Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3856
Gene name	Keratin 8
Gene symbol	KRT8
Synonyms (NCBI Gene)	CARD2CK-8CK8CYK8K2C8K8KO
Chromosome	12
Chromosome location	12q13.13
Summary	This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dime

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SNP ID	Visualize variation	Clinical significance	Consequence
rs11554495	C>A	Not-provided, pathogenic, risk-factor	Coding sequence variant, missense variant, non coding transcript variant
rs57749775	A>G,T	Not-provided, risk-factor, pathogenic, uncertain-significance	Missense variant, non coding transcript variant, coding sequence variant

272

Show/Hide all (272)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019995	hsa-miR-375	Microarray	20215506
MIRT030226	hsa-miR-26b-5p	Microarray	19088304
MIRT498607	hsa-miR-4779	PAR-CLIP	24398324
MIRT498606	hsa-miR-3929	PAR-CLIP	24398324
MIRT498605	hsa-miR-4419b	PAR-CLIP	24398324
MIRT498604	hsa-miR-4478	PAR-CLIP	24398324
MIRT498603	hsa-miR-4459	PAR-CLIP	24398324
MIRT498602	hsa-miR-3192-5p	PAR-CLIP	24398324
MIRT498601	hsa-miR-1914-3p	PAR-CLIP	24398324
MIRT498600	hsa-miR-5194	PAR-CLIP	24398324
MIRT498598	hsa-miR-6738-5p	PAR-CLIP	24398324
MIRT498599	hsa-miR-4722-5p	PAR-CLIP	24398324
MIRT498597	hsa-miR-885-3p	PAR-CLIP	24398324
MIRT498596	hsa-miR-4505	PAR-CLIP	24398324
MIRT498595	hsa-miR-5787	PAR-CLIP	24398324
MIRT498594	hsa-miR-7106-5p	PAR-CLIP	24398324
MIRT498593	hsa-miR-149-3p	PAR-CLIP	24398324
MIRT498592	hsa-miR-4728-5p	PAR-CLIP	24398324
MIRT498591	hsa-miR-6785-5p	PAR-CLIP	24398324
MIRT498590	hsa-miR-6883-5p	PAR-CLIP	24398324
MIRT498589	hsa-miR-6799-5p	PAR-CLIP	24398324
MIRT498588	hsa-miR-486-3p	PAR-CLIP	24398324
MIRT498586	hsa-miR-1273h-5p	PAR-CLIP	24398324
MIRT498587	hsa-miR-30b-3p	PAR-CLIP	24398324
MIRT498585	hsa-miR-3689a-3p	PAR-CLIP	24398324
MIRT498584	hsa-miR-3689b-3p	PAR-CLIP	24398324
MIRT498583	hsa-miR-3689c	PAR-CLIP	24398324
MIRT498581	hsa-miR-6779-5p	PAR-CLIP	24398324
MIRT498582	hsa-miR-6780a-5p	PAR-CLIP	24398324
MIRT451670	hsa-miR-329-5p	PAR-CLIP	24398324
MIRT451669	hsa-miR-7162-3p	PAR-CLIP	24398324
MIRT451668	hsa-miR-655-5p	PAR-CLIP	24398324
MIRT451667	hsa-miR-377-5p	PAR-CLIP	24398324
MIRT451666	hsa-miR-6086	PAR-CLIP	24398324
MIRT498580	hsa-miR-7160-5p	PAR-CLIP	24398324
