Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	3903
Gene name	Leukocyte associated immunoglobulin like receptor 1
Gene symbol	LAIR1
Synonyms (NCBI Gene)	CD305LAIR-1
Chromosome	19
Chromosome location	19q13.42
Summary	The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gen

260

Show/Hide all (260)

miRTarBase ID	miRNA	Experiments	Reference
MIRT037585	hsa-miR-744-5p	CLASH	23622248
MIRT713284	hsa-miR-181a-2-3p	HITS-CLIP	19536157
MIRT713283	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT713282	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT713281	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT713280	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT713279	hsa-miR-7973	HITS-CLIP	19536157
MIRT713278	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT713277	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT713276	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT713275	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT713274	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT676695	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676694	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676693	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676692	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676691	hsa-miR-1976	HITS-CLIP	23824327
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676688	hsa-miR-4454	HITS-CLIP	23824327
MIRT676687	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676686	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT713284	hsa-miR-181a-2-3p	HITS-CLIP	19536157
MIRT713283	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT713282	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT713281	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT713280	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT713279	hsa-miR-7973	HITS-CLIP	19536157
MIRT713278	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT713277	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT713276	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT713275	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT713274	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT676695	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676694	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676693	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676692	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676691	hsa-miR-1976	HITS-CLIP	23824327
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676688	hsa-miR-4454	HITS-CLIP	23824327
MIRT676687	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676686	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103171	hsa-miR-23a	CLIP-seq
MIRT1103172	hsa-miR-23b	CLIP-seq
MIRT1103173	hsa-miR-23c	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103180	hsa-miR-106a	CLIP-seq
MIRT1103181	hsa-miR-106b	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1103182	hsa-miR-1234	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103184	hsa-miR-150	CLIP-seq
MIRT1103185	hsa-miR-17	CLIP-seq
MIRT1103186	hsa-miR-20a	CLIP-seq
MIRT1103187	hsa-miR-20b	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103188	hsa-miR-302a	CLIP-seq
MIRT1103189	hsa-miR-302b	CLIP-seq
MIRT1103190	hsa-miR-302c	CLIP-seq
MIRT1103191	hsa-miR-302d	CLIP-seq
MIRT1103192	hsa-miR-302e	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1103193	hsa-miR-3614-3p	CLIP-seq
MIRT1103194	hsa-miR-372	CLIP-seq
MIRT1103195	hsa-miR-373	CLIP-seq
MIRT1103196	hsa-miR-4294	CLIP-seq
MIRT1103197	hsa-miR-4297	CLIP-seq
MIRT1103198	hsa-miR-4438	CLIP-seq
MIRT1103199	hsa-miR-4446-5p	CLIP-seq
MIRT1103200	hsa-miR-4650-5p	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103201	hsa-miR-4731-5p	CLIP-seq
MIRT1103202	hsa-miR-4755-5p	CLIP-seq
MIRT1103203	hsa-miR-501-3p	CLIP-seq
MIRT1103204	hsa-miR-502-3p	CLIP-seq
MIRT1103205	hsa-miR-5095	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103206	hsa-miR-512-3p	CLIP-seq
MIRT1103207	hsa-miR-519d	CLIP-seq
MIRT1103208	hsa-miR-520a-3p	CLIP-seq
MIRT1103209	hsa-miR-520b	CLIP-seq
MIRT1103210	hsa-miR-520c-3p	CLIP-seq
MIRT1103211	hsa-miR-520d-3p	CLIP-seq
MIRT1103212	hsa-miR-520e	CLIP-seq
MIRT1103213	hsa-miR-520g	CLIP-seq
MIRT1103214	hsa-miR-520h	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103215	hsa-miR-642a	CLIP-seq
MIRT1103216	hsa-miR-671-5p	CLIP-seq
MIRT1103217	hsa-miR-769-5p	CLIP-seq
MIRT1103218	hsa-miR-93	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103180	hsa-miR-106a	CLIP-seq
