Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	3903
Gene name Gene Name - the full gene name approved by the HGNC.	Leukocyte associated immunoglobulin like receptor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	LAIR1
Synonyms (NCBI Gene) Gene synonyms aliases	CD305, LAIR-1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.42
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gen

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miRTarBase ID	miRNA	Experiments	Reference
MIRT037585	hsa-miR-744-5p	CLASH	23622248
MIRT713284	hsa-miR-181a-2-3p	HITS-CLIP	19536157
MIRT713283	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT713282	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT713281	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT713280	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT713279	hsa-miR-7973	HITS-CLIP	19536157
MIRT713278	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT713277	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT713276	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT713275	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT713274	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT676695	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676694	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676693	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676692	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676691	hsa-miR-1976	HITS-CLIP	23824327
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676688	hsa-miR-4454	HITS-CLIP	23824327
MIRT676687	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676686	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT713284	hsa-miR-181a-2-3p	HITS-CLIP	19536157
MIRT713283	hsa-miR-1273g-3p	HITS-CLIP	19536157
MIRT713282	hsa-miR-6511a-3p	HITS-CLIP	19536157
MIRT713281	hsa-miR-6511b-3p	HITS-CLIP	19536157
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	19536157
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	19536157
MIRT713280	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT713279	hsa-miR-7973	HITS-CLIP	19536157
MIRT713278	hsa-miR-197-3p	HITS-CLIP	19536157
MIRT713277	hsa-miR-6509-3p	HITS-CLIP	19536157
MIRT713276	hsa-miR-4436b-5p	HITS-CLIP	19536157
MIRT713275	hsa-miR-6808-3p	HITS-CLIP	19536157
MIRT713274	hsa-miR-3692-3p	HITS-CLIP	19536157
MIRT676695	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT676694	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676693	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT676692	hsa-miR-3653-5p	HITS-CLIP	23824327
MIRT676691	hsa-miR-1976	HITS-CLIP	23824327
MIRT676690	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT676689	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT676688	hsa-miR-4454	HITS-CLIP	23824327
MIRT676687	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT676686	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103171	hsa-miR-23a	CLIP-seq
MIRT1103172	hsa-miR-23b	CLIP-seq
MIRT1103173	hsa-miR-23c	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103180	hsa-miR-106a	CLIP-seq
MIRT1103181	hsa-miR-106b	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1103182	hsa-miR-1234	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103184	hsa-miR-150	CLIP-seq
MIRT1103185	hsa-miR-17	CLIP-seq
MIRT1103186	hsa-miR-20a	CLIP-seq
MIRT1103187	hsa-miR-20b	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103188	hsa-miR-302a	CLIP-seq
MIRT1103189	hsa-miR-302b	CLIP-seq
MIRT1103190	hsa-miR-302c	CLIP-seq
MIRT1103191	hsa-miR-302d	CLIP-seq
MIRT1103192	hsa-miR-302e	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1103193	hsa-miR-3614-3p	CLIP-seq
MIRT1103194	hsa-miR-372	CLIP-seq
MIRT1103195	hsa-miR-373	CLIP-seq
MIRT1103196	hsa-miR-4294	CLIP-seq
MIRT1103197	hsa-miR-4297	CLIP-seq
MIRT1103198	hsa-miR-4438	CLIP-seq
MIRT1103199	hsa-miR-4446-5p	CLIP-seq
MIRT1103200	hsa-miR-4650-5p	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103201	hsa-miR-4731-5p	CLIP-seq
MIRT1103202	hsa-miR-4755-5p	CLIP-seq
MIRT1103203	hsa-miR-501-3p	CLIP-seq
MIRT1103204	hsa-miR-502-3p	CLIP-seq
MIRT1103205	hsa-miR-5095	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103206	hsa-miR-512-3p	CLIP-seq
MIRT1103207	hsa-miR-519d	CLIP-seq
MIRT1103208	hsa-miR-520a-3p	CLIP-seq
MIRT1103209	hsa-miR-520b	CLIP-seq
MIRT1103210	hsa-miR-520c-3p	CLIP-seq
MIRT1103211	hsa-miR-520d-3p	CLIP-seq