MIRT451665	hsa-miR-3619-3p	PAR-CLIP	24398324
MIRT451664	hsa-miR-4776-5p	PAR-CLIP	24398324
MIRT451663	hsa-miR-4535	PAR-CLIP	24398324
MIRT451662	hsa-miR-7150	PAR-CLIP	24398324
MIRT451661	hsa-miR-4520-2-3p	PAR-CLIP	24398324
MIRT451660	hsa-miR-4529-3p	PAR-CLIP	24398324
MIRT451659	hsa-miR-7850-5p	PAR-CLIP	24398324
MIRT451670	hsa-miR-329-5p	PAR-CLIP	23592263
MIRT451669	hsa-miR-7162-3p	PAR-CLIP	23592263
MIRT451668	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT451667	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT451666	hsa-miR-6086	PAR-CLIP	23592263
MIRT451665	hsa-miR-3619-3p	PAR-CLIP	23592263
MIRT451664	hsa-miR-4776-5p	PAR-CLIP	23592263
MIRT451663	hsa-miR-4535	PAR-CLIP	23592263
MIRT451662	hsa-miR-7150	PAR-CLIP	23592263
MIRT451661	hsa-miR-4520-2-3p	PAR-CLIP	23592263
MIRT451660	hsa-miR-4529-3p	PAR-CLIP	23592263
MIRT451659	hsa-miR-7850-5p	PAR-CLIP	23592263
MIRT736566	hsa-miR-186-5p	Luciferase reporter assayWestern blottingImmunohistochemistry (IHC)qRT-PCR	33061604
MIRT498607	hsa-miR-4779	PAR-CLIP	24398324
MIRT498606	hsa-miR-3929	PAR-CLIP	24398324
MIRT498605	hsa-miR-4419b	PAR-CLIP	24398324
MIRT498604	hsa-miR-4478	PAR-CLIP	24398324
MIRT498603	hsa-miR-4459	PAR-CLIP	24398324
MIRT498602	hsa-miR-3192-5p	PAR-CLIP	24398324
MIRT498601	hsa-miR-1914-3p	PAR-CLIP	24398324
MIRT498600	hsa-miR-5194	PAR-CLIP	24398324
MIRT498598	hsa-miR-6738-5p	PAR-CLIP	24398324
MIRT498599	hsa-miR-4722-5p	PAR-CLIP	24398324
MIRT498597	hsa-miR-885-3p	PAR-CLIP	24398324
MIRT498596	hsa-miR-4505	PAR-CLIP	24398324
MIRT498595	hsa-miR-5787	PAR-CLIP	24398324
MIRT498594	hsa-miR-7106-5p	PAR-CLIP	24398324
MIRT498593	hsa-miR-149-3p	PAR-CLIP	24398324
MIRT498592	hsa-miR-4728-5p	PAR-CLIP	24398324
MIRT498591	hsa-miR-6785-5p	PAR-CLIP	24398324
MIRT498590	hsa-miR-6883-5p	PAR-CLIP	24398324
MIRT498589	hsa-miR-6799-5p	PAR-CLIP	24398324
MIRT498588	hsa-miR-486-3p	PAR-CLIP	24398324
MIRT498586	hsa-miR-1273h-5p	PAR-CLIP	24398324
MIRT498587	hsa-miR-30b-3p	PAR-CLIP	24398324
MIRT498585	hsa-miR-3689a-3p	PAR-CLIP	24398324
MIRT498584	hsa-miR-3689b-3p	PAR-CLIP	24398324
MIRT498583	hsa-miR-3689c	PAR-CLIP	24398324
MIRT498581	hsa-miR-6779-5p	PAR-CLIP	24398324
MIRT498582	hsa-miR-6780a-5p	PAR-CLIP	24398324
MIRT451670	hsa-miR-329-5p	PAR-CLIP	24398324
MIRT451669	hsa-miR-7162-3p	PAR-CLIP	24398324
