GPR153 (G protein-coupled receptor 153)

Gene

• Entrez ID: 387509
• Gene name: G protein-coupled receptor 153
• Gene symbol: GPR153
• Synonyms (NCBI Gene): PGR1
• Chromosome: 1
• Chromosome location: 1p36.31
• Summary: This gene encodes an integral membrane protein that belongs to the Class A rhodopsin superfamily of G protein coupled receptors. The encoded protein is expressed primarily in the central nervous system. A knockdown of the orthologous gene in rat is associ

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs776061422	G>A,T	Likely-pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018324	hsa-miR-335-5p	Microarray	18185580
MIRT487782	hsa-miR-132-5p	PAR-CLIP	23592263
MIRT487781	hsa-miR-1254	PAR-CLIP	23592263
MIRT487780	hsa-miR-3116	PAR-CLIP	23592263
MIRT487779	hsa-miR-661	PAR-CLIP	23592263
MIRT487782	hsa-miR-132-5p	PAR-CLIP	23592263
MIRT487781	hsa-miR-1254	PAR-CLIP	23592263
MIRT487780	hsa-miR-3116	PAR-CLIP	23592263
MIRT487779	hsa-miR-661	PAR-CLIP	23592263
MIRT1030582	hsa-miR-103a	CLIP-seq
MIRT1030583	hsa-miR-107	CLIP-seq
MIRT1030584	hsa-miR-124	CLIP-seq
MIRT1030585	hsa-miR-1273f	CLIP-seq
MIRT1030586	hsa-miR-1286	CLIP-seq
MIRT1030587	hsa-miR-1287	CLIP-seq
MIRT1030588	hsa-miR-1293	CLIP-seq
MIRT1030589	hsa-miR-143	CLIP-seq
MIRT1030590	hsa-miR-1471	CLIP-seq
MIRT1030591	hsa-miR-15a	CLIP-seq
MIRT1030592	hsa-miR-15b	CLIP-seq
MIRT1030593	hsa-miR-16	CLIP-seq
MIRT1030594	hsa-miR-1827	CLIP-seq
MIRT1030595	hsa-miR-1910	CLIP-seq
MIRT1030596	hsa-miR-195	CLIP-seq
MIRT1030597	hsa-miR-2110	CLIP-seq
MIRT1030598	hsa-miR-223	CLIP-seq
MIRT1030599	hsa-miR-3150a-3p	CLIP-seq
MIRT1030600	hsa-miR-3150b-3p	CLIP-seq
MIRT1030601	hsa-miR-3175	CLIP-seq
MIRT1030602	hsa-miR-3187-3p	CLIP-seq
MIRT1030603	hsa-miR-331-3p	CLIP-seq
MIRT1030604	hsa-miR-3614-3p	CLIP-seq
MIRT1030605	hsa-miR-3652	CLIP-seq
MIRT1030606	hsa-miR-3978	CLIP-seq
MIRT1030607	hsa-miR-424	CLIP-seq
MIRT1030608	hsa-miR-4271	CLIP-seq
MIRT1030609	hsa-miR-4292	CLIP-seq
MIRT1030610	hsa-miR-4300	CLIP-seq
MIRT1030611	hsa-miR-4302	CLIP-seq
MIRT1030612	hsa-miR-4310	CLIP-seq
MIRT1030613	hsa-miR-4419a	CLIP-seq
MIRT1030614	hsa-miR-4430	CLIP-seq
MIRT1030615	hsa-miR-4435	CLIP-seq
MIRT1030616	hsa-miR-4436a	CLIP-seq
MIRT1030617	hsa-miR-4446-3p	CLIP-seq
MIRT1030618	hsa-miR-4483	CLIP-seq
MIRT1030619	hsa-miR-4492	CLIP-seq
MIRT1030620	hsa-miR-4493	CLIP-seq
MIRT1030621	hsa-miR-4498	CLIP-seq
MIRT1030622	hsa-miR-4510	CLIP-seq
MIRT1030623	hsa-miR-455-3p	CLIP-seq
MIRT1030624	hsa-miR-4635	CLIP-seq
MIRT1030625	hsa-miR-4649-3p	CLIP-seq
MIRT1030626	hsa-miR-4667-5p	CLIP-seq
MIRT1030627	hsa-miR-4685-5p	CLIP-seq
MIRT1030628	hsa-miR-4697-3p	CLIP-seq
MIRT1030629	hsa-miR-4700-5p	CLIP-seq
MIRT1030630	hsa-miR-4701-5p	CLIP-seq
MIRT1030631	hsa-miR-4725-3p	CLIP-seq
MIRT1030632	hsa-miR-4738-3p	CLIP-seq
MIRT1030633	hsa-miR-4749-3p	CLIP-seq
MIRT1030634	hsa-miR-4756-3p	CLIP-seq
MIRT1030635	hsa-miR-4770	CLIP-seq
MIRT1030636	hsa-miR-4784	CLIP-seq
MIRT1030637	hsa-miR-4802-5p	CLIP-seq
MIRT1030638	hsa-miR-497	CLIP-seq
MIRT1030639	hsa-miR-506	CLIP-seq
MIRT1030640	hsa-miR-516b	CLIP-seq
MIRT1030641	hsa-miR-541	CLIP-seq
MIRT1030642	hsa-miR-548s	CLIP-seq
MIRT1030643	hsa-miR-584	CLIP-seq
MIRT1030644	hsa-miR-588	CLIP-seq
MIRT1030645	hsa-miR-654-5p	CLIP-seq
