GFRAL (GDNF family receptor alpha like)

Gene

• Entrez ID: 389400
• Gene name: GDNF family receptor alpha like
• Gene symbol: GFRAL
• Synonyms (NCBI Gene): C6orf144, GRAL, UNQ9356, bA360D14.1
• Chromosome: 6
• Chromosome location: 6p12.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT488930	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT488928	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT488927	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT488926	hsa-miR-1253	PAR-CLIP	23592263
MIRT488925	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT488924	hsa-miR-4784	PAR-CLIP	23592263
MIRT488923	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT488922	hsa-miR-4306	PAR-CLIP	23592263
MIRT488921	hsa-miR-4644	PAR-CLIP	23592263
MIRT488930	hsa-miR-5197-3p	PAR-CLIP	23592263
MIRT488928	hsa-miR-6758-5p	PAR-CLIP	23592263
MIRT488927	hsa-miR-6856-5p	PAR-CLIP	23592263
MIRT488926	hsa-miR-1253	PAR-CLIP	23592263
MIRT488925	hsa-miR-3150b-3p	PAR-CLIP	23592263
MIRT488924	hsa-miR-4784	PAR-CLIP	23592263
MIRT488923	hsa-miR-185-5p	PAR-CLIP	23592263
MIRT488922	hsa-miR-4306	PAR-CLIP	23592263
MIRT488921	hsa-miR-4644	PAR-CLIP	23592263
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT1017615	hsa-miR-1827	CLIP-seq
MIRT1017616	hsa-miR-186	CLIP-seq
MIRT1017617	hsa-miR-219-5p	CLIP-seq
MIRT1017618	hsa-miR-2467-3p	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017620	hsa-miR-3133	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT1017622	hsa-miR-34b	CLIP-seq
MIRT1017623	hsa-miR-3609	CLIP-seq
MIRT1017624	hsa-miR-3612	CLIP-seq
MIRT1017625	hsa-miR-3614-5p	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017632	hsa-miR-4257	CLIP-seq
MIRT1017633	hsa-miR-432	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017635	hsa-miR-4443	CLIP-seq
MIRT1017636	hsa-miR-4445	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017640	hsa-miR-4765	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017642	hsa-miR-4782-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT1017644	hsa-miR-508-3p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT1017646	hsa-miR-548ah	CLIP-seq
MIRT1017647	hsa-miR-650	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq
MIRT1017649	hsa-miR-940	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT2234449	hsa-miR-1184	CLIP-seq
MIRT2234450	hsa-miR-1285	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT1017615	hsa-miR-1827	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT2234451	hsa-miR-217	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2234452	hsa-miR-3187-5p	CLIP-seq
MIRT2234453	hsa-miR-335	CLIP-seq
MIRT2234454	hsa-miR-3620	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT2234455	hsa-miR-3929	CLIP-seq
MIRT2234456	hsa-miR-4418	CLIP-seq
MIRT2234457	hsa-miR-4419b	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT2234458	hsa-miR-4478	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2234459	hsa-miR-4649-3p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT2234460	hsa-miR-4747-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT2234461	hsa-miR-509-3-5p	CLIP-seq
MIRT2234462	hsa-miR-509-5p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2234463	hsa-miR-612	CLIP-seq
MIRT2234464	hsa-miR-661	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq
MIRT1017649	hsa-miR-940	CLIP-seq
MIRT2234460	hsa-miR-4747-5p	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT2450230	hsa-miR-3675-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450232	hsa-miR-4684-5p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT2538575	hsa-miR-1271	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2538576	hsa-miR-182	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT2234454	hsa-miR-3620	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT2450230	hsa-miR-3675-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT2538577	hsa-miR-4470	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450232	hsa-miR-4684-5p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq
MIRT2538578	hsa-miR-96	CLIP-seq
MIRT2450227	hsa-miR-1268	CLIP-seq
MIRT2450228	hsa-miR-1268b	CLIP-seq
MIRT1017614	hsa-miR-1293	CLIP-seq
MIRT2001426	hsa-miR-1908	CLIP-seq
MIRT1017619	hsa-miR-3122	CLIP-seq
MIRT1017621	hsa-miR-3165	CLIP-seq
MIRT2450229	hsa-miR-3613-3p	CLIP-seq
MIRT2234454	hsa-miR-3620	CLIP-seq
MIRT1017626	hsa-miR-3622a-3p	CLIP-seq
MIRT1017627	hsa-miR-3622b-3p	CLIP-seq
MIRT1017628	hsa-miR-3672	CLIP-seq
MIRT2450230	hsa-miR-3675-3p	CLIP-seq
MIRT1017629	hsa-miR-3689a-3p	CLIP-seq
MIRT1017630	hsa-miR-3689c	CLIP-seq
MIRT1017631	hsa-miR-3913-5p	CLIP-seq
MIRT1017634	hsa-miR-4433	CLIP-seq
MIRT1017637	hsa-miR-4459	CLIP-seq
MIRT1017638	hsa-miR-4483	CLIP-seq
MIRT2450231	hsa-miR-4486	CLIP-seq
MIRT2450232	hsa-miR-4684-5p	CLIP-seq
MIRT1017639	hsa-miR-4728-5p	CLIP-seq
MIRT1017641	hsa-miR-4768-3p	CLIP-seq
MIRT1017643	hsa-miR-4786-5p	CLIP-seq
MIRT1017645	hsa-miR-544b	CLIP-seq
MIRT2450233	hsa-miR-548c-3p	CLIP-seq
MIRT2450234	hsa-miR-585	CLIP-seq
MIRT2001427	hsa-miR-663	CLIP-seq
MIRT1017648	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000187	Process	Activation of MAPK activity	IDA	28953886
GO:0002023	Process	Reduction of food intake in response to dietary excess	ISS
GO:0005515	Function	Protein binding	IPI	28846097, 28846098, 28846099, 28953886
GO:0007399	Process	Nervous system development	IBA	21873635
GO:0009897	Component	External side of plasma membrane	IBA	21873635
GO:0009897	Component	External side of plasma membrane	IDA	28953886
GO:0016021	Component	Integral component of membrane	IEA
GO:0016167	Function	Glial cell-derived neurotrophic factor receptor activity	IDA	28846097, 28846098, 28846099, 28953886
GO:0030971	Function	Receptor tyrosine kinase binding	IPI	28846097, 28846099, 28953886
GO:0031098	Process	Stress-activated protein kinase signaling cascade	IEA
GO:0035860	Process	Glial cell-derived neurotrophic factor receptor signaling pathway	IDA	28953886
GO:0038023	Function	Signaling receptor activity	IBA	21873635
GO:0043235	Component	Receptor complex	IBA	21873635
GO:0043410	Process	Positive regulation of MAPK cascade	IDA	28846099
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0051897	Process	Positive regulation of protein kinase B signaling	IDA	28846097
GO:2001240	Process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IEA