MIRT1103212	hsa-miR-520e	CLIP-seq
MIRT1103213	hsa-miR-520g	CLIP-seq
MIRT1103214	hsa-miR-520h	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103215	hsa-miR-642a	CLIP-seq
MIRT1103216	hsa-miR-671-5p	CLIP-seq
MIRT1103217	hsa-miR-769-5p	CLIP-seq
MIRT1103218	hsa-miR-93	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT1103180	hsa-miR-106a	CLIP-seq
MIRT1103181	hsa-miR-106b	CLIP-seq
MIRT1103169	hsa-miR-1193	CLIP-seq
MIRT2028213	hsa-miR-1281	CLIP-seq
MIRT1103184	hsa-miR-150	CLIP-seq
MIRT1103185	hsa-miR-17	CLIP-seq
MIRT1103186	hsa-miR-20a	CLIP-seq
MIRT1103187	hsa-miR-20b	CLIP-seq
MIRT1103170	hsa-miR-2392	CLIP-seq
MIRT1103174	hsa-miR-3152-3p	CLIP-seq
MIRT2028214	hsa-miR-3199	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028216	hsa-miR-4279	CLIP-seq
MIRT2028217	hsa-miR-4532	CLIP-seq
MIRT1103176	hsa-miR-4662a-5p	CLIP-seq
MIRT1103177	hsa-miR-4676-5p	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2028219	hsa-miR-4722-3p	CLIP-seq
MIRT2028220	hsa-miR-4740-3p	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT1103207	hsa-miR-519d	CLIP-seq
MIRT1103213	hsa-miR-520g	CLIP-seq
MIRT1103214	hsa-miR-520h	CLIP-seq
MIRT2028221	hsa-miR-552	CLIP-seq
MIRT1103179	hsa-miR-575	CLIP-seq
MIRT2028222	hsa-miR-764	CLIP-seq
MIRT2028223	hsa-miR-875-3p	CLIP-seq
MIRT1103218	hsa-miR-93	CLIP-seq
MIRT1103180	hsa-miR-106a	CLIP-seq
MIRT1103181	hsa-miR-106b	CLIP-seq
MIRT1103182	hsa-miR-1234	CLIP-seq
MIRT2028213	hsa-miR-1281	CLIP-seq
MIRT1103184	hsa-miR-150	CLIP-seq
MIRT1103185	hsa-miR-17	CLIP-seq
MIRT1103186	hsa-miR-20a	CLIP-seq
MIRT1103187	hsa-miR-20b	CLIP-seq
MIRT1103188	hsa-miR-302a	CLIP-seq
MIRT1103189	hsa-miR-302b	CLIP-seq
MIRT1103190	hsa-miR-302c	CLIP-seq
MIRT1103191	hsa-miR-302d	CLIP-seq
MIRT1103192	hsa-miR-302e	CLIP-seq
MIRT2028214	hsa-miR-3199	CLIP-seq
MIRT1103194	hsa-miR-372	CLIP-seq
MIRT1103195	hsa-miR-373	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028216	hsa-miR-4279	CLIP-seq
MIRT1103198	hsa-miR-4438	CLIP-seq
MIRT1103199	hsa-miR-4446-5p	CLIP-seq
MIRT2028217	hsa-miR-4532	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2028219	hsa-miR-4722-3p	CLIP-seq
MIRT1103201	hsa-miR-4731-5p	CLIP-seq
MIRT2028220	hsa-miR-4740-3p	CLIP-seq
MIRT1103202	hsa-miR-4755-5p	CLIP-seq
MIRT1103205	hsa-miR-5095	CLIP-seq
MIRT1103206	hsa-miR-512-3p	CLIP-seq
MIRT1103207	hsa-miR-519d	CLIP-seq
MIRT1103208	hsa-miR-520a-3p	CLIP-seq
MIRT1103209	hsa-miR-520b	CLIP-seq
MIRT1103210	hsa-miR-520c-3p	CLIP-seq
MIRT1103211	hsa-miR-520d-3p	CLIP-seq
MIRT1103212	hsa-miR-520e	CLIP-seq
MIRT1103213	hsa-miR-520g	CLIP-seq
MIRT1103214	hsa-miR-520h	CLIP-seq
MIRT2028221	hsa-miR-552	CLIP-seq
MIRT1103215	hsa-miR-642a	CLIP-seq
MIRT2028222	hsa-miR-764	CLIP-seq
MIRT1103218	hsa-miR-93	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT2452847	hsa-miR-141	CLIP-seq
MIRT2452848	hsa-miR-200a	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2452849	hsa-miR-4735-5p	CLIP-seq
MIRT2452850	hsa-miR-4775	CLIP-seq
MIRT2452851	hsa-miR-570	CLIP-seq
MIRT2452852	hsa-miR-590-3p	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT2028213	hsa-miR-1281	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1103175	hsa-miR-3170	CLIP-seq
MIRT2028214	hsa-miR-3199	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028216	hsa-miR-4279	CLIP-seq
MIRT2028217	hsa-miR-4532	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2028219	hsa-miR-4722-3p	CLIP-seq
MIRT2452849	hsa-miR-4735-5p	CLIP-seq
MIRT2028220	hsa-miR-4740-3p	CLIP-seq
MIRT2452850	hsa-miR-4775	CLIP-seq
MIRT1103178	hsa-miR-5096	CLIP-seq
MIRT2028221	hsa-miR-552	CLIP-seq
MIRT2452852	hsa-miR-590-3p	CLIP-seq
MIRT2028222	hsa-miR-764	CLIP-seq
MIRT1921658	hsa-miR-1273f	CLIP-seq
MIRT1103183	hsa-miR-129-5p	CLIP-seq
MIRT1921659	hsa-miR-3149	CLIP-seq
MIRT1921660	hsa-miR-411	CLIP-seq
MIRT2028215	hsa-miR-4258	CLIP-seq
MIRT2028218	hsa-miR-4707-3p	CLIP-seq
MIRT2452849	hsa-miR-4735-5p	CLIP-seq
MIRT2452850	hsa-miR-4775	CLIP-seq
MIRT2452852	hsa-miR-590-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0005515	Function	Protein binding	IPI	10660620, 10764762, 16754721
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0016021	Component	Integral component of membrane	IEA
GO:0035579	Component	Specific granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0050776	Process	Regulation of immune response	TAS
GO:0070821	Component	Tertiary granule membrane	TAS

