Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
3840
Gene name Gene Name - the full gene name approved by the HGNC.
Karyopherin subunit alpha 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KPNA4
Synonyms (NCBI Gene) Gene synonyms aliases
IPOA3, QIP1, SRP3
Chromosome Chromosome number
3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
3q25.33
Summary Summary of gene provided in NCBI Entrez Gene.
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019944 hsa-miR-375 Microarray 20215506
MIRT028598 hsa-miR-30a-5p Proteomics 18668040
MIRT522804 hsa-miR-148a-3p HITS-CLIP 21572407
MIRT522803 hsa-miR-148b-3p HITS-CLIP 21572407
MIRT522802 hsa-miR-152-3p HITS-CLIP 21572407
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 9168958, 10523667, 20554775, 20701745, 20818336, 25416956, 25599645, 26382858, 26496610, 26571498, 29370303, 32296183, 32911434, 32960270, 33060197
GO:0005634 Component Nucleus IBA 21873635
GO:0005654 Component Nucleoplasm IBA 21873635
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
602970 6397 ENSG00000186432
Protein
UniProt ID O00629
Protein name Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple
PDB 4UAE , 5TBK , 5XZX , 6BVV , 6BVZ , 6BW9 , 6BWA , 6BWB , 6WX8 , 7JJL , 7LF4 , 7LFC , 7RFY , 7RG5 , 8FUB , 8FZM , 8HKW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 11 93 Importin beta binding domain Family
PF00514 Arm 103 144 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 146 186 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 188 229 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 232 271 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 273 313 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 315 355 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 357 397 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 400 440 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 447 499 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9395085}.
Sequence
Sequence length 521
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Nucleocytoplasmic transport
Salmonella infection
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Bipolar Disorder Bipolar Disorder GWAS
Prostate cancer Prostate cancer Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population. GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 24866763
Carcinoma Hepatocellular Associate 33535183
Carcinoma Non Small Cell Lung Associate 36573325, 37455373, 37511221
Dental Caries Associate 24556642
Fever Associate 33537819
Osteosarcoma Associate 33537823, 34930332
Squamous Cell Carcinoma of Head and Neck Associate 31822798
Stomach Neoplasms Associate 33537819