Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	389400
Gene name Gene Name - the full gene name approved by the HGNC.	GDNF family receptor alpha like
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GFRAL
Synonyms (NCBI Gene) Gene synonyms aliases	C6orf144, GRAL, UNQ9356, bA360D14.1
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6p12.1

Show/Hide all(198)

miRTarBase ID	miRNA	Experiments	Reference
MIRT488930	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT488928	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT488927	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT488926	hsa-miR-1253	PAR-CLIP	23592263
MIRT488925	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT488924	hsa-miR-4784	PAR-CLIP	23592263
MIRT488923	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT488922	hsa-miR-4306	PAR-CLIP	23592263
MIRT488921	hsa-miR-4644	PAR-CLIP	23592263
MIRT488930	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT488928	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT488927	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT488926	hsa-miR-1253	PAR-CLIP	23592263
MIRT488925	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT488924	hsa-miR-4784	PAR-CLIP	23592263
MIRT488923	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT488922	hsa-miR-4306	PAR-CLIP	23592263
MIRT488921	hsa-miR-4644	PAR-CLIP	23592263
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT1017615	hsa-miR-1827	CLIP-seq
MIRT1017616	hsa-miR-186	CLIP-seq
MIRT1017617	hsa-miR-219-5p	CLIP-seq
MIRT1017618	hsa-miR-2467-3p	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017620	hsa-miR-3133	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT1017622	hsa-miR-34b	CLIP-seq
MIRT1017623	hsa-miR-3609	CLIP-seq
MIRT1017624	hsa-miR-3612	CLIP-seq
MIRT1017625	hsa-miR-3614-5p	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017632	hsa-miR-4257	CLIP-seq
MIRT1017633	hsa-miR-432	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017635	hsa-miR-4443	CLIP-seq
MIRT1017636	hsa-miR-4445	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017640	hsa-miR-4765	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017642	hsa-miR-4782-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT1017644	hsa-miR-508-3p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT1017646	hsa-miR-548ah	CLIP-seq
MIRT1017647	hsa-miR-650	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq
MIRT1017649	hsa-miR-940	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT2234449	hsa-miR-1184	CLIP-seq
MIRT2234450	hsa-miR-1285	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT1017615	hsa-miR-1827	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT2234451	hsa-miR-217	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2234452	hsa-miR-3187-5p	CLIP-seq
MIRT2234453	hsa-miR-335	CLIP-seq
MIRT2234454	hsa-miR-3620	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT2234455	hsa-miR-3929	CLIP-seq
MIRT2234456	hsa-miR-4418	CLIP-seq
MIRT2234457	hsa-miR-4419b	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT2234458	hsa-miR-4478	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2234459	hsa-miR-4649-3p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT2234460	hsa-miR-4747-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT2234461	hsa-miR-509-3-5p	CLIP-seq
MIRT2234462	hsa-miR-509-5p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2234463	hsa-miR-612	CLIP-seq
MIRT2234464	hsa-miR-661	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq
MIRT1017649	hsa-miR-940	CLIP-seq
MIRT2234460	hsa-miR-4747-5p	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT2450230	hsa-miR-3675-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450232	hsa-miR-4684-5p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT2538575	hsa-miR-1271	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2538576	hsa-miR-182	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT2234454	hsa-miR-3620	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT2450230	hsa-miR-3675-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT2538577	hsa-miR-4470	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450232	hsa-miR-4684-5p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq
MIRT2538578	hsa-miR-96	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT2234454	hsa-miR-3620	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT2450230	hsa-miR-3675-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450232	hsa-miR-4684-5p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq

Show/Hide all(30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002023	Process	Reduction of food intake in response to dietary excess	IEA
GO:0002023	Process	Reduction of food intake in response to dietary excess	ISS
GO:0005179	Function	Hormone activity	IEA
GO:0005515	Function	Protein binding	IPI	28846097, 28846098, 28846099, 28953886
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IDA	28953886
GO:0005886	Component	Plasma membrane	IEA
GO:0005925	Component	Focal adhesion	IDA
GO:0007399	Process	Nervous system development	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016020	Component	Membrane	IEA
GO:0016167	Function	Glial cell-derived neurotrophic factor receptor activity	IDA	28846097, 28846098, 28846099, 28953886, 31535977
GO:0016167	Function	Glial cell-derived neurotrophic factor receptor activity	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	IEA
GO:0030971	Function	Receptor tyrosine kinase binding	IPI	28846097, 28846099, 28953886
GO:0031098	Process	Stress-activated protein kinase signaling cascade	IEA
GO:0032099	Process	Negative regulation of appetite	IEA
GO:0032099	Process	Negative regulation of appetite	ISS
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038023	Function	Signaling receptor activity	IEA
GO:0043235	Component	Receptor complex	IBA
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	28846099, 28953886
GO:0043410	Process	Positive regulation of MAPK cascade	IEA
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	28846097
GO:0160144	Process	GDF15-GFRAL signaling pathway	IDA	28953886, 31535977, 35177851
GO:0160144	Process	GDF15-GFRAL signaling pathway	IEA
GO:1901558	Process	Response to metformin	IEA
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA

MIM	HGNC	e!Ensembl
617837	32789	ENSG00000187871

Protein

UniProt ID

Q6UXV0

Protein name

GDNF family receptor alpha-like

Protein function

Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886,

PDB

5VZ4 , 6Q2J , 6WMW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02351	GDNF	131 → 210	GDNF/GAS1 domain	Domain
PF02351	GDNF	220 → 316	GDNF/GAS1 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adip

Sequence

MIVFIFLAMGLSLENEYTSQTNNCTYLREQCLRDANGCKHAWRVMEDACNDSDPGDPCKM
RNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKEDKFKWNLTTR
SHHGFKGMWSCLEVAEACVGDVVCNAQLASYLKACSANGNPCDLKQCQAAIRFFYQNIPF
NIAQMLAFCDCAQSDIPCQQSKEALHSKTCAVNMVPPPTCLSVIRSCQNDELCRRHYRTF
QSKCWQRVTRKCHEDENCISTLSKQDLTCSGSDDCKAAYIDILGTVLQVQCTCRTITQSE
ESLCKIFQHMLHRKSCFNYPTLSNVKGMALYTRKHANKITLTGFHSPFNGEVIYAAMCMT
VTCGILLLVMVKLRTSRISSKARDPSSIQIPGEL

Sequence length

394

Interactions

View interactions

GFRAL (GDNF family receptor alpha like)