Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
392617
Gene name Gene Name - the full gene name approved by the HGNC.
Extracellular leucine rich repeat and fibronectin type III domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ELFN1
Synonyms (NCBI Gene) Gene synonyms aliases
PPP1R28
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p22.3
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT618026 hsa-miR-6767-3p HITS-CLIP 23824327
MIRT618025 hsa-miR-3138 HITS-CLIP 23824327
MIRT618024 hsa-miR-4800-5p HITS-CLIP 23824327
MIRT618023 hsa-miR-3911 HITS-CLIP 23824327
MIRT618022 hsa-miR-644a HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0004864 Function Protein phosphatase inhibitor activity IEA
GO:0005615 Component Extracellular space IBA 21873635
GO:0010923 Process Negative regulation of phosphatase activity IDA 19389623
GO:0016021 Component Integral component of membrane IEA
GO:0030425 Component Dendrite ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
614964 33154 ENSG00000225968
Protein
UniProt ID P0C7U0
Protein name Protein ELFN1 (Extracellular leucine-rich repeat and fibronectin type-III domain-containing protein 1) (Protein phosphatase 1 regulatory subunit 28)
Protein function Postsynaptic protein that regulates circuit dynamics in the central nervous system by modulating the temporal dynamics of interneuron recruitment. Specifically present in excitatory synapses onto oriens-lacunosum molecular (OLM) interneurons and
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13855 LRR_8 84 144 Leucine rich repeat Repeat
PF13855 LRR_8 133 192 Leucine rich repeat Repeat
Sequence
MAGRGWGALWVCVAAATLLHAGGLARADCWLIEGDKGFVWLAICSQNQPPYEAIPQQINS
TIVDLRLNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRL
RNLTEGMLRGLG
KLEYLYLQANLIEVVMASSFWECPNIVNIDLSMNRIQQLNSGTFAGLA
KLSVCELYSNPF
YCSCELLGFLRWLAAFTNATQTYDRMQCESPPVYSGYYLLGQGRRGHR
SILSKLQSVCTEDSYAAEVVGPPRPASGRSQPGRSPPPPPPPEPSDMPCADDECFSGDGT
TPLVALPTLATQAEARPLIKVKQLTQNSATITVQLPSPFHRMYTLEHFNNSKASTVSRLT
KAQEEIRLTNLFTLTNYTYCVVSTSAGLRHNHTCLTICLPRLPSPPGPVPSPSTATHYIM
TILGCLFGMVLVLGAVYYCLRRRRRQEEKHKKAASAAAAGSLKKTIIELKYGPELEAPGL
APLSQGPLLGPEAVTRIPYLPAAGEVEQYKLVESADTPKASKGSYMEVRTGDPPERRDCE
LGRPGPDSQSSVAEISTIAKEVDKVNQIINNCIDALKSESTSFQGVKSGPVSVAEPPLVL
LSEPLAAKHGFLAPGYKDAFGHSLQRHHSVEAAGPPRASTSSSGSVRSPRAFRAEAVGVH
KAAAAEAKYIEKGSPAADAILTVTPAAAVLRAEAEKGRQYGEHRHSYPGSHPAEPPAPPG
PPPPPPHEGLGRKASILEPLTRPRPRDLAYSQLSPQYHSLSYSSSPEYTCRASQSIWERF
RLSRRRHKEEEEFMAAGHALRKKVQFAKDEDLHDILDYWKGVSAQHKS
Sequence length 828
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Coronary artery disease Coronary artery disease GWAS
Myocardial Infarction Myocardial Infarction GWAS
Diabetes Diabetes GWAS
Stress Disorder Stress Disorder GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Non Small Cell Lung Associate 35431233
Colorectal Neoplasms Associate 31929141, 33111631, 33750326, 34337713, 35193569, 35265722, 35857351
Endometrial Neoplasms Associate 35634444
Intellectual Disability Associate 34452636
Lymphatic Metastasis Stimulate 35431233
Lymphoma Large B Cell Diffuse Associate 35874768
Mental Disorders Associate 39706190
Neoplasms Stimulate 32779991
Neoplasms Associate 33750326, 34337713, 35190823, 35431233, 35634444, 35857351, 36876422
Ovarian Neoplasms Associate 32779991