Other IDs

• MIM: 617837
• HGNC: 32789
• e!Ensembl: ENSG00000187871

Protein

• UniProt ID: Q6UXV0
• Protein name: GDNF family receptor alpha-like
• Protein function: Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886,
• PDB: 5VZ4, 6Q2J, 6WMW
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02351	GDNF	131 → 210	GDNF/GAS1 domain	Domain
  PF02351	GDNF	220 → 316	GDNF/GAS1 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adip
• Sequence:

  MIVFIFLAMGLSLENEYTSQTNNCTYLREQCLRDANGCKHAWRVMEDACNDSDPGDPCKM
  RNSSYCNLSIQYLVESNFQFKECLCTDDFYCTVNKLLGKKCINKSDNVKEDKFKWNLTTR
  SHHGFKGMWSCLEVAEACVGDVVCNAQLASYLKACSANGNPCDLKQCQAAIRFFYQNIPF
  NIAQMLAFCDCAQSDIPCQQSKEALHSKTCAVNMVPPPTCLSVIRSCQNDELCRRHYRTF
  QSKCWQRVTRKCHEDENCISTLSKQDLTCSGSDDCKAAYIDILGTVLQVQCTCRTITQSE
  ESLCKIFQHMLHRKSCFNYPTLSNVKGMALYTRKHANKITLTGFHSPFNGEVIYAAMCMT
  VTCGILLLVMVKLRTSRISSKARDPSSIQIPGEL

