KRT19 (keratin 19)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3880
Gene name Gene Name - the full gene name approved by the HGNC.
Keratin 19
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KRT19
Synonyms (NCBI Gene) Gene synonyms aliases
CK19, K19, K1CS
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.2
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratin
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(66)
miRTarBase ID miRNA Experiments Reference
MIRT016304 hsa-miR-193b-3p Proteomics 21512034
MIRT016860 hsa-miR-335-5p Microarray 18185580
MIRT1101175 hsa-miR-1207-5p CLIP-seq
MIRT1101176 hsa-miR-1253 CLIP-seq
MIRT1101177 hsa-miR-1912 CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(3)
Transcription factor Regulation Reference
ESR1 Activation 11026574
KLF4 Activation 10859317
SP1 Activation 10859317
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0005200 Function Structural constituent of cytoskeleton TAS 2448790
GO:0005515 Function Protein binding IPI 15846844, 16000376, 16189514, 20080707, 25416956, 25910212, 26871637, 29892012, 31515488, 32296183, 32814053
GO:0005829 Component Cytosol TAS
GO:0005882 Component Intermediate filament IEA
GO:0005886 Component Plasma membrane IDA 23377137
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
148020 6436 ENSG00000171345
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08727
Protein name Keratin, type I cytoskeletal 19 (Cytokeratin-19) (CK-19) (Keratin-19) (K19)
Protein function Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.
PDB 8XTN , 8XTO , 8Y3S , 8ZUG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00038 Filament 79 → 390 Intermediate filament protein Coiled-coil
Tissue specificity TISSUE SPECIFICITY: Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral
Sequence
Sequence length 400
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Estrogen signaling pathway
Staphylococcus aureus infection 		  Keratinization
Formation of the cornified envelope
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Autoimmune diseases Autoimmune Diseases rs869025224 25055964
Esophagus neoplasm Squamous cell carcinoma of esophagus rs28934578, rs121918714, rs1567556006, rs1575166666 21517111
Show/Hide Unknown Diseases (1)
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 15478392 ClinVar
Show/Hide Text Mining Associations (200)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 15710986, 23348905, 24078426, 33832101, 34102222
Adenocarcinoma Stimulate 34706517
Adenocarcinoma Follicular Associate 17728499, 27171147, 34711014
Adenocarcinoma Mucinous Associate 21699710
Adenocarcinoma of Lung Associate 12192603, 18329483, 2414994, 25189096, 32519739, 35441736, 39522011
Adenocarcinoma Papillary Associate 36705380
Adenolymphoma Associate 22990554
Adenoma Associate 20565793
Adrenal Gland Neoplasms Associate 24322017
Alagille Syndrome Associate 8701983