVTLRVVE
DLPHGFLTLAALCRETRQAAELCVERIRLVLTPPAGAGPSGETGAAGVDGGCGGRH
Sequence length 1076
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  cAMP signaling pathway
AMPK signaling pathway
Apelin signaling pathway
Thermogenesis
Insulin signaling pathway
Regulation of lipolysis in adipocytes
Aldosterone synthesis and secretion 		 
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal Diseases caused by PATHOGENIC or LIKELY PATHOGENIC variants from ClinVar only
Disease merge term Disease name dbSNP ID References
Lipodystrophy lipe-related familial partial lipodystrophy rs766817317 N/A
Show/Hide Text Mining Associations (39)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
ACTH Secreting Pituitary Adenoma Associate 35216289
Breast Neoplasms Associate 25751270, 27110560
Breast Neoplasms Inhibit 31292488
Carcinoma Lobular Associate 28124996
Colorectal Neoplasms Associate 36849520
Coronary Disease Associate 10946018
Diabetes Gestational Inhibit 24262292, 25118138
Diabetes Mellitus Stimulate 16940551
Diabetes Mellitus Associate 23688034, 24848981, 27862896
Diabetes Mellitus Type 1 Stimulate 16940551