Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	388325
Gene name Gene Name - the full gene name approved by the HGNC.	SLP adaptor and CSK interacting membrane protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SCIMP
Synonyms (NCBI Gene) Gene synonyms aliases	C17orf87, UNQ5783
Chromosome Chromosome number	17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	17p13.2
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immune synaps

Show/Hide all(99)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017059	hsa-miR-335-5p	Microarray	18185580
MIRT689487	hsa-miR-548ac	HITS-CLIP	23313552
MIRT689486	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT689485	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT689484	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT689483	hsa-miR-548z	HITS-CLIP	23313552
MIRT689482	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT689481	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT689480	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT689479	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT689478	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT689477	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT689476	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT689475	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT689474	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT689473	hsa-miR-5688	HITS-CLIP	23313552
MIRT689472	hsa-miR-338-3p	HITS-CLIP	23313552
MIRT689471	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689470	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT689469	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT689468	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689467	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT689466	hsa-miR-4435	HITS-CLIP	23313552
MIRT676127	hsa-miR-3155a	HITS-CLIP	23824327
MIRT676126	hsa-miR-3155b	HITS-CLIP	23824327
MIRT676125	hsa-miR-484	HITS-CLIP	23824327
MIRT676124	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676123	hsa-miR-764	HITS-CLIP	23824327
MIRT676122	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676121	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676120	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676119	hsa-miR-4454	HITS-CLIP	23824327
MIRT676118	hsa-miR-6131	HITS-CLIP	23824327
MIRT676117	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT676116	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT676115	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676114	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT661229	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT661228	hsa-miR-3126-5p	HITS-CLIP	23824327
MIRT661227	hsa-miR-6875-5p	HITS-CLIP	23824327
MIRT661225	hsa-miR-4419a	HITS-CLIP	23824327
MIRT661226	hsa-miR-4510	HITS-CLIP	23824327
MIRT661224	hsa-miR-6127	HITS-CLIP	23824327
MIRT661223	hsa-miR-6129	HITS-CLIP	23824327
MIRT661222	hsa-miR-6130	HITS-CLIP	23824327
MIRT661221	hsa-miR-6133	HITS-CLIP	23824327
MIRT661220	hsa-miR-6834-5p	HITS-CLIP	23824327
MIRT661219	hsa-miR-1226-5p	HITS-CLIP	23824327
MIRT661218	hsa-miR-6734-5p	HITS-CLIP	23824327
MIRT661217	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT689487	hsa-miR-548ac	HITS-CLIP	23313552
MIRT689486	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT689485	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT689484	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT689483	hsa-miR-548z	HITS-CLIP	23313552
MIRT689482	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT689481	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT689480	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT689479	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT689478	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT689477	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT689476	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT689475	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT689474	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT689473	hsa-miR-5688	HITS-CLIP	23313552
MIRT689472	hsa-miR-338-3p	HITS-CLIP	23313552
MIRT689471	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT689470	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT689469	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT689468	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT689467	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT689466	hsa-miR-4435	HITS-CLIP	23313552
MIRT676127	hsa-miR-3155a	HITS-CLIP	23824327
MIRT676126	hsa-miR-3155b	HITS-CLIP	23824327
MIRT676125	hsa-miR-484	HITS-CLIP	23824327
MIRT676124	hsa-miR-125a-3p	HITS-CLIP	23824327
MIRT676123	hsa-miR-764	HITS-CLIP	23824327
MIRT676122	hsa-miR-3934-5p	HITS-CLIP	23824327
MIRT676121	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT676120	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT676119	hsa-miR-4454	HITS-CLIP	23824327
MIRT676118	hsa-miR-6131	HITS-CLIP	23824327
MIRT676117	hsa-miR-6801-5p	HITS-CLIP	23824327
MIRT676116	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT676115	hsa-miR-6843-3p	HITS-CLIP	23824327
MIRT676114	hsa-miR-6848-3p	HITS-CLIP	23824327
MIRT661229	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT661228	hsa-miR-3126-5p	HITS-CLIP	23824327
MIRT661227	hsa-miR-6875-5p	HITS-CLIP	23824327
MIRT661225	hsa-miR-4419a	HITS-CLIP	23824327
MIRT661226	hsa-miR-4510	HITS-CLIP	23824327
MIRT661224	hsa-miR-6127	HITS-CLIP	23824327
MIRT661223	hsa-miR-6129	HITS-CLIP	23824327
MIRT661222	hsa-miR-6130	HITS-CLIP	23824327
MIRT661221	hsa-miR-6133	HITS-CLIP	23824327
MIRT661220	hsa-miR-6834-5p	HITS-CLIP	23824327
MIRT661219	hsa-miR-1226-5p	HITS-CLIP	23824327
MIRT661218	hsa-miR-6734-5p	HITS-CLIP	23824327
MIRT661217	hsa-miR-4446-5p	HITS-CLIP	23824327

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	ISS
GO:0001772	Component	Immunological synapse	IBA	21873635
GO:0001772	Component	Immunological synapse	IDA	21930792
GO:0002367	Process	Cytokine production involved in immune response	ISS
GO:0002732	Process	Positive regulation of dendritic cell cytokine production	ISS
GO:0005515	Function	Protein binding	IPI	21930792, 32296183
GO:0016020	Component	Membrane	IDA	21930792
GO:0016021	Component	Integral component of membrane	IEA
GO:0030175	Component	Filopodium	ISS
GO:0031256	Component	Leading edge membrane	IDA	21930792
GO:0031259	Component	Uropod membrane	IDA	21930792
GO:0031666	Process	Positive regulation of lipopolysaccharide-mediated signaling pathway	ISS
GO:0032735	Process	Positive regulation of interleukin-12 production	ISS
GO:0032755	Process	Positive regulation of interleukin-6 production	ISS
GO:0032874	Process	Positive regulation of stress-activated MAPK cascade	ISS
GO:0034138	Process	Toll-like receptor 3 signaling pathway	ISS
GO:0034142	Process	Toll-like receptor 4 signaling pathway	ISS
GO:0034154	Process	Toll-like receptor 7 signaling pathway	ISS
GO:0038123	Process	Toll-like receptor TLR1:TLR2 signaling pathway	ISS
GO:0043235	Component	Receptor complex	ISS
GO:0045335	Component	Phagocytic vesicle	ISS
GO:0060090	Function	Molecular adaptor activity	ISS
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	IDA	21930792
GO:0071226	Process	Cellular response to molecule of fungal origin	ISS
GO:0097197	Component	Tetraspanin-enriched microdomain	IDA	21930792

MIM	HGNC	e!Ensembl
614406	33504	ENSG00000161929

Protein

UniProt ID

Q6UWF3

Protein name

SLP adapter and CSK-interacting membrane protein (SLP65/SLP76, Csk-interacting membrane protein)

Protein function

Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:21930792). It is involved in major histocompatibility complex class II (MHC-II) signa

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15050	SCIMP	12 → 143	SCIMP protein	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level) (PubMed:21930792). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells

Sequence

MDTFTVQDSTAMSWWRNNFWIILAVAIIVVSVGLGLILYCVCKWQLRRGKKWEIAKPLKH
KQVDEEKMYENVLNESPVQLPPLPPRNWPSLEDSSPQEAPSQPPATYSLVNKVKNKKTVS
IPSYIEPEDDYDDVEIPANTEKASF

Sequence length

145

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	29777097, 24162737, 31473137

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	31473137, 33152005
Inflammation	Associate	37658353

SCIMP (SLP adaptor and CSK interacting membrane protein)