Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3841
Gene name Gene Name - the full gene name approved by the HGNC.
Karyopherin subunit alpha 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KPNA5
Synonyms (NCBI Gene) Gene synonyms aliases
IPOA6, SRP6
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q22.1
Summary Summary of gene provided in NCBI Entrez Gene.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can p
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026068 hsa-miR-196a-5p Sequencing 20371350
MIRT026470 hsa-miR-192-5p Microarray 19074876
MIRT032180 hsa-let-7d-5p Sequencing 20371350
MIRT710099 hsa-miR-5571-5p HITS-CLIP 19536157
MIRT710098 hsa-miR-412-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 15057270, 19412186, 22022502, 22770219, 25416956, 31515488
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm IBA 21873635
GO:0005654 Component Nucleoplasm TAS
GO:0005829 Component Cytosol IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604545 6398 ENSG00000196911
Protein
UniProt ID O15131
Protein name Importin subunit alpha-6 (Karyopherin subunit alpha-5)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore
PDB 4U2X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 10 102 Importin beta binding domain Family
PF00514 Arm 112 154 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 158 196 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 198 239 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 249 281 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 283 323 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 325 365 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 367 407 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 410 450 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 464 520 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Testis.
Sequence
Sequence length 536
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleocytoplasmic transport
Influenza A
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 22302350