Gene Gene information from NCBI Gene database.
Entrez ID 3840
Gene name Karyopherin subunit alpha 4
Gene symbol KPNA4
Synonyms (NCBI Gene)
IPOA3QIP1SRP3
Chromosome 3
Chromosome location 3q25.33
Summary The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore
miRNA miRNA information provided by mirtarbase database.
1492
miRTarBase ID miRNA Experiments Reference
MIRT019944 hsa-miR-375 Microarray 20215506
MIRT028598 hsa-miR-30a-5p Proteomics 18668040
MIRT522804 hsa-miR-148a-3p HITS-CLIP 21572407
MIRT522803 hsa-miR-148b-3p HITS-CLIP 21572407
MIRT522802 hsa-miR-152-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
34
GO ID Ontology Definition Evidence Reference
GO:0001673 Component Male germ cell nucleus IEA
GO:0005515 Function Protein binding IPI 9168958, 10523667, 17314511, 20554775, 20701745, 20818336, 25416956, 25599645, 26382858, 26496610, 26571498, 29370303, 32296183, 32911434, 32960270, 33060197, 33961781, 35044719, 35271311, 37219487, 39009827, 39251607
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IEA
GO:0005643 Component Nuclear pore IDA 10100610
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602970 6397 ENSG00000186432
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00629
Protein name Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)
Protein function Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple
PDB 4UAE , 5TBK , 5XZX , 6BVV , 6BVZ , 6BW9 , 6BWA , 6BWB , 6WX8 , 7JJL , 7LF4 , 7LFC , 7RFY , 7RG5 , 8FUB , 8FZM , 8HKW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01749 IBB 11 93 Importin beta binding domain Family
PF00514 Arm 103 144 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 146 186 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 188 229 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 232 271 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 273 313 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 315 355 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 357 397 Armadillo/beta-catenin-like repeat Repeat
PF00514 Arm 400 440 Armadillo/beta-catenin-like repeat Repeat
PF16186 Arm_3 447 499 Atypical Arm repeat Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9395085}.
Sequence
Sequence length 521
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport
Salmonella infection
Chemical carcinogenesis - receptor activation
  ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
5
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Likely benign rs1421471586 RCV005929776
Cholangiocarcinoma Likely benign rs1421471586 RCV005929779
Gastric cancer Likely benign rs1421471586 RCV005929778
Lung cancer Likely benign rs1421471586 RCV005929780
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 24866763
Carcinoma Hepatocellular Associate 33535183
Carcinoma Non Small Cell Lung Associate 36573325, 37455373, 37511221
Dental Caries Associate 24556642
Fever Associate 33537819
Osteosarcoma Associate 33537823, 34930332
Squamous Cell Carcinoma of Head and Neck Associate 31822798
Stomach Neoplasms Associate 33537819