MIRT1030646	hsa-miR-762	CLIP-seq
MIRT1030647	hsa-miR-765	CLIP-seq
MIRT1030648	hsa-miR-920	CLIP-seq
MIRT1030649	hsa-miR-939	CLIP-seq
MIRT1030650	hsa-miR-940	CLIP-seq
MIRT1030582	hsa-miR-103a	CLIP-seq
MIRT1030583	hsa-miR-107	CLIP-seq
MIRT2005772	hsa-miR-1178	CLIP-seq
MIRT2005773	hsa-miR-1207-5p	CLIP-seq
MIRT1030585	hsa-miR-1273f	CLIP-seq
MIRT2005774	hsa-miR-1285	CLIP-seq
MIRT1030587	hsa-miR-1287	CLIP-seq
MIRT1030590	hsa-miR-1471	CLIP-seq
MIRT1030591	hsa-miR-15a	CLIP-seq
MIRT1030592	hsa-miR-15b	CLIP-seq
MIRT1030593	hsa-miR-16	CLIP-seq
MIRT2005775	hsa-miR-1909	CLIP-seq
MIRT1030596	hsa-miR-195	CLIP-seq
MIRT2005776	hsa-miR-2355-5p	CLIP-seq
MIRT2005777	hsa-miR-3117-5p	CLIP-seq
MIRT2005778	hsa-miR-3144-5p	CLIP-seq
MIRT1030600	hsa-miR-3150b-3p	CLIP-seq
MIRT2005779	hsa-miR-3155	CLIP-seq
MIRT2005780	hsa-miR-3155b	CLIP-seq
MIRT2005781	hsa-miR-3184	CLIP-seq
MIRT1030602	hsa-miR-3187-3p	CLIP-seq
MIRT2005782	hsa-miR-3187-5p	CLIP-seq
MIRT2005783	hsa-miR-3191	CLIP-seq
MIRT2005784	hsa-miR-3199	CLIP-seq
MIRT1030605	hsa-miR-3652	CLIP-seq
MIRT2005785	hsa-miR-423-5p	CLIP-seq
MIRT1030607	hsa-miR-424	CLIP-seq
MIRT1030610	hsa-miR-4300	CLIP-seq
MIRT1030612	hsa-miR-4310	CLIP-seq
MIRT1030613	hsa-miR-4419a	CLIP-seq
MIRT1030614	hsa-miR-4430	CLIP-seq
MIRT1030615	hsa-miR-4435	CLIP-seq
MIRT1030617	hsa-miR-4446-3p	CLIP-seq
MIRT1030619	hsa-miR-4492	CLIP-seq
MIRT1030621	hsa-miR-4498	CLIP-seq
MIRT1030622	hsa-miR-4510	CLIP-seq
MIRT2005786	hsa-miR-4514	CLIP-seq
MIRT2005787	hsa-miR-4515	CLIP-seq
MIRT2005788	hsa-miR-4652-5p	CLIP-seq
MIRT1030627	hsa-miR-4685-5p	CLIP-seq
MIRT2005789	hsa-miR-4692	CLIP-seq
MIRT1030630	hsa-miR-4701-5p	CLIP-seq
MIRT1030633	hsa-miR-4749-3p	CLIP-seq
MIRT1030634	hsa-miR-4756-3p	CLIP-seq
MIRT2005790	hsa-miR-4757-5p	CLIP-seq
MIRT2005791	hsa-miR-4761-5p	CLIP-seq
MIRT2005792	hsa-miR-4763-3p	CLIP-seq
MIRT1030636	hsa-miR-4784	CLIP-seq
MIRT1030637	hsa-miR-4802-5p	CLIP-seq
MIRT2005793	hsa-miR-484	CLIP-seq
MIRT2005794	hsa-miR-486-3p	CLIP-seq
MIRT2005795	hsa-miR-491-5p	CLIP-seq
MIRT1030638	hsa-miR-497	CLIP-seq
MIRT1030642	hsa-miR-548s	CLIP-seq
MIRT1030644	hsa-miR-588	CLIP-seq
MIRT2005796	hsa-miR-612	CLIP-seq
MIRT1030646	hsa-miR-762	CLIP-seq
MIRT1030647	hsa-miR-765	CLIP-seq
MIRT1030648	hsa-miR-920	CLIP-seq
MIRT1030650	hsa-miR-940	CLIP-seq
MIRT1030585	hsa-miR-1273f	CLIP-seq
MIRT2238378	hsa-miR-1324	CLIP-seq
MIRT2238379	hsa-miR-1343	CLIP-seq
MIRT1030615	hsa-miR-4435	CLIP-seq
MIRT2238380	hsa-miR-4438	CLIP-seq
MIRT2238381	hsa-miR-4646-5p	CLIP-seq
MIRT1030627	hsa-miR-4685-5p	CLIP-seq
MIRT2005790	hsa-miR-4757-5p	CLIP-seq
MIRT2681999	hsa-miR-1224-3p	CLIP-seq
MIRT2682000	hsa-miR-1228	CLIP-seq
MIRT2682001	hsa-miR-1260	CLIP-seq
MIRT2682002	hsa-miR-1260b	CLIP-seq
MIRT2682003	hsa-miR-1280	CLIP-seq
MIRT2682004	hsa-miR-2682	CLIP-seq
MIRT2682005	hsa-miR-4423-3p	CLIP-seq
MIRT2238380	hsa-miR-4438	CLIP-seq
MIRT2682006	hsa-miR-449c	CLIP-seq
MIRT2682007	hsa-miR-4512	CLIP-seq
MIRT2682008	hsa-miR-4530	CLIP-seq
MIRT2682009	hsa-miR-4640-5p	CLIP-seq
MIRT2682010	hsa-miR-4726-5p	CLIP-seq
MIRT2682011	hsa-miR-532-3p	CLIP-seq
MIRT2682012	hsa-miR-646	CLIP-seq
MIRT1030650	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 614269
• HGNC: 23618
• e!Ensembl: ENSG00000158292