MIRT451668	hsa-miR-655-5p	PAR-CLIP	24398324
MIRT451667	hsa-miR-377-5p	PAR-CLIP	24398324
MIRT451666	hsa-miR-6086	PAR-CLIP	24398324
MIRT498580	hsa-miR-7160-5p	PAR-CLIP	24398324
MIRT451665	hsa-miR-3619-3p	PAR-CLIP	24398324
MIRT451664	hsa-miR-4776-5p	PAR-CLIP	24398324
MIRT451663	hsa-miR-4535	PAR-CLIP	24398324
MIRT451662	hsa-miR-7150	PAR-CLIP	24398324
MIRT451661	hsa-miR-4520-2-3p	PAR-CLIP	24398324
MIRT451660	hsa-miR-4529-3p	PAR-CLIP	24398324
MIRT451659	hsa-miR-7850-5p	PAR-CLIP	24398324
MIRT451670	hsa-miR-329-5p	PAR-CLIP	23592263
MIRT451669	hsa-miR-7162-3p	PAR-CLIP	23592263
MIRT451668	hsa-miR-655-5p	PAR-CLIP	23592263
MIRT451667	hsa-miR-377-5p	PAR-CLIP	23592263
MIRT451666	hsa-miR-6086	PAR-CLIP	23592263
MIRT451665	hsa-miR-3619-3p	PAR-CLIP	23592263
MIRT451664	hsa-miR-4776-5p	PAR-CLIP	23592263
MIRT451663	hsa-miR-4535	PAR-CLIP	23592263
MIRT451662	hsa-miR-7150	PAR-CLIP	23592263
MIRT451661	hsa-miR-4520-2-3p	PAR-CLIP	23592263
MIRT451660	hsa-miR-4529-3p	PAR-CLIP	23592263
MIRT451659	hsa-miR-7850-5p	PAR-CLIP	23592263
MIRT1101823	hsa-miR-10a	CLIP-seq
MIRT1101824	hsa-miR-10b	CLIP-seq
MIRT1101825	hsa-miR-125a-3p	CLIP-seq
MIRT1101826	hsa-miR-153	CLIP-seq
MIRT1101827	hsa-miR-1587	CLIP-seq
MIRT1101828	hsa-miR-1825	CLIP-seq
MIRT1101829	hsa-miR-1915	CLIP-seq
MIRT1101830	hsa-miR-193a-5p	CLIP-seq
MIRT1101831	hsa-miR-196a	CLIP-seq
MIRT1101832	hsa-miR-196b	CLIP-seq
MIRT1101833	hsa-miR-1976	CLIP-seq
MIRT1101834	hsa-miR-2052	CLIP-seq
MIRT1101835	hsa-miR-219-2-3p	CLIP-seq
MIRT1101836	hsa-miR-2355-5p	CLIP-seq
MIRT1101837	hsa-miR-2964a-3p	CLIP-seq
MIRT1101838	hsa-miR-3135b	CLIP-seq
MIRT1101839	hsa-miR-3155	CLIP-seq
MIRT1101840	hsa-miR-3155b	CLIP-seq
MIRT1101841	hsa-miR-3158-3p	CLIP-seq
MIRT1101842	hsa-miR-3184	CLIP-seq
MIRT1101843	hsa-miR-3192	CLIP-seq
MIRT1101844	hsa-miR-326	CLIP-seq
MIRT1101845	hsa-miR-330-5p	CLIP-seq
MIRT1101846	hsa-miR-3612	CLIP-seq
MIRT1101847	hsa-miR-3613-3p	CLIP-seq
MIRT1101848	hsa-miR-3616-3p	CLIP-seq
MIRT1101849	hsa-miR-3622b-5p	CLIP-seq
MIRT1101850	hsa-miR-3667-3p	CLIP-seq
MIRT1101851	hsa-miR-3674	CLIP-seq
MIRT1101852	hsa-miR-3934	CLIP-seq
MIRT1101853	hsa-miR-423-5p	CLIP-seq
MIRT1101854	hsa-miR-4417	CLIP-seq
MIRT1101855	hsa-miR-4443	CLIP-seq
MIRT1101856	hsa-miR-4446-3p	CLIP-seq
MIRT1101857	hsa-miR-4452	CLIP-seq
MIRT1101858	hsa-miR-4492	CLIP-seq
MIRT1101859	hsa-miR-4498	CLIP-seq
MIRT1101860	hsa-miR-4520b-3p	CLIP-seq
MIRT1101861	hsa-miR-4656	CLIP-seq
MIRT1101862	hsa-miR-4663	CLIP-seq
MIRT1101863	hsa-miR-4667-5p	CLIP-seq
MIRT1101864	hsa-miR-4675	CLIP-seq
MIRT1101865	hsa-miR-4700-5p	CLIP-seq
MIRT1101866	hsa-miR-4721	CLIP-seq
MIRT1101867	hsa-miR-4726-3p	CLIP-seq
MIRT1101868	hsa-miR-4741	CLIP-seq
MIRT1101869	hsa-miR-484	CLIP-seq
MIRT1101870	hsa-miR-541	CLIP-seq
MIRT1101871	hsa-miR-615-5p	CLIP-seq
MIRT1101872	hsa-miR-637	CLIP-seq
MIRT1101873	hsa-miR-650	CLIP-seq
MIRT1101874	hsa-miR-654-5p	CLIP-seq
MIRT1101875	hsa-miR-760	CLIP-seq
MIRT1101876	hsa-miR-762	CLIP-seq
MIRT1101877	hsa-miR-764	CLIP-seq
MIRT1101823	hsa-miR-10a	CLIP-seq
MIRT1101824	hsa-miR-10b	CLIP-seq
MIRT1101825	hsa-miR-125a-3p	CLIP-seq
MIRT1101826	hsa-miR-153	CLIP-seq
MIRT1101827	hsa-miR-1587	CLIP-seq
MIRT1101828	hsa-miR-1825	CLIP-seq
MIRT1101829	hsa-miR-1915	CLIP-seq
MIRT1101830	hsa-miR-193a-5p	CLIP-seq
MIRT1101831	hsa-miR-196a	CLIP-seq
MIRT1101832	hsa-miR-196b	CLIP-seq
MIRT1101833	hsa-miR-1976	CLIP-seq
MIRT1101834	hsa-miR-2052	CLIP-seq
MIRT1101835	hsa-miR-219-2-3p	CLIP-seq
MIRT1101836	hsa-miR-2355-5p	CLIP-seq
MIRT1101837	hsa-miR-2964a-3p	CLIP-seq
MIRT1101838	hsa-miR-3135b	CLIP-seq
MIRT1101839	hsa-miR-3155	CLIP-seq
MIRT1101840	hsa-miR-3155b	CLIP-seq
MIRT1101841	hsa-miR-3158-3p	CLIP-seq
MIRT1101842	hsa-miR-3184	CLIP-seq
MIRT1101843	hsa-miR-3192	CLIP-seq
MIRT1101844	hsa-miR-326	CLIP-seq
MIRT1101845	hsa-miR-330-5p	CLIP-seq
MIRT1101846	hsa-miR-3612	CLIP-seq
MIRT1101847	hsa-miR-3613-3p	CLIP-seq
MIRT1101848	hsa-miR-3616-3p	CLIP-seq
MIRT1101849	hsa-miR-3622b-5p	CLIP-seq
MIRT1101850	hsa-miR-3667-3p	CLIP-seq
MIRT1101851	hsa-miR-3674	CLIP-seq
MIRT1101852	hsa-miR-3934	CLIP-seq
MIRT1101853	hsa-miR-423-5p	CLIP-seq
MIRT1101854	hsa-miR-4417	CLIP-seq
MIRT1101855	hsa-miR-4443	CLIP-seq
MIRT1101856	hsa-miR-4446-3p	CLIP-seq
MIRT1101857	hsa-miR-4452	CLIP-seq
MIRT1101858	hsa-miR-4492	CLIP-seq
MIRT1101859	hsa-miR-4498	CLIP-seq
MIRT1101860	hsa-miR-4520b-3p	CLIP-seq
MIRT1101861	hsa-miR-4656	CLIP-seq
MIRT1101862	hsa-miR-4663	CLIP-seq
MIRT1101863	hsa-miR-4667-5p	CLIP-seq
MIRT1101864	hsa-miR-4675	CLIP-seq
MIRT1101865	hsa-miR-4700-5p	CLIP-seq
MIRT1101866	hsa-miR-4721	CLIP-seq
MIRT1101867	hsa-miR-4726-3p	CLIP-seq
MIRT1101868	hsa-miR-4741	CLIP-seq
MIRT1101869	hsa-miR-484	CLIP-seq
MIRT1101870	hsa-miR-541	CLIP-seq
MIRT1101871	hsa-miR-615-5p	CLIP-seq
MIRT1101872	hsa-miR-637	CLIP-seq
MIRT1101873	hsa-miR-650	CLIP-seq
MIRT1101874	hsa-miR-654-5p	CLIP-seq
MIRT1101875	hsa-miR-760	CLIP-seq
MIRT1101876	hsa-miR-762	CLIP-seq
MIRT1101877	hsa-miR-764	CLIP-seq
MIRT1101823	hsa-miR-10a	CLIP-seq
MIRT1101824	hsa-miR-10b	CLIP-seq
MIRT1101825	hsa-miR-125a-3p	CLIP-seq
MIRT1101826	hsa-miR-153	CLIP-seq
MIRT1101827	hsa-miR-1587	CLIP-seq
MIRT1101828	hsa-miR-1825	CLIP-seq
MIRT1101829	hsa-miR-1915	CLIP-seq
MIRT1101830	hsa-miR-193a-5p	CLIP-seq
MIRT1101831	hsa-miR-196a	CLIP-seq
MIRT1101832	hsa-miR-196b	CLIP-seq
MIRT1101833	hsa-miR-1976	CLIP-seq
MIRT1101834	hsa-miR-2052	CLIP-seq
MIRT1101835	hsa-miR-219-2-3p	CLIP-seq
MIRT1101836	hsa-miR-2355-5p	CLIP-seq
MIRT1101837	hsa-miR-2964a-3p	CLIP-seq
MIRT1101838	hsa-miR-3135b	CLIP-seq
MIRT1101839	hsa-miR-3155	CLIP-seq
MIRT1101840	hsa-miR-3155b	CLIP-seq
MIRT1101841	hsa-miR-3158-3p	CLIP-seq
MIRT1101842	hsa-miR-3184	CLIP-seq
MIRT1101843	hsa-miR-3192	CLIP-seq
MIRT1101844	hsa-miR-326	CLIP-seq
MIRT1101845	hsa-miR-330-5p	CLIP-seq
MIRT1101846	hsa-miR-3612	CLIP-seq
MIRT1101847	hsa-miR-3613-3p	CLIP-seq
MIRT1101848	hsa-miR-3616-3p	CLIP-seq
MIRT1101849	hsa-miR-3622b-5p	CLIP-seq
MIRT1101850	hsa-miR-3667-3p	CLIP-seq
MIRT1101851	hsa-miR-3674	CLIP-seq
MIRT1101852	hsa-miR-3934	CLIP-seq
MIRT1101853	hsa-miR-423-5p	CLIP-seq
MIRT1101854	hsa-miR-4417	CLIP-seq
MIRT1101855	hsa-miR-4443	CLIP-seq
MIRT1101856	hsa-miR-4446-3p	CLIP-seq
MIRT1101857	hsa-miR-4452	CLIP-seq
MIRT1101858	hsa-miR-4492	CLIP-seq
MIRT1101859	hsa-miR-4498	CLIP-seq
MIRT1101860	hsa-miR-4520b-3p	CLIP-seq
MIRT1101861	hsa-miR-4656	CLIP-seq
MIRT1101862	hsa-miR-4663	CLIP-seq
MIRT1101863	hsa-miR-4667-5p	CLIP-seq
MIRT1101864	hsa-miR-4675	CLIP-seq
MIRT1101865	hsa-miR-4700-5p	CLIP-seq
MIRT1101866	hsa-miR-4721	CLIP-seq
MIRT1101867	hsa-miR-4726-3p	CLIP-seq
MIRT1101868	hsa-miR-4741	CLIP-seq
MIRT1101869	hsa-miR-484	CLIP-seq
MIRT1101870	hsa-miR-541	CLIP-seq
MIRT1101871	hsa-miR-615-5p	CLIP-seq
MIRT1101872	hsa-miR-637	CLIP-seq
MIRT1101873	hsa-miR-650	CLIP-seq
MIRT1101874	hsa-miR-654-5p	CLIP-seq
MIRT1101875	hsa-miR-760	CLIP-seq
MIRT1101876	hsa-miR-762	CLIP-seq
MIRT1101877	hsa-miR-764	CLIP-seq

