KRT15 (keratin 15)

Gene

• Entrez ID: 3866
• Gene name: Keratin 15
• Gene symbol: KRT15
• Synonyms (NCBI Gene): CK15, K15, K1CO
• Chromosome: 17
• Chromosome location: 17q21.2
• Summary: The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043849	hsa-miR-340-3p	CLASH	23622248
MIRT1101143	hsa-miR-3941	CLIP-seq
MIRT1101144	hsa-miR-466	CLIP-seq
MIRT1101145	hsa-miR-4672	CLIP-seq
MIRT1101146	hsa-miR-4731-3p	CLIP-seq
MIRT1101147	hsa-miR-4801	CLIP-seq
MIRT1101148	hsa-miR-502-5p	CLIP-seq
MIRT1101149	hsa-miR-556-5p	CLIP-seq
MIRT1101148	hsa-miR-502-5p	CLIP-seq
MIRT2258835	hsa-miR-1207-5p	CLIP-seq
MIRT2258836	hsa-miR-3150a-3p	CLIP-seq
MIRT2258837	hsa-miR-3175	CLIP-seq
MIRT2258838	hsa-miR-3199	CLIP-seq
MIRT2258839	hsa-miR-3714	CLIP-seq
MIRT2258840	hsa-miR-3921	CLIP-seq
MIRT1101143	hsa-miR-3941	CLIP-seq
MIRT2258841	hsa-miR-4481	CLIP-seq
MIRT2258842	hsa-miR-4493	CLIP-seq
MIRT2258843	hsa-miR-4502	CLIP-seq
MIRT2258844	hsa-miR-4653-5p	CLIP-seq
MIRT1101144	hsa-miR-466	CLIP-seq
MIRT1101145	hsa-miR-4672	CLIP-seq
MIRT2258845	hsa-miR-4693-3p	CLIP-seq
MIRT2258846	hsa-miR-4712-3p	CLIP-seq
MIRT1101146	hsa-miR-4731-3p	CLIP-seq
MIRT2258847	hsa-miR-4745-5p	CLIP-seq
MIRT2258848	hsa-miR-4763-3p	CLIP-seq
MIRT1101147	hsa-miR-4801	CLIP-seq
MIRT2258849	hsa-miR-491-5p	CLIP-seq
MIRT1101148	hsa-miR-502-5p	CLIP-seq
MIRT1101149	hsa-miR-556-5p	CLIP-seq
MIRT2258850	hsa-miR-939	CLIP-seq
MIRT2258851	hsa-miR-940	CLIP-seq
MIRT2258835	hsa-miR-1207-5p	CLIP-seq
MIRT2258838	hsa-miR-3199	CLIP-seq
MIRT2258839	hsa-miR-3714	CLIP-seq
MIRT2258842	hsa-miR-4493	CLIP-seq
MIRT2390031	hsa-miR-4515	CLIP-seq
MIRT2390032	hsa-miR-4653-3p	CLIP-seq
MIRT2258848	hsa-miR-4763-3p	CLIP-seq
MIRT2258851	hsa-miR-940	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
FOXM1	Unknown	22761689

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002009	Process	Morphogenesis of an epithelium	IBA
GO:0005198	Function	Structural molecule activity	IEA
GO:0005200	Function	Structural constituent of cytoskeleton	TAS	2580298
GO:0005515	Function	Protein binding	IPI	16189514, 22458338, 24940650, 25416956, 25910212, 26871637, 27812135, 29892012, 31515488, 32296183
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IBA
GO:0005882	Component	Intermediate filament	IEA
GO:0005882	Component	Intermediate filament	TAS	2580298
GO:0008544	Process	Epidermis development	TAS	2452170
GO:0030280	Function	Structural constituent of skin epidermis	IBA
GO:0030855	Process	Epithelial cell differentiation	IBA
GO:0045095	Component	Keratin filament	IBA
GO:0045109	Process	Intermediate filament organization	IBA
GO:0070062	Component	Extracellular exosome	HDA	19199708
GO:0097110	Function	Scaffold protein binding	IPI	10852826

Other IDs

• MIM: 148030
• HGNC: 6421
• e!Ensembl: ENSG00000171346

Protein

• UniProt ID: P19012
• Protein name: Keratin, type I cytoskeletal 15 (Cytokeratin-15) (CK-15) (Keratin-15) (K15)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00038	Filament	104 → 416	Intermediate filament protein	Coiled-coil

• Tissue specificity: TISSUE SPECIFICITY: Expressed in a discontinuous manner in the basal cell layer of adult skin epidermis, but continuously in the basal layer of fetal skin epidermis and nail. Also expressed in the outer root sheath above the hair bulb in hair follicle (at
• Sequence:

  MTTTFLQTSSSTFGGGSTRGGSLLAGGGGFGGGSLSGGGGSRSISASSARFVSSGSGGGY
  GGGMRVCGFGGGAGSVFGGGFGGGVGGGFGGGFGGGDGGLLSGNEKITMQNLNDRLASYL
  DKVRALEEANADLEVKIHDWYQKQTPTSPECDYSQYFKTIEELRDKIMATTIDNSRVILE
  IDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYL
  KKNHEEEMKEFSSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSK
  TEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQ
  LQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI
  AIREASSGGGGSSSNFHINVEESVDGQVVSSHKREI

• Sequence length: 456

Pathways

KEGG:

Estrogen signaling pathway
Staphylococcus aureus infection

Reactome:

Keratinization
Formation of the cornified envelope