Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
3840
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Karyopherin subunit alpha 4 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
KPNA4 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
IPOA3, QIP1, SRP3 |
Chromosome
Chromosome number
|
3 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
3q25.33 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore |
UniProt ID |
O00629
|
Protein name |
Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4) |
Protein function |
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:10567565, PubMed:20818336, PubMed:28760339, PubMed:29042532, PubMed:38512451). Binds specifically and directly to substrates containing either a simple |
PDB |
4UAE
,
5TBK
,
5XZX
,
6BVV
,
6BVZ
,
6BW9
,
6BWA
,
6BWB
,
6WX8
,
7JJL
,
7LF4
,
7LFC
,
7RFY
,
7RG5
,
8FUB
,
8FZM
,
8HKW
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF01749
|
IBB |
11 → 93 |
Importin beta binding domain |
Family |
PF00514
|
Arm |
103 → 144 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514
|
Arm |
146 → 186 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514
|
Arm |
188 → 229 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514
|
Arm |
232 → 271 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514
|
Arm |
273 → 313 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514
|
Arm |
315 → 355 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514
|
Arm |
357 → 397 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF00514
|
Arm |
400 → 440 |
Armadillo/beta-catenin-like repeat |
Repeat |
PF16186
|
Arm_3 |
447 → 499 |
Atypical Arm repeat |
Family |
|
Tissue specificity |
TISSUE SPECIFICITY: Highly expressed in testis, ovary, small intestine, heart, skeletal muscle, lung and pancreas, but barely detectable in kidney, thymus, colon and peripheral blood leukocytes. {ECO:0000269|PubMed:9395085}. |
Sequence |
|
Sequence length |
521 |
Interactions |
View interactions
|