Show/Hide all (26)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	10852826, 10954706, 11684708, 12577067, 14756564, 15671067, 15731013, 15846844, 16608857, 19188445, 20936779, 21149639, 21988832, 22038833, 22458338, 24940650, 25416956, 26769854, 30021884, 31515488, 32296183, 32814053, 36012204
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005737	Component	Cytoplasm	IDA	15846844, 19188445
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005882	Component	Intermediate filament	IDA	10852826
GO:0005882	Component	Intermediate filament	IEA
GO:0005911	Component	Cell-cell junction	IEA
GO:0016327	Component	Apicolateral plasma membrane	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0030018	Component	Z disc	IEA
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IEA
GO:0042383	Component	Sarcolemma	IEA
GO:0045095	Component	Keratin filament	IEA
GO:0045095	Component	Keratin filament	IPI	10852826
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0051707	Process	Response to other organism	IEA
GO:0060706	Process	Cell differentiation involved in embryonic placenta development	IEA
GO:0070062	Component	Extracellular exosome	HDA	19199708, 23533145
GO:0071944	Component	Cell periphery	IEA
GO:0097110	Function	Scaffold protein binding	IPI	10852826
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IEA
GO:0097284	Process	Hepatocyte apoptotic process	IEA

MIM	HGNC	e!Ensembl
148060	6446	ENSG00000170421

P05787

Protein name

Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)

Protein function

Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

PDB

7K3C , 7K3X , 7K3Y

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16208	Keratin_2_head	6 → 87	Keratin type II head	Family
PF00038	Filament	90 → 401	Intermediate filament protein	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. {ECO:0000269|PubMed:10

Sequence

MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGM
GGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLE
TKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYE
DEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQIS
DTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDL
RRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAAL
QRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYA
GGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDV
LPK

Sequence length

483

Interactions

View interactions

	Reactome
			Keratinization Formation of the cornified envelope

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cholangiocarcinoma	Benign	rs13098	RCV005935589
Cirrhosis, cryptogenic	Benign; Likely benign	rs11554495, rs57749775	RCV000015735 RCV000015737
Colon adenocarcinoma	Uncertain significance	rs199648626	RCV005911105
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	rs2539428475	RCV004557765
Familial cancer of breast	Uncertain significance	rs199648626	RCV005911104
Hepatitis C virus, susceptibility to	Benign; not provided; Likely benign; Uncertain significance	rs57749775, rs386834221, rs386834223, rs386834222, rs59536457	RCV000988859 RCV000049579 RCV000049580 RCV000049581 RCV000988858
Hepatocellular carcinoma	Benign	rs13098	RCV005935587
Inflammatory bowel disease	Benign; Likely benign	rs59536457	RCV001258260
KRT8-related disorder	Benign; Likely benign	rs1065306, rs13098, rs112222496, rs202170959, rs771819471, rs7750, rs61730606, rs58573614, rs58912304	RCV003975973 RCV003964492 RCV003903823 RCV003911874 RCV003969086 RCV003933251 RCV003910466 RCV003935000 RCV003925017
Uterine carcinosarcoma	Benign	rs13098	RCV005935588