Protein

• UniProt ID: Q6NV75
• Protein name: Probable G-protein coupled receptor 153 (G-protein coupled receptor PGR1)
• Protein function: Orphan receptor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	24 → 297	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MSDERRLPGSAVGWLVCGGLSLLANAWGILSVGAKQKKWKPLEFLLCTLAATHMLNVAVP
  IATYSVVQLRRQRPDFEWNEGLCKVFVSTFYTLTLATCFSVTSLSYHRMWMVCWPVNYRL
  SNAKKQAVHTVMGIWMVSFILSALPAVGWHDTSERFYTHGCRFIVAEIGLGFGVCFLLLV
  GGSVAMGVICTAIALFQTLAVQVGRQADRRAFTVPTIVVEDAQGKRRSSIDGSEPAKTSL
  QTTGLVTTIVFIYDCLMGFPVLVVSFSSLRADASAPWMALCVLWCSVAQALLLPVFLWAC
  DRYRADLKAVREKCMALMANDEESDDETSLEGGISPDLVLERSLDYGYGGDFVALDRMAK
  YEISALEGGLPQLYPLRPLQEDKMQYLQVPPTRRFSHDDADVWAAVPLPAFLPRWGSGED
  LAALAHLVLPAGPERRRASLLAFAEDAPPSRARRRSAESLLSLRPSALDSGPRGARDSPP
  GSPRRRPGPGPRSASASLLPDAFALTAFECEPQALRRPPGPFPAAPAAPDGADPGEAPTP
  PSSAQRSPGPRPSAHSHAGSLRPGLSASWGEPGGLRAAGGGGSTSSFLSSPSESSGYATL
  HSDSLGSAS

• Sequence length: 609

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Childhood-onset schizophrenia	Likely pathogenic	rs776061422	RCV000202336

Associations from Text Mining
Disease Name	Relationship Type	References
Mental Disorders	Associate	26508570
Schizophrenia Childhood	Associate	26508570