MIRT1103181	hsa-miR-106b	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT2028213	hsa-miR-1281	CLIP-seq
MIRT1103184	hsa-miR-150	CLIP-seq
MIRT1103185	hsa-miR-17	CLIP-seq
MIRT1103186	hsa-miR-20a	CLIP-seq
MIRT1103187	hsa-miR-20b	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT2028214	hsa-miR-3199	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028216	hsa-miR-4279	CLIP-seq
MIRT2028217	hsa-miR-4532	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2028219	hsa-miR-4722-3p	CLIP-seq
MIRT2028220	hsa-miR-4740-3p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103207	hsa-miR-519d	CLIP-seq
MIRT1103213	hsa-miR-520g	CLIP-seq
MIRT1103214	hsa-miR-520h	CLIP-seq
MIRT2028221	hsa-miR-552	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT2028222	hsa-miR-764	CLIP-seq
MIRT2028223	hsa-miR-875-3p	CLIP-seq
MIRT1103218	hsa-miR-93	CLIP-seq
MIRT1103180	hsa-miR-106a	CLIP-seq
MIRT1103181	hsa-miR-106b	CLIP-seq
MIRT1103182	hsa-miR-1234	CLIP-seq
MIRT2028213	hsa-miR-1281	CLIP-seq
MIRT1103184	hsa-miR-150	CLIP-seq
MIRT1103185	hsa-miR-17	CLIP-seq
MIRT1103186	hsa-miR-20a	CLIP-seq
MIRT1103187	hsa-miR-20b	CLIP-seq
MIRT1103188	hsa-miR-302a	CLIP-seq
MIRT1103189	hsa-miR-302b	CLIP-seq
MIRT1103190	hsa-miR-302c	CLIP-seq
MIRT1103191	hsa-miR-302d	CLIP-seq
MIRT1103192	hsa-miR-302e	CLIP-seq
MIRT2028214	hsa-miR-3199	CLIP-seq
MIRT1103194	hsa-miR-372	CLIP-seq
MIRT1103195	hsa-miR-373	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028216	hsa-miR-4279	CLIP-seq
MIRT1103198	hsa-miR-4438	CLIP-seq
MIRT1103199	hsa-miR-4446-5p	CLIP-seq
MIRT2028217	hsa-miR-4532	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2028219	hsa-miR-4722-3p	CLIP-seq
MIRT1103201	hsa-miR-4731-5p	CLIP-seq
MIRT2028220	hsa-miR-4740-3p	CLIP-seq
MIRT1103202	hsa-miR-4755-5p	CLIP-seq
MIRT1103205	hsa-miR-5095	CLIP-seq
MIRT1103206	hsa-miR-512-3p	CLIP-seq
MIRT1103207	hsa-miR-519d	CLIP-seq
MIRT1103208	hsa-miR-520a-3p	CLIP-seq
MIRT1103209	hsa-miR-520b	CLIP-seq
MIRT1103210	hsa-miR-520c-3p	CLIP-seq
MIRT1103211	hsa-miR-520d-3p	CLIP-seq
MIRT1103212	hsa-miR-520e	CLIP-seq
MIRT1103213	hsa-miR-520g	CLIP-seq
MIRT1103214	hsa-miR-520h	CLIP-seq
MIRT2028221	hsa-miR-552	CLIP-seq
MIRT1103215	hsa-miR-642a	CLIP-seq
MIRT2028222	hsa-miR-764	CLIP-seq
MIRT1103218	hsa-miR-93	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT2452847	hsa-miR-141	CLIP-seq
MIRT2452848	hsa-miR-200a	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2452849	hsa-miR-4735-5p	CLIP-seq
MIRT2452850	hsa-miR-4775	CLIP-seq
MIRT2452851	hsa-miR-570	CLIP-seq
MIRT2452852	hsa-miR-590-3p	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT2028213	hsa-miR-1281	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT2028214	hsa-miR-3199	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028216	hsa-miR-4279	CLIP-seq
MIRT2028217	hsa-miR-4532	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2028219	hsa-miR-4722-3p	CLIP-seq
MIRT2452849	hsa-miR-4735-5p	CLIP-seq
MIRT2028220	hsa-miR-4740-3p	CLIP-seq
MIRT2452850	hsa-miR-4775	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT2028221	hsa-miR-552	CLIP-seq
MIRT2452852	hsa-miR-590-3p	CLIP-seq
MIRT2028222	hsa-miR-764	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2452849	hsa-miR-4735-5p	CLIP-seq
MIRT2452850	hsa-miR-4775	CLIP-seq
MIRT2452852	hsa-miR-590-3p	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002376	Process	Immune system process	IEA
GO:0002764	Process	Immune response-regulating signaling pathway	IBA
GO:0005515	Function	Protein binding	IPI	10660620, 10764762, 16754721
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0070821	Component	Tertiary granule membrane	TAS

MIM	HGNC	e!Ensembl
602992	6477	ENSG00000167613

Q6GTX8

Protein name

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)

Protein function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosph

PDB

3KGR , 3RP1 , 7F9L , 7F9M , 7F9N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13895	Ig_2	28 → 120	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cell

Sequence

MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRL
ERESRSTYNDTEDVSQASPSESEARFRIDSVSEGNAGPYRCIYYKPPKWSEQSDYLELLV
KETSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLL
LVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSA
LAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH

Sequence length

287

Interactions

View interactions

	Reactome
			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation

LAIR1 (leukocyte associated immunoglobulin like receptor 1)