Show/Hide Text Mining Associations (96)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
AA amyloidosis	Associate	32861330, 35637421
Adenocarcinoma	Associate	11923318, 15710986, 35328735
Adenocarcinoma of Lung	Associate	12192603, 2414994, 30634629, 32519739, 34323652, 36311801
Ameloblastoma	Associate	12013821
Ascites	Associate	8946143
Barrett Esophagus	Associate	35328735
Breast Neoplasms	Associate	14556659, 17605300, 19050795, 19845941, 21425134, 24489661, 25724181, 26769854, 29884220, 30732163, 8946143, 9786916
Cancer Pain	Associate	21425134
Cap Myopathy	Associate	26090004
Carcinoma	Associate	21960693
Carcinoma Embryonal	Associate	17993720
Carcinoma Hepatocellular	Associate	12717831, 18932288, 24914343, 30588199
Carcinoma Merkel Cell	Associate	31201352
Carcinoma Papillary	Stimulate	21076459
Carcinoma Renal Cell	Associate	16415791
Carcinoma Signet Ring Cell	Associate	23573317
Carcinoma Squamous Cell	Inhibit	1372155
Carcinoma Squamous Cell	Associate	16412231, 1717607, 19755983, 29427328, 7504888
Cardiomyopathy infantile histiocytoid	Associate	19843013
Central Nervous System Cysts	Associate	12296753
Chemical and Drug Induced Liver Injury	Associate	22246910, 26286715
Cholelithiasis	Associate	22246910
Chordoma	Associate	38282590
Cirrhosis Cryptogenic	Associate	12724528
Collagen Diseases	Associate	10193397
Colorectal Neoplasms	Associate	21219647, 24762493
Cystic Fibrosis	Associate	21548936
Death	Associate	18236071
Diabetes Mellitus	Inhibit	28403359
Diarrhea 5 With Tufting Enteropathy Congenital	Stimulate	38172172
Esophageal Squamous Cell Carcinoma	Associate	19755983
Exocrine Pancreatic Insufficiency	Associate	17039343
Fatty Liver Alcoholic	Associate	35637421
Fibrocartilaginous embolism	Associate	25561896
Fibrosis	Associate	17039343
Fistula	Associate	18626977
Flatfoot	Associate	35197508
Glioblastoma	Associate	34899682
Glucose Galactose Malabsorption	Associate	25633990
Granulosa Cell Tumor	Associate	26911253, 29401296
Helicobacter Infections	Inhibit	14711373
Hepatitis Autoimmune	Associate	11529922
Hepatitis B	Associate	19129556
Hepatitis C	Associate	24115814
Hepatitis C Chronic	Associate	11529922
Hepatitis Viral Human	Associate	18932288
Hyperkeratosis Epidermolytic	Associate	11788583
Idiopathic Pulmonary Fibrosis	Associate	10193397
Inflammatory Bowel Diseases	Associate	24915158
Insulin Resistance	Associate	28652657
Intervertebral Disc Degeneration	Inhibit	23801880, 24166186
Liver Diseases	Associate	11372009, 12724528, 32927888
Liver Failure	Associate	20538000
Liver Failure Acute	Associate	20538000, 26286715
Lung Neoplasms	Associate	26876307
Lymphatic Metastasis	Associate	25724181
Macular Degeneration	Associate	28045574
Melanoma	Associate	1378696
Metaplasia	Associate	17185354
Mixed Tumor Mullerian	Associate	8946143
Moyamoya Disease	Associate	40624255
Myositis	Associate	12707036
Nasopharyngeal Carcinoma	Associate	20124091
Necrosis	Associate	26769854
Neoplasm Metastasis	Associate	1378696, 27865045, 30634629
Neoplasms	Associate	11455036, 11923318, 12192603, 1378696, 1379783, 15710986, 15990899, 1689541, 1696538, 1717607, 1721491, 18803884, 19129556, 19643405, 21307656 View all (23 more)
Neoplasms Glandular and Epithelial	Associate	23264211
NOG Related Symphalangism Spectrum Disorder	Associate	1721491
Non alcoholic Fatty Liver Disease	Associate	28652657
Ovarian Neoplasms	Associate	7678716, 9266754
Pancreatic Neoplasms	Associate	1372155, 17039343, 21811100, 22335271, 33691026, 36522691
Pancreatitis	Associate	17039343, 36671463
Pancreatitis Chronic	Associate	17039343
Periapical Diseases	Associate	23264211
Primary Ovarian Insufficiency	Associate	29401296
Prostatic Hyperplasia	Associate	26090004
Prostatic Neoplasms	Associate	21960693, 29260398, 31328168, 32343676, 34973338, 37463569
Pulmonary Fibrosis	Associate	10193397
Rectal Neoplasms	Associate	33168793
Retinal Degeneration	Associate	28045574
Retinal Dysplasia	Associate	17039343
Sarcoma	Associate	1704194
Sick Sinus Syndrome	Associate	33580673
Skin Diseases	Associate	29427328
Spastic paraplegia 11 autosomal recessive	Associate	1689541
Squamous Cell Carcinoma of Head and Neck	Associate	16412231
Stomach Neoplasms	Associate	16101125
Stomach Neoplasms	Stimulate	27865045
Thyroid Carcinoma Anaplastic	Associate	29443941
Thyroid Neoplasms	Associate	35546566
Triple Negative Breast Neoplasms	Associate	25068292, 29884220
Uterine Cervical Dysplasia	Associate	15623485, 1690513
Uterine Cervical Neoplasms	Associate	1379783
Vitreoretinopathy Proliferative	Associate	32022439
Wieacker syndrome	Associate	27070589
Wilms Tumor	Associate	35578692

KRT8 (keratin 8)