MIM	HGNC	e!Ensembl
602992	6477	ENSG00000167613

Protein

UniProt ID

Q6GTX8

Protein name

Leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1) (hLAIR1) (CD antigen CD305)

Protein function

Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosph

PDB

3KGR , 3RP1 , 7F9L , 7F9M , 7F9N

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13895	Ig_2	28 → 120	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cell

Sequence

MSPHPTALLGLVLCLAQTIHTQEEDLPRPSISAEPGTVIPLGSHVTFVCRGPVGVQTFRL
ERESRSTYNDTEDVSQASPSESEARFRIDSVSEGNAGPYRCIYYKPPKWSEQSDYLELLV
KETSGGPDSPDTEPGSSAGPTQRPSDNSHNEHAPASQGLKAEHLYILIGVSVVFLFCLLL
LVLFCLHRQNQIKQGPPRSKDEEQKPQQRPDLAVDVLERTADKATVNGLPEKDRETDTSA
LAAGSSQEVTYAQLDHWALTQRTARAVSPQSTKPMAESITYAAVARH

Sequence length

287

Interactions

View interactions

	Reactome
			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Glomerulonephritis	IGA Glomerulonephritis	rs778043831	25133636

Show/Hide Text Mining Associations (40)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Stimulate	36960400
Arthritis Rheumatoid	Associate	29328500
Autoimmune Diseases	Associate	29915163
Breast Neoplasms	Associate	33053017
Carcinoma Hepatocellular	Stimulate	36293412
Carcinoma Hepatocellular	Associate	37406019, 37647449
Carcinoma Non Small Cell Lung	Associate	36960400
Chemical and Drug Induced Liver Injury	Associate	31019980
Chromosome Aberrations	Associate	20839337
Chromosome Aberrations	Inhibit	24415628
Chronic Disease	Associate	31019980
COVID 19	Associate	33979758, 34429372
Critical Illness	Associate	34429372
Endometrial Neoplasms	Associate	36199963
Glioma	Associate	35702880, 37845206
Hepatitis B Chronic	Inhibit	24415628
Hepatitis Viral Human	Associate	36293412
HIV Infections	Associate	14604962
Idiopathic Noncirrhotic Portal Hypertension	Associate	31019980
Inflammation	Associate	28325905, 29328500, 31019980, 31257148
Insulin Resistance	Associate	36293412
Leukemia	Associate	11069054, 11745387
Leukemia B Cell	Associate	20839337
Leukemia Lymphocytic Chronic B Cell	Associate	24415628
Leukemia Myeloid	Associate	11069054
Leukemia Myeloid Acute	Associate	11745387
Leukemia Prolymphocytic T Cell	Associate	20839337
Liver Cirrhosis	Associate	31019980, 36293412
Liver Cirrhosis Biliary	Associate	29328500
Lung Neoplasms	Associate	36960400
Lupus Erythematosus Systemic	Inhibit	21151495, 22355402, 28325905
Lupus Erythematosus Systemic	Associate	25247291
Malaria	Associate	31278068
Mixed Connective Tissue Disease	Inhibit	22355402
Neoplasms	Associate	11069054, 29915163, 32563267, 34691040, 36960400, 37845206
Osteosarcoma	Associate	32563267, 37858131
Ovarian Neoplasms	Associate	40000955
Precursor Cell Lymphoblastic Leukemia Lymphoma	Inhibit	30486600
Severe Acute Respiratory Syndrome	Associate	31257148, 31278068
Thyroid Carcinoma Anaplastic	Associate	36328145

LAIR1 (leukocyte associated immunoglobulin like receptor 1)