• Sequence length: 394

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Breast cancer	Malignant neoplasm of breast	rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158, rs80357524, rs80357115, rs80357945, rs80357729, rs80357609, rs80357259, rs80357981, rs80358063, rs80357389, rs80356862, rs80359876, rs80357580, rs80358053, rs80358089, rs80187739, rs397507241, rs80358069, rs80357590, rs80357284, rs80357941, rs80359261, rs80359272, rs80359276, rs276174813, rs80358474, rs80359316, rs1555282969, rs80359388, rs80359499, rs80359505, rs80359520, rs80359526, rs80359533, rs56253082, rs80358824, rs80359554, rs80359636, rs80359651, rs80359659, rs80359011, rs80359012, rs80359013, rs80359718, rs397507410, rs81002812, rs80359730, rs80359152, rs80359159, rs397507419, rs28897759, rs80359211, rs80359775, rs397514577, rs397507584, rs80358435, rs80358456, rs80359340, rs80359343, rs80359365, rs80358579, rs397507670, rs80358593, rs80359406, rs80359444, rs80359454, rs276174853, rs276174854, rs80359483, rs80359537, rs80358815, rs80358843, rs80359558, rs80359560, rs80359594, rs80358893, rs28897743, rs397507900, rs397507906, rs397507918, rs80358971, rs80358981, rs397507941, rs80359030, rs80359035, rs41293511, rs397507396, rs81002806, rs80359112, rs397508006, rs81002893, rs45580035, rs80359760, rs397508051, rs80359772, rs4987049, rs80359777, rs80357770, rs397508867, rs62625303, rs397508874, rs80357506, rs80357287, rs273898674, rs80358042, rs80358083, rs80357058, rs41286296, rs80357960, rs80356945, rs80357223, rs386134270, rs80358116, rs80357856, rs80357424, rs397509050, rs80357485, rs80357966, rs397509067, rs80357310, rs80356866, rs80357260, rs80357437, rs80358023, rs80358086, rs80357133, rs80356993, rs80357997, rs80357239, rs80357227, rs397509243, rs80356969, rs80356959, rs63750617, rs63751319, rs587779315, rs200640585, rs398122546, rs80357543, rs398122687, rs80359328, rs398122779, rs398122783, rs62517194, rs80358029, rs515726060, rs180177103, rs180177111, rs180177133, rs587776527, rs180177135, rs180177136, rs515726117, rs587779813, rs587779909, rs587780024, rs587780100, rs28909982, rs121908698, rs180177100, rs587780210, rs587780240, rs587780639, rs587781269, rs587781353, rs587781471, rs587781658, rs587781697, rs587781730, rs587781894, rs587781948, rs587782005, rs587782011, rs200928781, rs587781558, rs370228071, rs587782245, rs587782401, rs180177110, rs587782504, rs72552322, rs587782531, rs587782620, rs587782680, rs587782774, rs587782818, rs730881411, rs730881389, rs564652222, rs397507768, rs587776419, rs730881868, rs730881940, rs56383036, rs758972589, rs201089102, rs730881348, rs786202608, rs786201886, rs786203318, rs786203775, rs786203714, rs786202033, rs750621215, rs786203884, rs786203650, rs772821016, rs863224521, rs864622223, rs864622655, rs375699023, rs876659572, rs768362387, rs876659535, rs876658957, rs483353072, rs876659435, rs267608041, rs876661113, rs730881369, rs878853535, rs772228129, rs878855122, rs760551339, rs80359596, rs397509222, rs886039630, rs886039683, rs886040828, rs587781799, rs886040374, rs886040649, rs397507967, rs878854957, rs886040043, rs1057517589, rs1060502769, rs866380588, rs863224765, rs1064793243, rs747563556, rs1555074976, rs1064795885, rs753961188, rs1064794708, rs869312772, rs1064793887, rs1131690820, rs1135401928, rs1135401868, rs1135401859, rs1553370324, rs397507630, rs1555283160, rs1555283251, rs1555283262, rs1555283361, rs1555286298, rs1555288462, rs886040950, rs1555289566, rs776323117, rs80357123, rs1555579627, rs1555580697, rs80358054, rs1555593302, rs1328985852, rs763470424, rs1555139694, rs878854697, rs1555461217, rs1555461765, rs774684620, rs766416564, rs1554558613, rs1305740166, rs1555461460, rs1555461407, rs1555461586, rs1555567202, rs1555607022, rs1555069815, rs1442299125, rs1474786480, rs1555084947, rs1555457867, rs141087784, rs1482641121, rs1564830522, rs1565469955, rs1565503137, rs864622613, rs755263466, rs757679199, rs1593903166, rs1597801649, rs1603293306, rs879253880, rs80358754, rs1597062038, rs45494092, rs1603275367, rs887358871, rs1597091518, rs1966967065, rs1064793049, rs2082872908, rs2085078278, rs2072475243

Associations from Text Mining
Disease Name	Relationship Type	References
Anorexia	Associate	30772304
Blood Platelet Disorders	Associate	38254638
Cachexia	Associate	30772304
Insulin Resistance	Associate	33302552
Obesity	Associate	33302552
Stomach Neoplasms	Associate	37260027