Gene Gene information from NCBI Gene database.
Entrez ID 3841
Gene name Karyopherin subunit alpha 5
Gene symbol KPNA5
Synonyms (NCBI Gene)
IPOA6SRP6
Chromosome 6
Chromosome location 6q22.1
Summary The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can p
miRNA miRNA information provided by mirtarbase database.
380
miRTarBase ID miRNA Experiments Reference
MIRT026068 hsa-miR-196a-5p Sequencing 20371350
MIRT026470 hsa-miR-192-5p Microarray 19074876
MIRT032180 hsa-let-7d-5p Sequencing 20371350
MIRT710099 hsa-miR-5571-5p HITS-CLIP 19536157
MIRT710098 hsa-miR-412-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
18
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15057270, 19412186, 22022502, 22770219, 25416956, 26618866, 31515488, 32296183, 33961781, 35156780
GO:0005634 Component Nucleus IBA
GO:0005654 Component Nucleoplasm IBA
GO:0005654 Component Nucleoplasm NAS 20818336
GO:0005654 Component Nucleoplasm TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604545 6398 ENSG00000196911
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15131
Protein name Importin subunit alpha-6 (Karyopherin subunit alpha-5)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore
PDB 4U2X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 10 102 Importin beta binding domain Family
PF00514 Arm 112 154 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 158 196 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 198 239 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 249 281 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 283 323 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 325 365 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 367 407 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 410 450 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 464 520 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Testis.
Sequence
Sequence length 536
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport
Influenza A
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways